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| 1 | Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus–Di?erences in Etiology, Epidemiology and Prevention显示文摘In Germany, esophageal carcinoma is one of the ten most frequent causes of death. Normally the disease is found in men over the age of 50. Although squamous cell carcinoma (SCC) of the esophagus has been more commonly diagnosed over the past 30 years, there is increasing incidence of esophageal adenocarcinoma (AC) in Western industrialized countries. For SCC the known etiological risk factors are nicotine and alcohol abuse. For AC, they are moderate nicotine and alcohol consumption as well as gastro-esophageal re?ux and obesity. | Elfriede Bollschweiler Eva Wolfgarten | 2004 | The Chinese-German Journal of Clinical Oncology2004，3，4： | 8 |
| 2 | Cytochrome P450 levels are altered in patients with esophageal squamous-cell carcinoma显示文摘AIM: To investigate the role of cytochrome P450 (CYP) in the carcinogenesis of squamous-cell carcinoma (SCC) in human esophagus by determining expression patterns and protein levels of representative CYPs in esophageal tissue of patients with SCC and controls. METHODS: mRNA expression of CYP2E1, CYP2C, CYP3A4, and CYP3A5 was determined using RT-PCR in both normal and malignant esophageal tissues of patients with untreated esophageal SCC (n = 21) and in controls (n = 10). Protein levels of CYP2E1, CYP2C8, CYP3A4, and CYP3A5 were measured by Western blot. RESULTS: Within the group of SCC patients, mRNA expression of CYP 3A4 and CYP2C was significantly lower in malignant tissue (-39% and -74%, respectively, P < 0.05) than in normal tissue. Similar results were found in CYP3A4 protein levels. Between groups, CYP3A4, CYP3A5, and CYP2C8 protein concentration was significantly higher in non-malignant tissue of SCC patients (4.8-, 2.9-, and 1.9-fold elevation, P < 0.05) than in controls. In contrast, CYP2E1 protein levels were significantly higher in controls than in SCC patients (+46%, P < 0.05). CONCLUSION: Significant differences exist in protein levels of certain CYPs in non-malignant esophageal tissue (e.g. CYP2C8, CYP3A4, CYP3A5, and CYP2E1) between SCC patients and healthy subjects and may contribute to the development of SCC in the esophagus. | I Bergheim E Wolfgarten E Bollschweiler AH Hlscher C Bode A Parlesak | 2007 | World Journal of Gastroenterology2007，13，7： | 6 |
| 3 | Demographic var- iations in the rising incidence of esophageal adenocarcinoma in white males显示文摘 | Bollschweiler E Wolfgarten E Gutschow C | 2001 | Cancer2001，92，3： | 1 |
| 4 | Demographic variations in the rising incidence of esophageal adenocarcinoma in white males显示文摘 | Bollscweiler E Wolfgarten E Gutschow C | 2001 | Cancer2001，92，3： | 1 |
| 5 | Duodeno-gastric-esopha geal reflux-what is pathologic Comparison of patients with Barrett's esophagus and agematched volunteers显示文摘 | Wolfgarten E Putz B Heelscher AH | 2007 | J Gastrointest Surg2007，11，4： | 1 |
| 6 | Demographic variations in the rising incidence of esophageal adenocarcinoma in white males显示文摘 | Bollschweiler E Wolfgarten E Gutschow C st al | 2001 | Cancer2001，92，3： | 1 |
| 7 | Prevalence of reflux symptoms in the general population of Cologne显示文摘 | Bollschweiler E Knoppe K Wolfgarten E | 2007 | Z Gastroenterol2007，45，2： | 1 |
| 8 | Domographic variations in the rising incidence of esophageal adenocarcinomo in white males显示文摘 | Bollschweiler E Wolfgarten E Gutschow C | 2001 | Cancer2001，92，3： | 1 |
| 9 | Vitamin intake and risk of subtypes of esophageal cancer in Germany显示文摘 | Bollschweiler E Wolfgarten E Nowroth T | 2002 | J Cancer Res Clin Oncol2002，128，10： | 1 |
| 10 | Duodeno-gas ric-esophageal reflux--what is pathologic?Comparison of patients with Barrett's esophagus and age-matched volunteers显示文摘 | Wolfgarten E Putz B Holscher AH | 2007 | J Gastrointest Surg2007，11，4： | 1 |
| 11 | Demographic variations in the rising incidence of esophageal adenocarcinoma in white males显示文摘 | Bollschweiler E Wolfgarten E Gutschow C | 2001 | Cancer2001，92，3： | 1 |
| 12 | Vitamin intake and risk of subtypes of esophageal cancer in Germany 显示文摘 | Bollschweiler E Wolfgarten E Nowroth T | 2002 | J Cancer Res Clin Oncol2002，128，10： | 1 |
| 13 | Bile re-flux into the stomach and the esophagus for voluteers older than 40years显示文摘 | BOLLSCHWEILER E WOLFGARTEN E PUTZ B | 2005 | Digestion2005，71，： | 1 |
| 14 | Detection of lymphovascular invasion in vulvar cancer by D2-40 (podoplanin) as a predictor for inguinal lymph node metastases显示文摘 | Braun M Wardelmann E Debald M Walgenbach-Bruenagel G H(o)ller T Wolfgarten M | | 0，，： | 1 |
| 15 | Cervical anastomotic stenosis after gastric tube reconstruction in esophageal carcinoma Evaluation of a patient sample 1989-1995 显示文摘 | Bruns C J Gawenda M Wolfgarten B | 1997 | Langenbecks Arch Chir1997，382，3： | 1 |
| 16 | Vitamin intake and risk of subtypes of esophageal cancer in Germany显示文摘 | Elfriede Bollschweiler Eva Wolfgarten Thomas Nowroth Ursula Rosendahl Stefan P. M?nig Arnulf H. H?lscher | 2002 | Journal of Cancer Research and Clinical Oncology2002，，10： | 1 |
| 17 | Bile reflux into the stomach and the esophagus for voluteers older than 40 years显示文摘 | BOLLSCHWEILER E WOLFGARTEN E PUTZ B | 2005 | Digestion2005，71，： | 1 |
| 18 | Bile reflux into the stomach and the esophagus for volunteers older than 40 years 显示文摘 | Bollschweiler E Wolfgarten E Pntz B | 2005 | Digestion2005，71，3： | 1 |
| 19 | Duodenogastric esophageal reflux - what is pathologic Comparison of patients with Barretts e- sophagus and age - matched volunteers 显示文摘 | Wolfgarten E P tz B Hlscher AH | 2007 | J Gastro intest Surg2007，11，4： | 1 |
| 20 | Duodenogastric esophageal reflux-what is pathologic Comparison of patients with Barretts esophagus and age-matched volunters显示文摘 | Wolfgarten E Ptz B Hlscher AH | 2007 | J Gastro intest Surg2007，11，4： | 1 |
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