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| 1 | Glossy15 Plays an Important Role in the Divergence of the Vegetative Transition between Maize and Its Progenitor, Teosinte显示文摘 | Dingyi Xu Xufeng Wang Cheng Huang Guanghui Xu Yameng Liang Qiuyue Chen Chenglong Wang Dan Li Jinge Tian Lishuan Wu Yaoyao Wu Li Guo Xuehan Wang Weihao Wu Weiqiang Zhang Xiaohong Yang Feng Tian | 2017 | Molecular Plant2017，10，12： | 3 |
| 2 | TRIM47 is a novel endothelial activation factor that aggravates lipopolysaccharide-induced acute lung injury in mice via K63-linked ubiquitination of TRAF2显示文摘Endothelial activation plays an essential role in the pathogenesis of sepsis-induced acute lung injury,however,the detailed regulatory mechanisms remain largely unknown.Here,we reported that TRIM47,an E3 ubiquitin ligase of the tripartite motifcontaining protein family,was highly expressed in vascular endothelial cells.TRIM47-deficient mice were effectively resistant to lipopolysaccharide(LPS)-induced acute lung injury and death by attenuating pulmonary inflammation.TRIM47 was upregulated during TNFα-induced endothelial activation in vitro.Knockdown of TRIM47 in endothelial cells inhibited the transcription of multiple pro-inflammatory cytokines,reduced monocyte adhesion and the expression of adhesion molecules,and suppressed the secretion of IL-1βand IL-6 in endothelial cells.By contrast,overexpression of TRIM47 promoted inflammatory response and monocyte adhesion upon TNFαstimulation.In addition,TRIM47 was able to activate the NF-κB and MAPK signaling pathways during endothelial activation.Furthermore,our experiments revealed that TRIM47 resulted in endothelial activation by promoting the K63-linked ubiquitination of TRAF2,a key component of the TNFαsignaling pathway.Taken together,our studies demonstrated that TRIM47 as a novel activator of endothelial cells,promoted LPS-induced pulmonary inflammation and acute lung injury through potentiating the K63-linked ubiquitination of TRAF2,which in turn activates NF-κB and MAPK signaling pathways to trigger an inflammatory response in endothelial cells. | Yisong Qian Ziwei Wang Hongru Lin Tianhua Lei Zhou Zhou Weilu Huang Xuehan Wu Li Zuo Jie Wu Yu Liu Ling-Fang Wang Xiao-Hui Guan Ke-Yu Deng Mingui Fu Hong-Bo Xin | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 3 | Determination of nickel, chromium, copper, cadmium and manganese in silver nitrate by graphite furnace atomic absorption spectrophotometry显示文摘 | Wu Xuehan Cui Guangchen Peng yun | 1991 | Analytic Chemistry1991，19，11： | 1 |
| 4 | Highly efficient and non-doped red conjugated polymer dot for photostable cell imaging显示文摘By introducing a naphthothiadiazole(NT)unit as the main building block,a non-doped and red emissive conjugated polymer poly(9,9-dihexylfluorene-alt-naphthothiadiazole)(PFNT)is readily obtained through a two-step synthesis.Since the NT unit has a large twist angle with its neighboring segment,the aggregation-induced quenching(AIQ)effect of PFNT can be effectively suppressed in the condensed state.As a result,the corresponding PFNT polymer dot(Pdot)exhibits a high fluorescence quantum yield of53.2%with peak emission at 616 nm,which is one of the most efficient red Pdots known.PFNT Pdot shows good biocompatibility and can be employed for living cell fluorescent imaging with high brightness.It also can be used for specific subcellular organelle imaging through immunofluorescence labeling.Furthermore,the PFNT Pdot demonstrates much better photostability for long-time cell fluorescence imaging than commercial red dyes.The high performances of PFNT Pdot make it a promising fluorescent probe for practical bioapplications. | Mengqi Wu Qidong Wei Caihong Xian Chunlei Dai Xuehan He Changfeng Wu Guoming Sun Lei Chen | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
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