|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vitamin D deficiency and hepatitis viruses-associated liver diseases:a literature review显示文摘The secosteroid hormone vitamin D has, in addition to its effects in bone metabolism also functions in the modulation of immune responses against infectious agents and in inhibiting tumorigenesis. Thus, deficiency of vitamin D is associated with several malignancies, but also with a plethora of infectious diseases. Among other communicable diseases, vitamin D deficiency is involved in the pathogenesis of chronic liver diseases caused by hepatitis B and C viruses(HBV, HCV) and high prevalence of vitamin D deficiency with serum levels below 20 mg/mL in patients with HBV and HCV infection are found worldwide. Several studies have assessed the effects of vitamin D supplementation on the sustained virological response(SVR) to interferon(IFN) plus ribavirin(RBV) therapy in HBV and HCV infection. In these studies, inconsistent results were reported. This review addresses general aspects of vitamin D deficiency and, in particular, the significance of vitamin D hypovitaminosis in the outcome of HBVand HCV-related chronic liver diseases. Furthermore,current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. | Nghiem Xuan Hoan Hoang Van Tong Le Huu Song Christian G Meyer Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，4： | 9 |
| 2 | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection显示文摘AIM To investigate possible effects of IRF5 polymorphisms in the 3' UTR region of the IFR5 locus on susceptibilityto hepatitis B virus(HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.METHODS Four IFR5 SNPs(rs13242262 A/T, rs77416878 C/T, rs10488630 A/G, and rs2280714 T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B(CHB). n = 99; liver cirrhosis(LC), n = 131; hepatocellular carcinoma(HCC), n = 149] and in 242 healthy controls by direct sequencing and Taq Man realtime PCR assays. RESULTS Comparing patients and controls, no significant association was observed for the four IFR5 variants. However, the alleles rs13242262 T and rs10488630 G contributed to an increased risk of liver cirrhosis(LC vs CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted P = 0.04; LC vs CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted P = 0.019). Haplotype IRF5*TCGT constructed from 4 SNPs was observed frequently in LC compared to CHB patients(OR = 2.1, 95%CI: 1.2-3.3, adjusted P = 0.008). Haplotype IRF5*TCAT occurred rather among CHB patients than in the other HBV patient groups(LC vs CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted P = 0.03; HCC vs CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted P = 0.003). The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. CONCLUSION Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. | Bui Tien Sy Nghiem Xuan Hoan Hoang Van Tong Christian G Meyer Nguyen Linh Toan Le Huu Song Claus-Thomas Bock Thirumalaisamy P Velavan | 2018 | World Journal of Gastroenterology2018，24，2： | 9 |
| 3 | Air quality monitoring using mobile microscopy and machine learning显示文摘Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air quality.In fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health Organization.Here we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and machine-learning.This platform,termed c-Air,is also integrated with a smartphone application for device control and display of results.This mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in air.It provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air measurements.Furthermore,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing flights.With its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality. | Yi-Chen Wu Ashutosh Shiledar Yi-Cheng Li Jeffrey Wong Steve Feng Xuan Chen Christine Chen Kevin Jin Saba Janamian Zhe Yang Zachary Scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 4 | Adaptive response surface method based on a double weighted regression technique显示文摘 | Xuan Son Nguyen Alain Sellier Frédéric Duprat Gérard Pons | 2008 | Probabilistic Engineering Mechanics2008，，2： | 2 |
| 5 | Acute appendicitis–advances and controversies显示文摘Being one of the most common causes of the acute abdomen,acute appendicitis(AA)forms the bread and butter of any general surgeon’s practice.With the recent advancements in AA’s management,much controversy in diagnostic algorithms,possible differential diagnoses,and weighing the management options has been generated,with no absolute consensus in the literature.Since Alvarado described his eponymous clinical scoring system in 1986 to stratify AA risk,there has been a burgeoning of additional scores for guiding downstream management and mortality assessment.Furthermore,advancing literature on the role of antibiotics,variations in appendicectomy,and its adjuncts have expanded the surgeon’s repertoire of management options.Owing to the varied presentation,diagnostic tools,and management of AA have also been proposed in special groups such as pregnant patients,the elderly,and the immunocompromised.This article seeks to raise the critical debates about what is currently known about the above aspects of AA and explore the latest controversies in the field.Considering the ever-evolving coronavirus disease 2019 situation worldwide,we also discuss the pandemic’s repercussions on patients and how surgeons’practices have evolved in the context of AA. | Thomas Zheng Jie Teng Xuan Rong Thong Kai Yuan Lau Sunder Balasubramaniam Vishal G Shelat | 2021 | World Journal of Gastrointestinal Surgery2021，13，11： | 2 |
| 6 | Effect of con- straint induced by crack depth on creep crack-tip stress field in CT specimens显示文摘 | WANG G Z LIU X L XUAN F Z | 2010 | International Journal of Solids and Struc- tures2010，47，： | 1 |
| 7 | Distortionless data hiding based on integer wavelet transform 显示文摘 | Xuan G R Zhu J Chen J | 2002 | IEE Electronics Letters2002，38，25： | 1 |
| 8 | Quantitative char- acterization of creep constraint induced by crack depths in compact tension specimens显示文摘 | SUN P J WANG G Z XUAN F Z etal | 2011 | Engineering Fracture Mechan- ics2011，78，： | 1 |
| 9 | Brain metabolite changes in subcortical regions after exposure to cuprizone for 6 weeks:potential implications for schizophrenia显示文摘 | Yan G Xuan YH Dai ZZ | 2015 | Neurochem Res2015，40，： | 1 |
| 10 | Distortionless data hiding based on integer wavelet transform显示文摘 | Xuan G R Zhu J Chen J D | 2002 | IEE Electronics Letters2002，38，25： | 1 |
| 11 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 12 | Distortionless data hiding based on integer wavelet transform 显示文摘 | Xuan G Zhu J Chen J | 2002 | IEE Electronics Letters2002，38，25： | 1 |
| 13 | Heat Transfer Characteristics of Water Flowing through Microchannel显示文摘 | Peng X F Peterson G P Xuan B X | 1994 | Experimental Heat Transfer1994，7，3： | 1 |
| 14 | Distortion less data biding based on integer wavelet transform显示文摘 | XUAN G ZHU J CHEN J | 2002 | IEEE Electron Letters2002，38，24： | 1 |
| 15 | Weighted Network Proper- ties of Chinese Nature Science Basic Research 显示文摘 | J G Liu Z G Xuan Y Z Dang | 2007 | Physica A2007，，： | 1 |
| 16 | Frictional flow characteristics of water flowing through rectangular micro-channels显示文摘 | Peng Xiao Feng Peterson G P Wang Bu Xuan | 1994 | Exp Heat Transfer1994，7，4： | 1 |
| 17 | Petrology, Sr - Nd - Hf isotopic geochemistry and zircon chronology of the Late Palaeozoic volcanic rocks in the southwestern Tianshan Mountains, Xinjiang, NW China显示文摘 | Zhu YF Xuan G Song B Zhang LF | 2009 | Journal of the Geological Society London2009，166，： | 1 |
| 18 | The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene显示文摘 | Yiru G Keith W Xuan YT | 1999 | Proc Natl Acad Sci USA1999，96，11： | 1 |
| 19 | Effect of PEEP ventilation on re- nal function, plasma renin, aldosterone, neurophysins and urinary ADH, and prostaglandins显示文摘 | Annat G Viale JP Bui Xuan B | 1983 | Anesthesiology1983，58，2： | 1 |
| 20 | Concurrent changes in H MRS metabolites and antioxidant enzymes in the brain of C57BL/6 mouse short-termly exposed to cuprizone:possible implications for schizophrenia 显示文摘 | Xuan Y Yan G Peng H | 2014 | Neurochem Int2014，69，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员