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| 1 | Parthenolide protects human lens epithelial cells from oxidative stress-induced apoptosis via inhibition of activation of caspase-3 and caspase-9显示文摘透镜的 apoptosis 上皮的房间作为奔流形成的普通基础被建议了,与是的氧化应力主要原因。这研究被执行对人的透镜的导致 oxidativestress 的 apoptosis 调查草药的成分 parthenolide 的保护的效果上皮(HLE ) 房间和可能的分子的机制包含了。HLE 房间(SRA01-04 ) 在 parthenolide (10, 20 和 50 microM ) 的不同剂量的缺席或存在与 50 microM H (2 ) O (2 ) 被孵化。到学习 apoptosis,房间被词法检查和 Annexin V-propidium 碘化物估计两倍染色的流动 cytometry;调查内在的分子的机制, caspase-3 和 caspase-9 的表示旁边是 assayed 西方的污点和量的 RT-PCR,和 caspase-3 和 caspase-9 的活动我们由 Chemicon caspase 的 remeasured 比色的活动试金工具包。为 18 h 与 H (2 ) O (2 ) 刺激了,, HLE 房间的高部分面对不同集中的 parthenolide 经历了 apoptosis, HLE 房间 apoptosis 堵住的剂量依赖者被观察。H (2 ) O (2 ) 在 HLE 房间导致的表示 ofcaspase-3 和 caspase-9 被 parthenolideboth 显著地在蛋白质和信使 rna 层次减少,并且 caspase-3 和 caspase-9 的激活被 parthenolide 也以一种剂量依赖者方式压制。在结论, parthenolide 通过 caspase-3 andcaspase-9 的激活的抑制阻止 HLEcells 氧化导致压力的 apoptosis,建议对奔流形成的潜在的保护的效果。 | Hangping Yao Xiajing Tang Xueting Shao Lei Feng Nanping Wu Ke Yao | 2007 | Cell Research2007，17，6： | 16 |
| 2 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 3 | Involvements of chloride ion in decolorization of Acid Orange 7 by activated peroxydisulfate or peroxymonosulfate oxidation显示文摘The effects of chloride anion (Cl-) (up to 1.0 mol/L) on the decolorization of a model compound,azo dye Acid Orange 7 (AO7),by sulfate radical (SO4-) based-peroxydisulfate (PS) or peroxymonosulfate (PMS) oxidation under various activated conditions (UV 254 nm /PS,Thermal (70°C/PS,UV 254 nm /PMS,Co 2+ /PMS) were investigated.Methanol and NH4 + were used as quenching reagents to determine the contributions of active chlorine species (dichloride radical (Cl2-.) and hypochlorous acid (HClO)).The results indicated that the effects of Cl- on the reaction mechanism were different under various activated conditions.For UV/PS and Thermal/PS,the inhibition tendency became more clear as the Cl- concentration increased,probably due to the reaction between Cl- and SO4-.and the generation of Cl2-.or HClO.For UV/PMS,Cl- did not exhibit inhibition when the concentration was below 0.1 mol/L.As Cl- concentration reached to 1.0 mol/L,the decolorization rate of AO7 was,however,accelerated,possibly because PMS directly reacts with Cl- to form HClO.For Co2+ /PMS,Cl- exhibited a significant inhibiting effect even at low concentration ( 0.01 mol/L).When Cl- concentration exceeded 0.1 mol/L,the activation of PMS by Co 2+ was almost completely inhibited.Under this condition,HClO maybe played a major role in decolorization of AO7.The results implicated that chloride ion is an important factor in SO4-.-based degradation of organic contamination in chloride-containing water. | Ping Wang Shiying Yang Liang Shan Rui Niu Xueting Shao | 2011 | Journal of Environmental Sciences2011，23，11： | 7 |
| 4 | Honokiol: an effective inhibitor of tumor necrosis factor-α-induced up-regulation of inflammatory cytokine and chemokine production in human synovial fibroblasts显示文摘在这研究,我们调查了在肿瘤坏死因素(TNF ) 位于 honokiol 的反煽动性的效果下面的机制 -- 刺激风湿性关节炎 synovial 成纤维细胞(RASF ) 。RASF 与 honokiol (020 M ) 预先对待与 TNF-(20 ng/ml ) 被刺激。前列腺素 E2 ( PGE2 )的层次,氮的氧化物(没有),可溶的细胞间的粘附 molecule-1 ( sICAM-1 ),转变生长 factor-1 ( TGF-1 ),单核白血球趋化性的 protein-1 ( MCP-1 ),并且巨噬细胞在上层清液的煽动性的 protein-1 ( MIP-1 )被连接酶的 immunosorbent 试金( ELISA )和 Griess 试金决定。另外, cyclooxygenase-2 (COX-2 ) 的蛋白质表示层次,可诱导的氮的氧化物 synthase (iNOS ) ,和 phosphorylated Akt,原子因素 kappa B (NFB ) ,和细胞外的调整信号的 kinase (英皇家空军之阶级最低之兵) 1/2 被西方的污点决定。NFBp65 的表示被 immunocytochemical 分析估计。TNF- 处理显著地起来调整 PGE2 的层次,不在 RASF 的上层清液的 sICAM-1, TGF-1, MCP-1,和 MIP-1,在 RASF 增加了 Akt, IB- , NFB,和 ERK1/2 的 COX-2, iNOS,和导致的 phosphorylation 的蛋白质表示。TNF -- 这些分子的导致的表示被预告的处理与 honokiol 以一种剂量依赖者方式禁止。在 NFBp65 活动的 honokiol 的禁止的效果被 immunocytochemical 分析也证实。在结论, honokiol 是 TNF 的一个潜在的禁止者 -- 在 RASF 导致了煽动性的因素的表示,抓住作为潜在的反煽动性的药答应它。 | Jie Li Xueting Shao Lijuan Wu Tingting Feng Changzhong Jin Meixin Fang Nanping Wu Hangping Yao | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 4 |
| 5 | Activated carbon catalyzed persulfate oxidation of Azo dye acid orange 7 at ambient temperature显示文摘 | Shiying Yang Xin Yang Xueting Shao Rui Niu Leilei Wang | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 6 | Decolorization of Acid Orange 7 with peroxymonosulfate oxidation catalyzed by granular activated carbon 显示文摘 | Jun Zhang Xueting Shao Chao Shi | 2013 | Chemical Engineering Journal2013，232，： | 1 |
| 7 | Degradation efficiencies of azo dye Acid Orange 7 by the interaction of heat, UV and anions with common oxidants: Persulfate, peroxymonosulfate and hydrogen peroxide显示文摘 | Shiying Yang Ping Wang Xin Yang Liang Shan Wenyi Zhang Xueting Shao Rui Niu | 2010 | Journal of Hazardous Materials2010，，1： | 1 |
| 8 | Activated carbon cat-alyzed persulfate oxidation of A zo dye acid orange 7 at ambient tem-perature显示文摘 | Yang Shiying Yang Xin Shao Xueting | 2011 | Journal of Hazardous Materials2011，186，1： | 1 |
| 9 | Inhibitory effects of human immunodeficiency virus gp120 and Tat on CpG-A-induced inflammatory cytokines in plasmacytoid dendritic cells显示文摘Plasmacytoid 树枝状的房间(pDCs ) ,不是仅仅禁止病毒的复制,而且在连接天生、适应的免疫系统起一个必要作用。在这研究,我们探索了人的免疫不全的效果病毒(HIV ) gp120 并且在 pDCs 在 CpG-A-induced 煽动性的 cytokines 上梭织。结果提供了基本卓见进可以为预防和甚至药品策略保持诺言的 HIV 致病。pDCs 用血 DC 抗原 4 被孤立(BDCA-4 ) DC 隔离工具包,和纯净被流动 cytometry 用 BDCA-2 抗体分析。pDCs 和外部血 mononuclear 房间(PBMC ) 被任何一个 CpG 刺激 -- 一(5 敲吗? | Meixin Fang Ning Xu Xueting Shao Jin Yang Nanping Wu Hangping Yao | 2012 | Acta Biochimica et Biophysica Sinica2012，44，9： | 0 |
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