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| 1 | Hepatitis B virus infection, diabetes mellitus, and their synergism for cholangiocarcinoma development: A casecontrol study in Korea显示文摘AIM: To identify possible risk factors and their synergism for cholangiocarcinoma development.METHODS: A hospital-based, case-control study in which we included 276 cholangiocarcinoma patients [193 extrahepatic cholangiocarcinoma(ECC) and 83 intrahepatic cholangiocarcinoma(ICC)], diagnosed at a training hospital in Korea between 2007 and 2013, and 552 healthy controls matched 2:1 for age, sex, and date of diagnosis. Risk factors for cholangiocarcinoma and possible synergism between those factors were evaluated using conditional logistic regression and synergism index, respectively.RESULTS:There was an association between cholangiocarcinoma and hepatitis B virus(HBV) infection, diabetes mellitus(DM), cholecystolithiasis, choledocholithiasis, and hepatolithiasis, with the adjusted odds ratios(AORs) of 4.1, 2.6, 1.7, 12.4, and 39.9, respectively. Synergistic interaction on the additive model was investigated between HBV infection and DM(AOR = 12.2; 95%CI: 1.9-80.1). In the subgroup analyses, cholecystolithiasis, choledocholithiasis, hepatolithiasis, and DM were significant risk factors for ECC(AOR = 2.0, 18.1, 14.9, and 2.0, respectively), whereas choledocholithiasis, hepatolithiasis, HBV infection, and DM were risk factors for ICC(AOR = 8.6, 157.4, 5.3 and 4.9, respectively). Synergistic interaction was also observed between HBV infection and DM(OR = 22.7; 95%CI: 2.4-214.1). However, there was no synergistic interaction between other significant risk factors for cholangiocarcinoma.CONCLUSION: In this Korean study, HBV infection and DM were found to exert independent and synergistic effects on the risk for cholangiocarcinoma, including ICC. Exploring the underlying mechanismsfor such synergy may lead to the development of cholangiocarcinoma prevention strategies in high-risk individuals. | Ban Seok Lee Eun-Cheol Park Seung Woo Park Chung Mo Nam Jaehoon Roh | 2015 | World Journal of Gastroenterology2015，21，2： | 13 |
| 2 | Multiplanar reformations and minimum intensity projections using multi-detector row CT for assessing anomalies and disorders of the pancreaticobiliary tree显示文摘CT scan is regarded as the imaging modality of choice in patients with pancreaticobiliary ductal abnormalities. However, the axial orientation of the CT images provides only limited anatomical view of pancreaticobiliary ductal abnormalities. The technological advances of multi-de-tector row CT and three-dimensional image processing in workstations allows rapid image acquisition and a short postprocessing time. In particular, multiplanar reforma-tions (MPR) and minimum intensity projections (MinIP) offer rapid and accurate images of the anatomy and ab-normalities of the pancreaticobiliary tree. Moreover, MPR and MinIP help determine the relationship between the pancreaticobiliary ductal anatomy and the surrounding structures. This pictorial review illustrates the wide spec-trum of images obtained by the MPR and MinIP of the anomalies and disorders of the pancreaticobiliary tree. | Hyun Cheol Kim Dal Mo Yang Wook Jin Chang Woo Ryu Jung Kyu Ryu Sung Il Park Seong Jin Park Hyeong Cheol Shin Il Young Kim | 2007 | World Journal of Gastroenterology2007，13，31： | 10 |
| 3 | Association between acute pancreatitis and peptic ulcer disease显示文摘AIM:To evaluate the relationship between peptic ulcer disease(PUD) and acute pancreatitis.METHODS:A cohort of 78 patients with acute pancreatitis were included in this study.The presence of PUD and the Helicobacter pylori(H.pylori) status were assessed by an endoscopic method.The severity of acute pancreatitis was assessed using Ranson's score,the Acute Physiology and Chronic Health Evaluation(APACHE) □ score,computed tomography severity indexand the clinical data during hospitalization,all of which were compared between the patients with and without PUD.The risk factors for PUD were also evaluated.RESULTS:Among 78 patients,41 patients(52.6%) with acute pancreatitis suffered from PUD,but only 13(31.7%) patients with PUD were infected by H.pylori.On univariate analysis,male gender,an etiology of alcohol-induced pancreatitis,a history of smoking or alcohol consumption,elevated triglyceride and C-reactive protein levels,and high APACHE □ score were signif icantly associated with PUD.However,on multivariate logistic regressionanalysis,the APACHE □ score(odds ratio:7.69;95% conf idence interval:1.78-33.33;P < 0.01) was found to be the only independent risk factor for PUD.CONCLUSION:Patients with acute pancreatitis are liable to suffer from PUD.PUD is associated with severeacute pancreatitis according to the APACHE □ score,and treatment for PUD should be considered for patients with severe acute pancreatitis. | Kang-Moon Lee Chang-Nyol Paik Woo Chul Chung Jin Mo Yang | 2011 | World Journal of Gastroenterology2011，17，8： | 5 |
| 4 | Short-term overlap lamivudine treatment with adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B显示文摘AIM:To evaluate the efficacy of short-term overlap lamivudine therapy with adefovir in patients with lamivudine-resistant and nave chronic hepatitis B,we compared patients receiving overlap therapy with those receiving adefovir alone. METHODS:Eighty patients who had received lamivudine treatment for various periods and had a lamivudine- resistant liver function abnormality were enrolled.Forty of these patients received adefovir treatment combined with lamivudine treatment for≥2 mo,while the other 40 received adefovir alone.We assessed the levels of hepatitis B virus(HBV)DNA at 0,12 and 48 wk and serum alanine aminotransferase(ALT)levels after 0,12, 24 and 48 wk of adefovir treatment in each group. RESULTS:We found serum ALT became normalized in 72(87.5%)of the 80 patients,and HBV DNA decreased by≥2 log10 copies/mL in 60(75%)of the 80 patients at the end of a 48-wk treatment.HBV DNA levels were not significantly different between the groups.The improvements in serum ALT were also not significantly different between the two groups. CONCLUSION:These findings suggest short-term overlap lamivudine treatment results in no better virological and biological outcomes than non-overlap adefovir monotherapy. | Soon Woo Nam Si Hyun Bae Seung Woo Lee Yeon Soo Kim Sang Bum Kang Jong Young Choi Se Hyun Cho Seung Kew Yoon Joon-Yeol Han Jin Mo Yang Young Suk Lee | 2008 | World Journal of Gastroenterology2008，14，11： | 3 |
| 5 | Saeng-Kankunbi-Tang(生肝健脾汤) Protects Liver against Oxidative Damage through Activation of ERK/Nrf2 Pathway显示文摘Objective: To investigate the cytoprotective effects of Saeng-kankunbi-tang(生肝健脾汤, SKT), a herbal prescription consisting of Artemisia capillaris and Alisma canaliculatum, and its underlying mechanism involved. Methods: In mice, blood biochemistry and histopathology were assessed in carbon tetrachloride(CCl4)-induced oxidative hepatic injury in vivo. The animal groups included vehicle-treated control, CCl4, SKT 500 mg/(kg·day) CCl4+SKT 200 or 500 mg/(kg·day). In Hep G2 cell, tert-butyl hydroperoxide(t BHP) induced severe oxidative stress and mitochondrial dysfunction in vitro. The cyto-protective effects of SKT were determined by 3-(4,5-dimethylthiazol)-2,5-diphenyltetrazolium bromide(MTT) assay, fluorescence activated cell sorting analysis and western blotting. Results: The administration of SKT prevented liver damage induced by CCl4 in mice, by inhibition of hepatocyte degeneration and inflammatory cell infiltration as well as plasma parameters such as alanine aminotransferase(P<0.01). Moreover, treatment with t BHP induced hepatocyte death and cellular reactive oxygen species production in hepatocyte cell line. However, SKT pretreatment(30–300 μg/m L) reduced this cell death and oxidative stress(P<0.01). More importantly, SKT inhibited the ability of t BHP to induce changes in mitochondrial membrane transition in cell stained with rhodamine 123(P<0.01). Furthermore, treatment with SKT induced extracellular signal-regulated kinases-mediated nuclear factor erythroid-2-related factor 2(Nrf2) activation as well as the expressions of heme oxygenase 1 and glutamate-cystein ligase catalytic, Nrf2 target genes. Conclusion: SKT has the ability to protect hepatocyte against oxidative stress and mitochondrial damage mediated by Nrf2 activation. | In Woo Lee Hee Yoon Choi Ju-Hee Lee Sun-Dong Park Seung Mo Kim Sae Kwang Ku 赵容杰 Sang Chan Kim Young Woo Kim Hong Sik Choi | 2016 | Chinese Journal of Integrative Medicine2016，22，8： | 3 |
| 6 | Colonic lymphangiomatosis associated with anemia显示文摘Lymphangioma is an uncommon malformation of lymphatic system. Multiple colonic lymphangioma named as lymphangiomatosis is considered an extremely rare disease. Although lymphangioma is a benign tumor and most colonic lymphangiomas do not cause symptoms and do not require treatment, resection of lymphangioma is necessary in the presence of symptoms such as abdominal pain, bleeding, intussusceptions. We report a case of colonic lymphangiomatosis in a man who presented with abdominal discomfort and anemia, which was diagnosed and treated with endoscopic snare polypectomy. | Woo Chul Chung Hye-Kang Kim Jin Young Yoo Jeong Rok Lee Kang-Moon Lee Chang Nyol Paik U-Im Jang Jin Mo Yang | 2008 | World Journal of Gastroenterology2008，14，37： | 2 |
| 7 | Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives显示文摘β-Arrestins are a small family of proteins important for signal transduction at G protein-coupled receptors (GPCRs).β-Arrestins are involved in the desensitization of GPCRs. Recently, biased ligands possessing different ef?cacies in activating the G protein- versus the β-arrestin-dependent signals downstream of a single GPCR have emerged, which can be used to selectively modulate GPCR signal transduction in such a way that desirable signals are enhanced to produce therapeutic effects while undesirable signals of the same GPCR are suppressed to avoid side effects. In the present study, we evaluated agonist bias for compounds developed along a drug discovery project of β2-adrenoceptor agonists. About 150 compounds, including derivatives of fenoterol, 2-amino-1-phenylethanol and 2-amino-2-phenylethanol, were obtained or synthesized, and initially screened for their β-adrenoceptor-mediated activities in the guinea pig tracheal smooth muscle relaxation assay or the cardiomyocyte contractility assay. Nineteen bioactive compounds were further assessed using both the HTRF cAMP assay and the PathHunter β-arrestin assay. Their concentration-response data in stimulating cAMP synthesis and β-arrestin recruitment were applied to the Black–Leff operational model for ligand bias quantitation. As a result, three compounds (L-2, L-4, and L-12) with the core structure of 5-(1-amino-2-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one were identi?ed as a new series of β-arrestin-biased β2-adrenoceptor agonists, whereas salmeterol was found to be Gs-biased. These findings would facilitate the development of novel drugs for the treatment of both heart failure and asthma. | Yiu-Ho Woo Xin-yue Ge Li Pan Gang Xing Yong-mei Mo Rui-juan Xing Xiao-ran Li Yu-yang Zhang Irving W. Wainer Mao-sheng Cheng Rui-ping Xiao | 2019 | Acta Pharmacologica Sinica2019，40，8： | 2 |
| 8 | Human Papilloma virus L1 Capsid Protein and Human Papilloma virus Type 16 as Prognostic Markers in Cervical Intraepithelial Neoplasia 1显示文摘 | Young Sam Choi Woo Dae Kang Seok Mo Kim | | 0，，： | 1 |
| 9 | Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population显示文摘 | Yong-Ho Lee Eun Seok Kang So Hun Kim Seung Jin Han Chul Hoon Kim Hyeong Jin Kim Chul Woo Ahn Bong Soo Cha Moonsuk Nam Chung Mo Nam Hyun Chul Lee | 2008 | Journal of Human Genetics (-)2008，，11： | 1 |
| 10 | Absence of p15 INK4B and p16 INK4A Gene Alterations in Primary Cervical Carcinoma Tissues and Cell Lines with Human Papillomavirus Infection显示文摘 | Jin Woo Kim Sung Eun Namkoong Soon Won Ryu Ho Shik Kim Jin Woong Shin Joon Mo Lee Dae Hoon Kim In Kyung Kim | 1998 | Gynecologic Oncology1998，，1： | 1 |
| 11 | Aquaporln 1 Is Overexpressed in Lung Cancer and Stimulates NIH-3T3 Cell Proliferation and Anchorage-Independent Growth显示文摘 | Hoque MO Sofia JC Woo J | 2006 | Amer J Pathol2006，168，4： | 1 |
| 12 | Aquaporin 1is overex-pressed in lung cancer and stimulates NiH-3T3cell proliarationand andrage independent grouth显示文摘 | Hoqul MO Soria JC Woo J | 2006 | Am J Pathal2006，168，4： | 1 |
| 13 | Aquapofin 1 Is Overexpressed in Lung Cancer and Stimulates NIH-3T3 Cell Proliferation and Anchorage-Independent Growth显示文摘 | Hoque MO Sofia JC Woo J | 2006 | Am J Pathol2006，168，4： | 1 |
| 14 | Quantitative Analysis for Breast Density Estimation in Low Dose Chest CT Scans 显示文摘 | Woo Kyung Moon Chung-Ming Lo Jin Mo Goo | 2014 | J Ned Syst2014，38，： | 1 |
| 15 | Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3 T3 cell proliferation and anchorage-independent growth显示文摘 | Hoque MO Soria JC Woo J | 2006 | Am J Pathol2006，168，4： | 1 |
| 16 | Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 ceU proliferation and anchorage- independent growth显示文摘 | Hoque MO Soria JC Woo J | 2006 | Am J Pathol2006，168，4： | 1 |
| 17 | Formation of interfacial brittle phases sigma phase and IMC in hybrid titanium-to-stainless steel joint显示文摘The microstructures of the brazed joints for commercially pure Ti and stainless steel were investigated by the applications of various filler alloys including Ag-, Ti-, Zr- and Ni-based alloys. Generally, the dissimilar joints between Ti and stainless steel were dominated by the Ti-based intermetallic compounds (IMCs), e.g. (Ti, Zr)2(Fe, Ni), TiFe, TiCu, and Ti2(Fe, Ni), due to a significant dissolution of Ti from the base metal. The (Fe-Cr) σ phase was also observed near the stainless steel due to a segregation of Cr into the interface region. This research demonstrates empirically that the brittleness of the Ti and stainless steel joint can not be avoided only by applying single braze alloy or single insert metal, and thus an introduction of additional suitable interlayer between the filler alloy and the base metal is necessary to prevent the brittleness of the joint. | Min Ku LEE Jung Gu LEE Jong Keuk LEE Sung Mo HONG Sang Hoon LEE Jin Ju PARK Jae Woo KIM Chang Kyu RHEE | 2011 | Transactions of Nonferrous Metals Society of China2011，21，A01： | 1 |
| 18 | Aquaporin 1 is overex- pressed in lung cancer and stimulates NIH-3T3 cell pro- liferation and anchorage-independent growth 显示文摘 | Hoque MO Soria JC Woo J | 2006 | Am J Pathol2006，168，4： | 1 |
| 19 | Human Papillomavirus L1 Capsid Protein and Human Papillomavirus Type 16 as Prognostic Markers in Cervical Intraepithelial Neoplasia 1显示文摘 | Young Sam Choi Woo Dae Kang Seok Mo Kim Yoo Duk Choi Jong Hee Nam Chang Soo Park Ho Sun Choi | 2010 | International Journal of Gynecological Cancer2010，，2： | 1 |
| 20 | The study of seepage forees acting on the tunnel lining and tunnel face in shallow tunnels 显示文摘 | In- Mo Lee Seok - woo N am | 2001 | Tunnelling and Underground Space Technology2001，16，： | 1 |
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