|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Comparison of RECIST version 1.0 and 1.1 in assessment of tumor response by computed tomography in advanced gastric cancer显示文摘Objective:Response Evaluation Criteria in Solid Tumors(RECIST)guideline version 1.0(RECIST 1.0)was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure.With a number of issues being raised on RECIST 1.0,however,a revised RECIST guideline version 1.1(RECIST 1.1)was proposed by the RECIST Working Group in 2009.This study was conducted to compare CT tumor response based on RECIST 1.1 vs.RECIST 1.0 in patients with advanced gastric cancer(AGC).Methods:We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010.These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using theκstatistic.Results:The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0(P<0.0001).However,there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0(κ=0.844).The overall response rates(ORRs)according to RECIST1.0 and RECIST 1.1 were 32.7%(20/61)and 34.5%(20/58),respectively.One patient with partial response(PR)based on RECIST 1.0 was reclassified as stable disease(SD)by RECIST 1.1.Of two patients with SD by RECIST 1.0,one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1.Conclusions:RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC. | Gil-Su Jang Min-Jeong Kim Hong-Il Ha Jung Han Kim Hyeong Su Kim Sung Bae Ju Dae Young Zang | 2013 | Chinese Journal of Cancer Research2013，25，6： | 42 |
| 2 | Prognostic factors in patients with node-negative gastric carcinoma:A comparison with node-positive gastric carcinoma显示文摘瞄准:识别淋巴的 clinicopathological 特征节点否定的胃的癌,并且另外在淋巴评估结果指示物节点否定的病人。方法:2848 个胃的癌病人,(53.5%) 1524 是淋巴节点否定。统计分析用艇长模型被执行估计结果指示物。结果:在在节点否定的淋巴和淋巴之间的再发率有有效差量节点积极的病人(14.4% 对 41.0% , P<0.001 ) 。5 年的幸存率在比在淋巴节点积极的淋巴是显著地更低的节点否定的病人(31.1% 对 77.4% , P<0.001 ) 。Univariate 分析表明下列因素影响了 5 年的幸存率:耐心的年龄,肿瘤尺寸,侵略的深度,肿瘤地点,起作用的类型,和在起始的诊断的肿瘤舞台。比例的危险回归建模的艇长表明那种肿瘤尺寸, serosal 侵略,和治愈可能性是独立的,淋巴的统计上重要的、预示的指示物节点否定的胃的癌。结论:淋巴节点否定的病人与相对大的肿瘤和 serosal 侵略让对高治愈可能性,而是病人可归因的有利结果有差的预后。治愈可能性是为淋巴的长期的幸存的最可靠的预言者之一节点否定的胃的癌病人。 | Dong Yi Kim Kyeung Won Seo Jae Kyoon Joo Young Kyu Park Seong Yeob Ryu Hyeong Rok Kim Young Jin Kim Shin Kon Kim | 2006 | World Journal of Gastroenterology2006，12，8： | 20 |
| 3 | Overexpression of Arabidopsis YUCCA6 in Potato Results in High-Auxin Developmental Phenotypes and Enhanced Resistance to Water Deficit显示文摘Indole-3-acetic 酸(IAA ) ,主要植物植物生长素,在色氨酸依赖者和色氨酸无关的小径被生产。在 Arabidopsis thaliana 的一条主要小径从色氨酸在二反应产生 IAA。步骤一由把国际语音学协会变换成丝兰属植物蛋白质催化的 IAA 的一个限制率的步骤跟随的色氨酸 aminotransferases 把色氨酸变换成 indole-3-pyruvic 酸(国际语音学协会) 。我们识别了推出了氨基酸序列的基因分享的八通常认为的 StYUC (茄属 tuberosum 丝兰属植物) Arabidopsis 丝兰属植物蛋白质的有那些的 50%70% 身份。都包括正规、保存丝兰属植物序列:FATGY 主题, FMO 签名顺序和 NADP 有约束力的序列。另外,五基因与 ~ 被发现 50% 氨基酸顺序身份到 Arabidopsis 色氨酸 aminotransferases。转基因的土豆(茄属 tuberosum cv。Jowon ) 组成地, overexpressing Arabidopsis AtYUC6 显示了象狭窄的向下卷的叶子,增加的高度,直立的身高,和长寿那样的高植物生长素的显型。转基因的土豆植物 overexpressing AtYUC6 基于减少的水损失显示出提高的干旱忍耐。显型在叶子与反应的氧种类的减少的层次被相关。结果在可以被利用改变植物回答到环境的土豆建议植物生长素生合成的一条功能的丝兰属植物小径。 | Jeong Im Kim Dongwon Baek Hyeong Cheol Park Hyun Jin Chun Dong-Ha Oh Min Kyung Lee Joon-Yung Cha Woe-Yeon Kim Min Chul Kim Woo Sik Chung Hans J. Bohner Sang Yeol Lee Ray A. Bressan Shin-Woo Lee Dae-Jin Yun | 2013 | Molecular Plant2013，6，2： | 15 |
| 4 | Primary hepatic neuroendocrine tumor: A case report and literature review显示文摘Primary hepatic neuroendocrine tumors(PHNETs) are extremely rare and difficult to distinguish from other liver tumors, such as hepatocellular carcinoma(HCC) and cholangiocarcinoma, based on medical imaging findings. A 70-year-old man was referred for evaluation of liver mass incidentally discovered on abdominal computed tomography. The characteristic finding from dynamic liver magnetic resonance imaging led to a diagnosis of HCC. The patient underwent right hepatectomy. Histopathological and immunohistochemical examination revealed grade 2 neuroendocrine tumor. The postoperative 24-h urinary excretion of 5-hydroxy-indolacetic acid was within the normal range. Further imaging investigations were performed. No other lesions were found making probable the diagnosis of PHNET. This case shows that the diagnosis of PHNET is a medical challenge, requiring differentiation of PHNETs other hepatic masses and exclusion of occult primary neuroendocrine tumors. The diagnosis of PHNET can be ascertained after long term follow-up to exclude another primary origin. | Jeong Eun Song Byung Seok Kim Chang Hyeong Lee | 2016 | World Journal of Clinical Cases2016，4，8： | 11 |
| 5 | Multiplanar reformations and minimum intensity projections using multi-detector row CT for assessing anomalies and disorders of the pancreaticobiliary tree显示文摘CT scan is regarded as the imaging modality of choice in patients with pancreaticobiliary ductal abnormalities. However, the axial orientation of the CT images provides only limited anatomical view of pancreaticobiliary ductal abnormalities. The technological advances of multi-de-tector row CT and three-dimensional image processing in workstations allows rapid image acquisition and a short postprocessing time. In particular, multiplanar reforma-tions (MPR) and minimum intensity projections (MinIP) offer rapid and accurate images of the anatomy and ab-normalities of the pancreaticobiliary tree. Moreover, MPR and MinIP help determine the relationship between the pancreaticobiliary ductal anatomy and the surrounding structures. This pictorial review illustrates the wide spec-trum of images obtained by the MPR and MinIP of the anomalies and disorders of the pancreaticobiliary tree. | Hyun Cheol Kim Dal Mo Yang Wook Jin Chang Woo Ryu Jung Kyu Ryu Sung Il Park Seong Jin Park Hyeong Cheol Shin Il Young Kim | 2007 | World Journal of Gastroenterology2007，13，31： | 10 |
| 6 | MRI of gastric carcinoma:Results of T and N-staging in an in vitro study显示文摘AIM:To determine the accuracy of 1.5-T magnetic resonance imaging (MRI) in the evaluation of gastric wall invasion and perigastric lymph node metastasis in gastric adenocarcinoma.METHODS: Twenty resected gastric specimens containing 20 tumors were studied with a 1.5-T MR system using a commercial head surface coil. MR scanning was performed with a T1 weighted image (TR/TE = 500/20), and a T2 weighted image (TR/TE=2500/90). MR findings were compared with pathologic findings.RESULTS: A T1-weighted image demonstrated three layers in the normal gastric wall. All of the gastric tumors were well demonstrated by lesions and location. In a MRI findings of gastric wall invasion, there was 1 case of T1, 7 of T2, 11 of T3. Pathologic results of resected specimens included 3 cases of pT1, 4 of pT2, and 12 of pT3. The accuracy of T staging with MRI was 74% (14 of 19). MRI findings of lymph node me-tastasis included 6 cases of N0, 13 cases of N1. The accuracy of the N staging with MRI was 47% (9 of 19).CONCLUSION: MRI has a high diagnostic accuracy in the evaluation of the T staging of gastric cancer in vitro and thus potentially enables preoperative histo-pathologic staging. | Il Young Kim Sang Won Kim Hyeong Cheol Shin Moon Soo Lee Dong Jun Jeong Chang Jin Kim Young Tong Kim | 2009 | World Journal of Gastroenterology2009，15，32： | 9 |
| 7 | Removal of primary iron rich phase from aluminum-silicon melt by centrifugal separation显示文摘Recycling is a major consideration in continued aluminum use due to the enormous demand for high quality products. Some impurity elements gradually accumulate through the repetitive reuse of aluminum alloy scrap. Of them, the iron content should be suppressed under the allowed limit. In the present research, a novel separation method was introduced to remove primary iron-rich intermetallic compounds by centrifugation during solidification of Al-Si-Fe alloys. This method does not use the density difference between two phases as in other centrifugal methods, but uses the order of solidification in Al-Si-Fe alloys, because iron promotes the formation of intermetallic compounds with other alloying elements as a primary phase. Two Al-Si-Fe alloys which have different iron contents were chosen as the starting materials. The iron-rich phase could be efficiently removed by centrifuging under a centrifugal force of 40 g. Coarse intermetallic compounds were found in the sample inside the crucible, while rather fine intermetallic compounds were found in the sample outside the crucible. Primary intermetallic compounds were linked to each other via aluminum-rich matrix, and formed like a network. The highest iron removal fraction is 67% and the lowest one is 7% for Al-12Si-1.7Fe alloy. And they are 82% and 18% for Al-12Si-3.4Fe alloy, respectively. | Seong Woo Kim Un Ho Im Hyeong Cheol Cha Se Hyeong Kim Ji Eun Jang Ki Young Kim | 2013 | China Foundry2013，10，2： | 8 |
| 8 | Recurrent massive bleeding due to dissecting intramural hematoma of the esophagus: Treatment with therapeutic angiography显示文摘Spontaneous or traumatic intramural bleeding of the esophagus, which is often associated with overlying mucosal dissection, constitutes a rare spectrum of esophageal injury called dissecting intramural hematoma of the esophagus (DIHE). Chest pain, swallowing diffi culty, and minor hematemesis are common, which resolve spontaneously in most cases. This case report describes a patient with spontaneous DIHE with recurrent massive bleeding which required critical management and highlights a potential role for therapeutic angiography as an alternative to surgery. | Jaejun Shim Jae Young Jang Young Hwangbo Seok Ho Dong Joo Hyeong Oh Hyo Jong Kim Byung-Ho Kim Young Woon Chang Rin Chang | 2009 | World Journal of Gastroenterology2009，15，41： | 8 |
| 9 | Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction显示文摘AIM To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of selfexpandable metal stent(SEMS).METHODS This was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography(ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis(PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were classified.RESULTS Among the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients,pancreatic cancer in 79, and non-pancreatic or nonbiliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients(3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy(cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP complications.CONCLUSION Limited ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding. | Hyeong Seok Nam Dae Hwan Kang Hyung Wook Kim Cheol Woong Choi Su Bum Park Su Jin Kim Dae Gon Ryu | 2017 | World Journal of Gastroenterology2017，23，9： | 7 |
| 10 | Is endoscopic ultrasonography essential for endoscopic resection of small rectal neuroendocrine tumors?显示文摘AIM To evaluate the importance of endoscopic ultrasonography(EUS) for small(≤ 10 mm) rectal neuroendocrine tumor(NET) treatment.METHODS Patients in whom rectal NETs were diagnosed by endoscopic resection(ER) at the Pusan National University Yangsan Hospital between 2008 and 2014 were included in this study. A total of 120 small rectal NETs in 118 patients were included in this study. Histologic features and clinical outcomes were analyzed, and the findings of endoscopy, EUS and histology were compared. RESULTS The size measured by endoscopy was not significantly different from that measured by EUS and histology(r = 0.914 and r = 0.727 respectively). Accuracy for the depth of invasion was 92.5% with EUS. No patients showed invasion of the muscularis propria or metastasis to the regional lymph nodes. All rectal NETswere classified as grade 1 and demonstrated an L-cell phenotype. Mean follow-up duration was 407.54 ± 374.16 d. No patients had local or distant metastasis during the follow-up periods. CONCLUSION EUS is not essential for ER in the patient with small rectal NETs because of the prominent morphology and benign behavior. | Su Bum Park Dong Jun Kim Hyung Wook Kim Cheol Woong Choi Dae Hwan Kang Su Jin Kim Hyeong Seok Nam | 2017 | World Journal of Gastroenterology2017，23，11： | 7 |
| 11 | Transcription factor IRF8 controls Thl-like regulatory T-cell function显示文摘 | Wonyong Lee Hyeong Su Kim Song Yi Baek Gap Ryol Lee | 2016 | Cellular & Molecular Immunology2016，13，6： | 5 |
| 12 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 13 | Complete peritonectomy and intraperitoneal chemotherapy for recurrent rectal cancer with peritoneal metastasis显示文摘A 68-year-old man underwent laparoscopic low anterior resection for rectal carcinoma in December 2006.Nearly 19 mo after the operation,he developed recurrent rectal cancer with peritoneal metastasis. In September 2008,he subsequently underwent a laparotomy with a peritonectomy,omentectomy, splenectomy,and a Hartmann procedure.Hyperthermic intraperitoneal oxaliplatin 750 mg was administered. The patient was discharged with no postoperative complications and has been well with postoperative FOLFOX chemotherapy. | Jung Wook Huh Young Jin Kim Hyeong Rok Kim | 2009 | World Journal of Gastroenterology2009，15，6： | 5 |
| 14 | 三维电极法处理含氯废水过程中电解活性氯的研究显示文摘将软锰矿粒子电极应用于三维电极系统处理含氯SMP模拟废水,考察了电流强度、p H、氯化钠浓度、粒子电极投加量对活性氯浓度的影响,探索了活性氯对SMP降解效果的影响及其降解机理。结果表明:活性氯浓度随电流、氯化钠浓度、粒子电极投加量的增大而增加,碱性条件不利于活性氯生成,活性氯能提高COD去除率,但电解效果并不随活性氯增多而一直增强;活性氯对SMP的降解主要是通过氧化破坏苯环结构或取代苯环的氢转变为易降解的中间产物。 | 梁宏 任阳民 邱阳 崔明灿 Hyeong Khim Lee Sang-Hwan | 2017 | 工业水处理2017，37，9： | 5 |
| 15 | Tumor response assessment by the single-lesion measurement per organ in small cell lung cancer显示文摘Background: The criterion of two target lesions per organ in the Response Evaluation Criteria in Solid Tumors(RECIST) version 1.1 is an arbitrary one, being supported by no objective evidence. The optimal number of target lesions per organ still needs to be investigated. We compared tumor responses using the RECIST 1.1(measuring two target lesions per organ) and modified RECIST 1.1(measuring the single largest lesion in each organ) in patients with small cell lung cancer(SCLC).Methods: We reviewed medical records of patients with SCLC who received first-line treatment between January 2004 and December 2014 and compared tumor responses according to the two criteria using computed tomography.Results: There were a total of 34 patients who had at least two target lesions in any organ according to the RECIST 1.1 during the study period. The differences in the percentage changes of the sum of tumor measurements between RECIST 1.1 and modified RECIST 1.1 were all within 13%. Seven patients showed complete response and fourteen showed partial response according to the RECIST 1.1. The overall response rate was 61.8%. When assessing with the modified RECIST 1.1 instead of the RECIST 1.1, tumor responses showed perfect concordance between the two criteria(k=1.0).Conclusions: The modified RECIST 1.1 showed perfect agreement with the original RECIST 1.1 in the assessment of tumor response of SCLC. Our result suggests that it may be enough to measure the single largest target lesion per organ for evaluating tumor response. | Soong Goo Jung Jung Han Kim Hyeong Su Kim Kyoung Ju Kim Ik Yang | 2016 | Chinese Journal of Cancer Research2016，28，2： | 4 |
| 16 | Advantage of endoscopic mucosal resection with a cap for rectal neuroendocrine tumors显示文摘AIM: To compare the outcomes of endoscopic mucosal resection with a cap(EMR-C) with those of endoscopic submucosal dissection(ESD) for the resection of rectal neuroendocrine tumors.METHODS: One hundred and sixteen lesions in 114 patients with rectal neuroendocrine tumor(NET) resected with EMR-C or ESD were included in the study. This study was performed at Pusan National University Yangsan Hospital between July 2009 and August 2014. We analyzed endoscopic complete resection rate,pathologic complete resection rate,procedure time,and adverse events in the EMR-C(n = 65) and ESD(n = 51) groups. We also performed a subgroup analysis by tumor size.RESULTS: Mean tumor size was 4.62 ± 1.66 mm in the EMR-C group and 7.73 ± 3.14 mm in the ESD group(P < 0.001). Endoscopic complete resection rate was 100% in both groups. Histologic complete resection rate was significantly greater in the EMR-C group(92.3%) than in the ESD group(78.4%)(P = 0.042). Mean procedure time was significantly longer in the ESD group(14.43 ± 7.26 min) than in the EMR-C group(3.83 ± 1.17 min)(P < 0.001). Rates of histologic complete resection without complication were similar for tumor diameter ≤ 5 mm(EMR-C,96%; ESD,100%,P = 0.472) as well as in cases of 5 mm < tumor diameter ≤ 10 mm(EMR-C,80%; ESD,71.0%,P = 0.524).CONCLUSION: EMR-C may be simple,faster,and more effective than ESD in removing rectal NETs and may be preferable for resection of small rectal NETs. | Su Bum Park Hyung Wook Kim Dae Hwan Kang Cheol Woong Choi Su Jin Kim Hyeong Seok Nam | 2015 | World Journal of Gastroenterology2015，21，31： | 4 |
| 17 | 韩国农业发展经验及对我国农业发展的启示显示文摘简要介绍了韩国亲环境农业在提升农业生产能力、提高农民生产积极性、提升农产品质量等方面的发展经验,以及在智能农场循环农业研究、热带作物种植技术研究、未来农业专业人才培养等领域的先进理念和技术。结合国内发展现状,提出了3项发展建议:加强农业科技人才培养,推进植保体系建设;完善农业补贴制度,提高农民种粮积极性;加强宣传引导监管,促进绿色农业发展。 | 陆明红 刘万才 赵清 邹寿发 周晨 Roh Hyeong Ⅱ 金春香 | 2020 | 中国植保导刊2020，40，3： | 4 |
| 18 | Statistical Prediction of Heavy Rain in South Korea显示文摘This study is aimed at the development of a statistical model for forecasting heavy rain in South Korea. For the 3-hour weather forecast system, the 10 km × 10 km area-mean amount of rainfall at 6 stations (Seoul, Daejeon, Gangreung, Gwangju, Busan, and Jeju) in South Korea are used. And the corresponding 45 synoptic factors generated by the numerical model are used as potential predictors. Four statistical forecast models (linear regression model, logistic regression model, neural network model and decision tree model) for the occurrence of heavy rain are based on the model output statistics (MOS) method. They are separately estimated by the same training data. The thresholds are considered to forecast the occurrence of heavy rain because the distribution of estimated values that are generated by each model is too skewed. The results of four models are compared via Heidke skill scores. As a result, the logistic regression model is recommended. | Keon Tae SOHN Jeong Hyeong LEE Soon Hwan LEE Chan Su RYU | 2005 | Advances in Atmospheric Sciences2005，22，5： | 3 |
| 19 | Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells显示文摘AIM:To investigate the effect of bile acid on the expression of histidine decarboxylase(HDC),which is a major enzyme involved in histamine production,and gene expression of gastric transcription factors upon cooperative activation.METHODS:HDC expression was examined by immunohistochemistry,reverse transcriptase polymerase chain reaction,and promoter assay in human gastric precancerous tissues,normal stomach tissue,and gastric cancer cell lines.The relationship between gastric precancerous state and HDC expression induced by bile acid was determined.The association between the expression of HDC and various specific transcription factors in gastric cells was also evaluated.MKN45 and AGS human gastric carcinoma cell lines were transfected with farnesoid X receptor(FXR),small heterodimer partner(SHP),and caudal-type homeodomain transcription factor(CDX)1 expression plasmids.The effects of various transcription factors on HDC expression were monitored by luciferase-reporter promoter assay.RESULTS:Histamine production and secretion in the stomach play critical roles in gastric acid secretion and in the pathogenesis of gastric diseases.Here,we show that bile acid increased the expression of HDC,which is a rate-limiting enzyme of the histamine production pathway.FXR was found to be a primary regulatory transcription factor for bile acid-induced HDC expression.In addition,the transcription factors CDX1 and SHP synergistically enhanced bile acid-induced elevation of HDC gene expression.We confirmed similar expression patterns for HDC,CDX1,and SHP in patient tissues.CONCLUSION:HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR,SHP,and CDX1. | Hye Jin Ku Hye Young Kim Hyeong Hoe Kim Hee Ju Park Jae Hun Cheong | 2014 | World Journal of Gastroenterology2014，20，1： | 3 |
| 20 | Assessment of disease activity by fecal immunochemical test in ulcerative colitis显示文摘AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or active.RESULTS All of 21 patients with MES 0 had negative FIT(< 7 ng/mL), but 22 patients with MES 2 or 3 had a mean FIT of > 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not predict the extent of disease. | Dae Gon Ryu Hyung Wook Kim Su Bum Park Dae Hwan Kang Cheol Woong Choi Su Jin Kim Hyeong Seok Nam | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员