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| 1 | Pharmacokinetics and disposition of anlotinib, an oral tyrosine kinase inhibitor, in experimental animal species显示文摘 | Chen-chun ZHONG Feng CHEN Jun-ling YANG Wei-wei JIA Li LI Chen CHENG Fei-fei DU Su-ping ZHANG Chengying XIE Na-ting ZHANG Olajide E OLALEYE Feng-qing WANG Fang XU Li-guang LOU Dong-ying CHEN Wei NIU Chuan LI | 2018 | Acta Pharmacologica Sinica2018，39，6： | 24 |
| 2 | Effective treatment of manganese-induced occupational parkinsonism with p-aminosalicylic acid: a case of 17-year follow-up study.显示文摘 | Jiang YM Mo XA Du FQ Fu X Zhu XY Gao HY Xie JL Liao FL Pira E Zheng W | 2006 | 中国生物学文摘2006，20，8： | 23 |
| 3 | Disinfection byproducts in drinking water and regulatory compliance: A critical review显示文摘消毒副产品(DBP ) 在在很多个国家喝水被调整。这批评评论集中于与 DBP 规章的依从联系的问题,包括为 DBP 分析,出现层次,在各种各样的国家之中的规定比较, DBP 依从策略,和新兴的 DBP 的方法。在中国和美国(美国) 之间的规定比较显示在中国的 DBP 规定基于调整混合物和最大的层次的数字是更紧的。用信息收集规则(ICR ) 数据库的比较评价显示 500 大美国的依从率在中国规定下面浇植物在 US 规定下面是比那低得多的(例如 62.2% 对 89.6% 为全部的 trihalomethanes ) 。先锋移动和其他的 disinfectants 是为 DBP 规章的依从的普通惯例。包括为 haloacetic 酸移动为 trihalomethane 移动和 biodegradation 脱衣的空气,在形成以后的 DBP 移动在 DBP 控制获得了更多的接受。包括 iodinated DBP 和含氮的 DBP,新兴的 DBP 的形成是先锋移动和其他的消毒的非计划中的后果之一。然而,在许多底层,比碳的 DBP,新兴的 DBP 提出了更高的健康风险。 | Xiaomao WANG Yuqin MAO Shun TANG Hongwei YANG Yuefeng E XIE | 2015 | Frontiers of Environmental Science & Engineering2015，9，1： | 8 |
| 4 | Comparative stability analyses of traditional and selective room-and-pillar mining techniques for sub-horizontal tungsten veins显示文摘The stability and productivity concerning a modification on the traditional room and pillar for a new selective technique at the Portuguese Panasqueira Mine have been described.The traditional room-and-pillar stoping uses 5.0-m wide rooms with 3.0 m×3.0 m pillars,while the selective room-and-pillar mining technique consists in stoping with rooms of 4.0 m wide and pillars of 4 m×4 m with a subsequent selective cutting of the quartz veins at the mid pillar of approximately 0.5 m high,to obtain a pillar section with an area of 3.0 m×3.0 m.The stability and productivity analyses indicate that the selective technique obtains smaller average pillar safety factor,more rock mass displacement,more extraction and selectivity ratios,and ore grade improvement,compared with the traditional technique.These results show that the selective technique is also more convenient.This proposed selective room-and-pillar mining technique is applicable to any sub-horizontal narrow quartz veins with wolfram,gold,etc.such as the famous La Rinconada gold mine in the Peruvian Andes. | Vidal Felix Navarro Torres Carlos Dinis da Gama Matilde Costa e Silva Paula Falcao Neves Qiang Xie | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，1： | 7 |
| 5 | Deciphering the role of hedgehog signaling in pancreatic cancer显示文摘Pancreatic cancer,mostly pancreatic ductal adenocarcinoma(PDAC),is a leading cause of cancer-related death in the US,with a dismal median survival of 6 months.Thus,there is an urgent unmet need to identify ways to diagnose and to treat this deadly cancer.Although a number of genetic changes have been identified in pancreatic cancer,their mechanisms of action in tumor development,progression and metastasis are not completely understood.Hedgehog signaling,which plays a major role in embryonic development and stem cell regulation,is known to be activated in pancreatic cancer;however,specific inhibitors targeting the smoothened molecule failed to improve the condition of pancreatic cancer patients in clinical trials.Furthermore,results regarding the role of Hh signaling in pancreatic cancer are controversial with some reporting tumor promoting activities whereas others tumor suppressive actions.In this review,we will summarize what we know about hedgehog signaling in pancreatic cancer,and try to explain the contradicting roles of hedgehog signaling as well as the reason(s) behind the failed clinical trials.In addition to the canonical hedgehog signaling,we will also discuss several non-canonical hedgehog signaling mechanisms. | Dongsheng Gu Kelly E Schlotman Jingwu Xie | 2016 | The Journal of Biomedical Research2016，30，5： | 7 |
| 6 | Identification of a Ubiquitin-Binding Structure in the S-Locus F-Box Protein Controlling S-RNase-Based Self-Incompatibility显示文摘在 flowering 植物,自我障碍(SI ) 作为重要 intraspecific 服务繁殖障碍支持快。在从 Solanaceae, Plantaginaceae 和 Rosaceae, S-RNase 和 SLF (S 地点 F 盒子) 蛋白质的种类被显示了分别地控制 SI 的女、男的特性。然而,很少除了它的保存 F 盒子领域对 SLF 蛋白质的结构特征被知道。这里,我们证明 SLF C 终端区域拥有结构在 SLF 蛋白质家庭之中保存了的一个新奇 ubiquitin 有约束力的领域(UBD ) 。由使用 Nicotiana benthamiana 的一个 ex vivo 系统,我们发现 UBD 调停由 ubiquitin–proteasome 小径的 SLF 蛋白质周转。而且,我们检测了 SLF 蛋白质直接涉及 S-RNase 降级。一起拿,我们的结果提供新奇卓见进 SLF 结构并且在 S-RNase-based 自我障碍加亮 SLF 蛋白质稳定性和降级的一个潜在的角色。 | Guang Chen BinZhang Lijing Liu Qun Li Yu'e Zhang Qi Xie Yongbiao Xue | 2012 | Journal of Genetics and Genomics2012，39，2： | 7 |
| 7 | Development and calibration of the Moon-based EUV camera for Chang'e-3显示文摘The process of development and calibration for the first Moon-based extreme ultraviolet(EUV) camera to observe Earth's plasmasphere is introduced and the design, test and calibration results are presented. The EUV camera is composed of a multilayer film mirror, a thin film filter, a photon-counting imaging detector, a mechanism that can adjust the direction in two dimensions, a protective cover, an electronic unit and a thermal control unit. The center wavelength of the EUV camera is 30.2 nm with a bandwidth of 4.6 nm. The field of view is 14.7° with an angular resolution of 0.08°, and the sensitivity of the camera is 0.11 count s-1Rayleigh-1. The geometric calibration, the absolute photometric calibration and the relative photometric calibration are carried out under different temperatures before launch to obtain a matrix that can correct geometric distortion and a matrix for relative photometric correction,which are used for in-orbit correction of the images to ensure their accuracy. | Bo Chen Ke-Fei Song Zhao-Hui Li Qing-Wen Wu Qi-Liang Ni Xiao-Dong Wang Jin-Jiang Xie Shi-Jie Liu Ling-Ping He Fei He Xiao-Guang Wang Bin Chen Hong-Ji Zhang Xiao-Dong Wang Hai-Feng Wang Xin Zheng Shu-Lin E Yong-Cheng Wang Tao Yu Liang Sun Jin-Ling Wang Zhi Wang Liang Yang Qing-Long Hu Ke Qiao Zhong-Su Wang Xian-Wei Yang Hai-Ming Bao Wen-Guang Liu Zhe Li Ya Chen Yang Gao Hui Sun Wen-Chang Chen | 2014 | Research in Astronomy and Astrophysics2014，14，12： | 4 |
| 8 | Thermodynamic behaviors of Cu in interaction with chlorine, sulfur, phosphorus and minerals during sewage sludge co-incineration显示文摘Thermodynamic equilibrium calculations were performed to reveal effects of interactions among Cl, S, P and other minerals on Cu migration. Our results showed that HCl(g), SO2(g) and(P_2O_5)_2(g) were released from the sewage sludge co-incineration. Cl was found to weaken adsorption of Cu by Al_2O_3, CaO and Fe_2O_3, while S delayed reactions of Fe_2O_3 and Al_2O_3 with Cu, with P having no effect on reactions between the minerals and Cu.Among the coupled systems of Cl, S and P, the co-existences of Cl and S, and Cl, S and P were determined to inhibit Cu volatilization, and the co-existence of Cl and P had an enhancing effect. Cu migration was affected only by S in the S and P system. With the SiO_2, CaO and Al_2O_3 system, both Cl alone and Cl and P led to failed reactions between the minerals and Cu. In the systems of S, S and Cl, S and P, and S, Cl and P, the migration behavior of Cu was mainly affected by S at low temperatures and by Cl at high temperatures, whereas P had no effect on Cu migration during the entire process. | Jingyong Liu Chao Liu Guang Sun Wuming Xie Xiao'e Dang Jiahong Kuo Kenlin Chang Jian Sun Shuiyu Sun Musa Buyukada Fatih Evrendilek | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 3 |
| 9 | Cloning and optimization of a nitrilase for the synthesis of (3S)-3-cyano-5-methyl hexanoic acid显示文摘 | Feng J Garcia E | 2006 | J Mol Catal B:Enzymatic2006，41，34： | 1 |
| 10 | Roubustcontrol for linear systems with norm- bounded time- varying uncertainty 显示文摘 | XIE L DE SOUZA C E | 1992 | IEEE Transactions on Automatic Control1992，37，： | 1 |
| 11 | On the Validity of the Formation of Crystalline Carbon Nitrides, C3 N4 显示文摘 | Matsumoto S Xie E Q Izumi F | 1999 | Diam nelat Mater1999，8，7： | 1 |
| 12 | Effect of proline onthe antimicrobial mechanism of buforin D 显示文摘 | Xie Y Fleming E Chen J | 2011 | Peptides2011，32，4： | 1 |
| 13 | Robust Kalman Filtering for Uncertain Discrete-Time Systems显示文摘 | Xie L Soh C Souza C E | 1994 | 1EEE Trans on Automatic Control1994，39，6： | 1 |
| 14 | Comparison of near- infrared reflectance speetrosecopy and a texture analyzer for measuring wheat bread change in storage 显示文摘 | Xie F Dowell F E Sun X S | 2003 | Cereal Chem2003，80，： | 1 |
| 15 | microRNA-directed phasing during Trans-acting siRNA biogenesis in plants显示文摘 | Allen E Xie Z Gustafson AM | 2005 | Cell2005，121，2： | 1 |
| 16 | Robust control of discrete time uncertain dynamical systems显示文摘 | Xie L H Souza C E Wang Y Y | 1993 | Automatica1993，29，4： | 1 |
| 17 | Robust Control of a Class of Uncertain Nonlinear Systems 显示文摘 | Wang Y Xie L De Souza C E | 1992 | Systems and Control Letters1992，19，： | 1 |
| 18 | Transformation of arctiinto estrogenic and antiestrogenic substances by human intes-tinal bacteria显示文摘 | Xie lihua Ahn E Akao T | 2003 | Chem Pharm Bull2003，51，4： | 1 |
| 19 | Implementation of a viscoplastic model for a plasma sprayed ceramic thermal harrier coating显示文摘 | XIE Wangang Walker K P Jordan E H | 2003 | J Eng Mater Technol2003，125，： | 1 |
| 20 | Overexpression of S - adenosylhomo-cysteine hydrolase and down - regulation of prohibitin and c - Mycbinding protein in the human esophageal squamous cell line HEECexposed to N - nitrosomethylbenzylamine 显示文摘 | Xie Y Tang E Ren B | 2010 | Molecular Med Rep2010，3，3： | 1 |
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