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您的检索式：作者名="Xiandeng Wu"
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| 1 | CaMKIIα-driven,phosphatase-checked postsynaptic plasticity via phase separation显示文摘Ca^(2+)/calmodulin-dependent kinase Ila(CaMKIla)is essential for synaptic plasticity and learning by decoding synaptic Ca^(2+)oscillations.Despite decades of extensive research,new mechanisms underlying CaMKIIa's function in synapses are still being discovered.Here,we discover that Shank3 is a specific binding partner for autoinhibited CaMKIla.We demonstrate that Shank3 and GluN2B,via combined actions of Ca^(2+)and phosphatases,reciprocally bind to CaMKIla.Under basal condition,CaMKIla is recruited to the Shank3 subcompartment of postsynaptic density(PSD)via phase separation.Rise of Ca^(2+)concentration induces GluN2Bmediated recruitment of active CaMKIla and formation of the CaMKIIa/GluN2B/PSD-95 condensates,which are autonomously dispersed upon Ca^(2+)removal.Protein phosphatases control the Ca^(2+)-dependent shuttling of CaMKIla between the two PSD subcompartme nts and PSD condensate formation.Activation of CaMKIla further enlarges the PSD assembly and in duces structural LTP.Thus,Ca^(2+)-induced and phosphatase-checked shuttling of CaMKIla between distinct PSD nano-domains can regulate phase separation-mediated PSD assembly and synaptic plasticity. | Qixu Caic Menglong Zeng Xiandeng Wu Haowei Wu Yumeng Zhan Ruijun Tian Mingjie Zhang | 2021 | Cell Research2021，31，1： | 3 |
| 2 | Exploration of nano-surface chemistry for spectral analysis显示文摘The applications of nano-surface chemistry in the field of spectral analysis have attracted growing interest in recent years.In this article,we reviewed the applications of nanomaterials-based chemical reactions for spectral analysis,including the development in plasma-catalysis,surface-enhanced spectroscopy,separation and preconcentration,chemical vapor generation,labeling and signal amplification.Introduction of nano-surface chemistry to spectral analysis not only improves the sensitivity and selectivity,broadens the application range of spectral analysis,but also affords analytical community special characterization tools. | LI ChengHui LIU Rui Lü Yi HOU XianDeng WU Peng | 2013 | Chinese Science Bulletin2013，58，18： | 0 |
| 3 | Simultaneous extraction of level 2 and level 3 characteristics from latent fingerprints imaged with quantum dots for improved fingerprint analysis显示文摘Fingerprints are unique and life-long to everyone, so they occupy very important statuses in forensic science. However, due to the limit of current imaging technologies and instruments, recognition and matching of fingerprints are mostly based on their level 2 structures(bifurcation, crossover, and etc.).Moreover, in real-world cases, fingerprints collected in the field are often incomplete or damaged, which adds further difficulty in fingerprint analysis. Quantum dots(QDs) are superior fluorescent imaging agents for latent fingerprints, which can provide both level 2 and level 3(sweat pores) details. Here, we used red-emitting N-acetylcysteine-capped Cd Te QDs as imaging agent for staining of eccrine LFPs. The numbers of level 2 and level 3 features that can be mapped are significantly larger than those obtained by cyanoacrylate fuming, a standard technique being adopted at forensic scene. Therefore, the level 2 and level 3 characteristics from QD-staining were simultaneously extracted for improved fingerprint analysis.A preliminary fingerprint matching based modified Pore Matching algorithm was thus developed based on the integration of both level 2 and level 3 characteristics. Satisfactory results of fingerprint matching were obtained, demonstrating the advantage of the QD-staining for advanced fingerprint analysis. | Yuqin Li Chaoying Xu Chang Shu Xiandeng Hou Peng Wu | 2017 | Chinese Chemical Letters2017，28，10： | 0 |
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