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| 1 | Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model显示文摘Nerve conduit is one of strategies for spine cord injury(SCI)treatment.Recently,studies showed that biomaterials could guide the neurite growth and promote axon regeneration at the injury site.However,the scaffold by itself was difficult to meet the need of SCI functional recovery.The basic fibroblast growth factor(bFGF)administration significantly promotes functional recovery after organ injuries.Here,using a rat model of T9 hemisected SCI,we aimed at assessing the repair capacity of implantation of collagen scaffold(CS)modified by collagen binding bFGF(CBD-bFGF).The results showed that CS combined with CBD-bFGF treatment improved survival rates after the lateral hemisection SCI.The CS/CBD-bFGF group showed more significant improvements in motor than the simply CS-implanted and untreated control group,when evaluated by the 21-point Basso-Beattie-Bresnahan(BBB)score and footprint analysis.Both hematoxylin and eosin(H&E)and immunohistochemical staining of neurofilament(NF)and glial fibrillary acidic protein(GFAP)demonstrated that fibers were guided to grow through the implants.These findings indicated that administration of CS modified with CBD-bFGF could promote spinal cord regeneration and functional recovery. | SHI Qin GAO Wei HAN XingLong ZHU XueSong SUN Jie XIE Fang HOU XiangLin YANG HuiLin DAI JianWu CHEN Liang | 2014 | Science China(Life Sciences)2014，57，2： | 23 |
| 2 | Projected Shifts in Kppen Climate Zones over China and Their Temporal Evolution in CMIP5 Multi-Model Simulations显示文摘Previous studies have examined the projected climate types in China by 2100. This study identified the emergence time of climate shifts at a 1?scale over China from 1990 to 2100 and investigated the temporal evolution of K o¨ppen–Geiger climate classifications computed from CMIP5 multi-model outputs. Climate shifts were detected in transition regions(7%–8% of China's land area) by 2010, including rapid replacement of mixed forest(Dwb) by deciduous forest(Dwa) over Northeast China, strong shrinkage of alpine climate type(ET) on the Tibetan Plateau, weak northward expansion of subtropical winterdry climate(Cwa) over Southeast China, and contraction of oceanic climate(Cwb) in Southwest China. Under all future RCP(Representative Concentration Pathway) scenarios, the reduction of Dwb in Northeast China and ET on the Tibetan Plateau was projected to accelerate substantially during 2010–30, and half of the total area occupied by ET in 1990 was projected to be redistributed by 2040. Under the most severe scenario(RCP8.5), sub-polar continental winter dry climate over Northeast China would disappear by 2040–50, ET on the Tibetan Plateau would disappear by 2070, and the climate types in 35.9%and 50.8% of China's land area would change by 2050 and 2100, respectively. The results presented in this paper indicate imperative impacts of anthropogenic climate change on China's ecoregions in future decades. | Duo CHAN Qigang WU Guixiang JIANG Xianglin DAI | 2016 | Advances in Atmospheric Sciences2016，33，3： | 10 |
| 3 | Allotransplantation of adult spinal cord tissues after complete transected spinal cord injury: long-term survival and functional recovery in canines显示文摘Spinal cord injury(SCI), especially complete transected SCI, leads to loss of cells and extracellular matrix and functional impairments. In a previous study, we transplanted adult spinal cord tissues(aSCTs) to replace lost tissues and facilitate recovery in a rat SCI model. However, rodents display considerable differences from human patients in the scale, anatomy and functions of spinal cord systems, and responses after injury. Thus, use of a large animal SCI model is required to examine the repair efficiency of potential therapeutic approaches. In this study, we transplanted allogenic aSCTs from adult dogs to the lesion area of canines after complete transection of the thoracic spinal cord, and investigated the long-term cell survival and functional recovery. To enhance repair efficiency, a growth factor cocktail was added during aSCT transplantation, providing a favorable microenvironment. The results showed that transplantation of a SCTs, in particular with the addition of growth factors, significantly improves locomotor function restoration and increases the number of neurofilament-, microtubule-associated protein2-, 5-hydroxytryptamine-, choline acetyltransferase-and tyrosine hydroxylase-positive neurons in the lesion area at 6 months post-surgery. In addition, we demonstrated that donor neurons in a SCTs can survive for a long period after transplantation. This study showed for the first time that transplanting aSCTs combined with growth factor supplementation facilitates reconstruction of injured spinal cords, and consequently promotes long lasting motor function recovery in a large animal complete transected SCI model, and therefore could be considered as a possible therapeutic strategy in humans. | He Shen Shuyu Wu Xi Chen Bai Xu Dezun Ma Yannan Zhao Yan Zhuang Bing Chen Xianglin Hou Jiayin Li Yudong Cao Xianyong Fu Jun Tan Wen Yin Juan Li Li Meng Ya Shi Zhifeng Xiao Xingjun Jiang Jianwu Dai | 2020 | Science China(Life Sciences)2020，63，12： | 3 |
| 4 | The effect of collagen-binding vascular endothelial growth factor on the remodeling of scarred rat uterus following full-thickness injury显示文摘 | Nacheng Lin Xin’an Li Tianran Song Jingmei Wang Kui Meng Jun Yang Xianglin Hou Jianwu Dai Yali Hu | 2011 | Biomaterials2011，，： | 1 |
| 5 | Comparable outcomes but higher risks of prolonged viral RNA shedding duration and secondary infection in cancer survivors with COVID-19: A multi-center, matched retrospective cohort study显示文摘Results Sixty-one cancer survivors and 183 matched non-cancer patients were screened from 2,828 COVID-19 infected patients admitted to 4 hospitals in Wuhan,China.The median ages of the cancer survivor cohort and non-cancer patient cohort were 64.0(55.0–73.0)and 64.0(54.0–73.5),respectively(P=0.909).Cancer survivors reported a higher incidence of symptom onset than non-cancer patients.Fever(80.3%vs.65.0%;P=0.026)was the most prevalent symptom,followed by cough(65.6%vs.37.7%;P<0.001),myalgia,and fatigue(45.9%vs.13.6%;P<0.001).The risks of the development of severe events(adjusted hazard ratio[AHR]=1.25;95%confidence interval[CI]:0.76–2.06;P=0.378)and mortality(relative risk[RR]=0.90,95%CI:0.79–1.04;P=0.416)in the cancer survivor cohort were comparable to those of the matched non-cancer patient cohort.However,the cancer survivor cohort showed a higher incidence of secondary infection(52.5%vs.30.1%;RR=1.47,95%CI:1.11–1.95;P=0.002)and a prolonged viral RNA shedding duration(32 days[IQR 26.0–46.0]vs.24.0 days[IQR 18.0–33.0];AHR=0.54;95%CI:0.38–0.80;P<0.05).Conclusion Compared to non-cancer patients,cancer survivors with COVID-19 exhibited a higher incidence of secondary infection,a prolonged period of viral shedding,but comparable risks of the development of severe events and mortality.It is helpful for clinicians to take tailored measures to treat cancer survivors with COVID-19. | Hui Peng Sheng Wang Qi Mei Yuhong Dai Jian Li Ming Li Kathrin Halfter Xueyan Jiang Qin Huang Lei Wang Wei Wei Ru Liu Zhen cao Motuma Yigezu Daba Fangfang Wang Bingqing Zhou Hong Qiu Xianglin Yuan | 2020 | Oncology and Translational Medicine2020，6，6： | 1 |
| 6 | Collagen scaffolds modified with CNTF and bFGF promote facial nerve regeneration in minipigs显示文摘 | Yi Cui Chao Lu Danqing Meng Zhifeng Xiao Xianglin Hou Wenyong Ding Depeng Kou Yao Yao Bing Chen Zhen Zhang Jiayin Li Juli Pan Jianwu Dai | 2014 | Biomaterials2014，，： | 1 |
| 7 | Promotion of diabetic wound healing by collagen scaffold with collagen‐binding vascular endothelial growth factor in a diabetic rat model显示文摘 | Qian Tan Bing Chen Xin Yan Yue Lin Zhifeng Xiao Xianglin Hou Jianwu Dai | 2014 | J Tissue Eng Regen Med2014，，： | 1 |
| 8 | 中国东部有利于强霾污染形成的大气扩散条件的季节内变化及其未来预估显示文摘有利于强霾污染形成的大气扩散条件的未来预估对政府制定污染减排政策和公共健康具有重要意义。本文利用气候模式集合试验研究了有利于强霾污染形成的大气扩散条件在RCP8.5排放情景下的变化及其与气溶胶减排和温室气体增加的关系。研究结果发现华北平原污染事件的相对强度在未来情境下会增强,这主要是由更强并且持续时间更长的中国东部反气旋距平所引起的。北方波列辐合的增强引起了反气旋距平强度的增加,加强的局地斜压正反馈使得反气旋从背景流中获得更多的能量从而使其持续时间增加。气溶胶减少引起的气候效应对巴伦支卡拉海附近的波列和中国东部的反气旋变化起主导作用,而温室气体增加对其影响较小。研究结果表明,未来减排会导致扩散条件恶化,这表明中国需要采取更严格的污染减排措施,以达到相应的空气质量标准。 | FENG Weiyang WANG Minghuai ZHANG Yang DAI Xianglin LIU Xiaohong XU Yangyang | 2020 | Atmospheric and Oceanic Science Letters2020，13，4： | 0 |
| 9 | Timing of the formation of the Baiyinnuo'er skarn Zn–Pb deposit,NE China:evidence from sulfide Rb–Sr dating显示文摘The Baiyinnuo’er deposit in northern China is located in the south section of the Great Xing’an Range,and it is the largest skarn Zn–Pb deposit in the region.Skarn and Zn–Pb orebodies mainly occur between the different units of the Permian Huanggangliang Formation,or within the contact zone between the intrusive rocks and the marble.Although Baiyinnuo’er has been well investigated previously,the timing of the Zn–Pb mineralization is still controversial,largely due to the lack of appropriate ore or alteration minerals that could be directly used for isotopic dating.In this study,we report the results of Rb–Sr isotopic analysis for sphalerite and pyrite samples from the Baiyinnuo’er orebodies,which yielded two isochron ages of 137.4±3.4 and 140.0±7.8 Ma,respectively,constraining the Zn–Pb mineralization time of the deposit as the Early Cretaceous.The data are also consistent with the age of the granitoids in the mining area,indicating a potential genetic relationship between the Early Cretaceous magmatism and mineralization.Many other intrusion-related hydrothermal deposits(including the two typical skarns,Huanggang and Haobugao)in the southern Great Xing’an Range also share similar mineralization ages(i.e.,140–130 Ma).Together,these data suggest an Early Cretaceous mineralization event in this region,and this largescale mineralization could be related to the regional tectonic regime transition from compression to extension as a result of the rollback of the subducted Paleo-Pacific plate.The initial87 Sr/86 Sr ratios of the sphalerite and pyrite samples are 0.70569 and 0.70616,respectively,implying that the ore-forming material could have a significant contribution from the mantle components.The current study shows that sulfide Rb–Sr dating could be used in deciphering the timing of skarn deposit formation. | Yixin Li Qihai Shu Xudong Niu Fan Yu Qingwen Zeng Liangmin Wei Yang Xiao Xianglin Dai | 2022 | Acta Geochimica2022，41，2： | 0 |
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