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| 1 | Preparation and Properties of Nanocellulose/Sodium Alginate Composite Hydrogel显示文摘Cellulose nanofiber(CNF)was isolated from Okara using deep eutectic solvent(DES)with high-speed stirring.The composite hydrogels obtained by using different proportions of CNF and sodium alginate(SA)had different properties.The CNF/SA composite hydrogels were analyzed using Fourier transform infrared spectroscopy and scanning electron microscopy and tested for compression properties,rheological properties,water content,and swelling degree.Physical crosslinking between SA and Ca^(2+),and different degrees of hydrogen bond formation between SA and CNF were observed.The CNF/SA composite hydrogel have great potential as reinforcements in eco-friendly composite hydrogels for diverse applications. | Peiyi Li Ruiyan Liu Haozhe Lei Miaomiao Zhou Boxing Jian Xinping Li | 2021 | Paper And Biomaterials2021，6，4： | 4 |
| 2 | Effect of High Pressure Homogenization Treatment on Structure and Properties of Soybean Residue Cellulose Nanofibers显示文摘To reduce the adverse effects of non-cellulose materials on subsequent homogenization,the effects of a high-pressure homogenization treatment on the structure and properties of cellulose nanofibers(CNF)prepared by acid treatment of soybean residue were studied.The effects of the number of homogenization step on the microfibrillation degree,crystalline structure and mechanical properties of the soybean residue were analyzed by SEM,FT-IR,XRD,TG and DTG.The results showed that an increase in the number of homogenization steps led to an increase in the degree of microfibrillation,a more uniform distribution of the CNF diameter,and an increase in the crystallinity of CNF.However,but when the number of homogenization steps exceeded 15,the rate of change decreased,and the crystallinity of CNF decreased.As the number of homogenization steps increased,the average degree of polymerization and average molecular weight of CNF decreased continuously,and after 15 homogenization steps,their rate of change also decreased.Therefore,15 steps of high-pressure homogenization represented a suitable number of steps to prepare the soybean residue CNF with an average diameter of 15 nm. | Peiyi Li Yumeng Wang Binyao Zhou Qingqing Hou Hezhen Liu Haozhe Lei Boxing Jian Xinping Li | 2019 | Paper And Biomaterials2019，4，4： | 4 |
| 3 | Prediction of radiosensitivity in primary central nervous system germ cell tumors using dynamic contrast-enhanced magnetic resonance imaging显示文摘Objective: To evaluate the feasibility of dynamic contrast-enhanced magnetic resonance imaging(DCEMRI) for predicting tumor response to radiotherapy in patients with suspected primary central nervous system(CNS) germ cell tumors(GCTs).Methods: DCE-MRI parameters of 35 patients with suspected primary CNS GCTs were obtained prior to diagnostic radiation, using the Tofts and Kermode model. Radiosensitivity was determined in tumors diagnosed 2 weeks after radiation by observing changes in tumor size and markers as a response to MRI. Taking radiosensitivity as the gold standard, the cut-off value of DCE-MRI parameters was measured by receiver operating characteristic(ROC) curve. Diagnostic accuracy of DCE-MRI parameters for predicting radiosensitivity was evaluated by ROC curve.Results: A significant elevation in transfer constant(Ktrans) and extravascular extracellular space(Ve)(P=0.000), as well as a significant reduction in rate constant(Kep)(P=0.000) was observed in tumors. Ktrans, relative Ktrans, and relative Kep of the responsive group were significantly higher than non-responsive groups. No significant difference was found in Kep, Ve, and relative Ve between the two groups. Relative Ktrans showed the best diagnostic value in predicting radiosensitivity with a sensitivity of 100%, specificity of 91.7%, positive predictive value(PPV) of 95.8%, and negative predictive value(NPV) of 100%.Conclusions: Relative Ktrans appeared promising in predicting tumor response to radiation therapy(RT). It is implied that DCE-MRI pre-treatment is a requisite step in diagnostic procedures and a novel and reliable approach to guide clinical choice of RT. | Chenlu Feng Peiyi Gao Xiaoguang Qiu Tianyi Qian Yan Lin Jian Zhou Binbin Sui | 2015 | Chinese Journal of Cancer Research2015，27，3： | 3 |
| 4 | Construction of the Chinese Veteran Clinical Research (CVCR) Platform for the assessment of non-communicable diseases显示文摘 | Tan Jiping Li Nan Gao Jing Guo Yuhe Hu Wei Yang Jinsheng Yu Baocheng Yu Jianmin Du Wei Zhang Wenjun Cui Lianqi Wang Qingsong Xia Xiangnan Li Jianjun Zhou Peiyi Zhang Baohe Liu Zhiying Zhang Shaogang Sun Lanying Liu Nan Deng Ruixiang Dai Wenguang Yi Fang Chen Wenjun Zhang Yongqing Xue Shenwu Cui Bo Zhao Yiming Wang Luning | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 5 | Nascent Proteome and Glycoproteome Reveal the Inhibition Role of ALG1 in Hepatocellular Carcinoma Cell Migration显示文摘Asparagine-linked glycosylation protein 1 homolog(ALG1)participates in the initial stage of protein N-glycosylation and N-glycosylation has been implicated in the process of hepatocellular carcinoma(HCC)progression.However,whether ALG1 plays a role in human HCC remains unknown.In this study,the expression profile of ALG1 in tumorous and corresponding adjacent non-tumor tissues was analyzed.The relationship of ALG1 expression with clinical features and prognosis of HCC patients was also evaluated using immuno-histochemical method.Here we found ALG1 decreased in HCC tissues compared with adjacent normal liver tissues,which predicted an unfavorable prognosis.Combined with RNA interference,nascent proteome and glycoproteome were determined systematically in Huh7 cell line.Bioinformatics analysis indicated that the differentially expressed proteins participating in the response of ALG1 knockdown were most significantly associated with cell-cell adhesion.Functional studies confirmed that knockdown of ALG1 reduced cell adhesion capacity,and promoted cell migration.Furthermore,down-regulation of H8N2(on N-glycosite N651)and H5N4S2F1(on N-glycosite N692)from N-cadherin was identified as a feature of ALG1 knockdown.Our findings revealed that ALG1 controlled the expression of glycosylated N-cadherin and played a role in HCC migration,with implications for prognosis. | Xinyi Cao Yuyin Shao Peiyi Meng Zhao Cao Guoquan Yan Jun Yao Xinwen Zhou Chao Liu Lei Zhang Hong Shu Haojie Lu | 2022 | Phenomics2022，2，4： | 2 |
| 6 | Postharvest behavior and endogenous ethylene pattern of Paeonia suffruticosa cut flowers 显示文摘 | Jia Peiyi Zhou Lin Guo Wenwen | 2008 | Acta Horticulture2008，768，： | 1 |
| 7 | Expression of ethylene re- eeptor and transcription factor genes, and ethylene response dur- ing flower opening in tree peony ( Paeonia suffruticosa ) 显示文摘 | Zhou Lin Dong Li Jia Peiyi | 2010 | Plant Growth Regulation2010，62，2： | 1 |
| 8 | Molecular basis of ligand recognition and activation of human V2 vasopressin receptor显示文摘Dear Editor,Vasopressin type 2 receptor(V2R)belongs to the vasopressin(VP)/oxytocin(OT)receptor subfamily of G protein-coupled receptors(GPCRs),which comprises at least four closely related receptor subtypes:V1aR,V1bR,V2R,and OTR. | Fulai Zhou Chenyu Ye Xiaomin Ma Wanchao Yin Tristan I.Croll Qingtong Zhou Xinheng He Xiaokang Zhang Dehua Yang Peiyi Wang H.Eric Xu Ming-Wei Wang Yi Jiang | 2021 | Cell Research2021，31，8： | 1 |
| 9 | Sequence Stratigraphy and Tectonic Environment of the Chartai Group,Inner Mongolia显示文摘The Middle Proterozoic Chartai Group separated by two unconformities consists of three depositional se-quences: the Shujigou Formation-Zenglongchang Formation (DS Ⅰ), the Agulugou Formation (DS Ⅱ), andthe Liuhongwan Formation (DS Ⅲ). The carbonate platform and back-platform basin are the basic environ-ment model of the Chartai Group. The syndepositional faults on the oceanward side of the carbonate platformand large-scale slumping in the soft sediments are important marks of facies tracts. The newly establishedZenglongchan uplifting, an epeirogenetic uplifting, plays an important role in the formation of thepalaeogeographic framework of the Chartai Group. The stratigraphic correlation between the Chartai Groupand the Bayan Obo Group is made for the first time by using sequence stratigraphic principle and model estab-lished by P.R. Vail. The Chartai Group, which was deposited on the northern passive continental margin of theNorth China platfom, represents the platform cover. | Qiao Xiufu Yao Peiyi Wang Chengshu Tan Lin Zhu Shenyu Zhou Shengde Zhang Yuqing Institute of Geology,Chinese Academy of Geological Sciences, Beijing Regional Geological Survey Party,Geological Bureau of Inner Mongolia,Hohhot Sun Sheping | 1991 | Acta Geologica Sinica(English Edition)1991，65，3： | 1 |
| 10 | Hetero-bivalent nanobodies provide broad-spectrum protection against SARS-CoV-2 variants of concern including Omicron显示文摘SARS-CoV-2 variants with adaptive mutations have continued to emerge,causing fresh waves of infection even amongst vaccinated population.The development of broad-spectrum antivirals is thus urgently needed.We previously developed two hetero-bivalent nanobodies(Nbs),aRBD-2-5 and aRBD-2-7,with potent neutralization activity against the wild-type(WT)Wuhan isolated SARS-CoV-2,by fusing aRBD-2 with aRBD-5 and aRBD-7,respectively.Here,we resolved the crystal structures of these Nbs in complex with the receptor-binding domain(RBD)of the spike protein,and found that aRBD-2 contacts with highly conserved RBD residues and retains binding to the RBD of the Alpha,Beta,Gamma,Delta,Delta plus,Kappa,Lambda,Omicron BA.1,and BA.2 variants.In contrast,aRBD-5 and aRBD-7 bind to less conserved RBD epitopes non overlapping with the epitope of aRBD 2,and do not show apparent binding to the RBD of some variants.However,when fused with aRBD-2,they effectively enhance the overal binding affinity.Consistently,aRBD-2-5-Fc and aRBD-2-7 Fc potently neutralized all of the tested authentic or pseudotyped viruses,incuding WT,Alpha,Beta,Gamma,Delta,and Omicron BA.1,BA.1.1 and BA.2.Furthermore,aRBD-2-5-FC provided prophylactic protection against the WT and mouse-adapted SARS CoV-2 in mice,and conferred protection against the Omicron BA.1 variant in hamsters prophylatically and therapeutically,indicating that aRBD-2-5-Fc could potentially beneft the prevention and treatment of COVID-19 caused by the emerging variants of concern.Our strategy provides new solutions in the development of broad-spectrum therapeutic antibodies for COVID-19. | Huan Ma Xinghai Zhang Peiyi Zheng Peter H.Dube Weihong Zeng Shaohong Chen Qingyu Cheng Yunru Yang Yan Wu Junhui Zhou Xiaowen Hu Yan Xiang Huajun Zhang Sandra Chiu Tengchuan Jin | 2022 | Cell Research2022，32，9： | 1 |
| 11 | A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still rapidly spreading worldwide.Many drugs and vaccines have been approved for clinical use show efficacy in the treatment and prevention of SARS-CoV-2 infections.However,the emergence of SARS-CoV-2 variants of concern(VOCs),such as Delta(B.1.617.2)and the recently emerged Omicron(B.1.1.529),has seriously challenged the application of current therapeutics.Therefore,there is still a pressing need for identification of new broad-spectrum antivirals.Here,we further characterized a human antibody(58G6),which we previously isolated from a patient,with a broadly authentic virus-neutralizing activity that inhibits the Delta and Omicron variants with half-maximal inhibitory concentrations(ICso)of 1.69 ng/ml and 54.31 ng/ml,respectively.58G6 shows prophylactic and therapeutic effcacy in hamsters challenged with the Delta and Omicron variants through nasal delivery.Notably,a very low dosage(2 mg/kg daily)of 58G6 efficiently prevented Omicron variant replication in the lungs.These advantages may overcome the efficacy limitation of currently approved neutralizing antibodies that can be administered only by intravenous injection.In general,58G6 is a promising prophylactic and therapeutic candidate against current circulating VOCs and even future emerging mutants.To the best of our knowledge,58G6 is one of the most potent neutralizing antibodies against Omicron,with a broader spectrum than those approved for clinical use.58G6 could be developed as a nebulized therapy,which would be more cost effective and user friendly and enhance the clinical outcome comparedto thatobtainedwithdirect nasaldelivery. | Xinghai Zhang Huajun Zhang Tingting Li Shaohong Chen Feiyang Luo Junhui Zhou Peiyi Zheng Shuyi Song Yan Wu Tengchuan Jin Ni Tang Aishun Jin Chengyong Yang Guofeng Cheng Rui Gong Sandra Chiu Ailong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 12 | Expression of ethylene receptor andtranscription factor genes,and ethylene response during flower opening in tree peony(Paeonia suffruticosa)显示文摘 | Zhou L Dong L J Peiyi | 2010 | Plant Growth Regu- lation2010，62，2： | 1 |
| 13 | High-sensitive two-dimensional PbI_(2)photodetector with ultrashort channel显示文摘Photodetectors based on two-dimensional(2D)semiconductors have attracted many research interests owing to their excellent optoelectronic characteristics and application potential for highly integrated applications.However,the unique morphology of 2D materials also restricts the further improvement of the device performance,as the carrier transport is very susceptible to intrinsic and extrinsic environment of the materials.Here,we report the highest responsivity(172 A/W)achieved so far for a PbI_(2)-based photodetector at room temperature,which is an order of magnitude higher than previously reported.Thermal scanning probe lithography(t-SPL)was used to pattern electrodes to realize the ultrashort channel(~60 nm)in the devices.The shortening of the channel length greatly reduces the probability of the photo-generated carriers being scattered during the transport process,which increases the photocurrent density and thus the responsivity.Our work shows that the combination of emerging processing technologies and 2D materials is an effective route to shrink device size and improve device performance. | Kaiyue He Jijie Zhu Zishun Li Zhe Chen Hehe Zhang Chao Liu Xu Zhang Shuo Wang Peiyi Zhao Yu Zhou Shizheng Zhang Yao Yin Xiaorui Zheng Wei Huang Lin Wang | 2023 | Frontiers of physics2023，18，6： | 0 |
| 14 | NPC1蛋白介导胆固醇转运和埃博拉病毒入侵的结构基础显示文摘尼曼一匹克C型疾病是由NPC1或者NPC2基因突变造成的一类脂类代谢异常疾病。NPC1和NPC2蛋白在胆固醇的细胞内转运过程中发挥了重要功能,同时NPCI还作为埃博拉病毒位于细胞内的受体参与了病毒的入侵过程。 | Xin Gong Hongwu Qian Xinhui Zhou Jianping Wu Tao Wan Pingping Cao Weiyun Huang Xin Zhao Xudong Wang Peiyi Wang Yi Shi George F.Gao 周强 颜宁 | 2017 | 科学新闻2017，19，4： | 0 |
| 15 | Flexible Dry Hydrogel with Lamella-Like Structure Engineered via Dehydration in Poor Solvent显示文摘Hydrogels are among the most promising biologic materials in recent technology with numerous desired applications,including serving as biosensors,drug delivery vehicles,and tissue-engineered products for cell matrices.However,they often dehydrate,and become stiff and brittle in air,causing loss of flexibility and functions.Several layered structures have been proven to increase the strength,toughness,and even flexibility of these materials,which might provide a new clue for the sustenance of the flexibility of drying gels.Herein,we report a novel solvent-dehydrated hydrogel engineering approach,aimed to change the inner structure and keep the flexibility of a dehydrated hydrogel in the air via solvent-induced dehydration,for example,acetonedehydrated polyacrylic acid hydrogel.This flexible dry gel could be folded,twisted,and stretched without any damage due to the assumed lamella-like structures,contrary to dry gels without these microstructures or those with porous structures,which retain brittle consistency.The flexible dry gel also exhibited excellent self-healing capability with the assistance of solvents.Fascinatingly,this flexible gel film displayed strain-visualizing paper writing/erasing performance properties,with water acting as invisible ink.Thus,this fabricated flexible hydrogel film might function as confidential information storage material.Our current approach is versatile,hence applicable to other hydrogels,and provides insight into the engineering of other functional gels for extended future applications. | Feilong Zhang Jiajia Zhou Zhen Gu Man Yang Siheng Li Yongyang Song Jun-Bing Fan Jingxin Meng Peiyi Wu Lei Jiang Shutao Wang | 2020 | CCS Chemistry2020，2，1： | 0 |
| 16 | Archival Examination of the Change in Packaging Materials of Chemical Injections显示文摘Based on the deepening awareness of the risk of changing packaging materials of injections,the national regulatory authorities and the China National Pharmaceutical Packaging Association have issued the relevant guidelines and group standards for changing packaging materials in recent years,greatly improving the research and development and technical requirements of packaging materials of injections.In 2021,Guangdong Province carried out the archival examination of the change of listed drugs,among which the proportion of the acceptance of changed injection packaging materials has increased year by year.On the basis of sorting out the archival examination work and combining with the cases of changing packaging materials of chemical injections accepted by Guangdong Province during 2021-2022,the requirements and problems of archival examination were analyzed and discussed to provide a reference and idea for applicants when studying the change in packaging materials. | Lili YAN Weijun ZHOU Peiyi CHEN Bo SHEN | 2023 | Medicinal Plant2023，14，3： | 0 |
| 17 | Structure of intact human MCU supercomplex with the auxiliary MICU subunits显示文摘Dear Editor,Mitochondrial Ca2+homeostasis regulates energy production,cell division,and cell death.The basic properties of mitochondrial Ca2+uptake have been firmly established.The Ca2+influx is mediated by MCU,driven by membrane potential and using a uniporter mechanism(Vasington and Murphy,1962).Patch-clamp analysis of MCU currents demonstrated that MCU is a channel with exceptionally high Ca2+selectivity(Kirichok et al.,2004). | Wei Zhuo Heng Zhou Runyu Guo Jingbo Yi Laixing Zhang Lei Yu Yinqiang Sui Wenwen Zeng Peiyi Wang Maojun Yang | 2021 | Protein & Cell2021，12，3： | 0 |
| 18 | Development levels of pediatric palliative care teams and the extent of palliative care understanding and implementation among pediatric oncologists in China显示文摘Importance:Pediatric palliative care(PPC)is an interdisciplinary collaboration that focuses on the prevention and relief of patient suffering.PPC has emerged as a critical field of medical expertise and practice.However,no information is available regarding the progress of PPC in the Chinese mainland.Objective:This study investigated the geographic distribution,team structure,and services of PPC teams in the Chinese mainland.It also investigated the level of understanding and implementation among pediatric oncologists regarding PPC.Methods:The PPC subspecialty group of the Pediatrics Society of the Chinese Medical Association included 45 PPC teams.The team structure and services were investigated using questionnaires mailed to the team leader of each PPC team.In addition,we sent questionnaires regarding the level of PPC understanding and implementation of PPC practices to 170 pediatric oncologists in 11 hospitals.Results:The geographical distribution of PPC teams is uneven in China.Most PPC teams are concentrated in the eastern provincial capital of China.Most PPC teams had limited staff and services.The level of PPC understanding was considerably limited across all demographics;most pediatric oncologists reported“some understanding”(n=71,41.8%)or“poor understanding”(n=50,29.4%).Only 62.9%of pediatric oncologists had experience providing advice to family members regarding PPC matters.Interpretation:China is currently experiencing a critical shortage of PPC resources.Most pediatric oncologists had a limited understanding of PPC and reported limited practical implementation of PPC,which leads to underutilization of PPC resources. | Siyu Cai Qiaohong Guo Xianjing Wang Ruixin Wang Peiyi Yang Yuchen Zhou Yanhui Luo Xuan Zhou Xiaoxia Peng | 2021 | Pediatric Investigation2021，5，4： | 0 |
| 19 | Okara Cellulose Nanofibrils Produced by Pretreatment with Sustainable Deep Eutectic Solvent Coupled with Various Mechanical Treatments显示文摘In this study,a green,environmentally friendly method for rapid cellulose nanofribril(CNF)preparation with a significant cost advantage was developed.Pretreatment with a deep eutectic solvent(DES)synthesized from oxalic acid dihydrate and choline chloride(ChCl-O)was combined with various mechanical treatment methods to produce okara CNFs from agricultural waste,with different diameter distributions.The results showed that high-speed stirring produced CNFs with an average diameter of 27 nm.This method was advantageous because it consumed about 94%less energy than traditional high-pressure homogenization method.The DES recovery rate was more than 90%,and DES served as a highly effective treatment,indicating that DES pretreatment is an economical,convenient,and effective strategy for okara CNF preparation. | Peiyi Li Haozhe Lei Boxing Jian Ruiyan Liu Miaomiao Zhou Yumeng Wang Hezhen Liu Yun Wang Bingyao Zhou | 2022 | Paper And Biomaterials2022，7，2： | 0 |
| 20 | Antiviral and Antibacterial Activities of N-(4-Substituted phenyl) Acetamide Derivatives Bearing 1,3,4-Oxadiazole Moiety显示文摘在这份报纸,一系列 N-(4 代用品苯基) 乙酰胺衍生物适用 1,3,4-oxadiazole 一半是 synthesised。初步的生物鉴定表明这些混合物向烟草马赛克病毒(TMV ) 的不仅展出赞成抗病毒的活动而且表明的持续抑制活动对种病原的细菌,包括 Xanthomonas oryzae pv。oryzae, Ralstonia solanacearum,和 Xanthomonas axonopodis pv。citri。在衍生物之中, TC 8 和 TC 20 对 TMV 施加了最强壮的药品活动,与一半最大的有效集中(分别地, EC 50) 239.5 和 236.2 µg/mL 珍视哪个比得上 ningnanmycin (EC 50=273.2 µg/mL ) 的。给他们的简单合成,目标混合物能用作其他的抗病毒的候选人。 | Ling Chen Peiyi Wang Zhenxing Li Lei Zhou Zhibing Wu Baoan Song Song Yang | 2016 | Chinese Journal of Chemistry2016，34，12： | 0 |
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