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| 1 | Cerebrospinal fluid biomarkers of Alzheimer's disease显示文摘Alzheimer's disease(AD) is a fatal neurodegenerative disorder that takes about a decade to develop, making early diagnosis possible. Clinically, the diagnosis of AD is complicated, costly, and inaccurate, so it is urgent to fi nd specifi c biomarkers. Due to its multifactorial nature, a panel of biomarkers for the multiple pathologies of AD, such as cerebral amyloidogenesis, neuronal dysfunction, synapse loss, oxidative stress, and infl ammation, are most promising for accurate diagnosis. Highly sensitive and high-throughput proteomic techniques can be applied to develop a panel of novel biomarkers for AD. In this review, we discuss the metabolism and diagnostic performance of the well-established core candidate cerebrospinal fl uid(CSF) biomarkers(β-amyloid, total tau, and hyperphosphorylated tau). Meanwhile, novel promising CSF biomarkers, especially those identifi ed by proteomics, updated in the last fi ve years are also extensively discussed. Furthermore, we provide perspectives on how biomarker discovery for AD is evolving. | Xiaojing Sui Jianjun Liu Xifei Yang | 2014 | Neuroscience Bulletin2014，30，2： | 5 |
| 2 | Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and four PDZ domains显示文摘 | Li Zhang Xiaojing Wang Fenghui Fan Hong-Wei Wang Jiawei Wang Xueming Li Sen-Fang Sui | 2017 | Cell Research2017，27，4： | 1 |
| 3 | Oxidative phosphorylation safeguards pluripotency via UDP-N-acetylglucosamine显示文摘Dear Editor,Embryonic stem cells(ESCs)have been assumed to possess immature mitochondria and to favor anaerobic glycolysis over oxidative phosphorylation(OXPHOS)for energy production.This proposition is largely based on the findings that ESCs possess globular mitochondria with blurred cristae,and the facts that ESCs have higher glycolysis activity and lower mitochondrial respiration capacity than somatic cells(Kondoh et al.,2007;Folmes et al.,2011,2012;Zhang et al.,2012;Xu et al.,2013;Ito and Suda,2014;Gu et al.,2016).However,recent studies have shown that mitochondrial autophagy and mitochondrial dynamics are pivotal for ESC self-renewal and pluripotency(Todd et al.,2010;Liu et al.,2016,2020;Wang et al.,2019;Zhong et al.,2019).These studies have raised a fundamental question:what is the contribution and functional mechanism of mitochondrial respiration in pluripotency regulation? | Jiani Cao Meng Li Kun Liu Xingxing Shi Ning Sui Yuchen Yao Xiaojing Wang Shiyu Li Yuchang Tian Shaojing Tan Qian Zhao Liang Wang Xiahua Chai Lin Zhang Chong Liu Xing Li Zhijie Chang Dong Li Tongbiao Zhao | 2023 | Protein & Cell2023，14，5： | 1 |
| 4 | Susceptibility to morphine place conditioning: relationship with stress-induced locomotion and novelty-seeking behavior in juvenile and adult rats显示文摘 | Xigeng Zheng Xue Ke Beiping Tan Xiaojing Luo Wei Xu Xiaoyan Yang Nan Sui | 2003 | Pharmacology Biochemistry and Behavior2003，，4： | 1 |
| 5 | Rapid and sensitive analysis of cyclobenzaprine by LCeMS/MS:Application to a pharmacokinetic study of cyclobenzaprine in dog显示文摘A rapid and sensitive liquid chromatographyetandem mass spectrometry method was developed and validated for the quantification of cyclobenzaprine in dog plasma.After extracted with organic solvent,post-treatment samples were separated on an Agela C18 column interfaced with a triple quadrupole tandem mass spectrometer in positive electrospray ionization mode.Multiple reaction monitoring was performed using the transitions of m/z 276.2/216.1 and m/z 325.1/109.0 to quantify cyclobenzaprine and escitalopram(internal standard),respectively.The mobile phase consisted of acetonitrile:5 mM ammonium acetate:formic acid(90:10:0.01,v/v/v)at a flow rate of 0.3 ml/min.The total analysis time was 2.4 min.The method was linear over the concentration range of 0.0200e10.0 ng/ml.The intra-and inter-day precision was within 12.8%in terms of relative standard deviation(RSD%)and the accuracy within 5.6%in terms of relative error.This method was successfully applied in a pharmacokinetic study of extended-release cyclobenzaprine in dogs. | Wenhong Yu Xiaojing Yang Wenwen Sui Haiyan Xu Xinyi Luan Xiangjun Wang Yi Jin Bo Yuan | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，2： | 0 |
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