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| 1 | Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry显示文摘Because many therapeutic agents are contaminated by epimeric impurities or form epimers as a result of metabolism, analytical tools capable of determining epimers are increasingly in demand. This article is a proof-of-principle report of a novel DMS–MS/MS method to separate and simultaneously quantify epimers, taking PGF2α and its 8-epimer, 8-iso-PGF2α, as an example. Good accuracy and precision were achieved in the range of 10–500 ng/m L with a run time of only 1.5 min. Isopropanol as organic modifier facilitated a good combination of sensitivity and separation. The method is the first example of the quantitation of epimers without chromatographic separation. | Chunsu Liang Hui Sun Xiangjun Meng Lei Yina J.Paul Fawcett Huaidong Yu Ting Liu Jingkai Gu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 3 |
| 2 | LiFePO_4/C via fluoride doping显示文摘Non-stoichiometric compound fluoride-doped LiFePO4/C cathode materials were synthesized via solid-state reaction using MgF2 and AlF3 as dopant. The fluoride-doped LiFePO4/C samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and electrochemical testing. The results show that the materials are well crystallized and fluoride doping cannot change the space structure of LiFePO4. Slight amounts of Fe2O3 with no fluoride impurity were detected. Charge-discharge curves show that fluoride-doped samples have higher capacity at low rates compared with undoped LiFePO4/C. AlF3-doped samples have highest capacity at high discharge current. Both doped samples have larger polarization voltage than undoped samples. All samples exhibit good cycle stability. | Gu Yuan Zhang Xiangjun Lu Shigang Zhao Ting Jiang Danping Yang Rong Wu Aide | 2012 | Rare Metals2012，31，6： | 2 |
| 3 | Web-based Product Development and Simulation with Virtual Reality 显示文摘 | Xiangjun ZOU Bangjun GU Jian SUN | 2006 | Journal of Computational Information Systems (S0887-4417)2006，2，2： | 1 |
| 4 | Water target based cross-calibration of CBERS-02 CCD camera with MODIS data显示文摘 | Junwu Tang Xingfa Gu Shengli Niu Chaofei Ma Xiangjun Min | 2005 | Science in China Series E Engineering & Materials Science2005，，2： | 1 |
| 5 | Web-based Product Development and Simulation with Virtual Reality显示文摘 | Bangjun Gu Jian Sun Hanwu He | 2006 | Journal of Computational Information (S1553-9105)2006，2，1： | 1 |
| 6 | IGFl gene polymorphism and risk for hereditary nonpolyposis colorectal cancer显示文摘 | Maja Zecevic Christopher I Amos Xiangjun Gu | 2006 | J Nat Cancer Institute2006，98，2： | 1 |
| 7 | Web-based Product Development and Simulation with Virtual Reality显示文摘 | ZOU Xiangjun GU Bangjun SUN Jian HE Hanwu | 2006 | JOURNAL OF COMPUTATIONAL INFORMATION SYSTEMS2006，2，1： | 1 |
| 8 | The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)in rat显示文摘Monomethoxy poly(ethylene glycol)-block-poly(D,L-lactic acid)(PEG-PLA)is a typical amphiphilic di-block copolymer widely used as a nanoparticle carrier(nanocarrier)in drug delivery.Understanding the in vivo fate of PEG-PLA is required to evaluate its overall safety and promote the development of PEG-PLA-based nanocarrier drug delivery systems.However,acquiring such understanding is limited by the lack of a suitable analytical method for the bioassay of PEG-PLA.In this study,the pharmacokinetics,biodistribution,metabolism and excretion of PEG-PLA were investigated in rat after intravenous administration.The results show that unchanged PEG-PLA is mainly distributed to spleen,liver,and kidney before being eliminated in urine over 48 h mainly(>80%)in the form of its PEG metabolite.Our study provides a clear and comprehensive picture of the in vivo fate of PEG-PLA which we anticipate will facilitate the scientifc design and safety evaluation of PEG-PLA-based nanocarrier drug delivery systems and thereby enhance their clinical development. | Xiangjun Meng Zhi Zhang Jin Tong Hui Sun John Paul Fawcett Jingkai Gu | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 1 |
| 9 | Fabric-substrated capacitive biopotential sensors enhanced by dielectric nanoparticles显示文摘Wearable biopotential sensing devices are essential to long-term and real-time monitoring of human health.Non-contact,capacitive sensing electrodes prevent potential skin iritations,and are thus beneficial for long-term monitoring.Existing capacitive electrodes are either connected to a separate control circuit via external wires or have limited sensing capacitances,which leads to low signal qualities.This study demonstrates a stretchable capacitive sensing device with integrated electrodes and control electronics,with enhanced signal qualities.The electrodes and the control electronics are fabricated on a common fabric substrate for breathability and strain-limiting protection.The stretchable electrodes are based on an island-bridge design with a stretchability as high as-100%,and an area ratio as high as-80%.By using a dielectric calcium copper titanate(CCTO)composite as the adhesive layer,the electrode capacitance can be increased,yielding an enhanced signal-to-noise ratio(SNR)in the acquired biopotentials.This device offers a convenient and comfortable approach for long-term non-contact monitoring of biopotential signals. | Xiangjun Chen Xiaoxiang Gao Akihiro Nomoto Keren Shi Muyang Lin Hongjie Hu Yue Gu Yangzhi Zhu Zhuohong Wu Xue Chen Xinyu Wang Baiyan Qi Sai Zhou Hong Ding Sheng Xu | 2021 | Nano Research2021，14，9： | 1 |
| 10 | Web-based Product Development and Simulation with Virtual Reality显示文摘 | BangJnn Gu Jian Sun Hanwu He | 2006 | Journal of Computational Information Systems (S1553-9105)2006，2，1： | 1 |
| 11 | Side channel attack of multiplication in GF(q) –application to secure RSA-CRT显示文摘Dear editor,In the field of side-channel attacks (SCAs), the security of both block ciphers and public key cryptosystems is widely studied after the seminal differential power analysis (DPA)[1]. The straightforward implementations of both types of cryptographic algorithms are vulnerable to SCAs. The former attack methods are based on a comparison of actual leakages and a prior leakage model.The typical one is the correlation power analysis(CPA)[2],which is widely used in both practical attacks and security evalutition.Researchers are dedicated to constructing secure RSA-CRT(Chinese reminder theorem)algorithins to mitigate'both SCAs. | Sen XU Weija WANG Xiangjun LU Zheng GUO Junrong LIU Dawu GU | 2019 | Science China(Information Sciences)2019，62，3： | 1 |
| 12 | Virtual manipula- tion of Eon Studio-based for high speed label machine显示文摘 | Gu Bangjun Zou Xiangjun Luo Lufeng | 2006 | Journal of Computational Information Systems2006，，2： | 1 |
| 13 | Web-based product development and simulation with virtual reality 显示文摘 | ZOU Xiangjun GU Bangjun SUN Jian | 2006 | Journal of Computational Information Systems2006，2，1： | 1 |
| 14 | Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome显示文摘 | Viviana Romero Jose Azocar Joaquin Zú?iga Olga P. Clavijo Daniel Terreros Xiangjun Gu Zaheed Husain Raymond T. Chung Christopher Amos Edmond J. Yunis | 2008 | Molecular Immunology2008，，9： | 1 |
| 15 | To Construct High Level Secure Communication System: CTMI Is Not Enough显示文摘Public key cryptographic(PKC) algorithms, such as the RSA, elliptic curve digital signature algorithm(ECDSA) etc., are widely used in the secure communication systems, such as OpenSSL, and a variety of information security systems. If designer do not securely implement them, the secret key will be easily extracted by side-channel attacks(SCAs) or combinational SCA thus mitigating the security of the entire communication system. Previous countermeasures of PKC implementations focused on the core part of the algorithms and ignored the modular inversion which is widely used in various PKC schemes. Many researchers believe that instead of straightforward implementation, constant time modular inversion(CTMI) is enough to resist the attack of simple power analysis combined with lattice analysis. However, we find that the CTMI security can be reduced to a hidden t-bit multiplier problem. Based on this feature, we firstly obtain Hamming weight of intermediate data through side-channel leakage. Then, we propose a heuristic algorithm to solve the problem by revealing the secret(partial and full) base of CTMI. Comparing previous nec-essary input message for masking filtering, our procedure need not any information about the secret base of the inversion. To our knowledge, this is the first time for evaluating the practical security of CTMI and experimental results show the fact that CTMI is not enough for high-level secure communication systems. | Sen Xu Xiangjun Lu Aidong Chen Haifeng Zhang Haihua Gu Dawu Gu Kaiyu Zhang Zheng Guo Junrong Liu | 2018 | China Communications2018，15，11： | 0 |
| 16 | A nonprofiled side-channel analysis based on variational lower bound related to mutual information显示文摘In this paper,we attempt to improve the practical performance of the nonprofiled side-channel analysis(Non SCA)with the help of neural networks.We first derive a variational lower bound related to mutual information(VLBRMI)optimized for the context of Non SCA,which possesses a set of adjustable parameters and whose maximum value linearly depends on the mutual information.Then,we propose a new Non SCA method called neural mutual information analysis(NMIA)that exploits the maximum VLBRMI as the distinguisher.We present an estimator of the maximum VLBRMI,which uses neural networks to instantiate the VLBRMI and trains the neural networks to approximate the maximum VLBRMI so that we can implement the NMIA efficiently.Finally,we evaluate the NMIA on several datasets.The experimental results show that NMIA outperforms the correlation power analysis,the mutual information analysis(MIA)based on histograms,the MIA based on kernel density estimation,and the state-of-the-art Non SCA method based on neural networks. | Chi ZHANG Xiangjun LU Pei CAO Dawu GU Zheng GUO Sen XU | 2023 | Science China(Information Sciences)2023，66，1： | 0 |
| 17 | Analysis on the Epidemiological Characteristics of Escherichia coli O157:H7 Infection in Xuzhou,Jiangsu,China,1999显示文摘Objective:To determine epidemiologic features of an Escherichia coli O157:H7 outbreak occurred in Xuzhou,Jiangsu Province,China in 1999,and assess the incidence of E. coli O157:H7 in diarrhea patients and host animals and its relationship with disease onset,and provide a scientific basis for establishing prevention and control strategies. Methods: Epidemiological,microbiological,and molecular methods were performed to identify risk factors and describe the ecology of E. coli O157:H7 in the environment. Results: From May to September,in 1999,99 cases of E. coli O157:H7 infection were confirmed. Fifty-six patients were enrolled in the case-control study. Bad personal health habits and poor sanitary conditions in the kitchen were associated with increased risks of infection,whereas hand washing was protective. The household survey indicated that residents in the epidemic region during the outbreak had higher than expected rates of diarrhea. The total E. coli O157:H7 carrier rate in the livestock was 12.36%(22/178),specifically 19.15% in cattle,12.50% in goat,and 11.11% in swine. Numerical analysis of pulsed-field gel electrophoresis(PFGE) profiles divided strains into two clusters with 77.5% homology. One cluster contained 11 strains isolated from diarrheal patients,foods,and animals. The other cluster comprised 10 strains from patients and environment. Conclusion: In a large outbreak of E. coli O157:H7 infection among predominantly elderly residents in Xuzhou,high rates of carriage of E. coli O157: H7 among host animals most likely resulted in contamination of the environment,thereby leading to the outbreak. Effective and preventive control measures should be taken to avoid contamination,including environmental and family health improvement,good personal hygiene,and safe food handling practices. | Yefei Zhu Ling Gu Jiaxi Yu Jingchuan Yang Xiangjun Zhai Cheng Dong Huimin Qian Zhongming Tan Hongxing Pan Jiabin Liu Fengcai Zhu Hua Wang | 2009 | Journal of Nanjing Medical University2009，23，1： | 0 |
| 18 | Similar operation template attack on RSA-CRT as a case study显示文摘A template attack, the most powerful side-channel attack methods, usually first builds the leakage profiles from a controlled profiling device, and then uses these profiles to recover the secret of the target device. It is based on the fact that the profiling device shares similar leakage characteristics with the target device. In this study, we focus on the similar operations in a single device and propose a new variant of the template attack, called the similar operation template attack(SOTA). SOTA builds the models on public variables(e.g., input/output) and recovers the values of the secret variables that leak similar to the public variables. SOTA's advantage is that it can avoid the requirement of an additional profiling device. In this study, the proposed SOTA method is applied to a straightforward RSA-CRT implementation. Because the leakage is(almost) the same in similar operations, we reduce the security of RSA-CRT to a hidden multiplier problem(HMP) over GF(q), which can be solved byte-wise using our proposed heuristic algorithm. The effectiveness of our proposed method is verified as an entire prime recovery procedure in a practical leakage scenario. | Sen XU Xiangjun LU Kaiyu ZHANG Yang LI Lei WANG Weijia WANG Haihua GU Zheng GUO Junrong LIU Dawu GU | 2018 | Science China(Information Sciences)2018，61，3： | 0 |
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