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| 1 | Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project显示文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. | Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu | 2018 | Science China(Life Sciences)2018，61，5： | 60 |
| 2 | Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project显示文摘Evidence on the lifetime risk for atherosclerotic cardiovascular disease(ASCVD) is insufficient;yet,estimating an individual's lifetime risk allows for a comprehensive assessment of ASCVD burden.We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese,the China-PAR project(Prediction for ASCVD Risk in China).Sexspecific equations were developed using two cohorts(as the derivation cohort) of 21,320 participants.Two other independent cohorts with 14,123 and 70,838 participants were used for their external validation,respectively.We evaluated both calibration and discrimination measures for model performance.Furthermore,we estimated ASCVD-free years lost or excess absolute risk attributable to high 10-year risk(!10.0%) and/or high lifetime risk(!32.8%).After 12.3 years' follow-up of the derivation cohort,1048 ASCVD events and 1304 non-ASCVD deaths were identified.Our sex-specific equations had good internal validation,with discriminant C statistics of 0.776(95% confidence interval [CI]:0.757–0.794) and 0.801(95% CI:0.778–0.825),and calibration χ~2 of 9.2(P = 0.418) and 5.6(P = 0.777) for men and women,respectively.Good external validation was also demonstrated with predicted rates closely matched to the observed ones.Compared with men having both low 10-year and low lifetime risk,men would develop ASCVD 3.0,4.6 and 8.6 years earlier if they had high 10-year risk alone,high lifetime risk alone,or both high 10-year and high lifetime risk at the index age of 35 years,respectively.We developed wellperformed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China. | Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu | 2018 | Science Bulletin2018，63，12： | 30 |
| 3 | Prevalence of the metabolic syndrome and overweight among adults in China显示文摘 | Dongfeng Gu Kristi Reynolds Xigui Wu Jing Chen Xiufang Duan Robert F Reynolds Paul K Whelton Jiang He | 2005 | 2005 (9468)2005，，9468： | 3 |
| 4 | Geographic variations in the prevalence, awareness, treatment and control of hypertension in China显示文摘 | Kristi Reynolds Dongfeng Gu Paul Muntner Xigui Wu Jing Chen Guanyong Huang Xiufang Duan Paul K Whelton Jiang He | 2003 | Journal of Hypertension2003，，7： | 2 |
| 5 | Prevalence of the metabolic syndrome and overweight among adults in China显示文摘 | Dongfeng Gu Kristi Reynolds Xigui Wu Jing Chen Xiufang Duan Robert F Reynolds Paul K Whelton Jiang He | 2005 | The Lancet . 2005 (9468)2005，，9468： | 2 |
| 6 | Major causes of death among men and women in China显示文摘 | Jiang He Dongfeng Gu Xigui Wu | 2005 | N EnglJ Med2005，353，11： | 1 |
| 7 | Major causes of death among men and women in China显示文摘 | Jiang He Dongfeng Gu Xigui Wu | 2005 | N Engl J Med2005，353，11： | 1 |
| 8 | Prevalence of the metabolic syndrome and overweight among adults in China显示文摘 | GU Dongfeng Reynolds K WU Xigui | | 0，，： | 1 |
| 9 | Major Causes of Death among Men and Women in China显示文摘 | Jiang He Dongfeng Gu Xigui Wu Whelton | 2005 | N Engl J Med2005，353，： | 1 |
| 10 | Major causes of death among men and women in China显示文摘 | Jiang He Dongfeng Gu Xigui Wu | 2005 | N Engl J Med2005，353，： | 1 |
| 11 | Major causes of death among men and women in China显示文摘 | He Jiang Gu Dongfeng Wu Xigui | 2005 | N Engl J Med2005，353，： | 1 |
| 12 | Major causes of death among men and women in China显示文摘 | Jiang He Dongfeng Gu Xigui Wu | 2005 | N Engl J Med2005，353，： | 1 |
| 13 | Prevalence, Awareness, Treatment, and Control of Hypertension in China显示文摘 | Dongfeng Gu Kristi Reynolds Xigui Wu Jing Chen Xiufang Duan Paul Muntner Guanyong Huang Robert F. Reynolds Shaoyong Su Paul K. Whelton Jiang He | 2002 | Hypertension: Journal of the American Heart Association2002，，6： | 1 |
| 14 | Major causes of death among men and women in China 显示文摘 | Jiang He Dongfeng Gu Xigui Wu | 2005 | New England Journal of Medicine2005，353，11： | 1 |
| 15 | Major causes ofdeath in China显示文摘 | Jiang He Dongfeng Gu Xigui Wu | 2013 | NEJM2013，，54： | 1 |
| 16 | MajorCauses of Death among Men ang Women in China 显示文摘 | Jiang He Dongfeng Gu Xigui Wu | 2005 | N Engl J Med2005，353，： | 1 |
| 17 | Major causes of death among men and women in China显示文摘 | He Jiang Gu Dongfeng Wu Xigui | 2005 | N Engl J Med2005，353，11： | 1 |
| 18 | Prevalence of the Metabolic Syndrome and Overweight Among Adults in China 显示文摘 | GU Dongfeng Reynolds K WU Xigui | 2005 | Lancet2005，365，9468： | 1 |
| 19 | Major Causes of Death among Men and Women in China显示文摘 | JIANG HE DONGFENG GU XIGUI WU | 2005 | N Engl J Med2005，353，： | 1 |
| 20 | Prevalence of the metabolic syndrome and overweight among adults in China 显示文摘 | GU Dongfeng Reynolds K WU Xigui | 2005 | Lancet2005，365，9468： | 1 |
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