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| 1 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 2 | 小鼠TRIM59蛋白多克隆抗体的制备、鉴定与初步应用显示文摘【目的】制备兔抗鼠三结构域蛋白59(Tripartite motif-containing 59,TRIM59)多克隆抗体。【方法】利用PCR方法得到小鼠TRIM59基因片段,将其克隆至pGEX-2T原核表达载体中,转入大肠杆菌BL21,IPTG诱导表达GST-TRIM59融合蛋白。GST-TRIM59融合蛋白经亲和层析纯化浓缩后免疫新西兰大耳白兔,制备多克隆抗体,通过ELISA测定兔抗鼠TRIM59多克隆抗体效价,用Western blot测定其特异性。用免疫组织化学方法检测TRIM59在小鼠前列腺癌组织中的表达。【结果】成功构建了pGEX-2T-TRIM59原核表达重组质粒,并诱导表达出GST-TRIM59融合蛋白,免疫新西兰大耳白兔5周后获得多克隆抗体。ELISA测定结果表明,TRIM59多克隆抗体效价为1∶106以上;Western blot分析表明,TRIM59多克隆抗体具有良好的特异性。免疫组织化学检测发现,TRIM59在小鼠前列腺癌组织细胞中高表达。【结论】成功地制备了特异性良好的兔抗鼠TRIM59多克隆抗体,其具有良好的免疫学活性,能够用于相关研究。 | 姜飞 刘小林 李喜莲 Jim W Xuan | 2009 | 西北农林科技大学学报(自然科学版)2009，37，12： | 2 |
| 3 | New Phenolic Constituents from the Stems of Spatholobus suberectus显示文摘 | Zhang S W Xuan L J | 2006 | Helvetica Chimica Acta2006，89，： | 1 |
| 4 | Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A显示文摘 | WANG S-H WANG S-F XUAN W | 2008 | Bioorganic & Medicinal Chemistry2008，16，7： | 1 |
| 5 | Engineering homochiral metal- organic frameworks for heterogeneous asymmetric cataly- sis and enantioselective separation 显示文摘 | Liu Y Xuan W Cui Y | 2010 | Adv Mater2010，22，37： | 1 |
| 6 | 查看详情显示文摘 | Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y | | 0，，： | 1 |
| 7 | A routing protocol for anycast messages显示文摘 | Xuan D Jia W J Zhao W | 2000 | IEEE Transactions on Parallel and Distributed Systems2000，11，6： | 1 |
| 8 | Characterization of organic cation/camitine transporter family in human sperm显示文摘 | Xuan W Lamhonwah AM Librach C | 2003 | Bio-chem2003，306，： | 1 |
| 9 | Rehydration reactivity of recycled mortar from concretewaste experienced to thermal treatment显示文摘 | SHUI Z H XUAN D X WAN H W | 2008 | Constructionand Building Materials2008，22，8： | 1 |
| 10 | Preladenant,a selective adenosine A (2A) receptor antagonist, is not associated with QT/ QTe prolongation显示文摘 | Wang Z Xuan F Lin W H | 2013 | European Journal of Clinical Pharmacology2013，69，10： | 1 |
| 11 | Distributed admission control for anycast flows显示文摘 | Jia W J Xuan D Tu W Q | 2004 | IEEE Transactions on Parallel and Distributed Systems2004，15，8： | 1 |
| 12 | The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene显示文摘 | Yiru G Keith W Xuan YT | 1999 | Proc Natl Acad Sci USA1999，96，11： | 1 |
| 13 | Modified penile lengthening surgery:review of 52 cases显示文摘 | Shirong L Xuan Z Zhengxiang W | | 0，，02： | 1 |
| 14 | A routing protocol for anycast message显示文摘 | Xuan D Jia W Zhao W Zhu H | 2000 | IEEE Transaction on Parallel and Distributed System2000，11，6： | 1 |
| 15 | Highly birefringent optical microfibers 显示文摘 | XUAN H JU J JIN W | 2010 | Op- tics Express2010，18，4： | 1 |
| 16 | Distributed admission control for anycast flows with QoS requirements显示文摘 | Xuan D Jia W | 2001 | IEEE International Conference on Distributed Computing Systems2001，，： | 1 |
| 17 | Odontogenic tumours:a retrospectivestudy of 1642 cases in a Chinese population显示文摘 | Jing W Xuan M Lin Y | 2007 | Int J Oral Maxil-lofac Surg2007，36，1： | 1 |
| 18 | Aggregation struc- ture and thermal conductivity of nanofluids 显示文摘 | XUAN Y M LI Q HU W F | 2003 | AIChEJ2003，49，4： | 1 |
| 19 | Conception for Heat Transfer Correlation of Nanofluids显示文摘 | Roetzel W | 2000 | Int J Heat Mass Transfer2000，43，： | 1 |
| 20 | Magnetically sepa- rable Fe304/TiO2 hollow spheres :fabrication and photoeat- alytic activity显示文摘 | Xuan S H Jiang W Q Gong X L | 2009 | J Phys Chem C2009，113，2： | 1 |
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