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| 1 | Modeling and optimization of a single-drive push–pull silicon Mach–Zehnder modulator显示文摘We present an equivalent circuit model for a silicon carrier-depletion single-drive push–pull Mach–Zehnder modulator(MZM)with its traveling wave electrode made of coplanar strip lines.In particular,the partialcapacitance technique and conformal mapping are used to derive the capacitance associated with each layer.The PN junction is accurately modeled with the fringe capacitances taken into consideration.The circuit model is validated by comparing the calculations with the simulation results.Using this model,we analyze the effect of several key parameters on the modulator performance to optimize the design.Experimental results of MZMs confirm the theoretical analysis.A 56 Gb/s on–off keying modulation and a 40 Gb/s binary phase-shift keying modulation are achieved using the optimized modulator. | Yanyang Zhou Linjie Zhou Haike Zhu Chiyan Wong Yida Wen Lei Liu Xinwan Li Jianping Chen | 2016 | Photonics Research2016，4，4： | 5 |
| 2 | Robust,compact,and flexible neural model for a fiber Raman amplifier显示文摘 | Zhou Jjunhe Chen Jianping Li Xinwan | | 0，，06： | 1 |
| 3 | Blind zone-suppressed hybrid beam steering for solid-state Lidar显示文摘We demonstrate a blind zone-suppressed and flash-emitting solid-state Lidar based on lens-assisted beam-steering technology.As a proof-of-concept demonstration,with the design of a subwavelength-gap 1D long-emitter array and multiwavelength flash beam emitting,the device was measured to have 5%blind zone suppression,0.06°/point-deflection step,and 4.2μs scanning speed.In time-of-flight ranging experiments,Lidar systems have a field of view of 11.3°×8.1°(normal device)or 0.9°×8.1°(blind-zone suppressed device),far-field number of resolved points of 192,and a detection distance of 10 m.This work demonstrates the possibility that a new integrated beam-steering technology can be implemented in a Lidar without sacrificing other performance. | CHAO LI XIANYI CAO KAN WU GAOFENG QIU MINGLU CAI GUANGJIN ZHANG XINWAN LI JIANPING CHEN | 2021 | Photonics Research2021，9，9： | 1 |
| 4 | A novel algorithm for a multi-cavity Raman fiber laser 显示文摘 | Zhou Junhe Chen Jianping Li Xinwan | 2006 | Opt Express2006，14，8： | 1 |
| 5 | De- sign and analysis of a phase modulator based on amet- al-polymer-silicon hybrid plasmonic waveguide 显示文摘 | Xiaomeng Sun Linjie Zhou Xinwan Li | 2011 | Applied Optics2011，50，20： | 1 |
| 6 | Design and analysis of a phase modulator based on a metal-polymer-silicon hybrid plasmonic waveguide显示文摘 | Xiaomeng Sun kinjie Zhou Xinwan Li Zehua Hong Jianping Chen | | 0，，20： | 1 |
| 7 | A novel algorithm for multi-cavity Raman fiber laser显示文摘 | Zhou Junhe Chen J ianping Li Xinwan | 2006 | Opt Express2006，14，8： | 1 |
| 8 | On polarization characteristic in fiber Mach-Zehnder interferometer with short different length oftwo arms显示文摘 | Zehua Hong Xinwan Li | 2009 | Proceedings of the 15th Asia-Pacific conference on Communications2009，11，6： | 1 |
| 9 | Targeting iron metabolism using gallium nanoparticles to suppress ferroptosis and effectively mitigate acute kidney injury显示文摘Ferroptosis plays a critical pathophysiological role in several types of acute kidney injury(AKI).The development of nanomaterials targeting iron metabolism and ferroptosis is a promising approach for AKI treatment.Herein,we synthesized gallic acid-gallium polyvinyl pyrrolidone nanoparticles(GGP NPs)as a potential iron-scavenging agent because of their nearly ionic radius and chemical similarity with iron.The results indicated that GGP NPs accumulated in tubular epithelial cells and showed good biocompatibility.GGP NPs significantly inhibited cisplatin(CP)-induced ferroptosis in HK-2 cells by reducing the accumulation of intracellular free iron and mitochondrial dysfunction,and suppressing the perturbations of ferroptosis processes,including lipid peroxidation,nicotinamide adenine dinucleotide phosphate(NADPH)and glutathione(GSH)levels,glutathione peroxidase 4(GPX4)activity,and ferritinophagy.An in vivo study demonstrated that treatment with GGP NPs significantly ameliorated the renal tubular injury and mitochondrial damage induced by CP treatment or ischemia-reperfusion injury.Our study suggests that GGP NPs may be an effective and promising candidate for AKI treatment and enable potential clinical translation. | Xishao Xie Yunjing Zhang Xinwan Su Junni Wang Xi Yao Dou Lv Qin Zhou Jianhua Mao Jianghua Chen Fei Han Yangyang Li Weiqiang Lin | 2022 | Nano Research2022，15，7： | 0 |
| 10 | CWDM Module Fabricated by FBT Technology显示文摘In this paper, the process of fabricating coarse wavelength division multiplexing (CWDM) passive components using Fused Biconic Taper (FBT) technology is introduced. The performances and specifications of CWDM passive components are measured and reported. And the performances and cost of this kind of CWDM module are compared with the performances and cost of CWDM module based on thin-film-filter technology and dense wavelength division multiplexing (DWDM) module. | 游善红 Li Xinwan Yin Zongmin Cui Huaijun Jiang Yongjun | 2004 | High Technology Letters2004，10，3： | 0 |
| 11 | LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation显示文摘Ferroptosis, a unique type of non-apoptotic cell death resulting from iron-dependent lipid peroxidation, has a potential physiological function in tumor suppression, but its underlying mechanisms have not been fully elucidated. Here, we report that the long non-coding RNA(lncRNA) LncFASA increases the susceptibility of triple-negative breast cancer(TNBC) to ferroptosis. As a tumor suppressor, LncFASA drives the formation of droplets containing peroxiredoxin1(PRDX1), a member of the peroxidase family, resulting in the accumulation of lipid peroxidation via the SLC7A11-GPX4 axis. Mechanistically, LncFASA directly binds to the Ahpc-TSA domain of PRDX1, inhibiting its peroxidase activity by driving liquid-liquid phase separation, which disrupts intracellular ROS homeostasis. Notably, high LncFASA expression indicates favorable overall survival in individuals with breast cancer, and LncFASA impairs the growth of breast xenograft tumors by modulating ferroptosis. Together, our findings illustrate the crucial role of this lncRNA in ferroptosis-mediated cancer development and provide new insights into therapeutic strategies for breast cancer. | Xiao Fan Fangzhou Liu Xiang Wang Ying Wang Yu Chen Chengyu Shi Xinwan Su Manman Tan Qingfeng Yan Jinrong Peng Jianzhong Shao Yan Xiong Aifu Lin | 2024 | Science China(Life Sciences)2024，67，3： | 0 |
| 12 | Electroreduction of hexavalent chromium using a porous titanium flow-through electrode and intelligent prediction based on a back propagation neural network显示文摘Flow-through electrodes have been demonstrated to be effective for electroreduction of Cr(VI),but shortcomings are tedious preparation and short lifetimes.Herein,porous titanium available in the market was studied as a flow-through electrode for Cr(VI)electroreduction.In addition,the intelligent prediction of electrolytic performance based on a back propagation neural network(BPNN)was developed.Voltametric studies revealed that Cr(VI)electroreduction was a diffusion-controlled process.Use of the flow-through mode achieved a high limiting diffusion current as a result of enhanced mass transfer and favorable kinetics.Electroreduction of Cr(VI)in the flow-through system was 1.95 times higher than in a parallel-plate electrode system.When the influent(initial pH 2.0 and 106 mg/L Cr(VI))was treated at 5.0 V and a flux of 51 L/(h·m2),a reduction efficiency of~99.9%was obtained without cyclic electrolysis process.Sulfate served as the supporting electrolyte and pH regulator,as reactive CrSO72−species were formed as a result of feeding HSO4−.Cr(III)was confirmed as the final product due to the sequential three-electron transport or disproportionation of the intermediate.The developed BPNN model achieved good prediction accuracy with respect to Cr(VI)electroreduction with a high correlation coefficient(R2=0.943).Additionally,the electroreduction efficiencies for various operating inputs were predicted based on the BPNN model,which demonstrates the evolutionary role of intelligent systems in future electrochemical technologies. | Xinwan Zhang Guangyuan Meng Jinwen Hu Wanzi Xiao Tong Li Lehua Zhang Peng Chen | 2023 | Frontiers of Environmental Science & Engineering2023，17，8： | 0 |
| 13 | Renal tubule-targeted dexrazoxane suppresses ferroptosis in acute kidney injury by inhibiting ACMSD显示文摘Acute kidney injury(AKI)is a heterogeneous clinical complication with no existing definite or particular therapies.Therefore,molecular mechanisms and approaches for treating acute kidney injury are in urgent need.Herein,we demonstrated that dexrazoxane(DXZ),a U.S.Food and Drug Administration(FDA)-approved cardioprotective drug,can both functionally and histologically attenuate cisplatin or ischemia-reperfusion injury-induced AKI in vitro and in vivo via inhibiting ferroptosis specifically.This effect is characterized by decreasing lipid peroxidation,shown by the biomarker of oxidative stress 4-hydroxynonenal(HNE)and prostaglandinendoperoxide synthase 2(Ptgs2),while reversing the downregulation of glutathione peroxidase 4(GPX4)and ferritin 1(FTH-1).Mechanistically,the results revealed that DXZ targeted at the renal tubule significantly inhibits ferroptosis by suppressingα-amino-β-carboxymuconate-ε-semialdehyde decarboxylase(ACMSD).Furthermore,the conjugation of dexrazoxane and polysialic acid(DXZ-PSA)is specifically designed and utilized to enhance the therapeutic effect of DXZ by long-term effect in the kidney,especially retention and targeting in the renal tubules.This study provides a novel therapeutic approach and mechanistic insight for AKI by inhibiting ferroptosis through a new type drug DXZPSA with the enhanced renal distribution. | Yunjing Zhang Jicheng Wu Quanlin An Huanhuan Zhu Xinwan Su Ying Wang Xishao Xie Jian Zhang Xi Yao Chunhua Weng Shi Feng Jianhua Mao Xianghui Fu Fei Han Xin Cao Ben Wang Weiqiang Lin | 2023 | Nano Research2023，16，7： | 0 |
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