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| 1 | Effect of porosities of bilayered porous scaffolds on spontaneous osteochondral repair in cartilage tissue engineering显示文摘Poly(lactide-co-glycolide)-bilayered scaffolds with the same porosity or different ones on the two layers were fabricated,and the porosity effect on in vivo repairing of the osteochondral defect was examined in a comparative way for the first time.The constructs of scaffolds and bone marrow-derived mesenchymal stem cells were implanted into pre-created osteochondral defects in the femoral condyle of New Zealand white rabbits.After 12 weeks,all experimental groups exhibited good cartilage repairing according to macroscopic appearance,cross-section view,haematoxylin and eosin staining,toluidine blue staining,immunohistochemical staining and real-time polymerase chain reaction of characteristic genes.The group of 92%porosity in the cartilage layer and 77%porosity in the bone layer resulted in the best efficacy,which was understood by more biomechanical mimicking of the natural cartilage and subchondral bone.This study illustrates unambiguously that cartilage tissue engineering allows for a wide range of scaffold porosity,yet some porosity group is optimal.It is also revealed that the biomechanical matching with the natural composite tissue should be taken into consideration in the design of practical biomaterials,which is especially important for porosities of a multi-compartment scaffold concerning connected tissues. | Zhen Pan Pingguo Duan Xiangnan Liu Huiren Wang Lu Cao Yao He Jian Dong Jiandong Ding | 2015 | Regenerative Biomaterials2015，2，1： | 20 |
| 2 | POSITIVE SOLUTIONS TO m-POINT BOUNDARY VALUE PROBLEM OF NONLINEAR FRACTIONAL DIFFERENTIAL EQUATION WITH p-LAPLACIAN显示文摘In this paper,we are concerned with the existence of positive solutions to an m-point boundary value problem with p-Laplacian of nonlinear fractional differential equation.By means of Krasnosel'skii fixed-point theorem on a convex cone and Leggett-Williams fixed-point theorem,the existence results of solutions are obtained. | Anping Chen~1,2,Yi Chen~1 (1.School of Math.and Computational Science,Xiangtan University,Xiangtan 411005,Hunan 2.Dept.of Math.,Xiangnan University,Chenzhou 423000,Hunan) | 2011 | Annals of Differential Equations2011，27，4： | 15 |
| 3 | Regulation of mitophagy in ischemic brain injury显示文摘The selective degradation of damaged or excessive mitochondria by autophagy is termed mitophagy. Mitophagy is crucial for mitochondrial quality control and has been implicated in several neurodegenerative disorders as well as in ischemic brain injury. Emerging evidence suggested that the role of mitophagy in cerebral ischemia may depend on different pathological processes. In particular, a neuroprotective role of mitophagy has been proposed, and the regulation of mitophagy seems to be important in cell survival. For these reasons, extensive investigations aimed to profile the mitophagy process and its underlying molecular mechanisms have been executed in recent years. In this review, we summarize the current knowledge regarding the mitophagy process and its role in cerebral ischemia, and focus on the pathological events and molecules that regulate mitophagy in ischemic brain injury. | Yang Yuan Xiangnan Zhang Yanrong Zheng Zhong Chen | 2015 | Neuroscience Bulletin2015，31，4： | 12 |
| 4 | Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer显示文摘 | Xin Tian Baofa Sun Chuanyuan Chen Chunchun Gao Ji Zhang XingYu Lu Linchen Wang Xiangnan Li Yurong Xing Ruijuan Liu Xiao Han Zheng Qi Xiaojian Zhang Chuan He Dali Han Yun-Gui Yang Quancheng Kan | 2018 | Cell Research2018，28，5： | 12 |
| 5 | Liberation characteristics of coal middlings comminuted by jaw crusher and ball mill显示文摘The associated minerals make coal middlings possess a relatively high ash content.Subsequent liberation through size reduction can cause recovery increase.However,effect of comminution facilities on mineral liberation of middlings was ignored.This paper studied the liberation characteristics of middlings crushed with different kinds of fragmentation forces.Middlings of 3 mm+0.5 mm sampled from a dense medium cyclone were comminuted by a jaw crusher and a ball mill to 0.5 mm with similar size distribution respectively.The generating mechanism of fnes was also analyzed.Full densimetric analyses indicate that mineral liberation of the product crushed by the jaw crusher is better than that by the ball mill at each fraction.For sizes of 0.125 mm+0.074 mm and 0.074 mm,yields of the product with ash content 11%comminuted by jaw crusher are nearly 20%higher than that by the ball mill.Sectional micrographs observed by the scanning electron microscopy(SEM)also show the same law for these two fractions and some intergrowth particles still exist in the fraction of 0.5 mm+0.25 mm. | Xie Weining He Yaqun Zhu Xiangnan Ge Linhan Huang Yajun Wang Haifeng | 2013 | International Journal of Mining Science and Technology2013，23，5： | 12 |
| 6 | Projection micro stereolithography based 3D printing and its applications显示文摘Projection micro stereolithography(PμSL)is a high-resolution(up to 0.6μm)3D printing technology based on area projection triggered photopolymerization,and capable of fabricating complex 3D architectures covering multiple scales and with multiple materials.This paper reviews the recent development of the PμSL based 3D printing technologies,together with the related applications.It introduces the working principle,the commercialized products,and the recent multiscale,multimaterial printing capability of PμSL as well as some functional photopolymers that are suitable to PμSL.This review paper also summarizes a few typical applications of PμSL including mechanical metamaterials,optical components,4D printing,bioinspired materials and biomedical applications,and offers perspectives on the directions of the further development of PμSL based 3D printing technology. | Qi Ge Zhiqin Li Zhaolong Wang Kavin Kowsari Wang Zhang Xiangnan He Jianlin Zhou Nicholas X Fang | 2020 | International Journal of Extreme Manufacturing2020，2，2： | 11 |
| 7 | A fuzzy PID-controlled SMA actuator for a two-DOF joint显示文摘Shape memory alloy(SMA) actuator is a potential advanced component for servosystems of aerospace vehicles and aircraft. This paper presents a joint with two degrees of freedom(DOF) and a mobility range close to ±60 when driven by SMA triple wires. The fuzzy proportional-integral-derivative(PID)-controlled actuator drive was designed using antagonistic SMA triple wires, and the resistance feedback signal made a closed loop. Experiments showed that, with the driving responding frequency increasing, the overstress became harder to be avoided at the position under the maximum friction force. Furthermore, the hysteresis gap between the heating and cooling paths of the strain-to-resistance curve expanded under this condition. A fuzzy logic control was considered as a solution, and the curves of the wires were then modeled by fitting polynomials so that the measured resistance was used directly to determine the control signal. Accurate control was demonstrated through the step response, and the experimental results showed that under the fuzzy PID-control program, the mean absolute error(MAE) of the rotation angle was about 3.147. In addition, the investigation of the external interference to the system proved the controllable maximum output. | Shi Zhenyun Wang Tianmiao Liu Da Ma Chen Yuan Xiangnan | 2014 | Chinese Journal of Aeronautics2014，27，2： | 10 |
| 8 | Consensus Control of Leader-Following Multi-Agent Systems in Directed Topology With Heterogeneous Disturbances显示文摘This paper investigates the consensus problem for linear multi-agent systems with the heterogeneous disturbances generated by the Brown motion.Its main contribution is that a control scheme is designed to achieve the dynamic consensus for the multi-agent systems in directed topology interfered by stochastic noise.In traditional ways,the coupling weights depending on the communication structure are static.A new distributed controller is designed based on Riccati inequalities,while updating the coupling weights associated with the gain matrix by state errors between adjacent agents.By introducing time-varying coupling weights into this novel control law,the state errors between leader and followers asymptotically converge to the minimum value utilizing the local interaction.Through the Lyapunov directed method and It?formula,the stability of the closed-loop system with the proposed control law is analyzed.Two simulation results conducted by the new and traditional schemes are presented to demonstrate the effectiveness and advantage of the developed control method. | Qinglai Wei Xin Wang Xiangnan Zhong Naiqi Wu | 2021 | IEEE/CAA Journal of Automatica Sinica2021，8，2： | 8 |
| 9 | 5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer显示文摘Non-small-cell lung cancer(NSCLC), the most common type of lung cancer accounting for 85% of the cases, is often diagnosed at advanced stages owing to the lack of efficient early diagnostic tools. 5-Hydroxymethylcytosine(5 hmC) signatures in circulating cell-free DNA(cfDNA) that carries the cancer-specific epigenetic patterns may represent the valuable biomarkers for discriminating tumor and healthy individuals, and thus could be potentially useful for NSCLC diagnosis. Here,we employed a sensitive and reliable method to map genome-wide 5 hmC in the cfDNA of Chinese NSCLC patients and detected a significant 5 hmC gain in both the gene bodies and promoter regions in the blood samples from tumor patients compared with healthy controls. Specifically, we identified six potential biomarkers from 66 patients and 67 healthy controls(mean decrease accuracy>3.2, P < 3.68E-19) using machine-learning-based tumor classifiers with high accuracy. Thus,the unique signature of 5 hmC in tumor patient's cfDNA identified in our study may provide valuable information in facilitating the development of new diagnostic and therapeutic modalities for NSCLC. | Ji Zhang Xiao Han Chunchun Gao Yurong Xing Zheng Qi Ruijuan Liu Yueqin Wang Xiaojian Zhang Yun-Gui Yang Xiangnan Li Baofa Sun Xin Tian | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 7 |
| 10 | Spatial-temporal patterns of vegetation dynamics and their relationships to climate variations in Qinghai Lake Basin using MODIS time-series data显示文摘全球温暖在最近的年里导致了重要植被变化。为环境适应的更好的理解在植被变化上调查气候的变化(温度和降水) 的效果到气候的变化是必要的。在这份报纸,我们在 GIS 集中了于多方法和空间分析技术的集成和申请学习植被动力学的时间空间的变化并且探索植被变化机制。在在不同时间规模的 EVI 和气候因素之间的关联在从 2001 ~ 2012 的一年的金海·莱克盆分别地为包括每月、季节、年度的规模的每个象素是计算的。这研究的主要目的是揭示什么时候,植被变化在哪儿并且为什么练习以便为明智的地区性的生态系统管理支持对全球变化以及有用信息和技术的陆上的反应的更好的理解。主要结论如下:(1 ) 在这个区域的全面植被 EVI 增加了 6% 在期间最近 12 年。在种季节的 EVI 价值(即春天和夏天) 展出了很重要的改善趋势,分别地占了 12.8% 和 9.3% 。EVI 的空间模式看明显的空间异质哪个与热水的状况一致。一般来说,自从将近 78% 象素整个盆显示出增加的趋势,植被范围在区域的大多数部分改善了,当仅仅在区域的小部分稍微降级了时。(2 ) EVI 变化断然与平均温度和降水被相关。一般来说在金海·莱克盆,降水是为植被生长的主导的开车因素;然而,在不同时间规模,它到植被的重量有差别。(3 ) 基于 geo 统计的分析,秋天降水在整个区域与下一春天 EVI 价值有强壮的关联。这调查结果探索秋天降水是重要指示物,然后,限制下个弹簧的植物生长。 | GUO Weit NI Xiangnan JING Duanyang LI Shuheng | 2014 | Journal of Geographical Sciences2014，24，6： | 6 |
| 11 | Observations favor the crossing of phantom divide lines显示文摘Using three different parameterized dark energy models, we reconstruct the properties of dark energy from the latest 397 Sne Ia, CMB and BAO with the present matter density, Ωm0, given prior. We find that, when Ωm0 is not small, for example, Ωm0 = 0.28 or 0.32, an evolving dark energy with a crossing of phantom divide line is favored and this conclusion seems to be model independent. We also find that the evolving properties of dark energy become more and more evident with the increase of Ωm0 given prior. | HUANG TieTie1,2,3, WU PuXun2,3 & YU HongWei2,3 1Department of Physics, Xiangnan College, Chenzhou 423000, China 2Department of Physics and Institute of Physics, Hunan Normal University, Changsha 410081, China 3Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Education, Hunan Normal University, Changsha 410081, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，3： | 6 |
| 12 | CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss显示文摘Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increased risk for fracture.The present work aimed to compare the insulin-sensitizing efficacies and bone-loss side effects of CMHX008,a novel TZDs-like PPARg partial agonist,with those of rosiglitazone.A TR-FRET PPARg competitive binding assay was used to compare the binding affinity between CMHX008 and rosiglitazone.Mice were administered vehicle,CMHX008 or rosiglitazone for 16 weeks.Mesenchymal stem cells(MSCs)were used to examine differences in differentiation into osteoblasts after compounds treatment.TR-FRET showed lower affinity to PPARg by CMHX008 compared with rosiglitazone.Mice treated with CMHX008 showed insulin sensitization similar to that of mice treated with rosiglitazone,which was related to the significant inhibition of PPARg Ser273 phosphorylation and improved insulin sensitivity by facilitating the phosphorylation of insulin receptor and Akt in adipose tissues.Micro-CT and histomorphometric analyses demonstrated that the degree of trabecular bone loss after treatment with CMHX008 was weaker than that observed with rosiglitazone,as evidenced by consistent changes in BV/TV,Tb.N,Tb.Th,Tb.Sp,and the mineral apposition rate.MSCs treated with CMHX008 showed higher ALP activity and mRNA levels of bone formation markers than did cells treated with rosiglitazone in the osteoblast differentiation test.Thus,CMHX008 showed insulin-sensitizing effects similar to those of rosiglitazone with a lower risk of bone loss,suggesting that PPARg sparing eliminates the skeletal side effects of TZDs while maintaining their insulin-sensitizing properties. | Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao | 2018 | Genes & Diseases2018，5，3： | 6 |
| 13 | Overview of deep space laser communication显示文摘The deep space probe is a vital technology for observing and exploring the universe. It is thus intensifying as an aerospace research focus on an international scale. Despite improving the frequency band,the conventional microwave communication technique has difficulty satisfying the increased demand for the enormous volume of scientific data returning to the Earth. With a carrier frequency that is several orders of magnitude higher than the microwave, free-space optical communication is a robust and promising method for achieving both high bit rates and long distances in deep space communication. In this article, the history of this technology is summarized and the objective laws are formulated, while key techniques and development trends are analyzed. Finally, useful concepts and suggestions are proposed for the development of deep space laser communication in China. | Weiren WU Ming CHEN Zhe ZHANG Xiangnan LIU Yuhui DONG | 2018 | Science China(Information Sciences)2018，61，4： | 6 |
| 14 | Emerging role of natural products in cancer immunotherapy显示文摘Cancer immunotherapy has become a new generation of anti-tumor treatment,but its indications still focus on several types of tumors that are sensitive to the immune system.Therefore,effective strategies that can expand its indications and enhance its efficiency become the key element for the further development of cancer immunotherapy.Natural products are reported to have this effect on cancer immunotherapy,including cancer vaccines,immune-check points inhibitors,and adoptive immune-cells therapy.And the mechanism of that is mainly attributed to the remodeling of the tumorimmunosuppressive microenvironment,which is the key factor that assists tumor to avoid the recognition and attack from immune system and cancer immunotherapy.Therefore,this review summarizes and concludes the natural products that reportedly improve cancer immunotherapy and investigates the mechanism.And we found that saponins,polysaccharides,and flavonoids are mainly three categories of natural products,which reflected significant effects combined with cancer immunotherapy through reversing the tumor-immunosuppressive microenvironment.Besides,this review also collected the studies about nano-technology used to improve the disadvantages of natural products.All of these studies showed the great potential of natural products in cancer immunotherapy. | Songtao Dong Xiangnan Guo Fei Han Zhonggui He Yongjun Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 5 |
| 15 | Laser-based micro/nanofabrication in one, two and three dimensions显示文摘有各种各样的尺寸的功能的材料和结构的先进 micro/nanofabrication 在现代 nanoscience 和技术代表一个关键研究话题并且为象 nanoelectronics, nanophotonics 和 micro/nanoelectromechanical 系统那样的众多的出现技术变得极其重要。这评论系统地探索在制作挑战性经由常规途径被制作的各种各样的尺寸的 nanomaterials 和 micro/nanostructures 处理途径的非常规的材料。研究努力为生长和制造集中于基于激光的技术一个维(1D ) ,二维(2D ) 并且三维(3D ) nanomaterials 和 micro/nanostructures。下列研究话题被论及,包括:1 ) 为碳 nanotubes (CNT ) 的 1D nanomaterial 的高度有效的生长和集成的帮助激光的化学蒸汽免职(CVD ) , 2 ) 在周围的条件下面的 graphene 带子的直接写的激光(LDW ) ,并且 3 ) 经由添加剂和减少性的过程的 3D micro/nanostructures 的 LDW。与常规制造方法作比较,基于激光的方法在先进功能的材料和结构的 micro/nanofabrication 展出几个唯一的优点。为 1D CNT 生长,帮助激光的 CVD 进程能由于高度强烈的精力交货和导致激光的光近地的效果认识到两快速的材料合成和生长地点的紧密的控制和 CNT 的取向。为 2D graphene 合成和 patterning,房间温度并且露天绝缘的表面上的大规模 graphene 模式的制造被一个 LDW 过程成功地认识到。为 3D micro/nanofabrication,二光子的聚合(TPP ) 和减少性的多光子脱离(MPA ) 处理的添加剂的联合启用为常规制造方法挑战性的任意的复杂 3D micro/nanostructures 的制造。就基于激光的技术的众多的唯一的优点而言,基于激光的 micro/nanofabrication 被期望在先进功能的 micro/nano-devices 的制造起一个越来越重要的作用。 | Wei XIONG Yunshen ZHOU Wenjia HOU Lijia JIANG Masoud MAHJOURI-SAMANI Jongbok PARK Xiangnan HE Yang GAO Lisha FAN Tommaso BALDACCHINI Jean-Francois SILVAIN Yongfeng LU | 2015 | Frontiers of Optoelectronics2015，8，4： | 4 |
| 16 | Helicity‐dependent THz emission induced by ultrafast spin photocurrent in nodal‐line semimetal candidate Mg3Bi2显示文摘Helicity-dependent ultrafast spin current generated by circularly polarized photons in topological materials holds the crux to many technological improvements,such as quantum communications,on-chip communication processing and storage.Here,we present the manipulation of helicity-dependent terahertz emission generated in a nodal line semimetal candidate Mg3Bi2 by using photon polarization states.The terahertz emission is mainly ascribed to the helicity-dependent photocurrent that is originated from circular photogalvanic effects,and the helicity-independent photocurrent that is attributed to linear photogalvanic effect.Our work will inspire more explorations into novel nodal line semimetals and open up new opportunities for developing ultrafast optoelectronics in the topological system. | Mingyu Tong Yuze Hu Xiangnan Xie Xiegang Zhu Zhenyu Wang Xiang'ai Cheng Tian Jiang | 2020 | Opto-Electronic Advances2020，3，12： | 3 |
| 17 | Therapeutic potential of bone marrow-derived mononuclear cells for experimental cerebral ischemia in mice显示文摘Bone marrow mononuclear cells (BMMCs) can be directly harvested from the donor, allowing for easier application compared with bone marrow mesenchymal stem cells. The present study hypothesized that BMMC transplantation could ameliorate cerebral ischemia in a mouse model. BMMCs were double-labeled with PKH26 and 4', 6-diamidino-2-phenylindole (DAPI), followed by infusion into mice via the tail vein to induce focal cerebral ischemia. At 14 days after transplantation, morphological and neurofunctional recovery were analyzed. PKH26 and DAPI double-positive BMMCs were detected in the cerebral hemisphere of all transplantation mice. Following BMMC administration, there was significant difference in neurofunctional recovery, but no significant difference in survival rates between BMMC-treated mice and other mice. These results demonstrate that transplanted BMMCs migrate to brain tissue and | Xuemei Zhang Fang Du Dan Yang Chunjiang Yu Xiangnan Huang Wei Liu Jin Fu | 2010 | Neural Regeneration Research2010，5，23： | 3 |
| 18 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 19 | Innovation Requirements and Progress of Dialysis Water Treatment System显示文摘With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,People are constantly improving the water treatment system and its standardized,and the demand for dialysis water is also becoming more and more strict.Hemodialysis is an effective means of maintaining the life of renal failure patients,120~180L water will be used for a conventional dialysis treatment,and high flux dialysis will consume more. | Jun Ke Lifong Yan Taksui Wong Bo Hu Shuang Cui Sibo Huang Aiyun Cha Jie Huang Hongwei Hu Dawen Yun Shaofeng Huang Jie Shu Mingming Ma Lianghong Yin Xiangnan Dong Chen Yun Zuhui Chen Fanna Liu | 2017 | 临床医学工程2017，24，S1： | 2 |
| 20 | Estimating the Age of Oil-tea Camellia Trees显示文摘To determine the age of oil-tea camellia trees,regression equations including Logistic,Mitscherlich,Gompertz,Korf,and Richards were used to calculate accumulative growth rate using basal trunk disc and investigate the relations between the age of oil-tea camellia trees and their growth rate of secondary trunk.The Gompertz equation Y = 71. 296 1 exp(-3. 874 4 exp(-0. 006 4 t)) was the most optimal equation to simulate the accumulative growth rate of basal trunk disc.This equation could be used to estimate the age of oil-tea camellia trees that grow under similar environmental conditions. The Korf equation Y = 576. 900 1 exp(-4. 153 0 x^(-0. 314 2)) was the best equation to describe the relation between the age and growth rate of different secondary trunks. With the adjustment coefficient and average growth of different secondary trunk discs,it is possible to predict the age of ancient oil-tea camellia trees that grow under similar environmental conditions. In addition,taking three or more discs from the same diameter group and calculating their average growth rate could lead to more accurate results. For trees that grow in different areas,environmental conditions should be carefully considered when using the above two equations to predict the age of ancient oil-tea camellia trees. | Yanming XU Yongzhong CHEN Longsheng CHEN Zhen ZHANG Jian LUO Xiangnan WANG Shaofeng PENG | 2018 | Agricultural Biotechnology2018，7，4： | 2 |
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