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		题名	作者	年代	出处	被引量
	1	High frequency of p53 intronic point mutations in laryngeal squamous cell carcinoma显示文摘Intronic point mutations are rare and totally unknown for human laryngeal squamous cell carcinoma (LSCC). To explore the relationship of p53 gene intronic mutation to the development of human LSCC, DNA was extracted from both tumor tissues and matched normal tissues of 55 patients with LSCC in northeast of China. Polymerase chain reaction amplification-single strand conformational polymorphism (PCR-SSCP) combined with silver staining and DNA direct sequencing were used to detect mutations in exons 7~8 (p53E7 and p53E8) and introns 7~8 (p53I7 and p53I8) of p53 gene. The p53E7 mutation was detected in 17 out of 55 patients, and the p53I7 mutation in 21 patients. No mutation was found at p53E8 or p53I8 site. The difference between tumor group and paired normal group on the rates of both p53E7 and p53I7 mutations was statistically significant. The rate of p53I7 mutations in tumor tissue was higher than that of normal tissue, and so was that of p53E7. Sequence analysis revealed that most p53I7 mutations were at the nucleotides in the branch point sequence or the polypyrimidine tract in the 3′-splice acceptor site of the intron 7. The high incidence of p53 gene intronic mutation in LSCC indicates that genetic changes within the noncoding region of the p53 gene may serve as an alternative mechanism of activating the pathogenesis of human laryngeal squamous cell carcinoma. Mutations in the noncoding region of this gene should be further studied.	ZHAOXu LIFucai SONGYutong LIYinghui FUWeineng XUZhenming SUNKailai	2004	Progress in Natural Science:Materials International2004，14，7：	0
	2	Shaping Stability and Temperature Field in Dual Frequency Electromagnetic Confinement and Shaping显示文摘Dual frequency electromagnetic confinement and shaping (EMCS) makes it easier to adjust and control the shaping temperature field and magnetic field than single frequency EMCS. The shaping stability and temperature field of the dual frequency EMCS were investigated. The results indicate that to shape stably, the upper liquid/solid interface should be in appropriate position and the lower liquid/solid interface must be above the critical position. The current of heating induction coil and the drawing speed of sample affect the shaping temperature and its peak position, while the current of the shaping induction coil only influences the shaping temperature. During EMCS, the speed of shaped sample affects not the height of the molten metal, but the temperature of molten metal. The height of the molten metal for steady shaping was about 15 mm in the experimental conditions. Several stainless steel plate-like parts with high width to thickness ratio (≥3.5) and directional structure were obtained.	SONGChang-jiang XUZhenming LIANGGao-fei SHENJun LIJian-guo	2005	Journal of Iron and Steel Research(International)2005，12，3：	0

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