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| 1 | Systems metabolic engineering strategies for the production of amino acids显示文摘Systems metabolic engineering is a multidisciplinary area that integrates systems biology,synthetic biology and evolutionary engineering.It is an efficient approach for strain improvement and process optimization,and has been successfully applied in the microbial production of various chemicals including amino acids.In this review,systems metabolic engineering strategies including pathwayfocused approaches,systems biology-based approaches,evolutionary approaches and their applications in two major amino acid producing microorganisms:Corynebacterium glutamicum and Escherichia coli,are summarized. | Qian Ma Quanwei Zhang Qingyang Xu Chenglin Zhang Yanjun Li Xiaoguang Fan Xixian Xie Ning Chen | 2017 | Synthetic and Systems Biotechnology2017，2，2： | 10 |
| 2 | Potential Benefits of Biochar in Agricultural Soils:A Review显示文摘Soil degradation,characterized by declines in nutrient status and simultaneous accumulation of pesticide residues,is a major problem affecting agricultural ecosystems.Previous studies indicate that biochar application to soil has promise as a practical method to alleviate these pressures:increasing crop yield and enhancing pesticide degradation.Here,we review the roles of biochar in both chemical and biological promotion of pesticide degradation and the potential benefits of biochar relating to the efficiency of fertilizer use,availability of nutrients,and nutrient exchange.Biochar typically has a high surface area featuring many functional groups,a high cation exchange capacity,and high stability.Major factors that impact on the nutrient retention characteristics of biochar(e.g.,feedstock,pyrolysis temperature,and application rate) are also discussed herein.Nonetheless,more studies of the long-term impacts on soil properties from biochar addition are still required before it can be possible to accurately quantify the sustainability of this approach to sequester carbon and restore soil function. | DING Yang LIU Yunguo LIU Shaobo HUANG Xixian LI Zhongwu TAN Xiaofei ZENG Guangming ZHOU Lu | 2017 | Pedosphere2017，27，4： | 10 |
| 3 | The development of silicate matrix phosphors with broad excitation band for phosphor-convered white LED显示文摘This paper briefly reviews the recent progress in alkaline earth silicate host luminescent materials with broad excitation band for phosphor-convered white LED. Among them, the Sr-rich binary phases (Sr, Ba, Ca, Mg)2SiO4:Eu2+ and (Sr, Ba, Ca, Mg)3SiO5:Eu2+ are excellent phosphors for blue LED chip white LED. They have very broad excitation bands and exhibit strong absorption of blue radiation in the range of 450―480 nm. And they exhibit green and yellow-orange emission under the InGaN blue LED chip radiation, respectively. The luminous efficiency of InGaN-based (Sr, Ba, Ca, Mg)2SiO4:Eu2+ and (Sr, Ba, Ca, Mg)3SiO5:Eu2+ is about 70-80 lm/W, about 95%―105% that of the InGaN-based YAG:Ce, while the correlated color temperature is between 4600―11000 K. Trinary alkaline earth silicate host luminescent materials MO(M=Sr, Ca, Ba)-Mg(Zn)O-SiO2 show strong absorption of deep blue/near-ultraviolet radia- tion in the range of 370―440 nm. They can convert the deep blue/near-ultraviolet radiation into blue, green, and red emissions to generate white light. The realization of high-performance white-light LEDs by this approach presents excellent chromaticity and high color rendering index, and the application disadvantages caused by the mixture of various matrixes can be avoided. Moreover, the application prospects and the trends of research and development of alkaline earth silicate phosphors are also discussed. | LUO XiXian CAO WangHe SUN Fei | 2008 | Chinese Science Bulletin2008，53，19： | 9 |
| 4 | miR-410 induces both epithelial–mesenchymal transition and radioresistance through activation of the PI3K/mTOR pathway in non-small cell lung cancer显示文摘Radiotherapy remains one of the major treatments for non-small cell lung cancer(NSCLC)patients;whereas intrinsic or acquired radioresistance limits its efficacy.Nevertheless,most studies so far have only focused on acquired resistance.The exact mechanisms of intrinsic radioresistance in NSCLC are still unclear.A few studies have suggested that epithelial–mesenchymal transition(EMT)is associated with radioresistance in NSCLC.However,little is known about whether the abnormal expression of specific microRNAs induces both EMT and radioresistance.We previously found that miR-410 has multiple roles as an oncomiRNA in NSCLC.In this study,we revealed that miR-410 overexpression promoted EMT and radioresistance,accompanied by enhanced DNA damage repair both in vitro and in vivo.Conversely,knockdown of miR-410 showed the opposite effects.We further demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays,and the miR-410-induced EMT and radioresistance were reversed by PI3K,Akt,and mTOR inhibitors or by restoring the expression of PTEN in NSCLC cells.In addition,we preliminarily found that the expression of miR-410 was positively correlated with EMT and negatively associated with the expression of PTEN in NSCLC specimens.In summary,these results demonstrated that miR-410 is an important regulator on enhancing both NSCLC EMT and radioresistance by targeting the PTEN/PI3K/mTOR axis.The findings suggest that miR-410-induced EMT might significantly contribute to the enhanced radioresistance.Therefore,miR-410 may serve as a potential biomarker or therapeutic target for NSCLC radiotherapy. | Yue Yuan Hu Liao Qiang Pu Xixian Ke Xueting Hu Yongfang Ma Xinmei Luo Qianqian Jiang Yi Gong Min Wu Lunxu Liu Wen Zhu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 5 | Study on the Anti-Liver Fibrosis Effect of Benefit Liver Granule (益肝冲剂) and Its Mechanism in Rats显示文摘Objective:To explore the effect of Benefit Liver Granule (BLG), a traditional Chinese medical preparation, in antagonizing liver fibrosis and its possible mechanism. Methods:Carbon tetrachloride was used to establish the experimental liver fibrosis model of rat. The model rats were randomly divided into 4 groups and BLG, Astragalus (As), Salvia (Sa) and normal saline (for control) respectively were given to them by gastrogavage. Changes of serum alanine transaminase (ALT), aspartate aminotransferase (AST), transforming growth factor α(TGF α), interleukine 6 (IL 6), liver content of hydroxyproline (Hyp), superoxide dismutase (SOD), malonyldialdehyde (MDA) as well as liver pathology after treatment were observed. A normal control group was also established for control.Results: Pathological examination showed that in the saline group, the structure of normal hepatic lobuli was destroyed with swelled liver cells, focal necrosis, extensive fatty degeneration, and focal inflammatory cell infiltration. Small amounts of proliferated fiber tissue were found in the intra lobular area, peri central vein area, portal area and limiting plate area, and formation of pseudolobuli was also seen. In the 3 treated groups, the serum ALT, AST, TGF α and IL 6 as well as liver content of Hyp, and MDA were lower and SOD were higher than those in the control group significantly, P <0.05 or P <0.01.Conclusion: BLG, As and Sa have the action of anti liver fibrosis, while BLG has the best effect. The mechanisms are probably related to their effects in regulating TGF α and IL 6, reducing collagen fiber synthesis, promoting free radical scavenge and anti lipid peroxidation. | YAO Xixian(姚希贤) CUI Donglai(崔东来) SUN Yufeng(孙玉凤) FENG Liying(冯丽英) SUN Zemin(孙泽民) SONG Mei(宋梅) | 2002 | Chinese Journal of Integrative Medicine2002，8，2： | 4 |
| 6 | Blue,green,red upconversion luminescence and optical characteristics of rare earth doped rare earth oxide and oxysulfide显示文摘The cold isostatic press pretreatment process was adopted to prepare fine rare earth oxysulfide up-conversion phosphors with spherical shape, narrow size distribution and high luminescence efficiency. The upconversion optical characteristics and brightness of the blue (Y2O2SYb,Tm), green (Y2O2S: Yb,Er), red (Y2O3Yb,Er) emitter were also investigated, and a novel method was successfully developed for the brightness measurement of upconversion luminescence (UPL). It is shown that a white color can be obtained by the appropriate mixture of these primary blue, green and red emissions components. The Er3+ ions exhibit different upconversion mechanism in Y2O2S and Y2O3 host materials. The rare earth oxysulfide is an efficient upconversion matrix. The UPL brightness of Y2O2S: Yb,Er is 6.5 times higher than that of Y2O3: Yb,Er, and Y2O2S: Yb,Er shows UPL brightness of 1100 cd/m2 under 5.56 W/cm2 power density using a 980 nm laser diode. | LUO XiXian CAO WangHe | 2007 | Science China Chemistry2007，50，4： | 4 |
| 7 | Artificial intelligence-assisted automatic and index-based microbial single-cell sorting system for One-Cell-One-Tube显示文摘Identification,sorting,and sequencing of individual cells directly from in situ samples have great potential for in-depth analysis of the structure and function of microbiomes.In this work,based on an artificial intelligence(AI)-assisted object detection model for cell phenotype screening and a cross-interface contact method for single-cell exporting,we developed an automatic and index-based system called EasySort AUTO,where individual microbial cells are sorted and then packaged in a microdroplet and automatically exported in a precisely indexed,“One-Cell-One-Tube”manner.The target cell is automatically identified based on an AI-assisted object detection model and then mobilized via an optical tweezer for sorting.Then,a crossinterface contact microfluidic printing method that we developed enables the automated transfer of cells from the chip to the tube,which leads to coupling with subsequent single-cell culture or sequencing.The efficiency of the system for single-cell printing is>93%.The throughput of the system for single-cell printing is~120 cells/h.Moreover,>80%of single cells of both yeast and Escherichia coli are culturable,suggesting the superior preservation of cell viability during sorting.Finally,AI-assisted object detection supports automated sorting of target cells with high accuracy from mixed yeast samples,which was validated by downstream single-cell proliferation assays.The automation,index maintenance,and vitality preservation of EasySort AUTO suggest its excellent application potential for single-cell sorting. | Zhidian Diao Lingyan Kan Yilong Zhao Jingyun Song Chen Wang Yang Liu Fengli Zhang Teng Xu Rongze Chen Xixian Wang Xiaoyan Jing Jian Xu Yuandong Li Bo Ma | 2022 | mLife2022，1，4： | 2 |
| 8 | TJJE:An Effi- cient Algorithm for Top-k Join on Massive Data显示文摘 | HAN Xixian U Jianzhong WANG Jinbao | 2013 | Infoimation Sciences2013，，： | 1 |
| 9 | Preparation of Incompact Strontium Aluminate Phosphors显示文摘The incompact long afterglow pigment SrAl2O4: Eu, Dy was synthesized by ceramics technology.The agglomerated starting raw material had little effect on the synthesis of SrA12O4 matrix through solid-state reaction method,but the shrinkage and densification was retarded greatly by the agglomerated powder by the formation of large and extensive pore network.The sintering mechanism is surface diffusion ( without flux B2O3 ) and grain boundary diffusion (with B2O3 as flux)respectively, and the as-prepared long afterglow pigment glows in the dark for over 4000 min. | Luo Xixian Xiao Zhiguo Xia Wei Cao Wanghe | 2004 | Journal of Rare Earths2004，22，z1： | 1 |
| 10 | Supporting Early Pruning in Top-k Query Processing on Massive Data显示文摘 | HAN Xixian LI Jianzhong YANG Donghua | 2011 | Infor- mation Processing Letters2011，111，11： | 1 |
| 11 | Enhanced cytidine production by a recombinant Escherichiacoli strain using genetic manipulation strategies显示文摘 | FANG Haitian ZHANG Chenglin XIE Xixian | 2014 | Annalsof Microbiology2014，64，3： | 1 |
| 12 | White up-conversion luminescence and highly-sensitive optical temperature sensing in Na_(3)La(VO_(4))_(2):Yb,Er,Tm,Ho phosphors显示文摘In this work,tunable white up-conversion luminescence was achieved in the Yb^(3+),Er^(3+),Tm^(3+),Ho^(3+) codoped Na_(3)La(VO_(4))_(2) phosphors under 980 nm excitation.The emissions of three primary colors are mainly attributed to the ~2H_(11/2)/~4S_(3/2)→~4I_(15/2) transitions of Er^(3+),~1G_(4)→~3H_6 transition of Tm^(3+),and_5F_5→~5I_8 transition of Ho^(3+).White luminescence characteristics and mechanisms of up-conversion system were investigated in detail.In addition,the temperature sensing behaviors of multiple levels emission combinations for Na_(3)La(VO_(4))_(2):Yb^(3+),Er^(3+),Tm^(3+),Ho^(3+) were analyzed by employing thermally coupled and non-thermally coupled energy levels.Based on the emissions of ~3F_(2,3)/~1G_(4) energy levels,the maximum relative and absolute sensitivities were obtained to be 2.20%/K and 0.279 K^(-1).The design of up-conversion luminescence materials with high-quality white luminescence and excellent sensitivity performance is critical in the field of optical applications. | Qi Xiao Xiumei Yin Lin Lv Xinyao Dong Na Zhou Kuichao Liu Xixian Luo | 2023 | Journal of Rare Earths2023，41，7： | 1 |
| 13 | Enhancement of cytidine production by coexpression of gnd,zwf and prs genes in recombinant Escherichia coli CYT15显示文摘 | FANG Haitian XIE Xixian XU Qingyang | 2013 | Biotechnologgy letters2013，35，2： | 1 |
| 14 | Enhancement of cytidine production by coexpression ofgnd, zwf and prs genes in recombinant Escherichia coliCYT 15显示文摘 | FANG Haitian XIE Xixian XU Qingyang | 2013 | Biotechnologgy letters2013，35，2： | 1 |
| 15 | 显示文摘 | Tian Xia Cao Wanghe Luo Xixian | 2005 | J Mater Res2005，20，9： | 1 |
| 16 | Gene selection using hybrid particle swarm optimization and genetic algorithm显示文摘 | Shutao Li Xixian Wu Mingkui Tan | 2008 | Soft Computing2008，，11： | 1 |
| 17 | 显示文摘 | Luo Xixian Cao Wanghe Xiao Zhiguo | 2006 | Journal of Alloys and Compounds2006，416，： | 1 |
| 18 | 显示文摘 | Luo Xixian Cao Wanghe | 2007 | Material Letter2007，61，： | 1 |
| 19 | 显示文摘 | Luo Xixian Cao Wanghe | 2008 | Journal of the Material Research2008，23，8： | 1 |
| 20 | Modificationof tryptophan transport system and its impact onproduction of L-tryptophan in Escherichia coli显示文摘 | Liu Qian Cheng Yongsong Xie Xixian | 2012 | BioresourceTechnology2012，114，54： | 1 |
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