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| 1 | Potent antitumor efficacy of an E1B 55kDa-deficient adenovirus carrying murine endostatin in hepatocellular carcinoma显示文摘 | Li G Sham J Yang J Su C Xue H Chua D Sun L Zhang Q Cui Z Wu M Qian Q | 2005 | 第二军医大学学报2005，26，11： | 9 |
| 2 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 3 | Microbial biomass, N mineralization and nitrification, enzyme activities, and microbial community diversity in tea orchard soils显示文摘 | Xue D Yao HY Huang CY | 2007 | 中国生物学文摘2007，21，8： | 6 |
| 4 | Effects of a memory enhancing peptide on cognitive abilities of brain-lesioned mice: additivity with huperzine A and relative potency to tacrine显示文摘 | Xu Z Zheng H Law SL Dong So D Han Y Xue H | 2006 | 中国生物学文摘2006，20，10： | 3 |
| 5 | Rho A signaling and blood pressure: The consequence of failing to “Tone it Down”显示文摘Uncontrolled high blood pressure is a major risk factor for heart attack, stroke, and kidney failure and contributes to an estimated 25% of deaths worldwide. Despite numerous treatment options, estimates project that reasonable blood pressure(BP) control is achieved in only about half of hypertensive patients. Improvements in the detection and management of hypertension will undoubtedly be accomplished through a better understanding of the complex etiology of this disease and a more comprehensive inventory of the genes and genetic variants that influence BP regulation. Recent studies(primarily in pre-clinical models) indicate that the small GTPase Rho A and its downstream target, Rho kinase, play an important role in regulating BP homeostasis. Herein, we summarize the underlying mechanisms and highlight signaling pathways and regulators that impart tight spatial-temporal control of Rho A activity. We also discuss known allelic variations in the Rho A pathway and consider how these polymorphisms may affect genetic risk for hypertension and its clinical manifestations. Finally, we summarize the current(albeit limited) clinical data on the efficacy of targeting the Rho A pathway in hypertensive patients. | Xue Bai Rachel Dee Kevin D Mangum Christopher P Mack Joan M Taylor | 2016 | World Journal of Hypertension2016，6，1： | 3 |
| 6 | Immnopotentiation of bovine respiratory disease virus vaccines by interleukin-l and interleukin-2显示文摘 | Reddy D N Reddy P G Xue W | 1993 | Vet Immunol Immopathol1993，37，： | 2 |
| 7 | Structure and magnetic properties of Fe-Co nanowires in selfassembled arrays显示文摘 | Zhan Q F Chen Z Y Xue D S | 2002 | Phy Rev B2002，66，134436： | 2 |
| 8 | Web-based distributed system and database modeling for concurrent design显示文摘 | D Xue Y Xu | 2003 | Computer-Aided Design2003，35，： | 1 |
| 9 | Transfer hydrogenation of activatied C=C bonds catalyzed by ruthenium amido complexes: Reaction scope, limitation, and enantioselectivity 显示文摘 | Xue D Chen Y C Cui X | 2005 | Journal of Organic Chemistry2005，70，9： | 1 |
| 10 | Ages of ultrahigh pressure metamorphism and protolith orthogneisses from the eastern Dabie Shan: U/Pb zircon geochronology显示文摘 | Xue F Tucker R D | 1997 | Earth Planetary Science Letters1997，151，： | 1 |
| 11 | Fetal protection against bovine viral diarrhea virus types 1 and 2 after the use of a modified-live virus vaccine显示文摘 | XUE W MATTICK D SMITH L | 2009 | Can J Vet Res2009，73，4： | 1 |
| 12 | Enhanced 1,3-propanediol production by supply of organic acids and repeated fed-batch culture显示文摘 | Xue X D Li W Li Z M | 2010 | J Ind Microbiol Biotechnol2010，37，7： | 1 |
| 13 | A fuzzy mathematics based optimal delivery scheduling approach 显示文摘 | Xue D Wang H Norrie D H | 2001 | Computers in Industry2001，45，： | 1 |
| 14 | DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population显示文摘 | Chen S Tang D Xue K | 2002 | Carcinogenesis2002，23，8： | 1 |
| 15 | Combination of thrombin and matrix metalloproteinase-9 exacerbates neurotoxicity in cell culture and intracerebral hemorrhage in mice 显示文摘 | Xue M Hollenberg M D Yong V W | 2006 | J Neurosci2006，26，10： | 1 |
| 16 | Room Temperature Fabrication of Hollow ZnS and ZnO Architectures by a Sacrificial Template Route 显示文摘 | Yah C L Xue D F | 2006 | J Phys Chem B2006，0，14： | 1 |
| 17 | Identification of the optimal product configuration and parameters based on individual customer requirements on performance and costs in one - of - a - kind production 显示文摘 | HONG G HU L XUE D | 2008 | Interna- tional Journal of Production Research2008，46，12： | 1 |
| 18 | In situ measurements of denitrification in constructed wetlands显示文摘 | Xue Y Kovacic D A David M B | | 0，，01： | 1 |
| 19 | A review and perspec-tive about pavement monitoring 显示文摘 | Xue W J Wang D Wang L B | 2012 | InternationalJournal of Pavement Research and Technology2012，5，5： | 1 |
| 20 | Relationships between instrumental measurements and sensory evaluation in instant noodles studied by partial least squares regression显示文摘 | XUE D GAO H ZHAO L | 2010 | Journal of Texture Studies2010，41，2： | 1 |
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