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91篇 您的检索式：作者名="Wood ME"

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	题名	作者	年代	出处	被引量
1	Interferon-β induced in female genital epithelium by HIV-1 glycoprotein 120 via Toll-like-receptor 2 pathway acts to protect the mucosal barrier显示文摘More than 40%of HIV infections occur via female reproductive tract(FRT)through heterosexual transmission.Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens.These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses.Previously,we have shown that in response to HIV-1 gp120,the genital epithelial cells(GECs)from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection.In this study,we report that the endometrial and endocervical GECs simultaneously induce biologically active interferon-β(IFNβ)antiviral responses following exposure to HIV-1 that act to protect the epithelial tight junction barrier.The innate antiviral response was directly induced by HIV-1 envelope glycoprotein gp120 and addition of gp120 neutralizing antibody inhibited IFNβproduction.Interferon-βwas induced by gp120 in upper GECs through Toll-like receptor 2 signaling and required presence of heparan sulfate on epithelial cell surface.The induction of IFNβwas dependent upon activation of transcription factor IRF3(interferon regulatory factor 3).The IFNβwas biologically active,had a protective effect on epithelial tight junction barrier and was able to inhibit HIV-1 infection in TZM-bl indicator cells and HIV-1 replication in T cells.This is the first report that recognition of HIV-1 by upper GECs leads to induction of innate antiviral pathways.This could explain the overall low infectivity of HIV-1 in the FRT and could be exploited for HIV-1 prophylaxis.	Aisha Nazli Sara Dizzell Muhammad Atif Zahoor Victor H Ferreira Jessica Kafka Matthew William Woods Michel Ouellet Ali A Ashkar Michel J Tremblay Dawn ME Bowdish Charu Kaushic	2019	Cellular & Molecular Immunology2019，16，2：	2
2	Serotonin gene polymorphisms and bipolar 1 disorder: focus on the serotonin transporter显示文摘	Mansour HA Talkowski ME Wood J	2005	Ann Med2005，37，：	1
3	Facial nerve morbidity followingparotid surgeryfor benign disease the Cleveland clinicfoundation experience J 显示文摘	Mehle ME Kraus DH Wood BG	1993	Laryngoscope1993，103，：	1
4	Protardine allergy as a complication of insulin prypersensitivicy:A case report显示文摘	Bollinger ME Hadtoo RU Wood RA	1999	J A Hergy Clinipcpunni1999，104，：	1
5	Cholesteryl ester transfer protein variants have differential stability but uniform inhibition by torcetrapib显示文摘	Lira ME Wood LS	2005	J Biol Chem2005，280，14：	1
6	Adenocareinoma of the head of the panereas: determination of surgical unresectability with thin-section pancreatic-phase helical CT 显示文摘	O'Malley ME Boland GW Wood BJ	1999	AJR Am J Roentgenol1999，173，6：	1
7	Host defenses to Rickettsia rickettsii infecti- on contribute to increased microvascular permeability in human cerebral endothelial cells显示文摘	Woods ME Olano JP	2008	J Clin Immunol2008，28，2：	1
8	Facial nerve morbidity following parotid,Surgery for benign disease:the Clevdand clinic Foundation experience显示文摘	Mehle ME Kraus DH Wood BG	1993	Laryngoscope1993，103，4：	1
9	A phase Ⅰ study of paclitaxel, etoposlde, and cisplatin in extensive stage small cell lung cancer显示文摘	Kelly K Pan Z Wood ME	1999	Clin Cancer Res1999，5，11：	1
10	Optimum time to start antiretroviral therapy during HIV-associated opportunistic infections显示文摘	Lawn SD T(o)r(o)k ME Wood R	2011	Current Opinion in Infectious Diseases2011，24，1：	1
11	Selecting adjuvant endocrine therapy for breast cancer显示文摘	Eneman JD Wood ME Muss HB	2004	Oncology2004，18，14：	1
12	Selecting adjuvant endocrine therapy for breast cancer 显示文摘	Eneman JD Wood ME Muss HB	2004	Oncology2004，18，14：	1
13	T ension pneumocephalus following craniofacial resection 显示文摘	Wanamaker JR Mehle ME Wood BG	1994	Head Neck1994，17，：	1
14	Protamine allergy as a complication of insulin hypersensitivity: A case report 显示文摘	Bollinger ME Hamilton RG Wood RA	1999	J Allergy Clin Immunol1999，104，21：	1
15	Retrospective analysis of a novel method of transscleral suture fixation for posterior chamber intraocular lens implantation in the absence of capsular support显示文摘	Wood TD Ford JG Winnicki J Tyler ME Reed JW	1998	Cornea1998，17，：	1
16	Acoustic neuroma:A cost-effective approach显示文摘	Welling DB Glasscock ME Ⅲ Woods CI	1990	Otolaryngol Head Neck Surg1990，103，：	1
17	A unique structure for epidermal growth factor bound to GW572016(Lapatinib) :relationships among protein conformation, inhibitor off-rate and receptor activity in tumor cells 显示文摘	Wood ER Truesdale AT Me Donald OB	2004	Cancer Res2004，64，18：	1
18	Selecting adjuvant endocrine therapy for breast cancer 显示文摘	Eneman JD Wood ME Muss HB	2004	Oncology2004，18，14：	1
19	Adenocarcinoma of the head of the pancreas:determination of surgical unresectability with thin-section pancreatic-phase hefical CT 显示文摘	O'Malley ME Boland GW Wood BJ	1999	Am J Roentgenol1999，173，6：	1
20	Facial nerve morbidity following parotid surgery for benign disease: the cleve land clinic faundation experience 显示文摘	Mehle ME Kraus DH Wood BG	1993	Laryngoscope1993，103，41：	1

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