|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Therapeutic potential of brain-derived neurotrophic factor(BDNF)and a small molecular mimics of BDNF for traumatic brain injury显示文摘Traumatic brain injury(TBI) is a major health problem worldwide.Following primary mechanical insults,a cascade of secondary injuries often leads to further neural tissue loss.Thus far there is no cure to rescue the damaged neural tissue.Current therapeutic strategies primarily target the secondary injuries focusing on neuroprotection and neuroregeneration.The neurotrophin brain-derived neurotrophic factor(BDNF) has significant effect in both aspects,promoting neuronal survival,synaptic plasticity and neurogenesis.Recently,the flavonoid 7,8-dihydroxyflavone(7,8-DHF),a small Trk B agonist that mimics BDNF function,has shown similar effects as BDNF in promoting neuronal survival and regeneration following TBI.Compared to BDNF,7,8-DHF has a longer half-life and much smaller molecular size,capable of penetrating the blood-brain barrier,which makes it possible for non-invasive clinical application.In this review,we summarize functions of the BDNF/Trk B signaling pathway and studies examining the potential of BDNF and 7,8-DHF as a therapy for TBI. | Mary Wurzelmann Jennifer Romeika Dong Sun | 2017 | Neural Regeneration Research2017，12，1： | 21 |
| 2 | Oral Contraceptive Use and the Risk of Inflammatory Bowel Disease显示文摘 | Robert S. Sandler John I. Wurzelmann Cynthia M. Lyles | 1992 | Epidemiology1992，，： | 1 |
| 3 | Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden显示文摘 | Panchal SJ Muller-Schwefe P Wurzelmann JI | 2007 | IntJ Clin Pract2007，61，7： | 1 |
| 4 | In vivo activation of mitogen activated protein kinases in rat intestinal neoplasia 显示文摘 | Licato LL Keku TO Wurzelmann JI | 1997 | Gastroenterology1997，113，： | 1 |
| 5 | Opioid-induced bowel dysfunction: prevalence, pathophysiology and burden显示文摘 | Panchal SJ M ti ller-Schwefe P Wurzelmann JI | 2007 | Int J Clin Praet2007，61，7： | 1 |
| 6 | Childhood infections and the risk of inflammatory bowel disease显示文摘 | John I. Wurzelmann MD MPH Cynthia M. Lyles BS Dr. Robert S. Sandler MD MPH | 1994 | Digestive Diseases and Sciences1994，，3： | 1 |
| 7 | Opioid-induced bowel dysfunction:prevalence,pathophysiology and burden显示文摘 | Panchal S J Müller-Schwefe P Wurzelmann J I | 2007 | Int J Clin Pract2007，61，7： | 1 |
| 8 | Childhood infections and the risk of inflammatory bowel disease显示文摘 | John I. Wurzelmann MD MPH Cynthia M. Lyles BS Dr. Robert S. Sandler MD MPH | 1994 | Digestive Diseases and Sciences1994，，3： | 1 |
| 9 | Iron intake and the risk of colorectal cancer显示文摘 | Wurzelmann JI Silver A Schreinemachers DM | 1996 | Cancer Epidemiol Biomarkers Prev1996，5，7： | 1 |
| 10 | Enduring association between irritable bowel syndrome and war trauma during the Nicaragua civil war period:A population-based study显示文摘BACKGROUND Psychosocial and physical trauma are known risk factors for irritable bowel syndrome(IBS),including in war veterans,whereas war exposure in civilians is unclear.Nicaragua experienced two wars,1970-1990:The Sandinistas Revolution(1970s)and The Contra War(1980s).Our aim was to investigate the role of exposure to war trauma in the subsequent development of IBS in the context of an established health surveillance system(11000 households).AIM To investigate in a civilian population the relationship between exposure to war trauma and events and the subsequent development of IBS in the context of an established public health and demographic surveillance system in western Nicaragua.METHODS We conducted a nested population-based,cross-sectional study focused on functional gastrointestinal disorders based on Rome II criteria.1617 adults were randomly selected.The Spanish Rome II Modular Questionnaire and Harvard Trauma Questionnaire were validated in Nicaragua.War exposure was assessed with 10 measures of direct and indirect war trauma and post-war effects.Multiple exposures were defined by≥3 measures.RESULTS The prevalence of IBS was 15.2%[Female(F)17.1%,Male(M)12.0%],war exposure 19.3%(F 9.3%,M 36.7%),and post-traumatic stress disorder(PTSD)5.6%(F 6.4%,M 4.3%).Significant associations with IBS in the civilian population were observed(adjusted by gender,age,socioeconomic status,education):physical and psychological abuse[adjusted odds ratio(aOR):2.25;95%confidence interval:1.1-4.5],witnessed execution(aOR:2.4;1.1-5.2),family member death(aOR:2.2;1.2-4.2),and multiple exposures(aOR:2.7;1.4-5.1).PTSD was independently associated with IBS(aOR:2.6;1.2-5.7).CONCLUSION An enduring association was observed in the Nicaragua civilian population between specific civil war-related events and subsequent IBS.Civilian populations in regions with extended armed conflict may warrant provider education and targeted interventions for patients. | Edgar M Peña-Galo Daniel Wurzelmann Javier Alcedo Rodolfo Peña Loreto Cortes Douglas Morgan | 2023 | World Journal of Gastroenterology2023，29，45： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员