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| 1 | 艾叶醇提物对热敏通道TRPV1的影响显示文摘目的:探讨艾叶醇提物对热敏通道TRPV1的影响。方法:运用全细胞膜片钳技术,在转染人源TRPV1的HEK293细胞上,测量艾叶醇提物对细胞跨膜电流的影响。结果:全细胞膜片钳数据显示,艾叶醇提物可以激活TRPV1通道并产生较为明显的跨膜电流;与TRPV1激动剂辣椒素比较,艾叶诱发的电流密度、电流-电压的关系与其十分相似;在进行2个浓度测试中,艾叶生药3mg/ml与10mg/ml比较,10mg/ml的艾叶醇提物具有更强的激动剂效应,甚至超过了10μM辣椒素激动TRPV1所产生的电流。结论:艾叶醇提物中含有TRPV1激动剂,艾叶温经散寒、止痛功效的分子机制可能与其活化热敏通道TRPV1有关。 | 郭蓉 刘珍洪 汪文来 高蔚 陶旭光 佟海英 安致君 殷茵 韩雪珍 Michael XiZhu 杨桢 赵红霞 | 2019 | 中国中医基础医学杂志2019，25，3： | 10 |
| 2 | High current density Sc_2O_3-W matrix dispenser cathode显示文摘Sc2O3-W matrix dispenser cathodes have been prepared by powder metallurgy method and tested in Pierce electron guns.The emission current density can reach 72 A/cm2 at 900C and over 100 A/cm2 can be achieved at a temperature higher than 950C.The emission improves and then keeps stable with time throughout the life testing period of 330 h at a continuous loading of 88 A/cm2pulsed current density with a pulse width of 10μs and duty cycle of 0.2%.The cathode surface is covered by a semiconductor multilayer composed of Ba,Sc and O.The emission behavior of the cathode can be explained by a semiconductor model. | WANG JinShu ZHANG XiZhu LIU Wei WANG YiMan ZHOU MeiLing ZUO TieYong | 2012 | Science China(Information Sciences)2012，55，1： | 7 |
| 3 | Safety evaluation and the static-dynamic coupling analysis of counter-arched slab in plunge pool显示文摘The stability of plunge pool slab of drainage structure is crucial to energy dissipation,but the working conditions of counter-arched slab are very complex and its stress procedure is considerably nonlinear and coupling.Therefore,a nonlinear static and dynamic coupling method to analyze the counter-arched slab configuration is put forward,which can reflect the coupling of dynamic loads,slab,anchor bars,groundwork and abutment as well as the dynamic procedure of instability.Various nonlinear factors and static-dynamic coupling are taken into consideration,and the working conditions,stress mechanism,dynamic instability procedure and influential instability factors are revealed.The proposed method thus provides a comprehensive safety evaluation method of plunge pool,which further pro-vides an important theoretical basis for engineering design of counter-arched slab in plunge pool. | LIAN JiJian LIU XiZhu MA Bin | 2009 | Science China(Technological Sciences)2009，52，5： | 4 |
| 4 | BEM+Born series modeling schemes for wave propagation and their convergence analysis显示文摘This paper formulates two different boundary-element+Born series schemes for wave propagation simulation in multilayered media by incorporating a Born series and boundary integral equations.The first scheme directly decomposes the resulting boundary integral equation matrix into the self-interaction operators associated with each boundary itself and the extrapolation operators expressing cross-interactions between different boundaries in a subregion.For the second scheme,the matrix dimension is firstly reduced to a half by the elimination of the traction field in the equations.The resulting new matrix can also be split into the self-interaction matrices associated each subregion itself and the extrapolation matrices interpreting cross-interactions between different subregions in a whole model.Both the numerical schemes avoid the inversion of the relatively much larger boundary integral equation matrix of a full-waveform BE method and hence save computing time and memory greatly.The two schemes are validated by calculating synthetic seismograms for a homogeneous layered model,compared with the full-waveform BE numerical solution.Numerical experiments indicate that both the BEM+Born series modeling schemes are valid and effective.The tests also confirm that the second modeling scheme has a faster convergence in comparison with the first one. | Gengxin Yu Liyun Fu Xizhu Guan | 2010 | Earthquake Science2010，23，2： | 2 |
| 5 | Effect of Rare Earth Element Ce on Microstructure and Properties of Aluminum Rod for Electrical Purpose显示文摘The effect of rare earth element Ce on microstructure, electrical conductivity and mechanical properties was studied.Using optical microscope, scanning electron microscope, transmission electron microscope and X-ray diffractometer, the microstructure and phase composition of aluminum rod for electrical purpose were measured and analyzed.The results indicate that rare earth element Ce can considerably refine grain size of aluminum rod for electrical purpose,improve the regular distribution pattern of the impurity, such as silicon and iron which present in the aluminum matrix,form stable metal compound with pernicious impurity.This metal compound precipitates on the crystal boundary.As a result, the solid solubility of impurity in aluminum reduce, and the electrical conductivity of aluminum rod for electrical purpose is improved.It is found that the mechanical properties of aluminum rod for electrical purpose are improved by rare earth element in certain range of RE addition. | Li Pengfei Wang Yunli Gao Xizhu Wang Zaiyun | 2004 | Journal of Rare Earths2004，22，z1： | 2 |
| 6 | Discovering Spatial Patterns in Origin‐Destination Mobility Data显示文摘 | DianshengGuo XiZhu HaiJin PengGao ClioAndris | 2012 | Transactions in GIS2012，，3： | 1 |
| 7 | Quantitative determination of anti - cancer drug heptaplatin by HPLC 显示文摘 | He Xuefeng Zhen Ping Chen Xizhu | 2010 | Asian Journal of Chemistry2010，22，10： | 1 |
| 8 | Adsorption character for removal Cu (Ⅱ) by magnetic Cu ( Ⅱ ) ion imprinted composite adsorben显示文摘 | REN Yueming WEI Xizhu ZHANG Milin | 2008 | Journal of Hazardous Materials2008，158，： | 1 |
| 9 | Synthesis and structure of platinum (II) complexes containing an asymmetric chelating diamine 2 - morpholino - ethylamine as the carrier显示文摘 | Chen Xizhu Xie Mingjin Liu Weiping | 2007 | Inorg Chim Acta2007，360，： | 1 |
| 10 | An experimental study on closed-polyculture of penaeid shrimp with tilapia and constricted tagelus显示文摘 | Xiangli Tian Deshang Li Shuanglin Dong Xizhu Yan Zhenxiong Qi Guocai Liu Jing Lu | 2001 | Aquaculture2001，，1： | 1 |
| 11 | Hedonic house prices and spatial quantile regression 显示文摘 | Wen -Chi Liao Xizhu Wang | 2012 | Journal of Housing Economics2012，21，： | 1 |
| 12 | Evaluation indexes for completed oil and gas exploration projects and quantified evaluation显示文摘 | Huang Xunan Li Huaqi Wang Xizhu | 2010 | International Petroleum Economics2010，18，1： | 1 |
| 13 | Acoustic viscoelastic modeling by frequency-domain boundary element method显示文摘Earth medium is not completely elastic, with its viscosity resulting in attenuation and dispersion of seismic waves. Most viscoelastic numerical simulations are based on the finite-difference and finite-element methods. Targeted at viscoelastic numerical modeling for multilayered media, the constant-Q acoustic wave equation is transformed into the corresponding wave integral representation with its Green's function accounting for viscoelastic coefficients. An efficient alternative for full-waveform solution to the integral equation is proposed in this article by extending conventional frequency-domain boundary element methods to viscoelastic media. The viscoelastic boundary element method enjoys a distinct characteristic of the explicit use of boundary continuity conditions of displacement and traction, leading to a semi-analytical solution with sufficient accuracy for simulating the viscoelastic effect across irregular interfaces. Numerical experiments to study the viscoelastic absorption of different Q values demonstrate the accuracy and applicability of the method. | Xizhu Guan Li-Yun Fu Weijia Sun | 2017 | Earthquake Science2017，30，2： | 1 |
| 14 | Synthesis and Optical Properties of β‐BaB<sub>2</sub>O<sub>4</sub> Network‐Like Nanostructures显示文摘 | QingruiZhao XiZhu XueBai HaihuaFan YiXie | 2007 | Eur J Inorg Chem2007，，13： | 1 |
| 15 | HSPBAP1 is found extensively in the anterior temporal neocortex of patients with intractable epilepsy显示文摘 | Zhi‐QinXi Ji‐JunSun Xue‐FengWang Ming‐WeiLi Xian‐ZengLiu Lin‐YuanWang XiZhu FeiXiao Jin‐MeiLi YunGong Li‐FengGuan | 2007 | Synapse2007，，9： | 1 |
| 16 | The Current Situation and the Development Strategies of Rubber Farmer Cooperatives in Hainan Province显示文摘This article describes the distribution,member structure and industrial operation structure of the rubber farmer cooperatives in Hainan Province,and points out some problems in the cooperatives,such as small member scale,unbalanced regional development,lack of standardization in operation,and industrial operation structure imbalance. Finally some development strategies are put forward as follows: building large-scale cooperatives; attaching importance to the development of rubber farmer cooperatives,standardizing the cooperatives management, and guiding the adjustment of operating structure of rubber farmer cooperatives; attracting the college graduates to work in the cooperatives. | Huide HUANG Wanzhen ZHANG Xizhu ZHANG Haolun HUANG | 2014 | Asian Agricultural Research2014，6，5： | 0 |
| 17 | Preparation and immunoprotective effects of a virus-like particle candidate vaccine of the dominant epidemic D3 genotype coxsackievirus A6 in China显示文摘Coxsackievirus A6 of the D3a genotype(CVA6 D3a)is a primary pathogen causingmainland of China's hand,foot,and mouth disease(HFMD).Viral‐like particle(VLP)vaccines represent a potential candidate vaccine to prevent HFMD.This study collected Anti‐CVA6 D3a VLPs serum from BALB/c female mice immunized using CVA6 D3a VLPs.The neutralizing antibody levels were compared against the representative 14‐JX2018(D3a)and N4‐YN2015(D3b)strains between the antisera of different immune pathways.The immunoprotective effect of anti‐CVA6 D3a VLPs against these strains was monitored using pathological sections and immuno-histochemical results of lung and skeletal muscle tissues in seven‐day‐old Institute of Cancer Research(ICR)mice.Immunological protection against different branches of viruses was evaluated in 7‐day‐old(serum passive immune protection)and 14‐day‐old(VLPs active immune protection)neonatal ICR mice models.Serum‐neutralizing antibody levels were positively correlated with the number of immunizations and higher against 14‐JX2018 than against N4‐YN2015.Furthermore,these levels were significantly higher with abdominal injection than intramuscular injection.The immunized serum of 7‐day‐old ICR mice inoculated three times was 100%protected against CVA6 D3a 14‐JX2018(lethal titer:106.25 TCID 50)and CVA6 D3b N4‐YN2015(lethal titer:105.25TCID 50)fatal attacks,respectively.For ICR mice that have completed two active immunizations for 14 days,both CVA6 D3a 14‐JX2015(challenge titer:108.25 TCID 50)and CVA6 D3b N4‐YN2015(challenge titer:107.25 TCID 50)were used for the challenge,and the mice were able to survive.Overall,the CVA6 D3a VLPs prepared in this study are a potential vaccine candidate for CVA6,as it has the optimal protective effect against both CVA6 D3a and D3b evolutionary branches viruses. | Xiaoliang Li Xizhu Xu Jichen Li Huanhuan Lu Congcong Wang Rui Wang Jinbo Xiao Ying Liu Yang Song Jingdong Song Qiang Sun Yong Zhang | 2024 | Biosafety and Health2024，6，1： | 0 |
| 18 | Gender Conflicts and the Limits of Political Democratization in the Early Years of the Republic:As Exemplified by the Proposal for Women Suffrage显示文摘Soon after the outbreak of the Revolution of 1911 the Provisional Revolutionary Government was set up at Nanjing. Lin Zongsu, Tang Qunying and other woman revolutionaries submitted in March 1912 a proposal for woman suffrage to the Senate at Nanjing. The Senate turned down the motion, giving rise women petitioners' creating turmoil in the Senate. With the northward movement of the Provisional Senate, the center of the woman suffrage petition movement also shifted to Beijing. They | Li Xizhu, the Institute of Modern History, CASS Xiao Yun | 2006 | Social Sciences in China2006，27，1： | 0 |
| 19 | Study on Banana Cooperatives in Hainan Province显示文摘This paper gives an overview of the distribution,member scale,production and operation of banana cooperatives in Hainan Province,and points out the market risk and natural risk faced by the production of banana cooperatives in Hainan Province. In order to promote the banana cooperatives to form new agricultural management system integrating organization and intensification,this paper puts forth the production and operation recommendations,such as joint production of banana cooperatives,timely planting of banana,brand management,and improvement of production and operation technical level. | Huide HUANG Wanzhen ZHANG Enping LIU Xizhu ZHANG | 2013 | Asian Agricultural Research2013，5，7： | 0 |
| 20 | Clinical features of 162 fatal cases of COVID-19:a multi-center retrospective study显示文摘Background:The coronavirus disease 2019(COVID-19)has affected approximately 2 million individuals worldwide;however,data regarding fatal cases have been limited.Objective:To report the clinical features of 162 fatal cases of COVID-19 from 5 hospitals in Wuhan between December 30,2019 and March 12,2020.Methods:The demographic data,signs and symptoms,clinical course,comorbidities,laboratory findings,computed tomographic(CT)scans,treatments,and complications of the patients with fatal cases were retrieved from electronic medical records.Results:The median patient age was 69.5(interquartile range:63.0–77.25)years,and 80%of the patients were over 61 years.A total of 112(69.1%)patients were men.Hypertension(45.1%)was the most common comorbidity,while 59(36.4%)patients had no comorbidity.At admission,131(81.9%)patients had severe or critical COVID-19,whereas 39(18.1%)patients with hypertension or chronic lung disease had moderate COVID-19.In total,126(77.8%)patients received antiviral treatment,while 132(81.5%)patients received glucocorticoid treatment.A total of 116(71.6%)patients were admitted to the intensive care unit(ICU),and 137(85.1%)patients received mechanical ventilation.Most patients received mechanical ventilation before ICU admission.Approximately 93.2%of the patients developed respiratory failure or acute respiratory distress syndrome.There were no significant differences in the inhospital survival time among the hospitals(P=0.14).Conclusion:Young patients with moderate COVID-19 without comorbidity at admission could also develop fatal outcomes.The in-hospital survival time of the fatal cases was similar among the hospitals of different levels in Wuhan. | Xianlong Zhou Guoyong Ding Qing Fang Jun Guo Luyu Yang Ping Wang Shou-Zhi Fu Ang Li Jian Xia Jiangtao Yu Jianyou Xia Min Ma Zhuanzhuan Hu Lei Huang Ruining Liu Cheng Jiang Shaoping Li Mingxia Yu Xizhu Xu Yan Zhao Quan Hu Weijia Xing Zhigang Zhao | 2022 | Emergency and Critical Care Medicine2022，2，3： | 0 |
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