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| 1 | 砷的代谢机制、毒性和生物监测显示文摘砷化合物是备受关注的一类污染物,特别是饮用水中的砷污染引发了全球性的健康问题。本文综述了近年来人们对砷的代谢机制、毒性和生物监测的研究进展。砷在生物体内的代谢过程十分复杂,在氧化还原酶和甲基转移酶的参与下,产生一系列的代谢产物和中间产物。其中,砷的原始摄入形态、代谢产物及中间产物由于不同的物理化学性质,体现了不同的毒性。人类和不同的动物由于不同的砷代谢机理和甲基化能力,也表现了对砷毒性抵抗能力的差异。在生物体内,一些砷化合物与生物蛋白相互作用,影响它们的存在形式、分布和传输,是砷的生物代谢和毒理研究中不可或缺的内容。生物监测是一种直接有效的污染物健康风险评估方法。在尿液、血液、唾液、头发和指甲中砷化合物直接反映了暴露主体的砷暴露程度,这5种生物介质作为砷暴露的生物标志物各有优缺点。在砷的研究中,代谢机制和毒性的研究可以帮助选择合适的生物监测方法,做出合理准确的健康风险评估。生物监测也可促进对砷的代谢机制和毒性的理解,推断可能的代谢途径,定量毒性剂量效应,两者相互依赖相互促进。 | 陈保卫 那仁满都拉 吕美玲 X.Chris Le | 2009 | 化学进展2009，21，2： | 43 |
| 2 | 中国关于砷的研究进展显示文摘综述了近年来有关中国的砷污染状况、相关的分析监测技术及砷化合物毒性的研究进展.在中国部分地区,长期砷暴露导致了严重的区域性的砷中毒,主要的暴露途径是饮用水、食物和煤炭的燃烧.样品前处理、砷的富集和形态分析技术的丰富和发展,为环境科学、毒理学和流行病学的研究提供了可靠的技术支持.生物检测是一种直接有效的污染物健康风险评估方法,尿样、血液、唾液、头发和指甲中的砷及生理生化指标直接反映了暴露主体的砷暴露程度和砷相关的损伤程度.在砷的生物代谢过程中,产生活性氧和自由基,导致氧化应激的提高,影响亚铁血红蛋白的生物合成,导致细胞膜的过氧化,线粒体相关的细胞凋亡,DNA的氧化损伤而产生基因突变.砷中毒的易受程度,与年龄、营养状况、硒的摄入相关.砷化合物能穿过胎盘屏障影响胎儿的发育,穿过脑血屏障影响智力发育和导致神经毒性.慢性砷中毒的机理还有待进一步的研究. | 陈保卫 Le X.Chris | 2011 | 环境化学2011，30，11： | 40 |
| 3 | 高效液相色谱/氢化物发生/原子荧光快速检测尿砷形态显示文摘本文对砷形态分析方法进行了评述。提出了人尿中 As( )、As( )、一甲基砷( MMA)和二甲基砷 ( DMA)的快速、灵敏的形态分析方法。方法基于在 1 5cm长、3μm粒径的 HPL C柱上快速分离不同形态的砷后以灵敏的氢化物发生 /原子荧光检测。常见砷的四种形态的分析只须 4min即可完成 ,检出限在μg/L级。标准样品尿中砷的形态分析结果和标准值吻合很好。本法已应用于摄取砷糖前、后所采集的尿样中砷的形态分析研究。砷糖普遍存在于海藻、牡蛎、贻贝和蚌等海产品中。食用这些含有胂糖的食品后 ,尿液中的 DMA显著增加。环境和职业砷暴露的生物标志物 ( Biomarker)常基于尿液中无机砷及其代谢产物 MMA和 DMA的测定。砷糖的摄入影响这类生物标志物的可靠性 。 | Ming sheng Ma X.Chris Le 胡斌 江祖成 | 2000 | 分析科学学报2000，16，2： | 27 |
| 4 | 砷形态分析显示文摘综述了近几年砷形态分析方法的最新研究进展。以常见砷形态分析方法发展为主线,讨论了不同砷形态分析方法的发展过程和应用情况,对不同方法的优缺点进行了扼要评述。早期的砷形态分析方法主要是以色谱和原子光谱联用为主要手段,随着不同的、更为有效的砷化合物检测手段的出现,砷形态分析方法也不断进行完善、发展。目前,在定量分析方面以液相色谱和电感耦合等离子体质谱联用方法为主要常规分析手段;在砷化合物定性分析方面,色谱-电感耦合等离子体质谱与电喷雾质谱相互补充的联用方法逐渐成为了主要分析手段。砷形态分析在环境健康和毒理学方面的应用是目前该领域的主要研究方向,结合国际上最新的研究进展,讨论了砷形态分析方法在环境毒理学等研究中发挥的重要作用。 | 苑春刚 X.Chris Le | 2009 | 化学进展2009，21，2： | 23 |
| 5 | Comparative cytotoxicity of fourteen trivalent and pentavalent arsenic species determined using real-time cell sensing显示文摘The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species: arsenite(As~Ⅲ), monomethylarsonous acid(MMA~Ⅲ) originating from the oxide and iodide forms, dimethylarsinous acid(DMA~Ⅲ), dimethylarsinic glutathione(DMAG~Ⅲ), phenylarsine oxide(PAO~Ⅲ), arsenate(AsV), monomethylarsonic acid(MMA~Ⅴ), dimethylarsinic acid(DMA~Ⅴ),monomethyltrithioarsonate(MMTTA~Ⅴ), dimethylmonothioarsinate(DMMTA~Ⅴ),dimethyldithioarsinate(DMDTA~Ⅴ), 3-nitro-4-hydroxyphenylarsonic acid(Roxarsone, Rox),and 4-aminobenzenearsenic acid(p-arsanilic acid, p-ASA). Cellular responses were measured in real time for 72 hr in human lung(A549) and bladder(T24) cells. IC50 values for the arsenicals were determined continuously over the exposure time, giving rise to IC50 histograms and unique cell response profiles. Arsenic accumulation and speciation were analyzed using inductively coupled plasma-mass spectrometry(ICP-MS). On the basis of the 24-hr IC50 values, the relative cytotoxicity of the tested arsenicals was in the following decreasing order: PAO~Ⅲ? MMA~Ⅲ≥ DMA~Ⅲ≥ DMAG~Ⅲ≈ DMMTA~Ⅴ≥ As~Ⅲ? MMTTA~Ⅴ> AsV> DMDTA~Ⅴ>DMA~Ⅴ> MMA~Ⅴ≥ Rox ≥ p-ASA. Stepwise shapes of cell response profiles for DMA~Ⅲ, DMAG~Ⅲ,and DMMTA~Ⅴcoincided with the conversion of these arsenicals to the less toxic pentavalent DMA~Ⅴ. Dynamic monitoring of real-time cellular responses to fourteen arsenicals provided useful information for comparison of their relative cytotoxicity. | Birget Moe Hanyong Peng Xiufen Lu Baowei Chen Lydia W.L.Chen Stephan Gabos Xing-Fang Li X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 19 |
| 6 | Characterization of natural organic matter in water for optimizing water treatment and minimizing disinfection by-product formation显示文摘Introduction Natural organic matter(NOM)present in source water has significant impact on water treatment processes and on the quality of drinking water.NOM is a complex mixture of diverse groups of organic compounds,humic and fulvic acids,proteins,peptides,carbohydrates,and heterogeneous | Qi Zheng Xiaoqiu Yang Wenchao Deng X.Chris Le Xing-Fang Li | 2016 | Journal of Environmental Sciences2016，28，4： | 13 |
| 7 | Methylated and thiolated arsenic species for environmental and health research——A review on synthesis and characterization显示文摘Hundreds of millions of people around the world are exposed to elevated concentrations of inorganic and organic arsenic compounds, increasing the risk of a wide range of health effects. Studies of the environmental fate and human health effects of arsenic require authentic arsenic compounds. We summarize here the synthesis and characterization of more than a dozen methylated and thiolated arsenic compounds that are not commercially available. We discuss the methods of synthesis for the following14 trivalent(Ⅲ) and pentavalent() arsenic compounds: monomethylarsonous acid(MMA~Ⅲ), dicysteinylmethyldithioarsenite(MMA~Ⅲ(Cys)_2), monomethylarsonic acid(MMA~Ⅴ),monomethylmonothioarsonic acid(MMMTAⅤ) or monothio-MMA~Ⅴ, monomethyldithioarsonic acid(MMDTA~Ⅴ) or dithio-MMA~Ⅴ, monomethyltrithioarsonate(MMTTA~Ⅴ) or trithio-MMA~Ⅴ,dimethylarsinous acid(DMA~Ⅲ), dimethylarsino-glutathione(DMA~Ⅲ(SG)), dimethylarsinic acid(DMA~Ⅴ), dimethylmonothioarsinic acid(DMMTA~Ⅴ) or monothio-DMAⅤ, dimethyldithioarsinic acid(DMDTA~Ⅴ) or dithio-DMA~Ⅴ, trimethylarsine oxide(TMAO~Ⅴ), arsenobetaine(AsB), and an arsenicin-A model compound. We have reviewed and compared the available methods,synthesized the arsenic compounds in our laboratories, and provided characterization information. On the basis of reaction yield, ease of synthesis and purification of product, safety considerations, and our experience, we recommend a method for the synthesis of each of these arsenic compounds. | William R.Cullen Qingqing Liu Xiufen Lu Anthony McKnight-Whitford Hanyong Peng Aleksandra Popowich Xiaowen Yan Qi Zhang Michael Fricke Hongsui Sun X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 12 |
| 8 | Rice:Reducing arsenic content by controlling water irrigation显示文摘Arsenic has long been recognized as a poison.Arsenic in water supplies that are used for both drinking and crop irrigation can expose many people chronically to elevated levels of arsenic.The main health concern for chronic exposure to arsenic is the development of cancer.Although the World Health Organization(WHO)recommends that total arsenic in drinking water should be under 10μg/L(or 10 ppb),(WHO,2011),some | Ashley M.Newbigging Rebecca E.Paliwoda X.Chris Le | 2015 | Journal of Environmental Sciences2015，27，4： | 12 |
| 9 | Studying developmental neurotoxic effects of bisphenol A(BPA) using embryonic stem cells显示文摘There is little to no toxicity information regarding thousands of chemicals to which people are exposed daily.In fact,of the84,000 chemicals listed in the United States Toxic Substances Control Act Inventory,there is limited information available on their effects on neural development(Betts,2010;US EPA,2015).The number of chemicals tested remains low due to the high cost of conducting multi-generational animal | Jinhua Li Katherine Z.Fu Sai Vemula X.Chris Le Xing-Fang Li | 2015 | Journal of Environmental Sciences2015，27，10： | 6 |
| 10 | Consumption of rice and fish in an electronic waste recycling area contributes significantly to total daily intake of mercury显示文摘Mercury is a global pollutant due to its widespread use,emission,and long-range transport(Blum,2013;Pacyna et al.,2010).It is considered a priority pollutant due to its neurological toxicity,persistence,and bioaccumulation(Pacyna et al.,2010;Sharma et al.,2015).Mercury pollution can occur when products that contain mercury are improperly disposed of and mercury is released into the air,water,and soil(Zhang and Wong,2007).An estimated 22%of the annual world usage of mercury is in electrical equipment such as batteries,thermometers,and discharge lamps,and electronic devices such as monitors | Hanyong Peng Michael S.Reid X.Chris Le | 2015 | Journal of Environmental Sciences2015，27，12： | 5 |
| 11 | Genotoxic effects of microcystins mediated by nitric oxide and mitochondria显示文摘Microcystins are potent toxins,produced naturally by cyanobacteria(blue green algae),and they present significant threats to human and animal health(WHO,1999;Chorus,2001;Carmichael et al.,2001;Falconer,2005;IARC,2010;Ma et al.,2015).These cyclic peptides consist of five common core | Qingqing Liu X.Chris Le | 2015 | Journal of Environmental Sciences2015，27，5： | 4 |
| 12 | Highlights and new Editorial Advisory Board members of the Journal of Environmental Sciences显示文摘The Journal of Environmental Sciences(JES)is honored to welcome Professors/Drs William A.Mitch,Jiuhui Qu,Susan D.Richardson,Jerald L.Schnoor,Hongxiao Tang,Shu Tao,and Hugh A.Tilson to serve on the Editorial Advisory Board(EAB).Their tremendous experience in scientific publications,leading expertise in topic areas pertinent to JES,diverse international networks/perspectives,and exemplary dedication to scientific excellence will guide and help the continuing healthy growth of JES. | Qingcai Feng Suqin Liu Zhengang Mao Jian Xu Zixuan Wang X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，9： | 4 |
| 13 | Professor William R. Cullen and arsenic chemistry显示文摘This special issue of the Journal of Environmental Sciences honors Professor William R.Cullen for his outstanding contributions to synthetic chemistry,environmental chemistry,microbiology,and toxicology of arsenic and its compounds.It is very fitting that the papers in this issue cover a diverse range of topics of | X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，11： | 4 |
| 14 | Is there a silver lining? Aggregation and photo-transformation of silver nanoparticles in environmental waters显示文摘The nanotechnology industry advances rapidly,and at the vanguard are the promising silver nanoparticles(Ag NPs),which have diverse applications.These nanometer-sized particles have been shown to inhibit the ability of bacteria to produce adenosine triphosphate(ATP),a molecule necessary for chemical energy transport in cells.The antimicrobial properties of Ag NPs(and Ag+)make them valued | Qi Zheng Michael Zhou Wenchao Deng X.Chris Le | 2015 | Journal of Environmental Sciences2015，27，8： | 4 |
| 15 | Microbial methylation of mercury in the water-level fluctuation zone of the Three Gorges Reservoir,China显示文摘Methylmercury(MeHg)is an organic form of the global pollutant mercury(Hg)which readily accumulates in fish tissue.A majority of Hg methylation is a result of microbial activity and the abundance of inorganic Hg within the water reservoirs(Eckley et al.,2017).Compared to natural lakes and rivers,reservoirs have elevated Hg levels from the decomposition of recently flooded organic material which promote | Karen S.Hoy Wei Feng X.Chris Le | 2018 | Journal of Environmental Sciences2018，30，6： | 3 |
| 16 | Removal of nanoparticles by coagulation显示文摘Nanoparticles(NPs)from anthropogenic sources have applications in several commercial products,including cosmetics,pharmaceuticals,and materials.There is evidence that during their usage and disposal,engineered nanoparticles can and will be released into wastewater(Gottschalk et al.,2013;Pasricha et al.,2012;Westerhoff et al.,2013;Zheng et al.,2015).If water and wastewater treatment plants are inefficient or incapable of removing NPs from water,NPs will be released with the treated effluent,entering drinking water sources and natural aquatic environments,increasing exposure for plants,microorganisms, | Aleksandra Popowich Qi Zhang X.Chris Le | 2015 | Journal of Environmental Sciences2015，27，12： | 3 |
| 17 | Arsenic biotransformation and an arsenite Sadenosylmethionine methyltransferase in plankton显示文摘Arsenic(As)is a well-recognized toxicant and carcinogen.Chronic exposure to inorganic arsenic causes a range of human cancers(e.g.,skin,bladder,and lung)and increases the risk of developing diabetes,hypertension,and cardiovascular and neurological diseases.The prevalence of arsenic species and the severity of their health effects continue to drive and demand for extensive research(Carlin et al.,2016). | Jagdeesh S.Uppal Qin Shuai Zhuang Li X.Chris Le | 2017 | Journal of Environmental Sciences2017，29，11： | 3 |
| 18 | Rapid growth of environmental research in China显示文摘Environmental research in China has grown tremendously over the last thirty years.This rapid and sustained growth has been supported by the remarkable increases in research funding,the number of graduate students,the degree-offering programs in environmental sciences and engineering,the state-of-the-art facilities,and international collaboration.In 1986 when the National Natural Science Foundation | Guibin Jiang Chunxia Wang X.Chris Le | 2016 | Journal of Environmental Sciences2016，28，1： | 2 |
| 19 | Arsenobetaine:the ongoing mystery显示文摘Arsenobetaine(As B) is a non-toxic organoarsenical identiied as a major arsenic species in marine animals and a number of terrestrial mushrooms.Since its irst identiication nearly 40 years ago,numerous studies investigating the biosynthesis and function of As B have been carried out,although molecular mechanisms have not been fully elucidated.Where and how is As B formed? Why do marine animals acquire high concentrations of As B? his review briely summarizes the current progress of As B research toward understanding its origin,function and the putative pathways for its biosynthesis.his paper also suggests potential future studies in the atempt to solve the As B mystery. | Aleksandra Popowich Qi Zhang X.Chris Le | 2016 | National Science Review2016，3，4： | 2 |
| 20 | “Waste”-ing away:Presence of Cu ions influences microbial degradation kinetics and metabolite formation of the prevalent brominated flame retardant BDE-47显示文摘Have you ever wondered what happened to that old cell phone you threw out last month?How about the 150 million other cell phones that were also disposed of in the past year?Although the world population has doubled in the past 50 years,global consumption of electronic devices has increased six fold(Belkhir and Elmeligi,2018)with nearly 45 million tonnes of electronic waste(e-waste)being produced in 2016 alone(Balde et al.,2017).That equates to 6.1 kg of e-waste per person across the globe and is equivalent in weight to over four thousand Eiffel towers(Balde et al.,2017)! | Jie Chen Birget Moe Lizhong Zhu X.Chris Le | 2020 | Journal of Environmental Sciences2020，32，1： | 2 |
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