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| 1 | Regulation of cholesterol homeostasis in health and diseases:from mechanisms to targeted therapeutics显示文摘Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases,such as cardiovascular diseases(CVD),neurodegenerative diseases and cancers,particularly the CVD in which the accumulation of lipids(mainly the cholesteryl esters)within macrophage/foam cells underneath the endothelial layer drives the formation of atherosclerotic lesions eventually.More and more studies have shown that lowering cholesterol level,especially low-density lipoprotein cholesterol level,protects cardiovascular system and prevents cardiovascular events effectively.Maintaining cholesterol homeostasis is determined by cholesterol biosynthesis,uptake,efflux,transport,storage,utilization,and/or excretion.All the processes should be precisely controlled by the multiple regulatory pathways.Based on the regulation of cholesterol homeostasis,many interventions have been developed to lower cholesterol by inhibiting cholesterol biosynthesis and uptake or enhancing cholesterol utilization and excretion.Herein,we summarize the historical review and research events,the current understandings of the molecular pathways playing key roles in regulating cholesterol homeostasis,and the cholesterol-lowering interventions in clinics or in preclinical studies as well as new cholesterol-lowering targets and their clinical advances.More importantly,we review and discuss the benefits of those interventions for the treatment of multiple diseases including atherosclerotic cardiovascular diseases,obesity,diabetes,nonalcoholic fatty liver disease,cancer,neurodegenerative diseases,osteoporosis and virus infection. | Yajun Duan Ke Gong Suowen Xu Feng Zhang Xianshe Meng Jihong Han | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 3 |
| 2 | Synthesis of Hydrophilic Acid-resistant Ge-ZSM-5 Membranes via Secondary Growth Method Using Silicalite-1 Zeolite as Seeds显示文摘 | WANG Xiaodong HUANG Yujiao ZHANG Xiaoxiao FENG Xianshe HUANG Wei | 2017 | Chemical Research in Chinese Universities2017，33，1： | 2 |
| 3 | Pervaporation with chitosan membranes: separation of dimethyl carbonate/methanol/water mixtures 显示文摘 | Won Wooyoung Feng Xianshe Lawless Darren | 2002 | J Membr Sci2002，209，： | 1 |
| 4 | Preparation of hollow fiber poly (ether block amide)/polysulfone composite membranes for separation of carbon dioxide from nitrogen 显示文摘 | Liu Li Amit Chakma Feng Xianshe | 2004 | Chem Eng J2004，105，： | 1 |
| 5 | Separation of dimethyl carbonate/methanol/water mixtures by pervaporation using crosslinked chitosan membranes显示文摘 | Won Wooyoung Feng Xianshe Lawless Darren | 2003 | Sep Pur Technol2003，31，： | 1 |
| 6 | Separation of acetone-butanolethanol (ABE) from dilute aqueous solutions by pervaporatian显示文摘 | Liu Fangfang Liu Li Feng Xianshe | 2005 | Separation and Purification Technology2005，42，3： | 1 |
| 7 | Propylene separation from nitrogen by poly (ether block amide) composite membranes显示文摘 | Liu Li Amit Chakma Feng Xianshe | 2006 | J Membr Sci2006，279，： | 1 |
| 8 | Use of pervaporation for the separation of phenol from dilute aqueous solutions显示文摘 | Xiaogang Hao Mark Pritzker Xianshe Feng | 2009 | Journal of Membrane Science2009，335，： | 1 |
| 9 | Separation of dimethyl carbonate/methanol/water mixtures by pervaporation using crosslinked chitosan membranes显示文摘 | Wooyoung W Xianshe F Darren L | 2003 | Sep Pur Technol2003，31，2： | 1 |
| 10 | A novel method of preparing ultrathin poly (ether block amide) membranes 显示文摘 | Li Liu Amit Chakma Xianshe Feng | 2004 | Journal of Membrane Science2004，235，： | 1 |
| 11 | Pervaporation with chitosan membranes: separation of dimethyl carbonate/ methanol/water mixtures 显示文摘 | Wooyoung W Xianshe F Darren L | 2002 | J Membr Sci2002，209，2： | 1 |
| 12 | Separation of acetone-butanol-ethanol ( ABE ) from dilute aqueous solutions by pervaporation显示文摘 | Fangfang Liu Li Liu Xianshe Feng | 2005 | Separation and Purification Technology2005，42，： | 1 |
| 13 | Preparation of hollow fiber poly (ether block amide)/polysulfone composite membranes for separation of carbon dioxide from nitrogen 显示文摘 | LIU Li CHAKMA A FENG Xianshe | 2004 | Chemical Engineering Journal2004，，105： | 1 |
| 14 | Substrate resistance in composite membranes for organic vapour/gas separations显示文摘 | Li Liu Nan Jiang Charles M. Burns Amit Chakma Xianshe Feng | 2009 | Journal of Membrane Science2009，，1： | 1 |
| 15 | Preparation of erbium ion-doped TiO2 films and the study of their photocatalytic activity under simulated solar light显示文摘A series of erbium ion-doped TiO_2(Er^(3+)-TiO_2) films were prepared by a sol-gel dip/spin coating method, and the effect of the dosage of erbium ion(0–2.0 mol%), the films coating layers(1–5 layers), and calcination temperature(400–700 °C) on the film structure and photocatalytic activity were investigated in detail. The films were characterized by means of X-ray diffraction(XRD), scanning electron microscopy(SEM), thermal analysis(TG-DTG) and UV–Vis diffusive reflectance spectra(DRS). The results showed that the films were composed of anatase, and no other TiO_2 phases(rutile and brookite). With the increase of the erbium ion dosage, the crystal size decreased. Erbium ion doping could enhance the thermal stability of TiO_2 and inhibit the increase of the crystallite size. Meanwhile doping of erbium ions gave rise to three typical absorption peaks within the range of visible light(400–700 nm), locating at 490, 523, and 654 nm, attributed to the transition of 4 f electrons. The higher calcination temperature led to higher crystallinity and bigger crystal grains. The photocatalytic performance of the films was evaluated by degradation of methyl orange solution under simulated solar light. The highest quality film we prepared was with 4 layers, 1.0 mol% dosage of erbium ion, and the calcination temperature of 500 °C. With this film,the degradation percentage of 7.8 mg/L methyl orange solution was up to 53.3% under simulated solar light after 6 h photoreaction. | Hongfei Lin Yujiao Huang Shaoni Li Chunhui Luan Wei Huang Xiaodong Wang Xianshe Feng | 2017 | Journal of Semiconductors2017，38，11： | 1 |
| 16 | Salt transport in polymeric pervaporation membrane显示文摘The salt transport in a PEBA membrane used in pervaporative desalination was studied.The concentration profile of salt in the membrane during pervaporation was investigated experimentally using a multilayer membrane.The salt was found to be sorbed in the membrane but was not removed during the pervaporative desalination process,and the salt concentration in the membrane varied linearly with position.High purity water was obtained as the permeate as long as the permeate side was kept dry under vacuum.The accumulated salt uptake in the membrane follows the order of MgCl2 N NaCl N Na2 SO4.The solubility of salt in the membrane follows the order of MgCl2 N NaCl N Na2 SO4.Both the permeability and diffusivity of salt in the membrane follow the order of NaCl N MgCl2 N Na2 SO4.The permeability of salt in the membrane is not influenced by the feed salt concentration.It is mainly determined by the diffusion coefficients. | Dihua Wu Aoran Gao Xianshe Feng | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 1 |
| 17 | Pervapora- tion with Chitosan Membranes Separation of Dimethyl Carbo- nate/Methanol/Water Mixtures 显示文摘 | Won Wooyoung Feng Xianshe Lawless Darren | 2002 | J Membr Sci2002，209，2： | 1 |
| 18 | Separation mixtures by pervaporation using crossliiaked chitosan membranes显示文摘 | WOOYOUNG W XIANSHE F DARREN of dimethyl carbo L | 2003 | Separation and Purification Technology2003，31，2： | 1 |
| 19 | Separation of dimethyl carbonate/methanol/water mixtures by pervaporation using crosslinked chitosan membranes显示文摘 | Wooyoung W Xianshe F Darren L | 2003 | Separation and Purification Technology2003，31，2： | 1 |
| 20 | Pervaporation with chitosan membranes: separation of dimethyl carbonate/methanol/water mixtures 显示文摘 | WOOYOUNG W XIANSHE F DARREN L | 2002 | Journal of Membrane Science2002，209，2： | 1 |
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