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| 1 | Gambogic acid induces mitochondria-dependent apoptosis by modulation of Bcl-2 and Bax in mantle cell lymphoma JeKo-1 cells显示文摘Aim: To study the mechanisms in gambogic acid (GA) -induced JeKo-1 human Mantle Cell Lymphoma cell apoptosis in vitro. Methods: The proliferation of GA-treated JeKo-1 cells was measured by CCK-8 assay and Ki-67 immunocytochemical detection. Apoptosis, cell cycle and mitochondrial membrane potential were measured by flow cytometric analysis. Caspase-3,-8 and -9 were detected by colorimetric assay. Bcl-2 and Bax were analyzed by Western blotting. Results: GA inhibited cell growth in a time-and dose-dependent manner. GA induces apoptosis in JeKo-1 cells but not in normal bone marrow cells, which was involved in reducing the membrane potential of mitochondria, activating caspases-3, -8 and -9 and decreasing the ratio of Bcl-2 and Bax without cell cycle arresting. Conclusions: GA induced apoptosis in human MCL JeKo-1 cells by regulating Bcl-2/Bax and activating caspase-3, -8 and -9 via mitochondrial pathway without affecting cell cycle. | Jingyan Xu Min Zhou Jian Ouyang Jing Wang Qiguo Zhang Yong Xu Yueyi Xu Qian Zhang Xihui Xu Hui Zeng | 2013 | Chinese Journal of Cancer Research2013，25，2： | 18 |
| 2 | Fluid Inclusions and Isotope Geochemistry of the Emba Derho and the Debarwa VMS Deposits, Asmara District, Eritrea显示文摘Objective Recent exploration indicates several localities with significant gold,copper,and zinc resource potential in the Asmara district,Eritrea,including the Emba Derho and Debarwa volcanic-associated massive sulfide deposits.These deposits are hosted by the Neoproterozoic metamorphic volcanic rocks of Asmara green stone belt, | XU Jiuhua CHENG Xihui CHU Haixia XIAO Xing ZHANG Hui | 2016 | Acta Geologica Sinica(English Edition)2016，90，4： | 5 |
| 3 | Compositions and Pressure-Temperature Conditions of Metamorphic Fluids Overprinting the Talate VMS Pb-Zn Deposit,Southern Altay,China显示文摘Talate Pb-Zn 存款,在扩大泥盆纪 Kelan 的 NW-SE 的东方定位了南部的 Altaides 的暴烈沉积的盆,发生在更低的泥盆纪更低的 Kangbutiebao 形成的上面的秒 lithological 节的变形岩石系列(D 1 k 12) 。Pb-Zn orebodies 由迟了的硫化物石英静脉层状、套印。二个不同矿化作用时期被识别:一个海底的暴烈的沉积呼气时期和一个变形热水的矿化作用时期。变形套印时期能进一步被划分成二个阶段:透镜状的石英静脉在绿泥石片岩和忍受矿石的地平线的 leptite 开发了的床上用品平行描绘的一个早阶段,和一个迟了的阶段由横切绿泥石片岩和 leptite 或巨大的 Pb-Zn 矿石的 pyrite-chalcopyrite-quartz 静脉代表了。在早变形的石英静脉的液体包括主要是公司 2-H2 O-NaCl 并且碳(有次要的水的包括的公司 2±CH4±N2) 包括。公司 2-H2 O-NaCl 包括有 294-368 ° C 的 homogenization 温度, T m,到 -60.5°C, T > h, 7.7 ~ 29.6 °C 的 CO2 ( 一致进液体) ,并且 5.5-7.4 wt% NaCl eqv 的咸度。碳的包括有 T m,到 -58.5°C, 和 T > h,到 20.6 °C 的 -4.2 的 CO2 。在迟了的硫化物石英静脉的液体包括被公司 2-H2 O-NaCl 和公司 2±CH4 包括。公司 2-H2 O-NaCl 包括有 T h, 142 ~ 360 °C 的小孩 , T m,到 -56.6°C, T > h,到 29.4 °C 的 -6.0 的 CO2 ( 一致进液体) 并且 2.4-16.5 wt% NaCl eqv 的咸度。碳的包括有 T m,到 -57.3°C, 和 T > h,到 28.7 °C 的 -27.0 的 CO2 。水的包括(L-V ) 有 T m,到 -1.3°C 和 T > h, 205 ~ 412 °C 的小孩 。套住公司 2-rich 液体包括的条件的磅(100-370 MPa, 250-368 °C ) 是可比较的与迟了 -- 到 regional 以后变态条件。公司 2-rich 液体,可能源于地区性的变态,涉及重做和主要矿石的金属丰富。把结果基于这些, Talate Pb-Zn 存款作为变形液体修改的 VMS 存款被分类。有 banded 和角砾岩结构的巨大的 Pb-Zn 矿石在与 extensional 联系的海底的暴烈的沉积呼气的早时期被开发 subduction 相关的背弧盆,和忍受 polymetallic 硫化物的石英静脉在与二叠三叠纪的大陆人碰撞有关的变形热水的重迭的迟了的时期被形成。 | ZHANG Hui XU Jiuhua CHENG Xihui GUO Xuji LIN Longhua YANG Rui BIAN Chunjing | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 2 |
| 4 | Determination of sulfonylurea herbicides in water using solid-phase extraction followed by liquid chromatography with electrospray ion trap mass spectrometry显示文摘 | Xihui Ouyang Wei Zhang Jun Xu Na Chang Canping Pan Jingping Zhang Weimin Niu | 2009 | Journal of Analytical Chemistry2009，，9： | 1 |
| 5 | Beyond dueling: roles of the type VI secretion system in microbiome modulation, pathogenesis and stress resistance显示文摘Bacteria inhabit diverse and dynamic environments,where nutrients may be limited and toxic chemicals can be prevalent.To adapt to these stressful conditions,bacteria have evolved specialized protein secretion systems,such as the type VI secretion system(T6SS)to facilitate their survival.As a molecular syringe,the T6SS expels various effectors into neighboring bacterial cells,eukaryotic cells,or the extracellular environment.These effectors improve the competitive fitness and environmental adaption of bacterial cells.Although primarily recognized as antibacterial weapons,recent studies have demonstrated that T6SSs have functions beyond interspecies competition.Here,we summarize recent research on the role of T6SSs in microbiome modulation,pathogenesis,and stress resistance. | Jinshui Lin Lei Xu Jianshe Yang Zhuo Wang Xihui Shen | 2021 | Stress Biology2021，1，1： | 1 |
| 6 | A Fluid Inclusion Study of Vein-type Copper Mineralization in the East Wulasigou Pb-Zn-Cu Deposit,Altay,Northwestern China显示文摘The Wulasigou Cu-Pb-Zn deposit,located 15 km northwest of Altay city in Xinjiang,is one of many Cu-Pb-Zn polymetallic deposits in the Devonian Kelan volcanic-sedimentary basin in southern Altaids.Two mineralizing periods can be distinguished:the marine volcanic sedimentary PbZn mineralization period,and the metamorphic hydrothermal Cu mineralization period,which is further divided into an early bedded foliated quartz vein stage(Q1) and a late sulfide-quartz vein stage(Q2) crosscutting the foliation.Four types of fluid inclusions were recognized in the Q1 and Q2 quartz from the east orebodies of the Wulasigou deposit:H_2O-CO_2 inclusions,carbonic fluid inclusions,aqueous fluid inclusions,and daughter mineral-bearing fluid inclusions.Microthermometric studies show that solid CO_2 melting temperatures(T_(m,CO2)) of H_2O-CO_2 inclusions in Ql are from-62.3℃ to-58.5C,clathrate melting temperatures(T_(m,clath)l) are from 0.5 C to 7.5 C,partial homogenization temperatures(T_(h,CO2)) vary from 3.3℃ to 25.9℃(to liquid),and the total homogenization temperatures(T_(h,tot)) vary from 285℃ to 378℃,with the salinities being 4.9%-15.1%NaCl eqv.and the CO_2-phase densities being 0.50-0.86 g/cm^3.H_2O-CO_2 inclusions in Q2 have T_(m,CO_2) from-61.9℃ to-56.9℃,T_(m,clath)from 1.3℃ to 9.5℃,T_(h,CO2) from 3.4℃ to 28.7℃(to liquid),and T_(h,tot) from 242℃ to 388℃,with the salinities being 1.0%-15.5%NaCl eqv.and the CO_2-phase densities being 0.48-0.89 g/cm^3.The minimum trapping pressures of fluid inclusions in Q1 and Q2 are estimated to be 260-360 MPa and180-370 MPa,respectively.The δ^(34)S values of pyrite from the volcanic sedimentary period vary from2.3‰ to 2.8‰(CDT),and those from the sulfide-quartz veins fall in a narrow range of-1.9‰ to 2.6‰(CDT).The δD values of fluid inclusions in Q2 range from-121.0‰ to-100.8‰(SMOW),and theδ^(18)O_(H2O) values calculated from δ^(18)O of quartz range from-0.2‰ to 8.3‰(SMOW).The δD-δ^(18)O_(H2O)data are close to the magmatic and metamorphic fields.The fluid inclusion and stable isotope data documented in this study indicate that the vein-type copper mineralization in the Wulasigou Pb-Zn-Cu deposit took place in an orogenic-metamorphic enviroment. | BIAN Chunjing XU Jiuhua CHEN Deping ZHANG Hui CHENG Xihui | 2016 | Acta Geologica Sinica(English Edition)2016，90，5： | 1 |
| 7 | Complex granular flows of sticky-wet material on flip-flow screens:Calibration of discrete element simulations显示文摘Discrete element method(DEM)is an effective approach for studying the screening process of flip-flow screens.However,there have been few studies focusing on the thick layer of sticky-wet particles on flip-flow screens.To achieve accurate simulations of the thick layer of sticky-wet particles on a flip-flow screen,firstly,the movement law of particle flow was studied,and a multi-regime combination cali-bration method based on characteristics of particle flow regimes was proposed.Based on the Plackett-Burman experiment,the curse of dimensionality caused by multi-state and multi-contact parameters was overcome.Subsequently,the lifting cylinder,rotating drum,and trampoline tests were carried out to obtain macroscopic reference values under various granular flow regimes.The calibration results were then determined using the response surface method and climbing algorithm.Finally,the calibration results were tested at both macroscopic and mesoscopic scales and compared with a commonly used calibration method.The results demonstrate that the calibration method,which considers the multi-state characteristics,improves simulation accuracy by 2%-10%and reduces the simulation error to less than 10%,thus meeting the requirements for engineering optimization of flip-flow screens. | Ningning Xu Sen Tang Dongdong Lin Runhui Geng Xinwen Wang Xihui Liang | 2024 | Particuology2024，84，1： | 0 |
| 8 | Analysis of a Strong-Inhibition Polyamine Drilling Fluid显示文摘Drilling technologies based on oil-based drillingfluids and strong inhibitory saltwaterfluids are affected by draw-backs such as downhole accidents where sticking and wellbore instabilities occur.Existing polyamine drillingfluids also exhibit problems such as easy decomposition and poor inhibition performances.In order to mitigate these issues,additives can be used,such as polyamine inhibitors and the synthesis of nanometerfiltrate reducers.Tests conducted in the frame of this study with a polyamine drillingfluid and such additives show that thisfluid has the same inhibitory,plugging,lubricating,and wellbore-stability performances as oil-based drillingfluids.However,it has long-term anti-wear performances even better than those of oil-based drillingfluids.The out-comes of a series of comparisons with other sample cases(other wells)are reported and the advantages related to the proposedfluid discussed in detail. | Yu Fan Jianhua Guo Xihui Hu Rui Wang Weiqiang Xu | 2023 | Fluid Dynamics & Materials Processing2023，19，9： | 0 |
| 9 | Ore Forming Fluids of Several Gold Deposits in the Irtysh Gold Belt, Xinjiang, China显示文摘The metallogenic environment of the Irtysh gold belt in Xinjiang is studied in detail.The metallogenic geological background,metallogenic conditions and ore-controlling factors of the gold deposits in eastern,central and western regions of the metallogenic belt are compared.The metallogenic structure of the Irtysh tectonic belt has the characteristics of diverging to the west and converging to the east.Composite ore controlling by ductile shearing and magmatic activity in Irtysh gold belt result in zoned and segmented distribution of gold mineralization.Through the fluid inclusion research and H-O-S isotope analysis,the evolution regularity of gold ore-forming fluids in the region was analyzed.Synchrotron radiation X-ray fluorescence was used to analysis the concentration of metal elements in a single fluid inclusion,explaining the occurrence and migration process of Au in hydrothermal fluid.The source of ore forming minerals in western gold deposit is more closely related to magmatic activity,and the structural metamorphism of eastern gold deposit has greater influence on mineralization.Metallogenic fluids of gold deposits are characterized by metamorphic water(and magmatic water)in the early stage and mixed with meteoric water in the late stage.And the metallogenic elements are enriched in CO2 rich fluid.The Au is mainly activated,migrated and enriched with the mixed fluid of magmatic hydrothermal,metamorphic hydrothermal and atmospheric precipitation in the medium-low temperature,shallow to medium-deep environment. | Yingwei Wang Jiuhua Xu Rufu Ding Hui Zhang Xihui Cheng Chunjing Bian | 2020 | Journal of Earth Science2020，31，2： | 0 |
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