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| 1 | Micro RNA-124 slows down the progression of Huntington's disease by promoting neurogenesis in the striatum显示文摘Micro RNA-124 contributes to neurogenesis through regulating its targets,but its expression both in the brain of Huntington's disease mouse models and patients is decreased.However,the effects of micro RNA-124 on the progression of Huntington's disease have not been reported.Results from this study showed that micro RNA-124 increased the latency to fall for each R6/2 Huntington's disease transgenic mouse in the rotarod test.5-Bromo-2'-deoxyuridine(Brd U) staining of the striatum shows an increase in neurogenesis.In addition,brain-derived neurotrophic factor and peroxisome proliferator-activated receptor gamma coactivator 1-alpha protein levels in the striatum were increased and SRY-related HMG box transcription factor 9 protein level was decreased.These findings suggest that micro RNA-124 slows down the progression of Huntington's disease possibly through its important role in neuronal differentiation and survival. | Tian Liu Wooseok Im Inhee Mook-Jung Manho Kim | 2015 | Neural Regeneration Research2015，10，5： | 8 |
| 2 | Label‐free quantification for discovering novel biomarkers in the diagnosis and assessment of disease activity in inflammatory bowel disease显示文摘 | Na‐Young Han Wooseok Choi Jong‐Moon Park Eun Hee Kim Hookeun Lee Ki‐Baik Hahm | 2013 | Journal of Digestive Diseases2013，，4： | 2 |
| 3 | Photoinduced difunctionalization with bifunctional reagents containing N-heteroaryl moieties显示文摘Bifunctional reagents that serve as dual coupling partners with an activating species have emerged as valuable synthetic tools in organic chemistry.They allow for the development of diverse reaction modes with enhanced efficiency and structural variability,which is in high demand for atom-economic and sustainable synthesis.Among them,bifunctional reagents containing Nheteroaryl groups have received much attention due to their ability to introduce privileged N-heteroaryl moieties into complex molecules that are otherwise challenging to access.Furthermore,these reagents have been employed under visible-light conditions to achieve various synthetic applications,enabling difunctionalization of alkenes,alkynes,and[1.1.1]propellanes under mild reaction conditions,providing access to highly functionalized N-heteroarenes.In this review,we provide an overview of the recent achievements and applications of photoinduced difunctionalization using bifunctional reagents containing N-heteroaryl groups.We systematically categorize the representative contributions in the field based on bifunctional reagents and their reactivity patterns.This review aims to highlight the potential of these reagents as powerful synthetic tools for sustainable and diverse synthesis. | Wooseok Lee Inyoung Park Sungwoo Hong | 2023 | Science China Chemistry2023，66，6： | 2 |
| 4 | Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1(G93A)mice and SOD1(G17S and G86S)ALS patients显示文摘Background:MicroRNAs(miRNAs)are endogenous non-coding RNAS that regulate gene expression at the post-transcriptional level and are key modulators in neurodegenerative diseases.Overexpressed miRNAs play an important role in amyotrophic lateral sclerosis(ALS);however,the pathogenic mechanisms of deregulated miRNAS are still unclear.Methods:We aimed to assess the dysfunction of RNAS or miRNAs in fALS(SOD1 mutations).We compared the RNA-seq of subcellular fractions in NSC-34 WT(hSOD1)and MT(hSOD1(G93A))cells to find altered RNAs or miRNAs.We identified that Hif1a and Mef2c were upregulated,and Mctp1 and Rarb were downregulated in the cytoplasm of NSC-34 MT cells.Results:SOD1 mutations decreased the level of miR-18b-5p.Induced Hif1a which is the target for miR-18b increased Mef2c expression as a transcription factor.Mef2c upregulated miR-206 as a transcription factor.Inhibition of Mctp1 and Rarb,which are targets of miR-206,induced intracellular Ca^2+ levels and reduced cell differentiation,respectively.The miR-18b-5p pathway was also observed in G93A Tg mice,fALS(G86S)patient,and iPSC-derived motor neurons from fALS(G17S)patient.Conclusions:Our data indicate that SOD1 mutation decreases miR-18b-5p,which sequentially regulates Hif1a,Mef2c,miR-206,Mctp1 and Rarb in fALS-linked SOD1 mutation.These results provide new insights into the downregulation of miR-18b-5p-dependent pathogenic mechanisms of ALS. | Ki Yoon Kim Yu Ri Kim Kyung Won Choi Mijung Lee Somyung Lee Wooseok Im Je-Young Shin Jin Young Kim Yoon Ho Hong Manho Kim Jong-ll Kim Jung-Joon Sung | 2020 | Translational Neurodegeneration2020，9，3： | 2 |
| 5 | Photocatalytic oxidation of methyl orange in a three-phase fluidized bed reactor显示文摘 | Wooseok N Jimin K Guiyong H | 2002 | Chemosphere2002，47，： | 1 |
| 6 | Blind Adaptive I/Q Imbalance Compensation Algorithms for Direct-Conversion Receivers显示文摘 | WOOSEOK N HEEJIN R JUNGWON L | 2012 | Signal Processing Letters IEEE2012，19，8： | 1 |
| 7 | Photocatalytic oxidation of methyl orange in a three - phase fluidized bed reactor显示文摘 | Wooseok N Jimin K Guiyong H | 2002 | Chemosphere2002，47，： | 1 |
| 8 | Photocatalytic oxidation of methyl orange in a three-phase fluidized bed reactor 显示文摘 | Wooseok N Jimin K Guiyoung H | 2002 | Chemosphere2002，47，： | 1 |
| 9 | Advanced interference management for 5G cellular networks 显示文摘 | WOOSEOK N DONGWOON B JUNGWON L | 2014 | IEEE communications magazine2014，，5： | 1 |
| 10 | Low pH increases the yield of exosome isolation显示文摘 | Jae-Jun Ban Mijung Lee Wooseok Im Manho Kim | 2015 | Biochemical and Biophysical Research Communicatio2015，，： | 1 |
| 11 | TwoselectivegrowthmodesforgrapheneonaCusubGstrateusingthermalchemicalvapordeposition显示文摘 | Song Wooseok JeonCheolho Youn Kim Soo etal | 2014 | CarGbon2014，68，： | 1 |
| 12 | Earth-abundant element photovohaics directly from soluble precursors with high yield using a non-toxic solvent 显示文摘 | Ki Wooseok Hillhouse Hugh W | 2011 | Advanced Energy Materials2011，1，5： | 1 |
| 13 | Design and fabrication of a new traveling wave-type ultrosonic linear motor显示文摘 | Roh Yongrae Lee Susung Han Wooseok | 2001 | Sensors and Actuators A2001，94，： | 1 |
| 14 | Caspase -2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8显示文摘 | SOONAHS YOONMI L WOOSEOK K | 2005 | The EMBO Journal2005，24，： | 1 |
| 15 | Carbon Nanotube and Graphene Hybrid Thin Film for Transparent Electrodes and Field Effect Transistors显示文摘 | Sung Ho Kim Wooseok Song Min Wook Jung Min‐A Kang Kiwoong Kim Sung‐Jin Chang Sun Sook Lee Jongsun Lim Jinha Hwang Sung Myung Ki‐Seok An | 2014 | Mater2014，，25： | 1 |
| 16 | Design and fabrication of a new traveling wave-type ultrasonic Linear Motor显示文摘 | Lee Susung Han Wooseok | 2001 | Sensors and Actuators A2001，94，： | 1 |
| 17 | Dynamic bifurcation buckling of an impacted column 显示文摘 | Wooseok Ji Waas A M | 2008 | International Journal of Engineering Science2008，46，10： | 1 |
| 18 | Neuroprotective effects of adipose-derived stem cells against ischemic neuronal damage in the rabbit spinal cord显示文摘 | Jin Young Chung Woosuk Kim Wooseok Im Dae Young Yoo Jung Hoon Choi In Koo Hwang Moo-Ho Won In Bok Chang Byung Moon Cho Hyung Sik Hwang Seung Myung Moon | 2012 | Journal of the Neurological Sciences (-)2012，，1： | 1 |
| 19 | An oscillator with low phase noise based on active resonator using metamaterial in K-band显示文摘An oscillator(OSC)with a metamaterial resonator based on high-Q is designed to improve the phase noise in Kband.The proposed metamaterial resonator is a lattice structure resonator(LSR)that is designed to be high-Q by a strong coupling of E-field at the resonance frequency.Thus the output of OSC is about 12.5dBm at the f0.The phase noise is 109.477dBc/Hz at 100kHz offset frequency. | Wooseok Shim Chongmin Lee Chulhun Seo | 2013 | Journal of Measurement Science and Instrumentation2013，4，1： | 0 |
| 20 | Improving ionic conductivity of von-Alpen-type NASICON ceramic electrolytes via magnesium doping显示文摘NASICON (sodium (Na) superionic conductor) compounds have attracted considerable attention as promising solid electrolyte materials for advanced Na-based batteries. In this study, we investigated the improvement in ionic conductivities of von-Alpen-type NASICON (vA-NASICON) ceramic electrolytes by introducing a magnesium ion (Mg^(2+)) as a heterogeneous element. The optimal Mg-doped vA-NASICON exhibited a high ionic conductivity of 3.64×10^(−3) S·cm^(−1), which was almost 80% higher than that of un-doped vA-NASICON. The changes in physicochemical properties of the vA-NASICONs through the Mg introduction were systematically analyzed, and their effects on the ionic conductivities of the vA-NASICON were studied in detail. When the optimal ratio of Mg^(2+) was used in a synthetic process, the relative density (96.6%) and grain boundary ionic conductivity (σgb) were maximized, which improved the total ionic conductivity (σt) of the vA-NASICON. However, when Mg^(2+) was introduced in excess, the ionic conductivity decreased because of the formation of an undesired sodium magnesium phosphate (NaxMgyPO_(4)) secondary phase. The results of this study are expected to be effectively applied in the development of advanced sodium-based solid electrolytes with high ionic conductivities. | Il-Seop Jang Wooseok Go Bo-Ye Song Hayoung Park Yun Chan Kang Jinyoung Chun | 2023 | Journal of Advanced Ceramics2023，12，5： | 0 |
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