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| 1 | E2F transcription factors and digestive system malignancies: How much do we know?显示文摘E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We review current knowledge on the expression of E2Fs in digestive system malignancies and its clinical implications for patient prognosis and treatment. E2F1, the most extensively studied member and the only one with prognostic value, exhibits a tumor-suppressing activity in esophageal, gastric and colorectal adenocarcinoma, and in hepatocellular carcinoma (HCC), whereas in pancreatic ductal adenocarcinoma and esophageal squamous cell carcinoma may function as a tumorpromoter. In the latter malignancies, E2F1 immunohistochemical expression has been correlated with higher tumor grade and worse patient survival, whereas in esophageal, gastric and colorectal adenocarcinomas is a marker of increased patient survival. E2F2 has only been studied in colorectal cancer, where its role is not considered significant. E2F4's role in colorectal, gastric and hepatic carcinogenesis is tumor-promoting. E2F8 is strongly upregulated in human HCC, thus possibly contributing to hepatocarcinogenesis. Adenoviral transfer of E2F as gene therapy to sensitize pancreatic cancer cells for chemotherapeutic agents has been used in experimental studies. Other therapeutic strategies are yet to be developed, but it appears that targeted approaches using E2F-agonists or antagonists should take into account the tissue-dependent function of each E2F member. Further understanding of E2Fs' contribution in cellular functions in vivo would help clarify their role in carcinogenesis. | Athanasios Xanthoulis Dina G Tiniakos | 2013 | World Journal of Gastroenterology2013，19，21： | 10 |
| 2 | THE RIGHT TO OBLIVION IN THE INFORMATION AGE: A HUMAN-RIGHTS BASED APPROACH显示文摘 | Napoleon Xanthoulis | 2013 | US-China Law Review2013，10，1： | 7 |
| 3 | Results of surgery for colorectal carcinoma with obstruction显示文摘 | Antonios-Apostolos K. Tentes Charalambos G. Mirelis Stilianos Kakoliris Odisseas S. Korakianitis Ioannis G. Bougioukas Evanthia G. Tsalkidou Athanasios I. Xanthoulis Konstantina A. Bekiaridou Abraham I. Dimoulas | 2009 | Langenbeck’s Archives of Surgery2009，，1： | 2 |
| 4 | Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma, report of two cases显示文摘 | Xanthoulis A Mirelis C Markakidis S | 2006 | Gynecol Obstet Invest2006，62，2： | 1 |
| 5 | Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosarcoma, report of two cases显示文摘 | Xanthoulis A Mirelis C Markakidis S | 2006 | Gynecol Obstet Invest2006，62，2： | 1 |
| 6 | Complete cytoreduction combined with early postoperative intraperitoneal chemotherapy for ovarian carcinosareoma :report of two cases显示文摘 | Xanthoulis A Mirelis C Markakidis S | 2006 | Gyneeol Obstet Invest2006，62，2： | 1 |
| 7 | Complete cytore- duction combined with early postoperative intraperitoneal chemo- therapy for ovarian report of two cases显示文摘 | Xanthoulis A Mirelis C Markakidis S | 2006 | Gy- necol Obstet Invest2006，62，： | 1 |
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