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您的检索式：作者名="Xuejia Lin"
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| 1 | Survey on cyberspace security显示文摘Along with the rapid development and wide application of information technology, human society has entered the information era. In this era, people live and work in cyberspace. Cyberspace is the collection of all information systems; it is the information environment for human survival. Therefore, it is necessary to ensure the security of cyberspace. This paper gives a comprehensive introduction to research and development in this field, with a description of existing problems and some currently active research topics in the areas of cyberspace itself, cyberspace security, cryptography, network security, information system security and information content security. | ZHANG HuanGuo HAN WenBao LAI XueJia LIN DongDai MA JianFeng LI JianHua | 2015 | Science China(Information Sciences)2015，58，11： | 15 |
| 2 | Discussion on the theoretical results of white-box cryptography显示文摘White-box cryptography(WBC) aims to resist attacks from attackers who can control all the implementation details of cryptographic schemes. In 2009, Saxena et al. proposed a fundamental of white-box cryptography via the notion 'white-box property'(WBP). Under this model, they proved that there do not exist obfuscators that can satisfy every security notion for a program(the negative result). On the other hand,they proved that there exists an obfuscator satisfying WBP for some security notion(the positive result). These contributions provide us a general cognition of WBC, which is big progress for the theoretical research. To better understand them, we make discussion on each result and achieve some new results. For the negative result, we prove that insufficiently secure obfuscator is the real cause of the negative result. We point out that the security of a white-box scheme cannot be guaranteed if it is instantiated by a less secure obfuscator, since the obfuscator used in their proof does not satisfy the 'Virtual Black-box Property' with auxiliary input. From our proof,we also conclude that the notion WBP is equal to 'Virtual Black-box Property with auxiliary input'. For the positive result, we prove that security notion under black-box model should not be used in white-box context without any modification; although the positive result is meaningful, it is unlikely to prove that an obfuscator satisfies WBP for IND-CPA, since the security notion 'IND-CPA' is under black-box model, which has different adversary with WBP. | Tingting LIN Xuejia LAI Weijia XUE Geshi HUANG | 2016 | Science China(Information Sciences)2016，59，11： | 0 |
| 3 | CFTR is a negative regulator ofγδT cell IFN-γproduction and antitumor immunity显示文摘CFTR,a chloride channel and ion channel regulator studied mostly in epithelial cells,has been reported to participate in immune regulation and likely affect the risk of cancer development.However,little is known about the effects of CFTR on the differentiation and function ofγδT cells.In this study,we observed that CFTR was functionally expressed on the cell surface ofγδT cells.Genetic deletion and pharmacological inhibition of CFTR both increased IFN-γrelease by peripheralγδT cells and potentiated the cytolytic activity of these cells against tumor cells both in vitro and in vivo.Interestingly,the molecular mechanisms underlying the regulation ofγδT cell IFN-γproduction by CFTR were either TCR dependent or related to Ca^(2+)influx.CFTR was recruited to TCR immunological synapses and attenuated Lck-P38 MAPK-c-Jun signaling.In addition,CFTR was found to modulate TCR-induced Ca^(2+)influx and membrane potential(Vm)-induced Ca^(2+)influx and subsequently regulate the calcineurin-NFATc1 signaling pathway inγδT cells.Thus,CFTR serves as a negative regulator of IFN-γproduction inγδT cells and the function of these cells in antitumor immunity.Our investigation suggests that modification of the CFTR activity ofγδT cells may be a potential immunotherapeutic strategy for cancer. | Yuanyuan Duan Guangqiang Li Miaomiao Xu Xiaofei Qi Mingxia Deng Xuejia Lin Zhiwei Lei Yi Hu Zhenghu Jia Quanli Yang Guangchao Cao Zonghua Liu Qiong Wen Zhenhua Li Jie Tang Wei Kevin Zhang Pingbo Huang Limin Zheng Richard A.Flavell Jianlei Hao Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，8： | 0 |
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