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| 1 | 藏北乌兰乌拉湖地区第三纪陆相红层古地磁研究的初步结果及地质意义显示文摘过对乌兰乌拉湖地区第三纪风火山群上部岩性段共计 15 6件样品的古地磁采样和室内退磁研究 ,揭示出一组高温特征剩磁分量 ,在 95 %置信度下通过正倒转检验和正褶皱检验 ,说明这组高温分量很可能代表岩石形成时的原生剩磁。采样剖面获得的磁性地层显示多个正、反极性带交替出现的图案 ,参考晚期侵入红层中浅成岩脉钾 氩法同位素年龄对陆相红层沉积顶界的限定 ,可对比国际标准地磁年代表的C2 3n至C2 0n极性带 ,沉积时限为 5 2~ 4 2Ma ,相当于始新世中期。根据野外调查及区域地层对比 ,本文提出风火山群是一个跨区分布的穿时性岩石地层单元 ,它的沉积充填历史与印度 亚洲大陆碰撞是同步发生的。 | 伊海生 Zhao Xixi 林金辉 时志强 李保华 赵兵 | 2004 | 地球学报2004，25，6： | 16 |
| 2 | Potential role of strike-slip faults in opening up the South China Sea显示文摘Radiometric dates of key rock units indicate that a remnant Late Mesozoic ocean of the Huatung Basin is still preserved today east of the South China Sea(SCS).We integrate regional geology with a Cretaceous oceanic basement in the vicinity of the Huatung Basin to reconstruct the Huatung Plate east of the Eurasian continent.Results of geophysical investigations,four expeditions of deep-sea drilling and a renaissance of regional geology allow us to propose a hypothesis that the mechanism responsible for the SCS opening was raised from strike-slip fault on the east.The hypothesis suggests that the SCS opening could highly relate to the strike-slip faults inherited from Late Mesozoic structures onshore–offshore the SE Cathaysia Block to develop rhombic-shaped extensional basins en echelon on the thinned Eurasian continental crust in the Early Cenozoic.It was followed by sinistral strike-slip movements along the boundary between the Eurasian Plate and the Huatung Plate driven by oblique subduction of the Huatung Plate to the northwest coupled with slab-pull force by southward subduction of the Proto-SCS to open up the triangle-shaped oceanic East Sub-basin in the Early Oligocene(33/34 Ma).The spreading ridge then propagated southwestward in the step-over segment between the Zhongnan-Lile and the Red River strike-slip fault systems to open the triangle-shaped oceanic Southwest Sub-basin by 23 Ma.The plate boundary fault was subsequently converted into the Manila Trench when the Eocene Sierra Madre arc of the Huatung Plate had moved from the south to its present latitude by the Middle Miocene. | Chi-Yue Huang Pinxian Wang Mengming Yu Chen-Feng You Char-Shine Liu Xixi Zhao Lei Shao Guangfa Zhong Graciano P.Yumul Jr | 2019 | National Science Review2019，6，5： | 16 |
| 3 | 白垩纪中期地球磁场与全球地质现象(英文)显示文摘白垩纪超静磁带(CNS)是指白垩纪中期约40 Ma内(Aptian Santonian, 121~83 Ma)地球磁场没有出现倒转的异常现象。这一现象引起地球学界的极大关注,原因在于它与白垩纪中期(124~90 Ma)其他一系列事件在时间上非常吻合,包括洋底扩张速率的快速增加和洋底高原、海山链、大型火成岩省等生产速率的快速增加。过去20多年许多研究强调所有这些现象与下地幔对流的联系。近期研究的一个重要的进展在于把地球磁场的变化(反转频率和古强度)与许多重要的地质和地球物理过程结合起来,如周期性地幔对流、地幔柱活动、全球热流、真极移、大型火成岩省的产生和生物群集绝灭。文中回顾了白垩纪地球磁场研究以及与白垩纪中期所发生的全球性的地质事件之间的可能存在的关联,并讨论在这一重要研究领域内未来研究的发展方向。 | Xixi ZHAO | 2005 | 地学前缘2005，12，2： | 15 |
| 4 | A late Mesozoic high plateau in eastern China:Evidence from basalt vesicular paleoaltimetry显示文摘Eastern China is made of a number of large and small continental fragments throughout late Paleozoic and Mesozoic time,and is still the best natural laboratory for examining kinematic models of continent tectonics.The paleoelevation history of eastern China provides direct insight into the tectonic processes in China.Here we present basalt-vesicularity based estimates of the paleoaltimetry of the early Cretaceous basalts in northern East China,which indicate that the studied basalt units were at an elevation of more than 4 kilometers in late Mesozoic.Two vesicular basaltic rocks have been collected form bottom to top along the lava flow outcrop in eastern Inner Mongolia.After the digital precessing to the sample cross-sections,and taking advantage of the stereological conversion method to acquire the bubble size distributions,paleoelevation estimate was calculated for East China in the early Cretaceous.The results show that the elevation has been near 4700±750 m when the lava flows was cooling,implying that there were highland regions in the northern part of the East China Plateau during the early Cretaceous.Combined with other geological evidence,we conclude that there was a high plateau with elevation near 5000 m above sea level in Eastern China during the late Mesozoic.This ancient high plateau in eastern China was most likely formed by the collision of the north and south China blocks. | XIA GuoQing YI HaiSheng ZHAO XiXi GONG DaXing JI ChangJun | 2012 | Chinese Science Bulletin2012，57，21： | 9 |
| 5 | Activation of Rev-erbα attenuates lipopolysaccharide-induced inflammatory reactions in human endometrial stroma cells via suppressing TLR4-regulated NF-κB activation显示文摘Perturbation of the circadian rhythm damages the biological characteristics of cells and leads to their dysfunction. Rev-erbα, an important gene in the transcription-translation loop of circadian rhythm, is involved in regulating the balance between pro-inflammation and anti-inflammation. The disruption of this balance in human endometrial stroma cells (hESCs) destroys their biological behavior function in maintaining the menstrual cycle and embryonic implantation. Whether pharmacological modulation of Rev-erbα affects the inflammation of hESCs remains unclear. In this study, we treated hESCs with lipopolysaccharide (LPS) and found that LPS treatment increased the mRNA levels of pro-inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8, IL-18, and TNFα, and the secretion of IL-6. SR9009, a Rev-erbα agonist, significantly alleviated the LPS-induced production of pro-inflammatory cytokines in hESCs. Meanwhile, knockdown of Rev-erbα increased the expressions of IL-1β, IL-6, and IL-8, accompanied by an increased mRNA level of the core clock gene Bmal1. Western blot analysis showed that SR9009 inhibited the expression of toll-like receptor 4 (TLR4) and the activation of NF-κB induced by LPS. All these findings suggested that pharmacological activation of Rev-erbα attenuated the LPS-induced inflammatory response of hESCs by suppressing TLR4-regulated NF-κB activation. This study may provide a strategy for preventing inflammation-related endometrial dysfunction and infertility or recurrent implantation failure. | Weijie Zhao Liyuan Cui Xixi Huang Songcun Wang Dajin Li Liping Li Yan Sun Meirong Du | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 8 |
| 6 | High-quality Arabidopsis thaliana Genome Assembly with Nanopore and HiFi Long Reads显示文摘Arabidopsis thaliana is an important and long-established model species for plant molecular biology,genetics,epigenetics,and genomics.However,the latest version of reference genome still contains a significant number of missing segments.Here,we reported a high-quality and almost complete Col-0 genome assembly with two gaps(named Col-XJTU)by combining the Oxford Nanopore Technologies ultra-long reads,Pacific Biosciences high-fidelity long reads,and Hi-C data.The total genome assembly size is 133,725,193 bp,introducing 14.6 Mb of novel sequences compared to the TAIR10.1 reference genome.All five chromosomes of the Col-XJTU assembly are highly accurate with consensus quality(QV)scores>60(ranging from 62 to 68),which are higher than those of the TAIR10.1 reference(ranging from 45 to 52).We completely resolved chromosome(Chr)3 and Chr5 in a telomere-to-telomere manner.Chr4 was completely resolved except the nucleolar organizing regions,which comprise long repetitive DNA fragments.The Chrl centromere(CEN1),reportedly around 9 Mb in length,is particularly challenging to assemble due to the presence of tens of thousands of CEN180 satellite repeats.Using the cutting-edge sequencing data and novel computational approaches,we assembled a 3.8-Mb-long CEN1 and a 3.5-Mb-long CEN2.We also investigated the structure and epigenetics of centromeres.Four clusters of CEN180 monomers were detected,and the centromere-specific histone H3-like protein(CENH3)exhibited a strong preference for CEN180 Cluster 3.Moreover,we observed hypomethylation patterns in CENH3-enriched regions.We believe that this high-quality genome assembly,Col-XJTU,would serve as a valuable reference to better understand the global pattern of centromeric polymorphisms,as well as the genetic and epigenetic features in plants. | Bo Wang Xiaofei Yang Yanyan Jia Yu Xu Peng Jia Ningxin Dang Songbo Wang Tun Xu Xixi Zhao Shenghan Gao Quanbin Dong Kai Ye | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 6 |
| 7 | Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-κB and MAPK in macrophages显示文摘发炎是到损害和感染的身体纸巾的回答。能禁止发炎的混合物被显示了有潜在的治疗学的临床的申请。Gambogenic 酸(GEA ) 有有势力 antitumor 和反煽动性的活动。此处, GEA 反煽动性的效果的分子的机制在刺激的 lipopolysaccharide (LPS ) 被调查巨噬细胞房间。结果证明有 GEA 的那个预告的处理能显著地禁止 interleukin (IL )-1, IL-1,肿瘤坏死因素 -- ,以在导致 LPS 的模型的一种剂量依赖者方式的 IFN- , IL-12b,和 IL-23a 生产。而且,这药显著地减少了氮的氧化物的版本(没有) ,并且损害了蛋白质水平可诱导没有 synthase 和 cyclooxygenase 2。发现也证明 GEA 的效果可能与原子 factor-B (NF-B ) 和表明小径的激活 mitogen 的蛋白质 kinase (MAPK ) 的抑制有关。这些结果显示 GEA 能由 attenuating 部分压制模仿 LPS 的煽动性的反应没有合成和 NF-B 和 MAPK 激活,建议它可以成为一个有势力为煽动性的疾病的处理的治疗学的代理人。 | Xianjun Yu Qun Zhao Haiwei Zhang Cunxian Fan Xixi Zhang Qun Xie Chengxian Xu Yongbo Liu Xiaoxia Wu Quanbin Han Haibing Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 5 |
| 8 | The OsNAC23-Tre6P-SnRK1 a feed-forward loop regulates sugar homeostasis and grain yield in rice显示文摘Tre6P(trehalose-6-phosphate)mediates sensing of carbon availability to maintain sugar homeostasis in plants,which underpins crop yield and resilience.However,how Tre6P responds to fluctuations in sugar levels and regulates the utilization of sugars for growth remains to be addressed.Here,we report that the sugar-inducible rice NAC transcription factor OsNAC23 directly represses the transcription of the Tre6P phosphatase gene TPP1 to simultaneously elevate Tre6P and repress trehalose levels,thus facilitating carbon partitioning from source to sink organs.Meanwhile,OsNAC23 and Tre6P suppress the transcription and enzyme activity of SnRK1a,a low-carbon sensor and antagonist of OsNAC23,to prevent the SnRK1a-mediated phosphorylation and degradation of OsNAC23.Thus,OsNAC23,Tre6P,and SnRK1a form a feed-forward loop to sense sugar and maintain sugar homeostasis by transporting sugars to sink organs.Importantly,plants over-expressing OsNAC23 exhibited an elevated photosynthetic rate,sugar transport,and sink organ size,which consistently increased rice yields by 13%–17%in three elite-variety backgrounds and two locations,suggesting that manipulation of OsNAC23 expression has great potential for rice improvement.Collectively,these findings enhance our understanding of Tre6P-mediated sugar signaling and homeostasis,and provide a new strategy for genetic improvement of rice and possibly also other crops. | Zhiyong Li Xiangjin Wei Xiaohong Tong Juan Zhao Xixi Liu Huimei Wang Liqun Tang Yazhou Shu Guanghao Li Yifeng Wang Jiezheng Ying Guiai Jiao Honghong Hu Peisong Hu Jian Zhang | 2022 | Molecular Plant2022，15，4： | 4 |
| 9 | Coupling of Hierarchical Al_(2)O_(3)/TiO_(2) Nanofibers into 3D Photothermal Aerogels Toward Simultaneous Water Evaporation and Purification显示文摘Serious freshwater shortage and environmental pollution boost the rapid development of solar-driven water production.Although improved evaporation rate has achieved in recent years,undesirable impurity(e.g.,pollutant components)can also be inevitably evaporated and collected as impurity in produced freshwater.This work reports new ultra-light three-dimensional(3D)aerogels assembled by hierarchical Al_(2)O_(3)/TiO_(2) nanofibers and reduced graphene oxide(RGO)for excit-ing synchronized solar-driven evaporation and water purification.Hydrophilic Al_(2)O_(3)/TiO_(2) fibrous channels linked up the graphene hot-spots and water body for sufficient water supply and bulk water insulation.Meanwhile,featured with thermal insulation effect,the Al_(2)O_(3)/TiO_(2) nanofibers effectively locked the converted heat with less energy loss from sunlight.The introducing of Al_(2)O_(3)/TiO_(2) nanofibers into RGO aerogel led to the effective interfacial evaporation for a more rapid water evaporation rate(2.19 kg·m−2·h−1,normalized to evaporation area including both top and side surface),which was 36%higher than that of pristine RGO aerogel.Moreover,simultaneous with the strong steam generation,Al_(2)O_(3)/TiO_(2) nanofibers in situ removed the pollutants within steam by photodegradation,achieving polluted wastewater purification with high con-taminant removal ratio of 91.3%.Our work on coupling Al_(2)O_(3)/TiO_(2) nanofibers into photothermal aerogel provides attractive solutions for the challenges of clean water scarcity and serious environmental pollution. | Xiangyu Meng Wanlin Xu Zhihui Li Jianhui Yang Jingwu Zhao Xixi Zou Yueming Sun Yunqian Dai | 2020 | Advanced Fiber Materials2020，2，2： | 4 |
| 10 | Partial anhysteretic remanent magnetization (pARM) of synthetic single-and multidomain magnetites and its paleoenvironmental significance显示文摘In order to isolate magnetic signals carried by single-domain (SD) ferrimagnetic (FM) minerals from multi-domain (MD) FM minerals, we developed a few pa- rameters using partial anhysteretic remanent magnetization (pARM). Because MD fraction contains only soft (easy to be demagnetized) coercivity spectrum, pARM(>20 mT) was sensitive in eliminating MD contributions. Ratio of pARM(5 mT, 10 mT)/pARM(0, 5 mT) is useful in quantifying a rela- tive abundance of mass ratio between SD and MD fractions. These new proxies can quickly characterize the details of grain size distribution of magnetic minerals in paleoclimatic and paleomagnetic studies. | LIU Qingsong YU Yongjae PAN Yongxin ZHU Rixiang ZHAO Xixi | 2005 | Chinese Science Bulletin2005，50，20： | 3 |
| 11 | Comparative Study of Hydrogen and Carbon Isotopic Composition of Gases Generated from the Pyrolysis of a Peat under Saltwater and Freshwater Conditions显示文摘To understand the influence of the diagenetic water medium on the isotopic compositions of thermogenic coalbed gas, both hydrous and anhydrous closed-system pyrolyses were performed at temperatures of 250°C to 650°C on an herbaceous marsh peat. Compared to the results of anhydrous pyrolysis, the hydrocarbon gases generated from hydrous pyrolyses have very different hydrogen isotopic compositions. However, the carbon isotopic compositions of the hydrocarbon gases became only slightly heavier in hydrous pyrolysis, compared to that from anhydrous pyrolysis. With the progress of thermal evolution from peat to a more advanced thermal maturity of vitrinite reflectance values(Ro) of 5.5% during the pyrolysis, the difference in the average δD value increased from 52‰ to 64‰ between the hydrous pyrolysis with saltwater and anhydrous pyrolysis and increased from 18‰ to 29‰ between the hydrous pyrolysis with freshwater and anhydrous pyrolysis, respectively. The difference in the average δ^(13)C value was only 1‰–2‰ between the hydrous and anhydrous pyrolysis. The relationships between the δD values of the generated hydrocarbon gases and Ro values as well as among δD values of the hydrocarbon gas species are established. The close relationships among these parameters suggest that the water medium had a significant effect on the hydrogen isotopic composition and a minimal effect on the carbon isotopic composition of the hydrocarbon gases. The results of these pyrolyses may provide information for the understanding of the genesis of coalbed gas from herbaceous marsh material with the participation of different diagenetic water media. | WU Yingzhong DUAN Yi ZHAO Yang CAO Xixi MA Lanhua QIAN Yaorong LI Zhongping XING Lantian | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 3 |
| 12 | Discovery and identification of EIF2AK2 as a direct key target of berberine for anti-inflammatory effects显示文摘Using chemoproteomic techniques,we first identified EIF2AK2,eEF1A1,PRDX3 and VPS4B as direct targets of berberine(BBR)for its synergistically anti-inflammatory effects.Of them,BBR has the strongest affinity with EIF2AK2 via two ionic bonds,and regulates several key inflammatory pathways through EIF2AK2,indicating the dominant role of EIF2AK2.Also,BBR could subtly inhibit the dimerization of EIF2AK2,rather than its enzyme activity,to selectively modulate its downstream pathways including JNK,NF-κB,AKT and NLRP3,with an advantage of good safety profile.In EIF2AK2 gene knockdown mice,the inhibitory IL-1β,IL-6,IL-18 and TNF-a secretion of BBR was obviously attenuated,confirming an EIF2AK2-dependent anti-inflammatory efficacy.The results highlight the BBR's network mechanism on anti-inflammatory effects in which EIF2AK2 is a key target,and inhibition of EIF2AK2 dimerization has a potential to be a therapeutic strategy against inflammationrelated disorders. | Wei Wei Qingxuan Zeng Yan Wang Xixi Guo Tianyun Fan Yinghong Li Hongbin Deng Liping Zhao Xintong Zhang Yonghua Liu Yulong Shi Jingyang Zhu Xican Ma Yanxiang Wang Jiandong Jiang Danqing Song | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 13 | Magnetostratigraphy of Tertiary sediments from the Hoh Xil basin : implications for the Cenozoic tectonic history of the Tibetan Plateau 显示文摘 | Liu Zhifei Zhao Xixi Wang Chengshan | 2003 | Geophysical Journal International2003，154，： | 1 |
| 14 | New paleomagnetic results from northern China: Collision and suturing with Siberia andKazakhstan显示文摘 | Zhao Xixi Robert S C Zhou Yaoxiu | 1990 | Tectonophysics1990，181，1： | 1 |
| 15 | New Cambrian and Ordovician paleomagnetic poles for the North China block and their paleogeographic implication显示文摘 | Zhao Xixi Coe R S Liu Chun | 1992 | Journal of Geophysical Research1992，97，2： | 1 |
| 16 | Outward-growth of the Tibetan Plateau during the Cenozoic: A review显示文摘 | Chengshan Wang Jingen Dai Xixi Zhao Yalin Li Stephan A. Graham Dengfa He Bo Ran Jun Meng | 2014 | Tectonophysics2014，，： | 1 |
| 17 | Cenozoic Vertical-Axis Rotations of the Hoh Xil Basin, Central–Northern Tibet显示文摘Understanding the Cenozoic vertical-axis rotation in the Tibetan Plateau is crucial for continental dynamic evolution. Paleomagnetic and rock magnetic investigations were carried out for the Oligocene and Miocene continental rocks of the Hoh Xil basin in order to better understand the tectonic rotations of central Tibet. The study area was located in the Tongtianhe area located in the southern part of the Hoh Xil basin and northern margin of the Tanggula thrust system in central-northern Tibet. A total of 160 independently oriented paleomagnetic samples were drilled from the Tongtianhe section for this study. The magnetic properties of magnetite and hematite have been recognized by measurements of magnetic susceptibility vs. temperature curves and unblocking temperatures. The mean directions of the Oligocene Yaxicuo Group in stratigraphic coordinates(Declination/Inclination = 354.9°/29.3°, k = 33.0, α_(95) = 13.5°, N =5 Sites) and of the Miocene Wudaoliang Group in stratigraphic coordinates(Declination/Inclination = 3.6°/36.4°, k = 161.0, α_(95) = 9.7°, N =3 Sites) pass reversal tests, indicating the primary nature of the characteristic magnetizations. Our results suggested that the sampled areas in the Tuotuohe depression of the Hoh Xil basin have undergone no paleomagnetically detectable rotations under single thrusting from the Tanggula thrust system. Our findings, together with constraints from other tectonic characteristics reported by previous paleomagnetic studies, suggest tectonic rotations in the Cuoredejia and Wudaoliang depressions of the Hoh Xil basin were affected by strike-slip faulting of the Fenghuo Shan-Nangqian thrust systems. A closer examination of geological data and different vertical-axis rotation magnitudes suggest the tectonic history of the Hoh Xil basin may be controlled by thrust and strike-slip faulting since the Eocene. | RAN Bo ZHAO Xixi LIU Zhifei WANG Chengshan ZHU Lidong JIN Wei LI Yalin | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 1 |
| 18 | Journal of Geophysical Resarch显示文摘 | Glider S A Gill J Coe R S Zhao Xixi Liu Zhongwei Wang Genxian Yuan Kuirong Liu Wenlong Kuang Guodun Wu Haoruo | 1996 | Tectonophsics1996，101，16： | 1 |
| 19 | Environmental capacity of COD in the Bohai Sea:modeling and calculation显示文摘 | Zhao Xixi Wang Xiulin Shi Xiaoyong | 2010 | Chinese Journal of Oceanology and Limnology2010，28，5： | 1 |
| 20 | Constraints on the early uplift history of the Tibetan Plateau显示文摘 | Wang Chengshan Zhao Xixi Liu Zhifei Lippert P C Graham S A Coe R S Yi Haisheng Zhu Lidong Liu Shun Li Yalin | 2008 | PNAS2008，105，13： | 1 |
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