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| 1 | The complete reference genome for grapevine (Vitis vinifera L.) genetics and breeding显示文摘Grapevine is one of the most economically important crops worldwide.However,the previous versions of the grapevine reference genome tipically consist of thousands of fragments with missing centromeres and telomeres,limiting the accessibility of the repetitive sequences,the centromeric and telomeric regions,and the study of inheritance of important agronomic traits in these regions.Here,we assembled a telomere-to-telomere(T2T)gap-free reference genome for the cultivar PN40024 using PacBio HiFi long reads.The T2T reference genome(PN_T2T)is 69 Mb longer with 9018 more genes identified than the 12X.v0 version.We annotated 67%repetitive sequences,19 centromeres and 36 telomeres,and incorporated gene annotations of previous versions into the PN_T2T assembly.We detected a total of 377 gene clusters,which showed associations with complex traits,such as aroma and disease resistance.Even though PN40024 derives from nine generations of selfing,we still found nine genomic hotspots of heterozygous sites associated with biological processes,such as the oxidation–reduction process and protein phosphorylation.The fully annotated complete reference genome therefore constitutes an important resource for grapevine genetic studies and breeding programs. | Xiaoya Shi Shuo Cao Xu Wang Siyang Huang Yue Wang Zhongjie Liu Wenwen Liu Xiangpeng Leng Yanling Peng Nan Wang Yiwen Wang Zhiyao Ma Xiaodong Xu Fan Zhang Hui Xue Haixia Zhong Yi Wang Kekun Zhang Amandine Velt Komlan Avia Daniela Holtgräwe Jérôme Grimplet JoséTomás Matus Doreen Ware Xinyu Wu Haibo Wang Chonghuai Liu Yuling Fang Camille Rustenholz Zongming Cheng Hua Xiao Yongfeng Zhou | 2023 | Horticulture Research2023，10，5： | 3 |
| 2 | Blockade of the renin-angiotensin and endothelin systems on progressive renal injury 显示文摘 | Cao Z Cooper ME Wu LL | 2001 | JandeleitDahm K Hypertension2001，37，5： | 2 |
| 3 | Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo显示文摘 | Wu CR Zhang y Rose ME | 2004 | Brain Res Mol Brain Res2004，32，1： | 1 |
| 4 | Basic mechanical properties of retina in simple elongation显示文摘 | Wu W Peters WH 3rd Hammer ME | 1987 | Biomech Eng1987，109，1： | 1 |
| 5 | Primaiy intra-vitreal Bevacizumab(Avastin) for diabetic macular edema-results from the pan-A-merican Collaborative Retina Study Group at 6- month follow-up显示文摘 | Frevalo FJ Fromow-Guerra J Quiroz-Mercado H Wu L Berro-cal MH Farah ME | 2007 | Ophthalmology2007，114，4： | 1 |
| 6 | CaMK in sinoatrial node physiology anddysfunetion显示文摘 | Wu Y Anderson ME | 2014 | Front Pharmacol2014，548，： | 1 |
| 7 | Hysterectomy rates in the United States,2003显示文摘 | Wu JM Wechter ME Geller EJ | 2007 | Obstet Gynecol2007，110，： | 1 |
| 8 | Quantiative culture of endotranheal aspirates in the diagnosis of venti-lator-associated pneumonia in patients with treatment failure显示文摘 | CHIEN LIANG WU ME | 2002 | Chest2002，122，2： | 1 |
| 9 | Transforming growth factor beta 1 and renal injury following subtotal nephrectomy in the rat: role of the renin-angiotensin system显示文摘 | Cox A Roe CJ Dziadek M Cooper ME | 1997 | Kidney Int1997，51，5： | 1 |
| 10 | Adeno-associated virusmediated delivery of anti angiogenic factors as an antitumor strategy 显示文摘 | WU P Clouse ME | 1998 | Cancer Res1998，58，24： | 1 |
| 11 | Surface expression of the netrin receptor UNC5HI is regulated through a protein kinase C-interacting protein/protein kinasedependent mechanism 显示文摘 | Williams ME Wu SC McKenna WL | 2003 | J Neurosci2003，23，11： | 1 |
| 12 | Association of narrow angles with ante- rior chamber area and volume measured with anterior seg- ment optical coherence tomography显示文摘 | WU RY NONGPIUR ME HE MG SAKATA LM FRIEDMAN DS CHAN YH | 2011 | Arch Ophthalmol2011，129，5： | 1 |
| 13 | Cell death suggestive of apoptosis after spinal cord ischemia in rabbits显示文摘 | Mackey ME Pas BA Wu YJ | 1997 | Stroke1997，28，10： | 1 |
| 14 | KN-93, an inhibitor of multifunctional Ca2+ /calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart显示文摘 | Anderson ME Braun AP Wu Y | 1998 | J Pharmacol Exp Ther1998，287，： | 1 |
| 15 | Nebulized hypertonic saline for bronchiolitis: a randomized clinical trim 显示文摘 | Wu S Baker C Lang ME | 2014 | JAMA Pediatr2014，168，7： | 1 |
| 16 | Nebulized hypertonic saline for bronchiolitis:a randomized clinical trial显示文摘 | Wu S Baker C Lang ME | 2014 | JAMA Pediatr2014，168，7： | 1 |
| 17 | Severe intra-abdominal bleeding from neglected Omental implantation of ectopic tissue after methotrexate treatment for persistent ectopic pregnancy显示文摘 | Wu ME Huang WC Lin HH | 2011 | Fertility and sterility2011，95，7： | 1 |
| 18 | Calmodulin kinase inhibition prevents development of the arrhythmogenic transient inward current 显示文摘 | Wu Y Roden DM Anderson ME | 1999 | Circ Res1999，84，： | 1 |
| 19 | Management of Bartholin duct cysts and abscesses: a systematic review 显示文摘 | Wechter ME Wu JM Marzano D | 2009 | Obstet Gynecol Surv2009，64，6： | 1 |
| 20 | Management of Bartholin duct cysts and abscesses : a systematic review 显示文摘 | Weehter ME Wu JM Marzano D | 2009 | Obstet Gynecol Surv2009，64，6： | 1 |
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