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| 1 | PTPL1 suppresses lung cancer cell migration via inhibiting TGF-β1-induced activation of p38 MAPK and Smad 2/3 pathways and EMT显示文摘Epithelial-mesenchymal transition(EMT)enables dissemination of neoplastic cells and onset of distal metastasis of primary tumors.However,the regulatory mechanisms of EMT by microenvironmental factors such as transforming growth factor-β(TGF-β)remain largely unresolved.Protein tyrosine phosphatase L1(PTPL1)is a non-receptor protein tyrosine phosphatase that plays a suppressive role in tumorigenesis of diverse tissues.In this study we investigated the role of PTPL1/PTPN13 in metastasis of lung cancer and the signaling pathways regulated by PTPL1 in terms of EMT of non-small cell lung cancer(NSCLC)cells.We showed that the expression of PTPL1 was significantly downregulated in cancerous tissues of 23 patients with NSCLC compared with adjacent normal tissues.PTPL1 expression was positively correlated with overall survival of NSCLC patients.Then we treated A549 cells in vitro with TGF-β1(10 ng/mL)and assessed EMT.We found that knockdown of PTPL1 enhanced the migration and invasion capabilities of A549 cells,through enhancing TGF-β1-induced EMT.In nude mice bearing A549 cell xenografts,knockdown of PTPL1 significantly promoted homing of cells and formation of tumor loci in the lungs.We further revealed that PTPL1 suppressed TGF-β-induced EMT by counteracting the activation of canonical Smad2/3 and non-canonical p38 MAPK signaling pathways.Using immunoprecipitation assay we demonstrated that PTPL1 could bind to p38 MAPK,suggesting that p38 MAPK might be a direct substrate of PTPL1.In conclusion,these results unravel novel mechanisms underlying the regulation of TGF-βsignaling pathway,and have implications for prognostic assessment and targeted therapy of metastatic lung cancer. | Ning Zhu Xiu-juan Zhang Hai Zou Yuan-yuan Zhang Jing-wen Xia Peng Zhang You-zhi Zhang Jing Li Liang Dong Gulinuer Wumaier Sheng-qing Li | 2021 | Acta Pharmacologica Sinica2021，42，8： | 5 |
| 2 | Bismuth doped lead-free two-dimensional tin based halide perovskite single crystals显示文摘Heterovalent-metal doping is an efficient tool to tune the optoelectronic properties of the famous halide perovskites.Previous studies have focused on the heterovalent-doping in three-dimensional(3D) halide perovskites.However, there is a lack of such doping in two-dimensional perovskites which possess unique optoelectronic properties and improved chemical stability as compared to 3D analogues.Here, we present successful doping of Bismuth into the lattice of lead-free, two-dimensional perovskite PEA2SnBr4 single crystals.Structural characterizations demonstrate that the doped crystals possess identical crystal structure and layered morphology with the pristine one.Intriguingly, we find the PL peak and spectral shape can be tailored by tuning the concentration of Bi dopants.Femtosecond transient absorption spectroscopy is performed to understand the underlying mechanism related to tunable PL behaviors, and a clear picture of the Bismuth-doping impact is provided. | Ruiling Zhang Xin Mao Pengfei Cheng Yang Yang Songqiu Yang Tuerdi Wumaier Weiqiao Deng Keli Han | 2019 | Journal of Energy Chemistry2019，28，9： | 2 |
| 3 | Human infection with West Nile virus, Xinjiang, China, 2011 显示文摘 | Lu Z Fu SH Cao L Tang CJ Zhang S Li ZX Tusong M Yao XH Zhang IlL Wang PY Wumaier M Yuan XY Li MH Zhu CZ Fu LP Liang GD | 2014 | Emerg Infect Dis2014，20，8： | 1 |
| 4 | Chapter 8 Two-dimensional native electrophoresis for fluorescent and functional assays of mitochondrial complexes显示文摘 | Wumaier Z Nubel E Wittig I | | 0，，02： | 1 |
| 5 | Preparation of activated carbon from cotton stalkand its application in supercapacitor显示文摘 | Chen M D Kang X Y Wumaier T | 2013 | Solid State Electrochem2013，17，： | 1 |
| 6 | High incidence of urinary stones in Uyghur children may be related to local environmental factors显示文摘 | Aikebaier Wumaner Aziguli Keremu Dilixiati Wumaier | 2014 | Journal of Pediatric Urology2014，10，2： | 1 |
| 7 | High incidence of urinary stones in Uyghur children may be related to local environmental factors显示文摘 | Wumaner A Keremu A Wumaier D | 2014 | J Pediatr Urol2014，10，2： | 1 |
| 8 | 1H-NMR based metabolomics approach to evaluate effect of Cydonia oblanga Miller total flavonoid on atherosclerosis apoE(-/-) mice显示文摘OBJECTIVE ~1H-NMR-based metabolomics approach was conducted to holistically explore the effect and mechanisms of Cydonia oblanga Mill flavonoids(COMF) on high-fat diet induced Atherosclerosis(AS) apoE-/-mice.METHODS AS model was established on the apolipoprotein e knockout mice by high-fat diet.The ApoE-/-mice were split into 6 groups including control group,AS model group,COMF High dose(COMF-H) group,COMF medium dose(COMF-M) group,COMF Low dose(COMF-L) group and Simvastatin group as the positive control group.Serum samples from all groups were analyzed by ~1H-NMR technology and the OPLS-DA was conducted to distinguish the metabolic phenotypes.RESULTS Compared to the control group,serum levels of cholesterol,VLDL,leucine,isoleucine,valine,blood lipid,citrulline,methylamine,glucose,glycine,glycerol,myo-inositol,fructose,phenylalanine,unsaturated lipid,urea and other metabolites content significantly increased,while HDL,lactate,alanine,glutamate,glutamine,pyruvate,carnitine,citrate,choline content signifi.cantly decreased and the difference was statistically significant(P<0.05).The trend of metabolites in serum samples of COMF low,medium and high group was opposite to that of atherosclerosis model group and the difference was statistically significant(P<0.05).CONCLUSION Through functional analysis of these biomakers,amino acid metabolism,lipid metabolism,cholesterol metabolism,energy metabolism and inflammation reaction were considered as the most relevant pathological biomakers in the serum of AS mice.This study also demonstrates that COMF had the therapeutic effectiveness on AS through partly reversing the lipid,cholesterol,amino acid,energy metabolism and Inflammation reaction. | Ainiwaer WUMAIER Adili ABUDOUREHEMAN Wen-ting ZHOU | 2018 | 中国药理学与毒理学杂志2018，32，4： | 1 |
| 9 | Effect of lithium boronoxide glass coating on the electrochemical performance of LiNi]/3-CowMn1/302 显示文摘 | DOU J Q KANG X WUMAIER T | 2012 | Journal of Solid State Electrochemistry2012，16，4： | 1 |
| 10 | Zinc Phthalocyanine Thin Film-Based Optical Waveguide H_(2)S Gas Sensor显示文摘The detection of hydrogen sulfide(H_(2)S)is essential because of its toxicity and abundance in the environment.Hence,there is an urgent requisite to develop a highly sensitive and economical H_(2)S detection system.Herein,a zinc phthalocyanine(ZnPc)thin film-based K+-exchanged optical waveguide(OWG)gas sensor was developed for H_(2)S detection by using spin coating.The sensor showed excellent H_(2)S sensing performance at room temperature with a wide linear range(0.1 ppm 500 ppm),reproducibility,stability,and a low detection limit of 0.1ppm.The developed sensor showed a significant prospect in the development of cost-effective and highly sensitive H_(2)S gas sensors. | Kediliya WUMAIER Gulgina MAMTMIN Qingrong MA Asiya MAIMAITI Patima NIZAMIDIN Abliz YIMIT | 2022 | Photonic Sensors2022，12，1： | 1 |
| 11 | Effect of lithium boron oxide glass coating on the electrochemical performance of LiNi1/3- Co1/3Mn,/3〇2显示文摘 | DOU J Q KANG X WUMAIER T | 2012 | Journal of Solid State Electrochemistry2012，16，4： | 1 |
| 12 | Preparation of activated carbon from cotton stalk and its application in supercapacitor显示文摘 | CHEN Ming-de KANG Xue-ya Wumaier Tuerdi | 2013 | Journal of Solid State Electrochemistry2013，17，4： | 1 |
| 13 | Prepa- ration of activated carbon from cotton stalk and its ap- plication in supercapaeitor 显示文摘 | Chen M D Kang X Y Wumaier Tuerdi | 2013 | J Solid State Electro- chem2013，17，： | 1 |
| 14 | Effect of lithium boron oxide glass coatingon the electrochemical performance of LiNit- Co:3Mn302 显示文摘 | DOU J Q KANG X WUMAIER T | 2012 | J Solid State Electrochem2012，16，4： | 1 |
| 15 | Wind-speed forecasting model based on DBN-Elman combined with improved PSO-HHT显示文摘Random and fluctuating wind speeds make it difficult to stabilize the wind-power output,which complicates the execution of wind-farm control systems and increases the response frequency.In this study,a novel prediction model for ultrashort-term wind-speed prediction in wind farms is developed by combining a deep belief network,the Elman neural network,and the Hilbert-Huang transform modified using an improved particle swarm optimization algorithm.The experimental results show that the prediction results of the proposed deep neural network is better than that of shallow neural networks.Although the complexity of the model is high,the accuracy of wind-speed prediction and stability are also high.The proposed model effectively improves the accuracy of ultrashort-term wind-speed forecasting in wind farms. | Wei Liu Feifei Xue Yansong Gao Wumaier Tuerxun Jing Sun Yi Hu Hongliang Yuan | 2023 | Global Energy Interconnection2023，6，5： | 0 |
| 16 | 1H-NMR-based Metabolomic approach to evaluating total flavonoids of Ocimum Basilicum Linn in apolipomtein E knockout mice显示文摘OBJECTIVE To observe the effects of serum metabolites by using ~1H-NMR-based metabonomic approach to explore the possible mechanisms of total flavonoids in Ocimum BasilicumLinn(OBL) on atherosclerosis in apolipomtein E knockout(ApoE-/-) mice.METHODS Six-week-old male apoE knockout mice were divided into four groups(n=10) and fed with high fet diet:model,Simv.astatin,OBL-H,OBL-M and OBL-L groups.The homogeneous male mice of C57 BL/6 J were used as the normol group and fed with normal chow diet.After 14 weeks,~1H-NMR technology was used to ex.plore the variability of serum metabolites by the method of PLS-DA and OPLS-DA.RESULTS Com.pared with normal group,Model group showed a significant increase in the serum levels of VLDL,LDL,β-hydroxyisobutyrate,lactate,myo-inositol and showed a significant decrease in the serum levels of al.anine,glutamine,proline,carnitine,methylamine,citrate,creatine,choline,taurine,pyruvate,β-glu.cose,α-glucose,glycine,lysine.Combined with model group OBL-H,OBL-M,OBL-L groups showed the effects of regulating the levels of different metabolites of the glucose,lipid and amino acid metabo.lism.CONCLUSION The anti-atheros-clerotic activity of total flavonoids in Ocimum BasilicumLinn may be related not only to regulation of lipid metabolism,but also glycometabolism and amino acid metabolism. | Wen-ting ZHOU Adili ABUDOUREHEMAN Ainiwaer WUMAIER | 2018 | 中国药理学与毒理学杂志2018，32，4： | 0 |
| 17 | Perspective Material for Photoenergetics on the Basis of Silicon with Binary Elementary Cells显示文摘The paper proposes a scientifically grounded - principally new approach to managing the fundamental parameters of the basic material of electronic engineering as like silicon. The essense of the proposed approach is that the formation of binary elementary cells in the silicon lattice involving elements III (B, Al, Ga, Zn) and V (P, As, Sb) groups in the form of Si2GaAs, Si2GaSb, etc., taking into account electrical and chemical parameters of these impurity atoms, as well as their diffusion parameters in Si, are determined by the most suitable pairs of atoms of groups III and V that allow obtaining silicon with the necessary composition and structure of binary elementary cells, as well as their more complex associations, up to the formation of nanocrystals of semiconductor connections AIIIBV. It is shown that by controlling the composition and structure, as well as the concentration of binary elementary cells, it is possible to significantly expand the spectral sensitivity of silicon, both in the IR and hλ> Eg directions. The formation of nanoclusters of AIIIBV semiconductor compounds in the silicon lattice significantly changes the emissivity of the material. It is established that the successive diffusion of elements of groups III and V in silicon and additional low-temperature annealing under certain thermodynamic conditions makes it possible to ensure the maximum participation of the impurity atoms introduced in the formation of binary elementary cells. It is shown that silicon with binary elementary cells involving atoms of groups III and V is a new class of semiconductor material with unique functionality for modern optoelectronics and photoenergetics. | M.K. Bakhadyrhanov U.X. Sodikov Kh.M. Iliev S.A. Tachilin Tuerdi Wumaier | 2019 | Materials Physics and Chemistry2019，1，1： | 0 |
| 18 | Protein tyrosine phosphatase L1 represses endothelialmesenchymal transition by inhibiting IL-1β/NF-κB/Snail signaling显示文摘Endothelial-mesenchymal transition(EnMT)plays a pivotal role in various diseases,including pulmonary hypertension(PH),and transcription factors like Snail are key regulators of EnMT.In this study we investigated how these factors were regulated by PH risk factors(e.g.inflammation and hypoxia)in human umbilical vein endothelial cells(HUVECs).We showed that treatment with interleukin 1β(IL-1β)induced EnMT of HUVECs via activation of NF-κB/Snail pathway,which was further exacerbated by knockdown of protein tyrosine phosphatase L1(PTPL1).We demonstrated that PTPL1 inhibited NF-κB/Snail through dephosphorylating and stabilizing IκBα.IL-1βor hypoxia could downregulate PTPL1 expression in HUVECs.The deregulation of PTPL1/NF-κB signaling was validated in a monocrotaline-induced rat PH(MCT-PH)model and clinical PH specimens.Our findings provide novel insights into the regulatory mechanisms of EnMT,and have implications for identifying new therapeutic targets for clinical PH. | Xiao-min Wei Gulinuer Wumaier Ning Zhu Liang Dong Cheng-wei Li Jing-wen Xia You-zhi Zhang Peng Zhang Xiu-juan Zhang Yuan-yuan Zhang Sheng-qing Li | 2020 | Acta Pharmacologica Sinica2020，41，8： | 0 |
| 19 | NDRG1 promotes endothelial dysfunction and hypoxia-induced pulmonary hypertension by targeting TAF15显示文摘Background:Pulmonary hypertension(PH)represents a threatening pathophysiologic state that can be induced by chronic hypoxia and is characterized by extensive vascular remodeling.However,the mechanism underlying hypoxia-induced vascular remodeling is not fully elucidated.Methods and Results:By using quantitative polymerase chain reactions,western blotting,and immunohistochemistry,we demon-strate that the expression of N-myc downstream regulated gene-1(NDRG1)is markedly increased in hypoxia-stimulated endothelial cells in a time-dependent manner as well as in human and rat endothelium lesions.To determine the role of NDRG1 in endothelial dysfunction,we performed loss-of-function studies using NDRG1 short hairpin RNAs and NDRG1 over-expression plasmids.In vitro,silencing NDRG1 attenuated proliferation,migration,and tube formation of human pulmonary artery endothelial cells(HPAECs)un-der hypoxia,while NDRG1 over-expression promoted these behaviors of HPAECs.Mechanistically,NDRG1 can directly interact with TATA-box binding protein associated factor 15(TAF15)and promote its nuclear localization.Knockdown of TAF15 abrogated the effect of NDRG1 on the proliferation,migration and tube formation capacity of HPAECs.Bioinformatics studies found that TAF15 was involved in regulating PI3K-Akt,p53,and hypoxia-inducible factor 1(HIF-1)signaling pathways,which have been proved to be PH-related pathways.In addition,vascular remodeling and right ventricular hypertrophy induced by hypoxia were markedly alleviated in NDRG1 knock-down rats compared with their wild-type littermates.Conclusions:Taken together,our results indicate that hypoxia-induced upregulation of NDRG1 contributes to endothelial dysfunction through targeting TAF15,which ultimately contributes to the development of hypoxia-induced PH. | Chengwei Li Junzhu Lv Gulinuer Wumaier Yu Zhao Liang Dong Yuzhen Zeng Ning Zhu Xiujuan Zhang Jing Wang Jingwen Xia Shengqing Li | 2023 | Precision Clinical Medicine2023，6，4： | 0 |
| 20 | Study on smooth wheezing effect of polysaccharide of Cydonia oblonga Mill in bronchial asthma rat显示文摘OBJECTIVE Using bronchial asthma rats,to observe the effects of Smooth wheezing effect of polysaccharide.In addition,to study the effects of COM in different bronchial asthma model.METHODS Bronchial rats established by ovalbumin(OVA),were randomly divided into different group.Every other week building reference literature intraperitoneal injection of OVA,21 d after injection of 3 consecutive ultrasonic atomization inhalation of 1% OVA stimulating 30 d,stimulate the 31 d began to medicine.Lavage for 4 weeks ELISA test ratio of IgE,SP-A,IL-4 and IL-5 was serum and bronchoal veolar lavage fluid etc.Data was in x±s tabular format,SPSS16.0 statistics software is used to perform statistical analysis on the data,and P<0.05 shows meaningful statistical difference.RESULTS Quince polysac.charide can reduce the IgE,IL-4 level and elevated the SP-A,IL-5 level in serum and bronchoal veolar lavage fluid.CONCLUSION Quince polysaccharide has antiasthmatic effect on bronchial asthma rats. | Adili ABUDOUREHEMAN Wen-ting ZHOU Ainiwaer WUMAIER | 2018 | 中国药理学与毒理学杂志2018，32，4： | 0 |
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