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		题名	作者	年代	出处	被引量
	1	Attenuation of oxidative stress-induced neuronal cell death by Hydnophytum formicar-um Jack.显示文摘Objective: To investigate protective effects of Hydnophytum formicarum Jack.(H. formicarum) extracts via regulation of SIRT1-FOXO3a-ADAM10 signaling and antioxidant activity against H_2O_2-induced neurotoxicity in neuroblastoma SH-SY5Y cells. Methods: Cell viability and apoptosis of neuronal cells pretreated with H. formicarum Jack. extracts under oxidative stress were determined by MTT assay and flow cytometry. The intracellular reactive oxygen species(ROS) was performed using Carboxy-DCFDA assay. Additionally, a profile of protein expressions related to neuroprotection was detected by western blot analysis. Results: The plant extracts(methanol and ethyl acetate) elicited protective effects on the neuronal cell death as performed by the MTT assay and by apoptosis analysis via the activation of BCL-2. Both ethyl acetate and methanol extracts exerted inhibitory effects against H_2O_2-induced ROS generation in the SH-SY5Y cells. Furthermore, the possible mechanism of neuroprotection of H. formicarum Jack. was observed through its antioxidant properties by maintaining the levels of catalase and SOD2 proteins as well as activating SIRT1-FOXO3a pathway. Importantly, pretreatment of neuronal cells with H. formicarum Jack. significantly recovered the levels of ADAM10 protein compared with the H_2O_2 treatment alone. Conclusions: The recent findings suggest the protective effects of H. formicarum Jack. plant extracts on attenuating H_2O_2-induced neurotoxicity in human SH-SY5Y cells.	Naw Hser Gay Kamonrat Phopin Wilasinee Suwanjang Waralee Ruankham Prapimpun Wongchitrat Supaluk Prachayasittikul Virapong Prachayasittikul	2018	Asian Pacific Journal of Tropical Medicine2018，11，7：	1
	2	Endogenous rhythmicity of Bmal1 and Rev-erb alpha in the hamster pineal gland is not driven by norepi-nephrine显示文摘	Wongchitrat P Felder-Schmittbuhl M P Phansuwan-Pujito P Pévet P Simonneaux V	2009	Eur J Neurosci2009，29，：	1
	3	The ex-pression of Perl and Aa-nat genes in the pineal gland of postna-tal rats 显示文摘	Wongchitrat P Govitrapong P Phansuwan- Pujito P	2012	J Med Assoc Thai2012，95，12：	1
	4	Lymphopla-snmcytic lymphoma with IgA hyperganunaglobulinemia and liver involvement显示文摘	Polprasert C Wongchitrat C Assanasen T		0，，3：	1

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