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| 1 | Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease显示文摘AIM To compare transcriptomes of non-alcoholic fatty liver disease(NAFLD) and alcoholic liver disease(ALD) in a meta-analysis of liver biopsies.METHODS Employing transcriptome data from patient liver biopsies retrieved from several public repositories we performed a meta-analysis comparing ALD and NAFLD.RESULTS We observed predominating commonalities at the transcriptome level between ALD and NAFLD,most prominently numerous down-regulated metabolic pathways and cytochrome-related pathways and a few up-regulated pathways which include ECM-receptor interaction,phagosome and lysosome.However some pathways were regulated in opposite directions in ALD and NAFLD,for example,glycolysis was down-regulated in ALD and up-regulated in NAFLD.Interestingly,we found rate-limiting genes such as HMGCR,SQLE and CYP7A1 which are associated with cholesterol processes adversely regulated between ALD(down-regulated) and NAFLD(up-regulated).We propose that similar phenotypes in both diseases may be due to a lower level of the enzyme CYP7A1 compared to the cholesterol synthesis enzymes HMGCR and SQLE.Additionally,we provide a compendium of comparative KEGG pathways regulation in ALD and NAFLD.CONCLUSION Our finding of adversely regulated cholesterol processes in ALD and NAFLD draws the focus to regulation of cholesterol secretion into bile.Thus,it will be interesting to further investigate CYP7A1-mediated cholesterol secretion into bile-also as possible drug targets.The list of potential novel biomarkers may assist differential diagnosis of ALD and NAFLD. | Wasco Wruck James Adjaye | 2017 | World Journal of Hepatology2017，9，8： | 8 |
| 2 | Xdigitise :visualization of hybridization experiments显示文摘 | Wruck W Griffiths H Steinfath M | 2002 | Bioinformation2002，18，： | 1 |
| 3 | Stock prices and top management changes显示文摘 | Warner J B Watts R L Wruck K H | 1988 | Journal of Financial Eco-nomics1988，20，12： | 1 |
| 4 | Asset liquidity, debt covenants, and managerial discretion in financial distress: the collapse of LA Gear显示文摘 | DeAngelo H DeAngelo L Wruck K H | 2002 | Journal of financial economics2002，64，1： | 1 |
| 5 | Equity Ownership Concentration and Firm Value:Evidence from Private Equity Financings 显示文摘 | Karen Hopper Wruck | 1989 | Journal of Financial Economics1989，，23： | 1 |
| 6 | Advanced technologies and devices for inhalational anesthetic drug dosing 显示文摘 | Meyer JU Kullik G Wruck N | 2008 | Handb Exp Pharmacol2008，，182： | 1 |
| 7 | Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-reeeptors in the human colonic cell line HT29显示文摘 | Brandenburg LO Seyferth S Wruck CJ | 2009 | Mol Membr Biol2009，26，5： | 1 |
| 8 | Stock prices and top management changes显示文摘 | Warner J B Watts R L Wruck K H | 1988 | Journal of Financial Economics1988，20，： | 1 |
| 9 | Assessing infants, cortical response to speech using near - infrared spectroscopy 显示文摘 | Bortfeld H Wruck E Boas DA | 2009 | Neurol Image2009，34，1： | 1 |
| 10 | Role of oxidative stress in rheumatoid arthritis:insights from the Nrf2-knockout mice显示文摘 | Wruck C J Fragoulis A Gurzynski A | | 0，，05： | 1 |
| 11 | Relationships, Corporate Governance,and Performance: Evidence from Private Placements of Common Stock 显示文摘 | WRUCK K H WU Y L | 2009 | Journal of Corporate Finance2009，15，1： | 1 |
| 12 | Stock Prices and Top Management Changes 显示文摘 | Warner J B Watts R L Wruck K H | 1988 | Journal of Financial Economics1988，20，12： | 1 |
| 13 | Stock prices and top-management changes显示文摘 | Warner J B Watts R L and Wruck K H | 1988 | Journal of Financial Economics1988，20，2： | 1 |
| 14 | New Insights into the Pathogenesis of Preeclampsia-The Role of Nrf2 Activators and their Potential Therapeutic Impact 显示文摘 | Kweider N Wruck C J Rath W | 2013 | Geburtshilfe Frauenheilkd2013，73，12： | 1 |
| 15 | Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation显示文摘 | Wruck C J Gotz ME Herdegen T | | 0，，06： | 1 |
| 16 | Sputtered electrochromic V2O5 films显示文摘 | Ramamurthi S Rubin M | 1989 | Thin Solid Films1989，182，： | 1 |
| 17 | Equity ownership concentration and firm value: Evidence from private equity financings 显示文摘 | Wruck K H | 1989 | Journal of Financial Economics1989，23，1： | 1 |
| 18 | Equity ownership concentration and firm val-ue:Evidence from private equity financings显示文摘 | Wruck K H | 1989 | Journalof Financial Economics1989，23，1： | 1 |
| 19 | Incorporation of rare earths into II-VI compounds during MBE growth:Optical and structural studies of Sm-doped telluride 显示文摘 | Wruck D Boyn R Parthier L | 1997 | Semiconductor Science and Technology1997，12，2： | 1 |
| 20 | Stock prices and top management changes显示文摘 | Warner J B Watts R L Wruck K H | 1988 | Journal d Financial Economics1988，，20： | 1 |
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