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| 1 | Bcl-2 over-expression and activation of protein kinase C suppress the Trail-induced apoptosis in Jurkat T cells显示文摘Trail, a tumor necrosis factor-related apoptosis-inducing ligand, is a novel potent endogenous activator of the cell death pathway through the activation of cell surface death receptors Trail-R1 and Trail-R2. Its role, like FasL in activation-induced cell death (AICD), has been demonstrated in immune system. However the mechanism of Trail induced apoptosis remains nuclear. In this report, the recombinant Trail protein was expressed and purified. The apoptosis-inducing activity and the regulation mechanism of recombinant Trail on Jurkat T cells were explored in vitro. Trypan blue exclusion assay demonstrated that the recombinant Trail protein actively killed Jurkat T cells in a dose-dependent manner. Trail-induced apoptosis in Jurkat T cells were remarkably reduced by Bcl-2 over expression in BcL-2 gene transfected cells. Treatment with PMA (phorbol 12-myristate 13-acetate), a PKC activator, suppressed nail-induced apoptosis in Jurkat T cells. The inhibition of apoptosis by PMA was abolished by pretreatment with Bis, a PKC inhibitor. Taken together, it was suggested that Bcl-2 over-expression and PMA activated PKC actively down-regulated the Trail-mediated apoptosis in Jurkat T cell. | GuoBC XuYU | 2001 | Cell Research2001，11，2： | 16 |
| 2 | Applications of graphene-based materials in environmental protection and detection显示文摘Many efficient adsorbents and sensors based on graphene and functionalized graphene have been constructed for the removal and detection of environmental pollutants due to its unique physicochemical properties. In this article, recent research achievements are reviewed on the application of graphene-based materials in the environmental protection and detection. For environmental protection, modified graphene can adsorb heavy metal ions in a high efficiency and selectivity, and thus reduces them to metals for recycling. High adsorption capacity of graphene-based materials to kinds of organic pollutants in water was also presented. Several graphene-based sensors with high limit of detection were reported to detect heavy metal ions, toxic gases and organic pollutants in environment. Finally, a perspective on the future challenge of adsorbents and detection devices based on graphene is given. | Lü MeiJiao LI Jing YANG XuYu ZHANG ChangAn YANG Jia HU Hao WANG XianBao | 2013 | Chinese Science Bulletin2013，58，22： | 9 |
| 3 | News Text Topic Clustering Optimized Method Based on TF-IDF Algorithm on Spark显示文摘Due to the slow processing speed of text topic clustering in stand-alone architecture under the background of big data,this paper takes news text as the research object and proposes LDA text topic clustering algorithm based on Spark big data platform.Since the TF-IDF(term frequency-inverse document frequency)algorithm under Spark is irreversible to word mapping,the mapped words indexes cannot be traced back to the original words.In this paper,an optimized method is proposed that TF-IDF under Spark to ensure the text words can be restored.Firstly,the text feature is extracted by the TF-IDF algorithm combined CountVectorizer proposed in this paper,and then the features are inputted to the LDA(Latent Dirichlet Allocation)topic model for training.Finally,the text topic clustering is obtained.Experimental results show that for large data samples,the processing speed of LDA topic model clustering has been improved based Spark.At the same time,compared with the LDA topic model based on word frequency input,the model proposed in this paper has a reduction of perplexity. | Zhuo Zhou Jiaohua Qin Xuyu Xiang Yun Tan Qiang Liu Neal N.Xiong | 2020 | Computers, Materials & Continua2020，，1： | 7 |
| 4 | Factors influencing the natural regeneration of arrow bamboo in giant panda habitat of the north Minshan Mountains,southwestern China显示文摘To determine the effects of eco-factors on the regeneration of arrow bamboo in giant panda habitat,a field study was conducted in the Baozuo and Gonggangling Nature Reserves,Sichuan Province,China.A total of 183 quadrats(10 m×10 m) and 717 small quadrats(1 m×1 m) were investigated within the study site.Bamboo seedling density was used as an indicator of natural regeneration.Twelve factors were measured,which included topography and forest factors(elevation,slope aspect,slope degree,slope position,canopy cover,and shrub cover) and microhabitat factors(upper vegetation cover,herb cover,litter layer cover,moss cover,moss thickness,and dead bamboo density).A One-Way ANOVA was used to analyze the effects of topography and forest factors on seedling density,and a GLM(Generalized Linear Model) procedure was performed to examine the relationship between seedling density and microhabitat factors.The results indicated that elevation and canopy cover had highly significant effects on seedling density:bamboo seedling density was highest and showed the best regeneration at middle elevations(2800-3000 m) and under medium to medium-high canopy cover.Moss thickness,moss cover,and dead bamboo density were the most important microhabitat factors influencing the natural regeneration of bamboo:seedling density increased with increasing moss cover and moss thickness and decreased with increasing dead bamboo density.We propose that removal of dead bamboo and controlling grazing activities may accelerate the process of bamboo regeneration. | LI Bo ZHANG Man ZHONG Xue MOERMOND Timothy RAN JiangHong YANG XuYu | 2013 | Chinese Science Bulletin2013，58，17： | 4 |
| 5 | A wave of Foxp3^(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance显示文摘Newborn animals require tightly regulated local and systemic immune environments to govern the development and maturation of multiple organs/tissues even though the immune system itself is far from mature during the neonatal period.Regulatory T cells(Tregs)are essential for maintaining immune tolerance/homeostasis and modulating inflammatory responses.The features of Tregs in the neonatal liver under steady-state conditions are not well understood.The present study aimed to investigate the phenotype,functions,and significance of neonatal Tregs in the liver.We found a wave of thymus-derived Treg influx into the liver during 1–2 weeks of age.Depletion of these Tregs between days 7 and 11 after birth rapidly resulted in Th1-type liver inflammation and metabolic disorder.More Tregs in the neonatal liver than in the spleen underwent MHC II-dependent activation and proliferation,and the liver Tregs acquired stronger suppressive functions.The transcriptomic profile of these neonatal liver Tregs showed elevated expression of PPARγand T-bet and features of Tregs that utilize lipid metabolic machinery and are capable of regulating Th1 responses.The accumulation of Tregs with unique features in the neonatal liver is critical to ensure self-tolerance and liver maturation. | Mingyang Li Weijia Zhao Yifan Wang Lixue Jin Gaowen Jin Xiuyuan Sun Wei Wang Ke Wang Xi Xu Jie Hao Rong Jin Wenxian Fu Ying Sun Yingjun Chang Xiaojun Huang Xuyu Zhou Hounan Wu Kunshan Zhang Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 6 | Regulatory T cells turn pathogenic显示文摘规章的 T (Treg ) 房间被认为由于他们在维持有免疫力的动态平衡和自我忍耐的必要角色对 autoimmunity 是保护的 CD4 + T 房间的一个亚系的 Foxp3 + 。然而, Treg 房间以系专门化和镇压功能在 vivo 是不稳定的。这些不稳定的 Treg 房间在疾病的致病起作用,它关于人的 Treg 房间治疗引起安全担心。在这评论,我们加亮最近的调查结果在不同疾病模型表明 Treg 房间的病原的变换。 | Jitao Guo Xuyu Zhou | 2015 | Cellular & Molecular Immunology2015，12，5： | 4 |
| 7 | Microsatellite variability reveals high genetic diversity and low genetic differentiation in a critical giant panda population显示文摘 | Jiandong YANG Zhihe ZHANG Fujun SHEN Xuyu YANG Liang ZHANG Limin CHEN Wenping ZHANG Qing ZHU Rong HOU | 2011 | Current Zoology2011，57，6： | 3 |
| 8 | Dynamically measuring the holo-information of light fields in three-dimensional space using a periodic polarization-structured light显示文摘Spatially structured light field has attracted great attention due to its novel properties and application potential in numerous fields.Among them,the most striking one is the polarization-structured light,known as the vector beam.Here,using a periodic polarization-structured light,we propose a method to dynamically measure the holo-information of light fields,including the amplitude,phase,and polarization distributions,in three-dimensional(3D)space.The measurement system is composed of a Mach-Zender interferometer involving a liquid crystal polarized grating in the reference arm,which is simple,stable,and easy to operate.Featuring the single-shot measurement,this method supports observing the dynamic variation of object light fields.The accuracy,3D polarimetry,and dynamic observation of this method are validated by measuring a calibrated quarter-wave plate,a vector vortex beam,a Poincarébeam,and a stressed polymethyl methacrylate sample. | ShuXia Qi Sheng Liu Lei Han BingYan Wei Peng Li JinZhan Zhong XuYue Guo JianLin Zhao | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，6： | 3 |
| 9 | Effects and mechanisms of store-operated calcium channel blockade on hepatic ischemia-reperfusion injury in rats显示文摘AIM:To further investigate the important role of store-operated calcium channels (SOCs) in rat hepatocytes and to explore the effects of SOC blockers on hepatic ischemia-reperfusion injury (HIRI).METHODS:Using freshly isolated hepatocytes from a rat model of HIRI (and controls),we measured cyto-solic free Ca 2+ concentration (by calcium imaging),net Ca 2+ fluxes (by a non-invasive micro-test technique),the SOC current (I SOC ;by whole-cell patch-clamp record-ing),and taurocholate secretion [by high-performance liquid chromatography and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays].RESULTS:Ca 2+ oscillations and net Ca 2+ fluxes medi-ated by Ca 2+ entry via SOCs were observed in rat he-patocytes.I SOC was significantly higher in HIRI groups than in controls (57.0 ± 7.5 pA vs 31.6 ± 2.7 pA,P <0.05) and was inhibited by La 3+.Taurocholate secretion by hepatocytes into culture supernatant was distinctly lower in HIRI hepatocytes than in controls,an effect reversed by SOC blockers.CONCLUSION:SOCs are pivotal in HIRI.SOC blockers protected against HIRI and assisted the recovery of se-cretory function in hepatocytes.Thus,they are likely to become a novel class of effective drugs for prevention or therapy of HIRI patients in the future. | Li-Jie Pan,Zi-Chao Zhang,Zhen-Ya Zhang,Zong-Ming Zhang,Department of General Surgery,Digestive Medical Center,The First Affiliated Hospital,School of Medicine,Tsinghua University,Beijing 100016,China Wen-Jun Wang,Yue Xu,Xuyue (Beijing) Science and Technology Co.,Ltd.,Haidian District,Beijing 100080,China | 2012 | World Journal of Gastroenterology2012，18，4： | 3 |
| 10 | Preparation and Corrosion Resistance of Rare Earth Conversion Coatings on AZ91 Magnesium Alloy显示文摘The feasibility of forming Ce-containing rare earth conversion coating (short for RECCs),which is nonpoisonous and green to the environment,onto the AZ91 magnesium alloy surface in order to increase the corrosion resistance was studied. And the optimum technological conditions, such as the appropriate concentrations of the components in the solution,temperature and duration of the coatings formation were also settled. The protection of conversion coatings on magnesium alloy surface was evaluated by moisture/heating test, anodie polarization, etc. | XuYue ChenXiang LüZushun LiYingjie | 2005 | Journal of Rare Earths2005，23，1： | 3 |
| 11 | Enhanced stretch formability and mechanical properties of a magnesium alloy processed by cold forging and subsequent annealing显示文摘 | Xinxing Wu Xuyue Yang Jijun Ma Qinghuan Huo Jun Wang Huan Sun | 2013 | Materials and Design2013，，： | 2 |
| 12 | Effects of hot pressing on electric performances of Bi_(0.5)Sb_(1.5)Te_3显示文摘The effects of hot pressing on electric performance and mechanical strength of Bi0.5Sb1.5Te3 thermoelectric material prepared through vacuum melting and milling were studied. The phase constituent and microstructure were analyzed by X-ray Diffraction and cold field emission Scanning Electric Microscope. Aeolotropisms of the material on microstructure and electric performances are approved. With the rise of hot pressing temperature (from 300-500 ℃) and pressure (30-70 MPa), electric conductivity and power factor are improved. Moreover, Bi0.5Sb1.5Te3 material can gain ideal thermoelectric performances and increased mechanical strength by hot pressing. | XIAO Bo CHEN Hui WU Borong ZHU Lei LIU Mingyi JIAN Xuyu LI Lin | 2006 | Rare Metals2006，25，z1： | 2 |
| 13 | Image Augmentation-Based Food Recognition with Convolutional Neural Networks显示文摘Image retrieval for food ingredients is important work,tremendously tiring,uninteresting,and expensive.Computer vision systems have extraordinary advancements in image retrieval with CNNs skills.But it is not feasible for small-size food datasets using convolutional neural networks directly.In this study,a novel image retrieval approach is presented for small and medium-scale food datasets,which both augments images utilizing image transformation techniques to enlarge the size of datasets,and promotes the average accuracy of food recognition with state-of-the-art deep learning technologies.First,typical image transformation techniques are used to augment food images.Then transfer learning technology based on deep learning is applied to extract image features.Finally,a food recognition algorithm is leveraged on extracted deepfeature vectors.The presented image-retrieval architecture is analyzed based on a smallscale food dataset which is composed of forty-one categories of food ingredients and one hundred pictures for each category.Extensive experimental results demonstrate the advantages of image-augmentation architecture for small and medium datasets using deep learning.The novel approach combines image augmentation,ResNet feature vectors,and SMO classification,and shows its superiority for food detection of small/medium-scale datasets with comprehensive experiments. | Lili Pan Jiaohua Qin Hao Chen Xuyu Xiang Cong Li Ran Chen | 2019 | Computers, Materials & Continua2019，，4： | 2 |
| 14 | Automatic Detection of Aortic Dissection Based on Morphology and Deep Learning显示文摘Aortic dissection(AD)is a kind of acute and rapidly progressing cardiovascular disease.In this work,we build a CTA image library with 88 CT cases,43 cases of aortic dissection and 45 cases of health.An aortic dissection detection method based on CTA images is proposed.ROI is extracted based on binarization and morphology opening operation.The deep learning networks(InceptionV3,ResNet50,and DenseNet)are applied after the preprocessing of the datasets.Recall,F1-score,Matthews correlation coefficient(MCC)and other performance indexes are investigated.It is shown that the deep learning methods have much better performance than the traditional method.And among those deep learning methods,DenseNet121 can exceed other networks such as ResNet50 and InceptionV3. | Yun Tan Ling Tan Xuyu Xiang Hao Tang Jiaohua Qin Wenyan Pan | 2020 | Computers, Materials & Continua2020，，3： | 2 |
| 15 | Conjugated Random Tpeoilymer Donors towards High-Efficiency Polymer Solar Cells显示文摘Over the past decades,polymer solar cells(PSCs)which contain conjugated polymers as electron donor and/or acceptor materials in active layers have achieved the power con version efficiency(PCE)over 17%.Among them,tremendous alternative donor-acceptor(D-A)type conjugated copolymers have been reported as donor materials.Nevertheless,plenty of rooms still exist to further improve the photovoltaic performs nee for practical applications.Besides the exploration of the increasingly challenging novel D and/or A monomers to construct new D-A copolymer donors,conjugated random terpolymer donors which involve a third existing monomer(D or A)provide an extra simple promising strategy to promote the photovoltaic performance to a higher level.Herein,recent progress on random terpolymer donors for efficient PSCs was reviewed.Firstly,random terpolymer donors were classified by several typical molecular building blocks.Then,the influences of the third monomer on various random terpolymers were highlighted according to the enhancement of light-harvesting ability,modification of energy levels and optimization of the bulk-heterojunction(BHJ)morphology.Finally,several issues which might be concerned in future research on random terpolymer donors were proposed.This review may be helpful for providing guidelines to design efficient random terpolymer donors as well as better-understanding of the structure-property-performance correlations towards high performance PSCs via random terpolymer approach. | Xuyu Gao Yijing Wu Youtian Tao Wei Huang | 2020 | Chinese Journal of Chemistry2020，38，6： | 2 |
| 16 | Modulation of orbital angular momentum on the propagation dynamics of light fields显示文摘Optical vortices carrying orbital angular momentum(OAM)have attracted extensive attention in recent decades because of their interesting applications in optical trapping,optical machining,optical communication,quantum information,and optical microscopy.Intriguing effects induced by OAMs,such as angular momentum conversion,spin Hall effect of light(SHEL),and spin– orbital interaction,have also gained increasing interest.In this article,we provide an overview of the modulations of OAMs on the propagation dynamics of scalar and vector fields in free space.First,we introduce the evolution of canonical and noncanonical optical vortices and analyze the modulations by means of local spatial frequency.Second,we review the Pancharatnam–Berry(PB)phases arising from spin–orbital interaction and reveal the control of beam evolution referring to novel behavior such as spindependent splitting and polarization singularity conversion.Finally,we discuss the propagation and focusing properties of azimuthally broken vector vortex beams. | Peng LI Sheng LIU Yi ZHANG Lei HAN Dongjing WU Huachao CHENG Shuxia QI Xuyue GUO Jianlin ZHAO | 2019 | Frontiers of Optoelectronics2019，12，1： | 2 |
| 17 | Seasonal Variability of Phytoplankton Community Structure in Relation to Different Nitrogen-Phosphorus Ratios in the Southern Coastal Waters of Zhejiang, China显示文摘With the rapid development of economy and increase of population in the drainage areas,the nutrient loading has increased dramatically in the Changjiang estuary and adjacent coastal waters.To properly assess the impact of nutrient enrichment on phytoplankton community,seasonal microcosm experiments were conducted during August 2010 July 2011 in the coastal waters of Zhejiang Province.The results of the present study indicated that the chl a concentration,cell abundance,diversity indices,species composition and community succession of the phytoplankton varied significantly with different N/P ratios and seasons.Higher growth was observed in the 64:1(spring),32:1(summer),16:1(autumn)and 128:1,256:1(winter)treatments,respectively.The values of Shannon-Wiener index(H′)and Pielou evenness index(J)were lower in the 8:1 and 16:1 treatments in autumn test,while H'value was higher in the 128:1 and 8:1 treatments in winter test.A definite community succession order from diatoms to dinoflagellates was observed in the autumn and winter tests,while the diatoms dominated the community throughout the culture in the spring and summer tests. | HUANG Wei ZHU Xuyu CHEN Quanzhen HE Qing LIAO Yibo DU Ping ZHANG Peng ZENG Jiangning | 2013 | Journal of Ocean University of China2013，12，4： | 2 |
| 18 | Criss-Cross Attentional Siamese Networks for Object Tracking显示文摘Visual object tracking is a hot topic in recent years.In the meanwhile,Siamese networks have attracted extensive attention in this field because of its balanced precision and speed.However,most of the Siamese network methods can only distinguish foreground from the non-semantic background.The fine-tuning and retraining of fully-convolutional Siamese networks for object tracking(SiamFC)can achieve higher precision under interferences,but the tracking accuracy is still not ideal,especially in the environment with more target interferences,dim light,and shadows.In this paper,we propose crisscross attentional Siamese networks for object tracking(SiamCC).To solve the imbalance between foreground and non-semantic background,we use the feature enhancement module of criss-cross attention to greatly improve the accuracy of video object tracking in dim light and shadow environments.Experimental results show that the maximum running speed of SiamCC in the object tracking benchmark dataset is 90 frames/second.In terms of detection accuracy,the accuracy of shadow sequences is greatly improved,especially the accuracy score of sequence HUMAN8 is improved from 0.09 to 0.89 compared with the original SiamFC,and the success rate score is improved from 0.07 to 0.55. | Zhangdong Wang Jiaohua Qin Xuyu Xiang Yun Tan Neal N.Xiong | 2022 | Computers, Materials & Continua2022，，11： | 1 |
| 19 | Characterization of human αβTCR repertoire and discovery of D-D fusion in TCRβ chains显示文摘 | Peipei Liu Di Liu Xi Yang Jing Gaoai Ma3, Fangqing Zhaos, Xuyu Zhou~'2~, George F. Gao1'2'4'5~, Baoli Zhu~'2~ Yan Chen Xue Xiao Fei Liu Jing Zou Jun Wu Juncai Ma Fangqing Zhao Xuyu Zhou George F. Gao Baoli Zhu | 2014 | Protein & Cell2014，5，8： | 1 |
| 20 | Steganalysis based on difference statistics for LSB matching steganography显示文摘 | QIN JIAOHUA SUN XINGMING XIANG XUYU | 2009 | Information Technology Journal2009，8，8： | 1 |
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