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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Enhanced Offset Averaging Technique for Flash ADC Design显示文摘This paper presents a new combined AC/DC-coupled output averaging technique for input amplifier design of flash analog-to-digital converters (ADC). The new offset averaging design technique takes full advantage of traditional DC-coupled resistance averaging and AC-coupled capacitance averaging techniques to minimize offset-induced ADC nonlinearities. Circuit analysis allows selection of optimum resistance and capacitance averaging factors to achieve maximum offset reduction in ADC designs. The new averaging method is verified in designing a 4 bit 1 Gs/s flash ADC that is implemented in foundry 0.13 μm CMOS technology. | Siqiang FAN He TANG Hui ZHAO Xin WANG Albert WANG Bin ZHAO Gary G ZHANG | 2011 | Tsinghua Science and Technology2011，16，3： | 2 |
| 3 | Induction of cold hardiness by salt stress involves synthesis of cold and abscisic acid responsive proteins in Pmato显示文摘 | Ryu S tS Costa A Xin Z G Li P H | 1995 | Plant Cell Physiol1995，36，： | 1 |
| 4 | Detection rate and antigenic specificities of antineutrophil cytoplasmic antibodies in Chinese patients with clinically suspected vasculitis显示文摘 | Xin G Zhao MH Wang HY | 2004 | Clin Diagn Lab Immunol2004，11，6： | 1 |
| 5 | Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway 显示文摘 | XIA G XIN N LID W | 2014 | Mol Med Rep2014，9，4： | 1 |
| 6 | Antitumor activity of caffeic acid 3,4-dihydrox- yphenetbyl ester and itspharmacokinetic and metabolic properties显示文摘 | Xin G | 2013 | Phytomedicine2013，，20： | 1 |
| 7 | Changes in masseter muscle following curved ostectomy of the prominent mandibular angle:an initial study with real-time 3D ultrasongraphy显示文摘 | MIN L LAI G XIN L | 2008 | J Oral Maxillofac Surg2008，66，12： | 1 |
| 8 | Induction of cold hardiness by salt stress involves synthesis of cold-and abscisic acid-responsive proteins in potato显示文摘 | RYU S B Costa A Xin Z G | 1995 | Plant Cell Physiol1995，36，： | 1 |
| 9 | Lipase-catalyzed naproxen methyl ester hydrolysis in water-saturated ionic liquid:Significantly enhanced enantioselectivity and stability显示文摘 | Xin J Y Zhao Y J Shi Y G | 2005 | World J of Microbiology and Biotechnology2005，21，2： | 1 |
| 10 | Preparation of Mo2C/HZSM-5 and its catalytic performance for the conversion of n-butane into aromatics显示文摘 | YUAN S DERANOUE-ABD HAMIDB S B LI Y YING P XIN Q DEROUANE E G LI C | 2002 | J Mol Catal A2002，184，12： | 1 |
| 11 | Simulation of a LHP- based thermal Control System Under Orbital Environment显示文摘 | Xin G M N Chen Y Cheng L | 2009 | Applied Thermal Engineering2009，29，： | 1 |
| 12 | Strain Rate and Texture Effects on Microstructural Characteristics of Mg- 3Al-1Zn Alloy During Compression 显示文摘 | WANG B S XIN R L HUANG G J | 2012 | Scripta Materialia2012，66，5： | 1 |
| 13 | Transient interference excision in over-the-horizon radar using adaptive time-frequency analysis显示文摘 | Xin G Hongbo S Tat S Y | 2005 | Geoscience and Remote Sensing IEEE Transactions on2005，43，4： | 1 |
| 14 | Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features显示文摘 | Xin G Shi W Xu LX | | 0，，04： | 1 |
| 15 | Simulation and performance evaluation of the anoxic/anaerobic/ aerobic process for biological nutrient removal 显示文摘 | Zhou Z Wu Z Wang Z Tang S Gu G Wang L Wang Y Xin Z | 2011 | Korean Journal of Chemical Engineering2011，28，5： | 1 |
| 16 | Lithology and Fluid Differentiation Using Rock Physics Templates 显示文摘 | Xin G Han D | 2009 | The Leading Edge2009，28，： | 1 |
| 17 | Preparation and char- acterization of Pt supported on graphene with enhanced electrocatalytic activity in fuel cell 显示文摘 | Xin Y C Liu J G Zhou Y | 2011 | J Power Sources2011，196，3： | 1 |
| 18 | An optical biosensing film for biochemical oxygen demand determination in seawater with an automatic flow sampling system显示文摘 | Xin L L Wang X D Guo G M | 2007 | Meas Sci Technol2007，18，9： | 1 |
| 19 | To determine and explore the effect of Astragalus saponin IV(AS-IV) on ischemia/ reperfusion(IR)-induced renal injury and its mechanisms显示文摘 | Xin Y Li G Liu H | 2015 | Int J Clin Exp Med2015，8，18： | 1 |
| 20 | Municipal landfill leachate induces cytogenetie damage in root tips of Hordettm vulgare显示文摘 | Sang N Li G K Xin X Y | 2006 | Ecotoxicology and environ- mental safety2006，63，3： | 1 |
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