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| 1 | Failure of P-selectin blockade alone to protect the liver from ischemia-reperfusion injury in the isolated blood-perfused rat liver显示文摘AIM:To determine if blockade of P-selectin in the isolated blood-perfused cold ex vivo rat liver model protects the liver from ischemia-reperfusion injury. METHODS:The effect of P-selectin blockade was assessed by employing an isolated blood-perfused cold ex vivo rat liver with or without P-selectin antibody treatment before and after 6 h of cold storage in University of Wisconsin solution. RESULTS:In our isolated blood-perfused rat liver model,pre-treatment with P-selectin antibody failed to protect the liver from ischemia-reperfusion injury,as judged by the elevated aspartate aminotransferase activity. In addition,P-selectin antibody treatment did not significantly reduced hepatic polymorphonuclear leukocyte accumulation after 120 min of perfusion. Histological evaluation of liver sections obtained at 120 min of perfusion showed significant oncotic necrosis in liver sections of both ischemic control and P-selectin antibody-treated groups. However,total bile production after 120 min of perfusion was signifi cantly greater in P-selectin antibody-treated livers,compared to control livers. No signifi cant difference in P-selectin and ICAM-1 mRNAs and proteins,GSH,GSSG,and nuclear NF-κB was found between control and P-selectin antibody-treated livers. CONCLUSION:In conclusion,we have shown that blockade of P-selectin alone failed to reduced polymorphonuclear leukocyte accumulation in the liver and protect hepatocytes from ischemia-reperfusion injury in the isolated blood-perfused cold-ex vivo rat liver model. | Samuel Wyllie Neal R Barshes Saul J Karpen John A Goss | 2008 | World Journal of Gastroenterology2008，14，44： | 4 |
| 2 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 3 | Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics显示文摘 | KERR J F WYLLIE A H CUEEIE A R | 1972 | Br J Cancer1972，26，： | 1 |
| 4 | The role of growth hormone and insulin - like growth factor - 1 in Crohn's disease: Implications for therapeutic use of human growth hormone in pediatric patients 显示文摘 | Vortia E Kay M Wyllie R | 2011 | Curr Opin Pe- diatr2011，23，5： | 1 |
| 5 | Cell death:the significance of apoptosis显示文摘 | Wyllie A H Kerr J F Currie A R | 1980 | Int Rev Cytol1980，68，1： | 1 |
| 6 | Elastic wave velocities in heterogeneous and porous media 显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 7 | Elastic wave velocities in heterogeneous and porous media显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 8 | Cell death: the significance of apoptosis 显示文摘 | WYLLIE A H KERR J F CURRIE A R | 1980 | Int Rev Cytol1980，68，： | 1 |
| 9 | An experimental investigation of factors affecting elastic wave velocities in porous media显示文摘 | Wyllie M R J Gregory A R and Gardner L W | 1958 | 23 (3) : 459-4931958，23，3： | 1 |
| 10 | An experimental investigation of factors affecting elastic wave velocities in porous media显示文摘 | Wyllie M R J Gregory A R Gardner G H F | 1958 | Geophysics1958，23，： | 1 |
| 11 | Elastic wave velocities in heterogeneous and porous media显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，129： | 1 |
| 12 | Apoptosis: A basic phenomenon with wide-ranging implications in tissue kinetics显示文摘 | KREE J F WYLLIE A H CURRIE A R | 1972 | Br J Cancer1972，26，4： | 1 |
| 13 | The relationship between health related knowledge, attitudes and dental health behaviours in 14-16-year-old adolescents 显示文摘 | Freeman R Maizels J Wyllie M | 1993 | Community Dent Health1993，10，4： | 1 |
| 14 | Elastic Wave Velocity in Heterogeneous and Porous Media显示文摘 | Wyllie M R J Gregory A R Gardner L W | 1956 | Geophysics1956，21，1： | 1 |
| 15 | Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics显示文摘 | Kerr J F Wyllie A H Currie A R | 1972 | Br J Cancer1972，26，4： | 1 |
| 16 | Apoptosis : a basic biological phe- nomenon with wide-ranging implications in tissue kinetics 显示文摘 | Kerr J F Wyllie A H CmTie A R | 1972 | Br J Cancer1972，26，： | 1 |
| 17 | An Experimental Investigation of Factors Affecting Elastic Wave Velocity Porous Media显示文摘 | Wyllie M R J Gardner G H F | 1958 | Geophysics1958，23，3： | 1 |
| 18 | An experimen- tal investigation of factors affecting elastic wave velocities in porous media 显示文摘 | Wyllie M R J C-regory A R C-ardner G H F | 1958 | Geophysics1958，23，3： | 1 |
| 19 | Apoptosis:a basic biological phenomenon with wide-ranging implications in tissue kinetics显示文摘 | Kerr J F Wyllie A H Currie A R | 1972 | Br J Cancer1972，26，4： | 1 |
| 20 | The major outer membrane protein of Chlamydia psittaci functions as a porin-like ion channel显示文摘 | Wyllie S Ashley R H Longbottom D | 1998 | Infect Immun1998，66，： | 1 |
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