| 1 | KIF2C:a novel link between Wnt/β-catenin and mTORCI signaling in the pathogenesis of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and is the fourth-leading cause of cancer-related deaths worldwide.HCC is refractory to many standard cancer treatments and the prognosis is often poor,highlighting a pressing need to identify biomarkers of aggressiveness and potential targets for future treatments.Kinesin family member 2C(KIF2C)is reported to be highly expressed in several human tumors.Nevertheless,the molecular mechanisms underlying the role of KIF2C in tumor development and progression have not been investigated.In this study,we found that KIF2C expression was significantly upregulated in HCC,and that KIF2C up-regulation was associated with a poor prognosis.Utilizing both gain and loss of function assays,we showed that KIF2C promoted HCC cell proliferation,migration,invasion,and metastasis both in vitro and in vivo.Mechanistically,we identified TBC1D7 as a binding partner of KIF2C,and this interaction disrupts the formation of the TSC complex,resulting in the enhancement of mammalian target of rapamycin complexl(mTORCI)signal transduction.Additionally,we found that KIF2C is a direct target of the Wnt/β-catenin pathway,and acts as a key factor in mediating the crosstalk between Wnt/β-catenin and mTORCI signaling.Thus,the results of our study establish a link between Wnt/β-catenin and mTORCI signaling,which highlights the potential of KIF2C as a therapeutic target for the treatment of HCC. | Shi Wei Miaomiao Dai Chi Zhang Kai Teng Fengwei Wang Hongbo Li Weipeng Sun Zihao Feng Tiebang Kang Xinyuan Guan Ruihua Xu Muyan Cai Dan Xie | 2021 | Protein & Cell2021，12，10： | 8 |
| 3 | Heat Storage/Heat Release of Phase-Change Filling Body with Casing Heat Exchanger for Extracting Geothermal Energy显示文摘Arranging heat exchanger in filling body to extract geothermal energy is an effective way to alleviate the problems of high ground pressure and high ground temperature in deep resource exploitation.Filling body with casing heat exchanger was acted as research object,encapsulating phase change materials(PCMs)in annular space.During heat storage and heat release process,the effects of different PCMs on temperature distribution,phase-change process and heat transfer performance were studied.The result indicates:During heat storage process,the temperature increases rapidly and the melting process is accelerated for the position closer surrounding rock.CaCl_(2)·6H_(2)O/EG can make filling body complete heat storage process in the shortest time because of its good thermal diffusivity.The heat storage capacity of PCMs backfill is significantly higher than that of ordinary backfill;it increases by 36.6%-67.3%at heat storage of 10 h.During heat release process,the closer to the heat exchange tube,the greater the temperature drop in filling body.The maximum value of heat release rate and heat release capacity is in CaCl_(2)·6H_(2)O/EG backfill,it can release 116.4%more heat than RT35backfill after heat release of 12 h,the maximum value of effectiveness and its heat transfer rate also is in CaCl_(2)·6H_(2)O/EG backfill.This paper provides the basic data for the selection of PCMs in phase-change thermal storage filling body. | ZHANG Xiaoyan XU Muyan LIU Lang YANG Qixing KI-IL Song | 2023 | Journal of Thermal Science2023，32，3： | 0 |
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