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| 1 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 2 | Experimental study of gold distribution in the algae-organic matter-fluid system显示文摘THE previous simulating experiments show that many algae can greatly accumulate goldfrom solution under some conditions. Some other experiments further indicate that organ-ic matter and crude oil can also play an important role in gold geochemistry processes such asleaching, migration, reduction and precipitation. However, these biometallogeneses are | Xie, SC Yin, HF Wang, HM Zhou, XG Fu, JM Sheng, GY Zhang, HZ Lu, JL | 1997 | Chinese Science Bulletin1997，42，19： | 3 |
| 3 | A CONVENIENT AND EFFICIENT SYNTHESIS OF BIS-IMIDAZOLES显示文摘ACONVENIENTANDEFFICIENTSYNTHESISOFBIS-IMIDAZOLES￥ChengHeZHOU;ShengJinGUO;RuGangXIE,HuaMingZHAO(DepartmentofChemistry.Facultyo... | Zhou, CH Guo, SJ Xie, RG Zhao, HM | 1996 | Chinese Chemical Letters1996，7，4： | 2 |
| 4 | STUDIES ON DERIVATIVES OF CLERODANE DITERPENOIDSFROM AJUGA DECUMBENS显示文摘STUDIESONDERIVATIVESOFCLERODANEDITERPENOIDSFROMAJUGADECUMBENSHuandingCHEN(InstituteofElemento-OrganicChemistry,NankaiUniversi... | Chen, HM Xie, N Min, ZD | 1996 | Chinese Chemical Letters1996，7，6： | 2 |
| 5 | The investigation and analysis of 11 myotonic dystrophy cases from one family 显示文摘 | Deng BQ Zheng HM Xie HJ Cui Y Xu JM Wang Y | 1999 | Chinese Journal of medical genetics1999，16，4： | 1 |
| 6 | Full-field strain measure- ment using a two-dimensional Savitzky-Golay digital differ- entiator in digital image correlation 显示文摘 | Pan B Xie HM Guo ZQ | | Opt Eng0，46，03： | 1 |
| 7 | Chemical characterization of individual particles (PM10) from ambient air in Guiyang City 显示文摘 | Xie RK Seip HM Leinum JR | 2005 | China Sci Total Environ2005，343，： | 1 |
| 8 | Visualization of k-tuple distribution in procaryote complete genomes and their randomized counterparts 显示文摘 | Hao BL | 2003 | IEEE Proc comp sys Bioinf2003，，： | 1 |
| 9 | Stabilized β-catenin potentiates fas-me diated T cell apoptosis显示文摘 | Huang ZF Wang RQ Xie HM | 2008 | Immunol2008，180，10： | 1 |
| 10 | Isolation and difference in Anti-Staphylococcus aureus bioactivity of curvularin derivates from fungus Eupeni-cilliumsp显示文摘 | Xie LW Ouyang YC Zou K Wang GH Chen MJ Sun HM Dai SK LiX | | 0，，： | 1 |
| 11 | Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β 显示文摘 | Pan RH Xie FY Chen HM | 2011 | Arch Pharm Res2011，34，3： | 1 |
| 12 | Belief in a just world when encountering the 5/12 Wenchuan earthquake显示文摘 | Xie XF Liu HM Gan Y Q | 2011 | Environ Behav2011，43，4： | 1 |
| 13 | Optimized LiFe- PO4-polyacene cathode material for lithium-ion bat- teries显示文摘 | Xie HM Wang RS Ying JR | 2006 | Advanced Materials2006，18，19： | 1 |
| 14 | Adipogenesis of murine embryonic stem cells in a three - dimensional culture system using electrospun polymer scaffolds显示文摘 | Kang X Xie Y Powell HM | 2007 | Biomaterials2007，28，3： | 1 |
| 15 | Salvianolic acid B reverses theepithelial-to-mesenehvmal transition of I-IK-2 cells that is in- duced by transforming growth factor-B 显示文摘 | Pan RH Xie FY Chen HM | 2011 | Arch Phalto Res2011，34，： | 1 |
| 16 | Regulation of neutrophil gelatinase-associated lipocalin expression by C/EBP 13 in lung carcinoma cells显示文摘 | Zhang-PX Chang JX Xie J J Yuan HM DU ZP Zhang FR | 2012 | Oncol Lett2012，4，5： | 1 |
| 17 | Fluorescence detection of total countof Escherichia coli and Staphylococcus aureus on water-soluble CdSequantum dots coupled with bacteria显示文摘 | XUE XH PAN J XIE HM | 2009 | Talanta2009，77，5： | 1 |
| 18 | Two-dimensional digital image correlation for in-plane displacement and strain measurement:a review显示文摘 | Pan B Qian K Xie HM | | 0，，： | 1 |
| 19 | Measurement of the repreated number of trinutide of PMPK gene in 91 normal persons in shanghai显示文摘 | Xie HJ Xu JM | 1998 | Di'' er Xue Bao1998，19，3： | 1 |
| 20 | Application of mini-cut for artificial hip joint replacement in old patients显示文摘 | Tu YH Xie HM Cai MW | 2007 | Chin J Bone Joint Injury2007，8，22： | 1 |
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