|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preclinical and clinical applications of specific molecular imaging for HER2-positive breast cancer显示文摘Precision medicine and personalized therapy are receiving increased attention, and molecular-subtype classification has become crucial in planning therapeutic schedules in clinical practice for patients with breast cancer. Human epidermal growth factor receptor 2(HER2) is associated with high-grade breast tumors, high rates of lymph-node involvement, high risk of recurrence, and high resistance to general chemotherapy. Analysis of HER2 expression is highly important for doctors to identify patients who can benefit from trastuzumab therapy and monitor the response and efficacy of treatment. In recent years, significant efforts have been devoted to achieving specific and noninvasive HER2-positive breast cancer imaging in vivo. In this work, we reviewed existing literature on HER2 imaging in the past decade and summarized the studies from different points of view, such as imaging modalities and HER2-specific probes. We aimed to improve the understanding on the translational process in molecular imaging for HER2 breast cancer. | Wei Chen Xiaofeng Li Lei Zhu Jianjing Liu Wengui Xu Ping Wang | 2017 | Cancer Biology & Medicine2017，14，3： | 2 |
| 2 | Value of metabolic parameters in distinguishing primary mediastinal lymphomas from thymic epithelial tumors显示文摘Objective:A high rate of unnecessary thymectomies has been reported.This study aimed to distinguish primary mediastinal lymphomas(PMLs)from thymic epithelial tumors(TETs)by evaluating volumetric and metabolic parameters with l8F-FDG PET/CT.Methods:A total of 136 patients who were pathologically diagnosed with TETs or PMLs were enrolled,and 18F-FDG PET/CT was performed before therapy.Volumetric parameters,including the mean SUV(SUVmean),metabolic tumor volume(MTV),total lesion glycolysis(TLG),and SUVmax,were determined and compared between the 2 subtypes.The diagnostic performance of these parameters was evaluated with receiver operating characteristic(ROC)curve analysis.Results:All parameters significantly differed between patients with PMLs and TETs.Patients with lymphomas were younger and had higher SUVmean,SUVmax,TLG,and MTV values than patients with TETs.The MTV and TLG values had similar diagnostic performance.ROC analysis indicated that the areas under the curves of the SUVmean and SUVmax values performed similarly(approximately 0.76)in differentiating patients with PMLs from TETs,and both values were better than the MTV and TLG values.When age was included with the SUVmax in differentiating TETs from PMLs,the AUC was 0.91,and the sensitivity and specificity increased to 80%and 93%,respectively.Conclusions:The SUVmax and volumetric parameters of 18F-FDG PET/CT can be used to distinguish patients with PMLs versus TETs,and thus may aid in preventing unnecessary thymectomies or other invasive operations. | Lei Zhu Xiaofeng Li Jian Wang Qiang Fu Jianjing Liu Wenchao Ma Wengui Xu Wei Chen | 2020 | Cancer Biology & Medicine2020，17，2： | 1 |
| 3 | A meta-analysis of cytokine-induced killer cells therapy in combination with minimally invasive treatment for hepatocellular carcinoma显示文摘 | Xiaofeng Li Dong Dai Xiuyu Song Jianjing Liu Lei Zhu Wengui Xu | 2014 | Clinics and Research in Hepatology and Gastroenterology2014，，： | 1 |
| 4 | 放射性核素标记心肌肌球蛋白重链单抗检测心肌损伤的实验研究显示文摘为探讨急性心肌梗塞病灶心肌细胞损伤程度,采用放射性核素标记心肌肌球蛋白重链(CMHC)单克隆抗体(McAb)进行了实验性心肌损伤大鼠和心梗模型犬的研究。125I-CMHCMcAb注射大鼠后4h,标记抗体即已进入坏死心肌靶组织,8h达最高值。实验组心肌/对照组心肌比值为2.86。99mTC-CMHCMcAb犬显像,实验组中有3只于6h心肌梗塞灶显影清晰,4只于8h显影清晰,阳性检出率为70%。动物实验提示;大鼠损伤心肌对CMHCMcAb的结合力高于正常心肌,心梗模型犬CMHCMcAb放免显像阳性检出率高,可为临床急性心肌损伤检测提供可靠的定位诊断依据。 | ZHAO Jie MA Qingjie ZHU Xiaojuan ZHENG Jun XU Wengui NIU Gang GUO Lingyun GAO Fengtong(The Third Clinical Medical College, Norman Bethune University of Medical Sciences, Changchun 130031)(Nouth East Normal University, Changchun 130021)(208th, Hospital of | 1998 | 核技术1998，21，11： | 0 |
| 5 | Multidisciplinary team for the diagnosis and treatment of 2cases of primary intestinal yolk sac tumor显示文摘Extragonadal primary yolk sac tumor of the intestinal tract origin is exceedingly rare. Through a multiple disciplinary team, the diagnosis and treatment of primary intestinal yolk sac tumor were further defined. We report 2 such cases with detailed histologic and immunohistochemical analysis. The two patients were a 7-year-old girl and a 29-year-old woman. Both of them preoperatively had an elevated serum alpha fetoprotein(AFP) level(≥ 1,210 ng/mL). The tumors are located in the intestine and imaging examination indicated the rectum as the primary site. Grossly the mass was grey-white and crisp texture. Microscopic examination featured reticular, microcystic, macrocystic, papillary, solid, and some glandular patterns. Immunohistochemically,tumor cells of both cases were positive for SALL4, AFP, pan-cytokeratin(AE1/AE3), and glypican-3. Simultaneously, a stain for EMA, OCT4, CD30, HCG, vimentin and CK20 were negative in all 2 neoplasms. The features of morphology,immunohistochemistry, laboratory examinations and imaging studies consist of the diagnosis of primary yolk sac tumor of the intestine. | Qiujuan Huang Changxu Liu Ruijun Tang Jie Li Wei Li Lei Zhu Yuhong Guo Lin Zhang Tongyuan Qu Lingyi Yang Lingmei Li Yalei Wang Baocun Sun Bin Meng Jie Yan Wengui Xu Huilai Zhang Dengfeng Cao Wenfeng Cao | 2018 | Cancer Biology & Medicine2018，15，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员