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| 1 | Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKca channels and reducing intracellular Ca2+ levels显示文摘 | Xiang-yun GAI Yu-hai WEI Wei ZHANG Ta-na WUREN Ya-ping WANG Zhan-qiang LI Shou LIU Lan MA Dian-xiang LU Yi ZHOU Ri-li GE | 2015 | Acta Pharmacologica Sinica2015，36，5： | 11 |
| 2 | Effects of cotton straw amendment on soil fertility and microbial communities显示文摘 | Wuren HUANG Zhihui BAI Daniel HOEFEL Qing HU Xin LV Guoqiang ZHUANG Shengjun XU Hongyan QI Hongxun ZHANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 8 |
| 3 | Formation mechanisms,potentials and exploration practices of large lithologic gas reservoirs in and around an intracratonic rift:Taking the Sinian-Cambrian of Sichuan Basin as an example显示文摘By examining structures,sediments,reservoirs and accumulation assemblages in the Deyang-Anyue rift and its surrounding area,four new understandings are obtained.First,during the initiation period of Deyang-Anyue rift,multiple groups of faults developed in the rift due to the effect of tensile force,bringing about multiple mound and shoal belts controlled by horsts in the second member of the Sinian Dengying Formation;in the development stage of the rift,the boundary faults of the rift controlled the development of mound and shoal belts at the platform margin in the fourth member of Dengying Formation;during the shrinkage period of the rift,platform margin grain shoals of the Cambrian Canglangpu Formation developed in the rift margin.Second,four sets of large-scale mound and shoal reservoirs in the second member of Dengying Formation,the fourth member of Dengying Formation,Canglangpu Formation and Longwangmiao Formation overlap with several sets of source rocks such as Qiongzhusi Formation source rocks and Dengying Formation argillaceous limestone or dolomite developed inside and outside the rift,forming good source-reservoir-cap rock combinations;the sealing of tight rock layers in the lateral and updip direction results in the formation model of large lithologic gas reservoirs of oil pool before gas,continuous charging and independent preservation of each gas reservoir.Third,six favorable exploration zones of large-scale lithologic gas reservoirs have been sorted out through comprehensive evaluation,namely,mound and shoal complex controlled by horsts in the northern part of the rift in the second member of Dengying Formation,isolated karst mound and shoal complex of the fourth member of Dengying Formation in the south of the rift,the superimposed area of multi-stage platform margin mounds and shoals of the second and fourth members of Dengying Formation and Canglangpu Formation in the north slope area,the platform margin mounds and shoals of the second and fourth members of Dengying Formation in the west side of the rift,the platform margin mound and shoal bodies of the fourth member of Dengying Formation in the south slope area,etc.Fourth,Well Pengtan-1 drilled on the mound and shoal complex controlled by horsts of the second member of Dengying Formation in the rift and Well Jiaotan-1 drilled on the platform margin mound and shoal complex of the North Slope have obtained high-yield gas flows in multiple target layers,marking the discovery of a new gas province with reserves of(2-3)×10^(12) m^(3).This has proved the huge exploration potential of large lithologic gas reservoir group related to intracratonic rift. | WEI Guoqi YANG Wei XIE Wuren SU NanX IE Zengye ZENG Fuying MA Shiyu JIN Hui WANG Zhihong ZHU Qiuying HAO Cuiguo WANG Xiaodan | 2022 | Petroleum Exploration and Development2022，49，3： | 2 |
| 4 | Geological characteristics of the southern segment of the Late Sinian–Early Cambrian Deyang-Anyue rift trough in Sichuan Basin, SW China显示文摘Based on the latest drilling, seismic and field outcrop data, the geological characteristics(e.g. strata, development and sedimentary evolution) of the southern segment of the Late Sinian–Early Cambrian Deyang–Anyue rift trough in the Sichuan Basin are analyzed. First, the strata in the southern segment are complete. The first to second members of Dengying Formation(Deng 1 + Deng 2) are found with relatively stable thickness(400–550 m), and the third to fourth members(Deng 3+ Deng 4) show great thickness difference between the marginal trough and the inner trough, which is up to 250 m. The Cambrian Maidiping Formation and Qiongzhusi Formation in southern Sichuan Basin are relatively thin, with the thickness changing greatly and frequently. Second, the Deyang–Anyue rift trough extended southward during the Deng 4 period, affecting southern Sichuan Basin. Compared to the middle and northern segments of the rift trough, the southern segment is generally wide, gentle and shallow, with multiple steps, and alternating uplifts and sags, which are distributed in finger shape. Third, the Deng 1 + Deng 2 in southern Sichuan Basin records the dominance of carbonate platform and unobvious sedimentary differentiation, and the Deng 4 exhibits obvious sedimentary differentiation, namely, basin–slope–secondary slope–slope–secondary slope–platform margin–restricted platform, from the inner trough to the marginal trough. Fourth, the rift trough in southern Sichuan Basin has evolved in four stages: stabilization of Deng 1–Deng 2, initialization of Deng 3–Deng 4, filling of Maidiping–Qiongzhusi, and extinction of Canglangpu Formation. | LI Rong WANG Yongxiao WANG Zecheng XIE Wuren LI Wenzheng GU Mingfeng LIANG Zirui | 2023 | Petroleum Exploration and Development2023，50，2： | 1 |
| 5 | Enhancement of Astragalus polysaccharide on the immune responses in pigs inoculated with foot-and-mouth disease virus vaccine显示文摘 | Jiefeng Li Yougang Zhong Huanrong Li Nuowei Zhang Wuren Ma Guilin Cheng Faqiang Liu Fenghua Liu Jianqin Xu | 2011 | International Journal of Biological Macromolecules2011，，3： | 1 |
| 6 | Exploring the potential of oil and gas resources in Sichuan Basin with Super Basin Thinking显示文摘Based on the contemporary strategy of Petro China and the“Super Basin Thinking”initiative,we analyze the petroleum system,the remaining oil and gas resource distribution,and the Super Basin development scheme in the Sichuan Basin with the aim of unlocking its full resource potential.We conclude that,(1)The three-stage evolution of the Sichuan Basin has resulted in the stereoscopic distribution of hydrocarbon systems dominated by natural gas.The prospecting Nanhua-rift stage gas system is potentially to be found in the ultra-deep part of the basin.The marine-cratonic stage gas system is distributed in the Sinian to Mid-Triassic formations,mainly conventional gas and shale gas resources.The foreland-basin stage tight sand gas and shale oil resources are found in the Upper Triassic-Jurassic formations.Such resource base provides the foundation for the implementation of Super Basin paradigm in the Sichuan Basin.(2)To ensure larger scale hydrocarbon exploration and production,technologies regarding deep to ultra-deep carbonate reservoirs,tight-sand gas,and shale oil are necessarily to be advanced.(3)In order to achieve the full hydrocarbon potential of the Sichuan Basin,pertinent exploration strategies are expected to be proposed with regard to each hydrocarbon system respectively,government and policy supports ought to be strengthened,and new cooperative pattern should be established.Introducing the“Super Basin Thinking”provides references and guidelines for further deployment of hydrocarbon exploration and production in the Sichuan Basin and other developed basins. | WANG Zecheng SHI Yizuo WEN Long JIANG Hua JIANG Qingchun HUANG Shipeng XIE Wuren LI Rong JIN Hui ZHANG Zhijie YAN Zengmin | 2022 | Petroleum Exploration and Development2022，49，5： | 1 |
| 7 | Petroleum geology of marl in Triassic Leikoupo Formation and discovery significance of Well Chongtan1 in central Sichuan Basin,SW China显示文摘In 2022,the risk exploration well Chongtan1(CT1)in the Sichuan Basin revealed commercial oil and gas flow during test in a new zone–the marl of the second submember of the third member of Leikoupo Formation(Lei-32)of Middle Triassic,recording a significant discovery.However,the hydrocarbon accumulation in marl remains unclear,which restricts the selection and deployment of exploration area.Focusing on Well CT1,the hydrocarbon accumulation characteristics of Lei-32 marl are analyzed to clarify the potential zones for exploration.The following findings are obtained.First,according to the geochemical analysis of petroleum and source rocks,oil and gas in the Lei-32 marl of Well CT1 are originated from the same marl.The marl acts as both source rock and reservoir rock.Second,the Lei-32 marl in central Sichuan Basin is of lagoonal facies,with a thickness of 40–130 m,an area of about 40000 km^(2),a hydrocarbon generation intensity of(4–12)×10^(8) m^(3)/km^(2),and an estimated quantity of generated hydrocarbons of 25×10^(12) m^(3).Third,the lagoonal marl reservoirs are widely distributed in central Sichuan Basin.Typically,in Xichong–Yilong,Ziyang–Jianyang and Moxi South,the reservoirs are 20–60 m thick and cover an area of 7500 km^(2).Fourth,hydrocarbons in the lagoonal marl are generated and stored in the Lei-32 marl,which means that marl serves as both source rock and reservoir rock.They represent a new type of unconventional resource,which is worthy of exploring.Fifth,based on the interpretation of 2D and 3D seismic data from central Sichuan Basin,Xichong and Suining are defined as favorable prospects with estimated resources of(2000–3000)×10^(8) m^(3). | WANG Zecheng XIN Yongguang XIE Wuren WEN Long ZHANG Hao XIE Zengye ZHANG Jianyong TIAN Han LI Wenzheng FU Xiaodong SUN Haofei WANG Xiaofang HU Guoyi ZHANG Yu | 2023 | Petroleum Exploration and Development2023，50，5： | 0 |
| 8 | Effects of the grazing systems on germinable soil seed bank of desert steppe显示文摘We studied a soil seed bank in the Stipa breviflora desert steppe under three grassland management systems,namely continuous grazing,rotational grazing,and no grazing,from 1999 until 2007.The germinable seed bank species in rotational,continuous and no grazing were 11,9 and 8 species,respectively.Rotational grazing increased the number of seed bank plant species and perennial grasses.The density of germinal soil seed bank was significantly higher in the enclosed area(19,533.33 seeds/m 2) than those in rotational(3,233.33 seeds/m 2) and continuous grazing areas(2,553.60 seeds/m 2).The vertical distribution of the soil seed bank had a similar trend:75.06%-83.19% of the seeds are distributed in the top 0-5 cm soil layer,14.16%-21.68% in the 5-10 cm layer,and 2.65%-4.95% in the 10-15 cm layer,which varied between the grazing treatments.Density of the soil seed bank was significantly higher in the enclosed area,and there was no significant difference between rotational and continuous grazing.The Margalef and Shannon-Wiener indices for the soil seed bank were higher for rotational grazing treatment than for continuous grazing.The Sorensen's similarity index for the soil seed bank between the enclosed and rotational grazing areas reached 0.857. | RuiRui Yan ZhiJun Wei XiaoPing Xin HongMei Liu Jing Yang Qiqige Wuren | 2012 | Research in Cold and Arid Regions2012，4，1： | 0 |
| 9 | Regional unconformities and their controls on hydrocarbon accumulation in Sichuan Basin, sW China显示文摘Based on outcrop,seismic and drilling data,the main regional unconformities in the Sichuan Basin and their controls on hydrocarbon accumulation were systematically studied.Three findings are obtained.First,six regional stratigraphic unconformities are mainly developed in the Sichuan Basin,from the bottom up which are between pre-Sinian and Sinian,between Sinian and Cambrian,between pre-Permian and Permian,between middle and upper Permian,between middle and upper Triassic,and between Triassic and Jurassic.Especially,16 of 21l conventional(and tight)gas fields discovered are believed to have formed in relation to regional unconformities.Second,regional unconformity mainly controls hydrocarbon accumulation from five aspects:(1)The porosity and permeability of reservoirs under the unconformity are improved through weathering crust karstification to form large-scale karst reservoirs;(2)Good source-reservoir-caprock assemblage can form near the unconformity,which provides a basis for forming large gas field;(3)Regional unconformity may lead to stratigraphic pinch-out and rugged ancient landform,giving rise to a large area of stratigraphic and lithologic trap groups;(4)Regional unconformity provides a dominant channel for lateral migration of oil and gas;and(5)Regional unconformity is conducive to large-scale accumulation of oil and gas.Third,the areas related to regional unconformities are the exploration focus of large gas fields in the Sichuan Basin.The pre-Sinian is found with source rocks,reservoir rocks and other favorable conditions for the formation of large gas fields,and presents a large exploration potential.Thus,it is expected to be an important strategic replacement. | YANG Weij WEI Guoqi WU Saijun XIE Wuren JIN Hui ZENG Fuying HAO Cuiguo BAI Zhuangzhuang SU Yiqing LI Rong | 2023 | Petroleum Exploration and Development2023，50，3： | 0 |
| 10 | The pre-Sinian rift in central Sichuan Basin and its control on hydrocarbon accumulation in the overlying strata显示文摘Based on the latest seismic data, resistivity profile, outcrop evidence and logging data, the structural features of basement in Sichuan Basin and its control on the hydrocarbon accumulation in the Sinian-Cambrian strata was discussed. It was found that a NE striking pre-Sinian rift was developed across the whole basin. Controlled by a series of rift-parallel normal faults, horst-graben structures were developed inside the rift, large horst-graben structures and later activity of their boundary faults controlled the distribution of beach facies of the overlying strata. The horst-graben structures induced the formation of local highs of ancient landform and controlled the successive development of overlapped bioherm beach facies in long-term marine setting from the Sinian period to the Permian period, and as a result a widely distributed favorable sedimentary facies belt was developed. The pre-Sinian rift and later activities of related normal faults controlled the development of the grain beach and karst reservoirs and the deposition of high quality source rock, which form structural-lithologic traps. Through comprehensive evaluation, two large structural-lithologic composite trap favorable exploration areas in the south and north of the Gaoshiti-Moxi area, were selected. | WEI Guoqi YANG Wei ZHANG Jian XIE Wuren ZENG Fuying SU Nan JIN Hui | 2018 | Petroleum Exploration and Development2018，45，2： | 0 |
| 11 | Genotoxicity Induced by Low Dose and Mixed Exposure to Haloacetaldehydes,an Emerging Class of Drinking Water Disinfection By-products显示文摘Haloacetaldehydes(HALs)are the third largest disinfection by-products(DBPs)class by mass in drinking water.Most of them alone in high doses are more cytotoxic and genotoxic than regulated DBPs.However,the toxic effects of mixed exposure to HALs at environmentally relevant levels are still unknown.Given that genotoxicity is critical for risk assessment,we employed multiple genotoxic tests including the Salmonella typhimurium revertant mutation assay(Ames assay),the single cell gel electrophoresis(SCGE)assay,the cytoplasmic blocking micronucleus(CBMN)assay,and theγ-H2AX assay to investigate the genotoxicity of HALs based on the HALs concentrations and components detected in the finished drinking water of Shanghai,China.The results demonstrated the concentrations of HALs were low,ranging from 0.04µg/L to 4.47µg/L,and the total concentration was 10.85µg/L.Although the mutagenicity of HALs was negative even at 1000-fold concentrations in the real world,mixed exposure to 100 and 1000-fold concentrations HALs resulted in DNA and chromosomal damage in human hepotocyte(HepG2)cells.HALs significantly increased the levels of reactive oxygen species(ROS)andγ-H2AX and activated nuclear factor erythroid-derived factor 2-related factor 2(NRF2)pathway-related protein expressions in HepG2 cells.The antioxidant NAC could ameliorate NRF2 pathway-related protein expression and DNA damage caused by HALs,suggesting that the genotoxicity of mixed exposure to HALs involved cellular oxidative stress and NRF2 pathway activation. | YANG Lili MA Wuren JIANG Zhiqiang CHEN Yu QIU Meiyue ZHOU Ying James C.CRABBE ZHENG Weiwei QU Weidong | 2023 | Chemical Research in Chinese Universities2023，39，3： | 0 |
| 12 | EFFECT OF HCG AND E2 ON ELECTRICAL ACTIVITY OF RABBIT OVIDUCT WITH CHRONIC RECORDING METHOD显示文摘In this study, we observed the chronic effects ofhCG and E2 estradiol ) on the electrical activity of the rabbit oviducts by means of implanted electrodes. | QIANWei XIAJmg-Zhong CHENGShu-Mo TIANXian-Zi FENGTong-Dao WURen | 1989 | Journal of Reproduction and Contraception1989，1，1： | 0 |
| 13 | Sinian hydrocarbon accumulation conditions and exploration potential at the northwest margin of the Yangtze region, China显示文摘Based on outcrop, drilling, logging and seismic data, the reservoir forming conditions, reservoir forming model and exploration potential of the ultra-deep Sinian Dengying Formation at the northwest margin of Yangtze craton region were examined.(1) This area is in craton rifting stage from Sinian to Early Cambrian, characterized by syn-sedimentary faults and rapid subsidence, significant sedimentary differences, and development of Dengying Formation platform margins on both sides of the rift.(2) The Sinian–Cambrian in this area has two sets of high-quality source rocks, Doushantuo Formation and Maidiping-Qiongzhusi Formation;of which, the latter has a thickness of 150–600 m and hydrocarbon generation intensity of(100-200)×10;m;/km;.(3) The mounds and shoals in the platform margin of Sinian Dengying Formation controlled by faults are thick and distributed in rows and zones;they are reformed by contemporaneous–quasi-contemporaneous and supergene karstification jointly, forming pore-type reservoirs with a thickness of 200-400 m.(4) The two sets of source rocks enter oil generation windows from Permian to Early Triassic, and the oil migrates a short distance to the lithologic traps of mounds and shoals to form a huge scale paleo-oil reservoir group;from Late Triassic to Jurassic, the oil in the paleo-oil reservoirs is cracked into gas, laying the foundation of present natural gas reservoirs.(5) The mound-shoal body at the platform margin of Dengying Formation and the two sets of high-quality source rocks combine into several types of favorable source-reservoir combinations, which, with the advantage of near-source and high-efficiency reservoir formation, and can form large lithologic gas reservoirs. The Mianyang-Jiange area is a potential large gas field with trillion cubic meters of reserves. According to seismic prediction, the Laoguanmiao structure in this area has the Deng-2 Member mound-shoal reservoir of about 1300 km^(2), making it a ultra-deep target worthy of exploration in the near future. | YANG Yu WANG Zecheng WEN Long XIE Wuren FU Xiaodong LI Wenzheng | 2022 | Petroleum Exploration and Development2022，49，2： | 0 |
| 14 | Comparison of nomogram and machine-learning methods for predicting the survival of non-small cell lung cancer patients显示文摘Background:Most patients with advanced non-small cell lung cancer(NSCLC)have a poor prognosis.Predicting overall survival using clinical data would benefit cancer patients by allowing providers to design an optimum treatment plan.We compared the performance of nomograms with machine-learning models at predicting the overall survival of NSCLC patients.This comparison benefits the development and selection of models during the clinical decision-making process for NSCLC patients.Methods:Multiple machine-learning models were used in a retrospective cohort of 6586 patients.First,we modeled and validated a nomogram to predict the overall survival of NSCLC patients.Subsequently,five machine-learning models(logistic regression,random forest,XGBoost,decision tree,and light gradient boosting machine)were used to predict survival status.Next,we evaluated the performance of the models.Finally,the machine-learning model with the highest accuracy was chosen for comparison with the nomogram at predicting survival status by observing a novel performance measure:time-dependent prediction accuracy.Results:Among the five machine-learning models,the accuracy of random forest model outperformed the others.Compared with the nomogram for time-dependent prediction accuracy with a follow-up time ranging from 12 to 60 months,the prediction accuracies of both the nomogram and machinelearning models changed as time varied.The nomogram reached a maximum prediction accuracy of 0.85 in the 60th month,and the random forest algorithm reached a maximum prediction accuracy of 0.74 in the 13th month.Conclusions:Overall,the nomogram provided more reliable prognostic assessments of NSCLC patients than machine-learning models over our observation period.Although machine-learning methods have been widely adopted for predicting clinical prognoses in recent studies,the conventional nomogram was competitive.In real clinical applications,a comprehensive model that combines these two methods may demonstrate superior capabilities. | Haike Lei Xiaosheng Li Wuren Ma Na Hong Chun Liu Wei Zhou Hong Zhou Mengchun Gong Ying Wang Guixue Wang Yongzhong Wu | 2022 | Cancer Innovation2022，1，2： | 0 |
| 15 | Formation conditions of Sinian–Cambrian large lithologic gas reservoirs in the north slope area of central Sichuan Basin,SW China显示文摘Based on analyses of characteristics,hydrocarbon charging history and geological conditions for the formation of Sinian-Cambrian reservoirs in the north slope area of central Sichuan paleo-uplift,the natural gas origin,accumulation evolution,accumulation pattern and formation conditions of large lithologic gas reservoirs have been investigated.Through comprehensive analyses of natural gas composition,carbon and hydrogen isotopic compositions,fluid inclusions,reservoir bitumen,and geological conditions such as lithofacies paleogeography and beach body characterization,it is concluded that:(1)The natural gas in the Sinian-Cambrian of the north slope area is mainly oil cracking gas,and different contribution ratios of multiple sets of source rocks lead to different geochemical characteristics of natural gas in different reservoirs.(2)Although the both Sinian and Cambrian gas reservoirs in this area are lithologic gas reservoirs under monocline background,the former has normal-pressure and the latter has high-pressure.There are three types of source-reservoir-caprock combinations:single source with lower generation and upper reservoir,double sources with lower generation and upper reservoir or with side source and lateral reservoir,double sources with lower generation and upper reservoir or with upper generation and lower reservoir.The Permian-Triassic is the main generation period of oil,Early-Middle Jurassic is the main generation period of oil cracking gas and wet gas,and Late Jurassic-Cretaceous is the main generation period of dry gas.(3)The Sinian-Cambrian system of the north slope area has two favorable conditions for formation of large lithologic gas reservoirs,one is that the large scale beach facies reservoirs are located in the range of ancient oil reservoirs or near the source rocks,which is conducive to the'in-situ'large-scale accumulation of cracked gas in the paleo-oil reservoirs,the other is that the large scale mound-beach complex reservoirs and sealing layers of inter beach tight zones match effectively to form large lithologic traps under the slope background.The research results confirm that the north slope area has large multi-layer lithologic gas reservoirs with more than one trillion cubic meters of natural gas resources and great exploration potential. | WEI Guoqi XIE Zengye YANG Yu LI Jian YANG Wei ZHAO Luzi YANG Chunlong ZHANG Lu XIE Wuren JIANG Hua LI Zhisheng LI Jin GUO Jianying | 2022 | Petroleum Exploration and Development2022，49，5： | 0 |
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