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| 1 | Temporal variability of iron concentrations and fractions in wetland waters in Sanjiang Plain, Northeast China显示文摘Chemical forms, reactivities and transformation of iron fractions in marshy waters were investigated with cross-flow filtration technique to study the iron environmental behavior. Iron fractions were divided into four parts: acid-labile iron (pre-acidification of unfiltered marshy water samples, > 0.7 μm), high-molecular-weight iron (0.7-0.05 μm), medium-molecular-weight iron (0.05-0.01 μm), and low-molecular-weight iron (< 0.01 μm). The cross-flow filtration suggested that iron primarily exist in both the > 0.7 μm and < 0.01 μm size fractions in marshy waters. Rainfall is the key for rain-fed wetland to determine fate of iron by changing the aquatic biochemical conditions. By monitoring the variation of iron concentrations and fractions over three years, it was found that dissolved iron and acid-labile iron concentrations exhibit a large variation extent under different annual rainfalls from 2006 to 2008. The seasonal variation for iron species proved that the surface temperature could control some conversion reactions of iron in marshy waters. Low- molecular-weight iron would convert to acid-labile iron gradually with temperature decreasing. The photochemical reactions of iron fractions, especially low-molecular-weight iron had occurred under solar irradiation. The relative proportion of low-molecular-weight in total dissolved iron ranging from 28.3% to 43.2% were found during the day time, which proved that the observed decreasing concentration of acid lability iron was caused by its degradation to low molecular weight iron. | Xiaofeng Pan Baixing Yan Muneoki Yoh Lixia Wang Xiuqi Liu | 2010 | Journal of Environmental Sciences2010，22，7： | 4 |
| 2 | Relationships between tree-ring cell features of Pinus koraiensis and climate factors in the Changbai Mountains,Northeastern China显示文摘Anatomical characteristics have been proven useful for extracting climatic signals. To examine the climatic signals recorded by tree-ring cell features in the Changbai Mountains, we measured cell number and cell lumen diameter, in addition to ring widths, of Korean pine(Pinus koraiensis) tree rings at sites of varied elevation,and we developed chronologies of cell number(CN), mean lumen diameter(MLD), maximum lumen diameter(MAXLD) and tree-ring width(TRW). The chronologies were correlated with climatic factors monthly mean temperature and the sum of precipitation. As shown by our analysis, the cell parameter chronologies were suitable for dendroclimatology studies. CN and TRW shared relatively similar climatic signals which differed from MLD andMAXLD, and growth-climate relationships were elevationdependent, as shown by the following findings:(1) at each elevation, MLD and MAXLD recorded different monthly climatic signals from those recorded by TRW for the same climatic factors; and(2) MLD and MAXLD recorded climatic factors that were absent from TRW at lower and middle elevations. Cell lumen diameter proved to be an effective archive for improving the climate reconstruction for this study area. | Hui Wang Xuemei Shao Xiuqi Fang Yuan Jiang Chunlan Liu Qing Qiao | 2017 | Journal of Forestry Research2017，28，1： | 3 |
| 3 | The 1920S Drought Recorded by Tree Rings and Historical Documents in the Semi-Arid and Arid Areas of Northern China显示文摘 | Eryuan Liang Xiaohong Liu Yujiang Yuan Ningsheng Qin Xiuqi Fang Lei Huang Haifeng Zhu Lily Wang Xuemei Shao | 2006 | Climatic Change (-)2006，，3： | 1 |
| 4 | The 1920S Drought Recorded by Tree Rings and Historical Documents in the Semi-Arid and Arid Areas of Northern China显示文摘 | Eryuan Liang Xiaohong Liu Yujiang Yuan Ningsheng Qin Xiuqi Fang Lei Huang Haifeng Zhu Lily Wang Xuemei Shao | 2006 | Climatic Change (-)2006，，3： | 1 |
| 5 | OPTIMUM DESIGN OF HIGH-SPEED RAILWAY LOCOMOTIVE TRACTION GEAR显示文摘OPTIMUMDESIGNOFHIGH-SPEEDRAILWAYLOCOMOTIVETRACTIONGEARLiLixing;WangXiuqi;HeWeidong;ZhaoWenzhong;QianYuanmei(DalianRailwayInst... | Li Lixing Wang Xiuqi He Weidong Zhao Wenzhong Qian Yuanmei (Dalian Railway Institute) Liu Youmei Gui Linfang Xiao Peng Pan Xiaoming Xu Zongxiang (Zhuzhou Electric Locomotive Works ) | 1996 | Chinese Journal of Mechanical Engineering1996，9，4： | 1 |
| 6 | Antibiotics in global rivers显示文摘Antibiotics have received extensive attention due to their sophisticated effects on human health and ecosystems.However,there is an extreme scarcity of information on composition,content,geographic distribution,and risk of riverine antibiotics at a large spatial scale.Based on a systematic review of over 600 pieces of literature(1999-2021),we established a global dataset containing more than 90,000 records covering 169 antibiotics and their metabolites in surface water and sediment across 76 countries.The occurrence of prioritized antibiotics largely depended on socioeconomic developmental levels,and the current“hotspots”of polluted rivers were found mostly in less developed countries or emerging economies(e.g.,some in Africa,South America,and Asia).By developing the screening protocol for risk-based prioritization of antibiotics,we advanced a rank list of antibiotics for guiding formulation of region-specific strategies,which highlighted the importance of whole life cycle management of antibiotics in health maintenance of the world’s rivers. | Si Li Yi Liu Yang Wu Jingrun Hu Yiqing Zhang Qian Sun Weiling Sun Jiagen Geng Xiaoying Liu Dantong Jia Xiuqi You Dianqing Qi Moran Tang Yitao Lyu Fanguang Kong Leilei Cai Yufan Ai Yichu Wang Jinren Ni | 2022 | National Science Open2022，1，2： | 1 |
| 7 | Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway显示文摘Roof plate-specific spondin 1(R-spondin1,RSPO1)is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway,which is key to hair regeneration.However,it is not clear whether recombinant RSPO1(rRSPO1)affects hair regeneration.Here,we treat C57BL/6 male mice with rRSPO1 and investigate the expression of the Wnt/β-catenin signaling pathway and the activation of hair follicle stem cells in the dorsal skin.The mouse skin color score and hair-covered area are determined to describe hair growth,and the skin samples are subjected to H&E staining,western blot analysis and immunofluorescence staining to evaluate hair follicle development and the expressions of Wnt/β-catenin signaling pathway-related proteins.We find that rRSPO1 activates mouse hair follicle stem cells(mHFSCs)and accelerates hair regeneration.rRSPO1 increases the hair-covered area,the number of hair follicles,and the hair follicle diameter and length.Moreover,rRSPO1 enhances the activity of Wnt/β-catenin signaling pathway-related proteins and the expressions of HFSC markers,as well as mHFSC viability.These results indicate that subcutaneous injection of rRSPO1 can improve hair follicle development by activating the Wnt/β-catenin signaling pathway,thereby promoting hair regeneration.This study demonstrates that rRSPO1 has the potential to treat hair loss by activating the Wnt/β-catenin signaling pathway. | Yijun Chen Zhujin Lu Jiaxin Feng Zefeng Chen Zejian Liu Xiuqi Wang Huichao Yan Chunqi Gao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 8 | Rising grain prices in response to phased climatic change during 1736–1850 in the North China Plain显示文摘Grain price volatility during historical periods is regarded as an important indicator of the impact of climate change on economic system, as well as a key link to adjust food security and social stability. The present study used the wheat prices in Baoding Prefecture, China, during 1736–1850 to explore connections between climatic transition and grain price anomalies in the North China Plain. The main findings were as follows:(1) The grain price change showed an apparent correspondence with climatic transition. The period 1781–1820 was a transition phase, with more extremes and decreased precipitations when the climate shifted from a warm phase to a cold one. Corresponding with the climatic transition, the grain price during 1781–1820 was characterized by that the mean of the original grain price series was significantly higher(lower) than the previous(later)phase, and the variance and anomaly amplitude of the detrended grain price series was the highest during 1736–1850.(2) The correspondence between grain price extremes and drought events occurred in phases. Five grain price extremes occurred following drought events during 1781–1810, while extreme droughts were the direct cause of the grain price spike during 1811–1820.(3) Social stability affected by climate change also played an important role in the grain price spike between 1811 and 1820. Paralleling the pathway of 'precipitation-grain production-grain price', climate change could have an impact on grain price via the pathway of 'precipitation-grain production-grain price-famine-uprising-grain price', as shown during the Tianli Uprising in 1813. These findings could contribute to an improved understanding of the interaction between climate change and human society during the historical period. | Yanjun WEN Xiuqi FANG Yang LIU Yikai LI | 2019 | Science China Earth Sciences2019，62，11： | 0 |
| 9 | TET1蛋白亚型转换调控DNA去甲基化和小鼠发育显示文摘文章简介DNA甲基化氧化酶TET蛋白在介导DNA去甲基化和调控个体发育中均起着非常重要的作用。但是,TET蛋白如何识别基因组中的催化位点仍然有待研究。本研究通过细致地观测转录组学数据,意外发现了TET蛋白家族成员TET1在小鼠不同发育时期中存在两个亚型。其中全长TET1亚型(TET1e)仅在小鼠早期胚胎、小鼠胚胎干细胞和原始生殖细胞中表达; | Wenhao Zhang Weikun Xia Qiujun Wang Aaron J Towers Jiayu Chen Rui Gao Yu Zhang Chia-an Yen Ah Young Lee Yuanyuan Li Chen Zhou Kaili Liu Jing Zhang Tian-Peng Gu Xiuqi Chen Zai Chang Danny Leung Shaorong Gao Yong-hui Jiang 颉伟 | 2017 | 科学新闻2017，19，4： | 0 |
| 10 | Manganese-doped mesoporous polydopamine nanoagent for T1-T2 magnetic resonance imaging and tumor therapy显示文摘Theranostic nanodrugs combining magnetic resonance imaging(MRI)and cancer therapy have attracted extensive interest in cancer diagnosis and treatment.Herein,a manganese(Mn)-doped mesoporous polydopamine(Mn-MPDA)nanodrug incorporating the nitric oxide(NO)prodrug BNN6 and immune agonist R848 was developed.The nanodrug responded to the H^(+)and glutathione being enriched in tumor microenvironment to release R848 and Mn^(2+).The abundant Mn^(2+)produced through a Fenton-like reaction enabled a highly sensitive T1-T2 dual-mode MRI for monitoring the tumor accumulation process of the nanodrug,based on which an MRI-guided laser irradiation was achieved to trigger the NO gas therapy.Meanwhile,R848 induced the re-polarization of tumor-promoting M2-like macrophage to a tumoricidal M1 phenotype.Consequently,a potent synergistic antitumor effect was realized in mice bearing subcutaneous 4T1 breast cancer,which manifested the great promise of this multifunctional nanoplatform in cancer treatment. | Xiuqi Hou Xi Yang Yanwen Xu Jiayin Lin Fang Zhang Xiaohui Duan Sitong Liu Jie Liu Jun Shen Xintao Shuai Zhong Cao | 2023 | Nano Research2023，16，2： | 0 |
| 11 | Global Environmental Change and National Security of China显示文摘The concept of security has been redefined since the 1990s. As one of the important factors threatening human security, global environmental change has become a new challenge to the national security and social development. The national security problems caused by global environmental change, on one hand, are closely related to the global environmental problems, and, on the other hand, are manifested in the conflicts of international affairs. The global environmental change severely challenges the future development of China. When it comes to the study on human dimensions of global environmental change in China, much more attention should be paid to issues of important environmental change that may have great impacts on the national security of China, to the scientific assessment of the vulnerabilities of the natural and socialeconomic system of China to the impacts of global environmental change, and to the active establishment of the national risk management system, in which global environmental change should be included, so as to make contribution to sustainable development and construction of harmonious society of China. | Liu Yanhua Ge Quansheng Fang Xiuqi Zhang Xueqin | 2011 | Chinese Journal of Population,Resources and Environment2011，9，1： | 0 |
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