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| 1 | Fracture of two three-dimensional parallel internal cracks in brittle solid under ultrasonic fracturing显示文摘Similar to hydraulic fracturing(HF), the coalescence and fracture of cracks are induced within a rock under the action of an ultrasonic field, known as ultrasonic fracturing(UF). Investigating UF is important in both hard rock drilling and oil and gas recovery. A three-dimensional internal laser-engraved crack(3D-ILC) method was introduced to prefabricate two parallel internal cracks within the samples without any damage to the surface. The samples were subjected to UF. The mechanism of UF was elucidated by analyzing the characteristics of fracture surfaces. The crack propagation path under different ultrasonic parameters was obtained by numerical simulation based on the Paris fatigue model and compared to the experimental results of UF. The results show that the 3D-ILC method is a powerful tool for UF research.Under the action of an ultrasonic field, the fracture surface shows the characteristics of beach marks and contains powder locally, indicating that the UF mechanism includes high-cycle fatigue fracture, shear and friction, and temperature load. The two internal cracks become close under UF. The numerical result obtained by the Paris fatigue model also shows the attraction of the two cracks, consistent with the test results. The 3D-ILC method provides a new tool for the experimental study of UF. Compared to the conventional numerical methods based on the analysis of stress-strain and plastic zone, numerical simulation can be a good alternative method to obtain the crack path under UF. | Haijun Wang Hanzhang Li Lei Tang Xuhua Ren Qingxiang Meng Chun Zhu | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，3： | 4 |
| 2 | Structural basis for the neutralization of hepatitis E virus by a cross-genotype antibody显示文摘肝炎 E 病毒(HEV ) ,一个非包的、积极感觉的、搁浅单人赛的 RNA 病毒,是伤寒肝炎的一个主要原因。分类进家庭 Hepeviridae, HEV 包括四遗传型(遗传型 1-4 ) ,它属于单个 serotype。我们描述 monoclonal 抗体(mAb ) ,有 ~ 2.53-3.45 nM 的 8G12,同等地认出 HEV 的所有四遗传型,有约束力的亲密关系。mAb 8G12 有一保护,抵销能力,它能显著地在主人房间堵住病毒感染。动物与 1, 3 和 4 证实了跨遗传型的抵销的遗传型学习 8G12 和它肝炎 E 疾病的有效预防的能力。有丰富的遗传型的 HEV E2s 领域(病毒衣壳的最耸出的区域) 的 8G12 的复杂水晶结构 1 和 4 在 4.0 和 2.3 Å 被决定;分辨率分别地。这些结构表明 8G12 在 E2s dimerization 区域通过 epitopes 认出两遗传型。有像病毒的粒子的基于结构的 mutagenesis 和房间模型试金识别了为 8G12 中立化是必要的几保存残余(Glu549, Lys554 和 Gly591 ) 。而且, 8G12 的 epitope 作为涉及病毒主人相互作用的关键 epitope 被识别。这些调查结果将帮助为 HEV 感染的最丰富的形式的预防开发普通策略。 | Ying Gu Xuhua Tang Xiao Zhang Cuiling Song Minghua Zheng Kaihang Wang Jun Zhang Mun-Hon Ng Choy-Leong Hew Shaowei Li Ningshao Xia J. Sivaraman | 2015 | Cell Research2015，25，5： | 3 |
| 3 | Fracturing behavior of brittle solids containing 3D internal crack of different depths under ultrasonic fracturing显示文摘Ultrasonic fracturing(UF)can be used to form crack networks for oil or gas in the mining industry and hard rock excavation.In this paper,the three-dimensional internal laser-engraved crack method(3DILC)is introduced to make penny-shaped internal crack within the samples without any damage to the surfaces.Physical experiments were performed on the transparent samples with internal cracks at different depths.The macro-and micro-fracture fractography characteristics were focused on and analyzed in details.Based on fractography,the mechanisms of the UF were revealed.The propagation paths of cracks of different depths were simulated based on the Paris fatigue model and compared with experimental results.The results show that the 3D-ILC method is a powerful tool for the experimental research on the internal crack propagation in the UF.Under the action of ultrasonic field,fractography shows the characteristics of beach marks,lance-like pattern,rime-like pattern and glass powder.It can be judged that the mechanisms of UF include high cycle fatigue fracture,shear fracture,and friction.The results of the numerical simulation using the Paris fatigue model are consistent with the experimental results. | Haijun Wang Hanzhang Li Lei Tang Jianchun Li Xuhua Ren | 2022 | International Journal of Mining Science and Technology2022，32，6： | 1 |
| 4 | Determination of D-saccharic acid-l,4-1actone from brewed kombucha broth by high-performance capillary electrophoresis显示文摘 | WANG Kan GAN Xuhua TANG Xinyun | 2010 | Journal of Chromatography B2010，878，： | 1 |
| 5 | 拟杆菌Bacteroides sp Pif1蛋白解旋酶机制的结构与功能探究显示文摘Pif1蛋白是一个保守的DNA解旋酶,属于SF1B家族成员。Pif1通过解旋双链DNA(dsDNA)、DNA/RNA杂合体、G4结构等,参与基因组稳定性维持的调控过程。 | Xianglian Zhou Wendan Ren SakshibeeduR.Bharath Xuhua Tang Yang He Chen Chen Zhou Liu Dewang Li 宋海卫 | 2017 | 科学新闻2017，19，4： | 0 |
| 6 | A Brief Summary of Current Therapeutic Strategies for Spinal Cord Injury显示文摘Spinal cord injury(SCI)is a tremendous disaster in a person’s life.It interrupts the brain-body neuronal circuits,resulting in functional deficits.Pathogenesis of SCI is a progressive and comprehensive event.In clinical trials,attempts to promote nerve regeneration and functional recovery after SCI have met with failures.Recently,with the development of transcriptome sequencing and biomaterials,researchers have struggled to explore novel efficient therapeutic treatments for SCI.Here,we summarize the recent pro-gress that has been made in SCI repair based on the lesion microenvironment,neural circuits,and bioma-terial scaffolds.We also propose several important directions for future research,including targeted-microRNA therapy,blood vessel interventions,and multiple treatment combinations.In short,we hope this review will enlighten researchers in the field and pave the way for SCI therapy. | Chun Yao Xin Tang Yuqi Cao Xuhua Wang Bin Yu | 2022 | Engineering2022，8，6： | 0 |
| 7 | Structural basis for specific recognition of pre-snRNA by Gemin5显示文摘 | Xuhua Tang Sakshibeedu R Bharath Shunfu Piao Vanessa Qianmin Tan Matthew W Bowler Haiwei Song | 2016 | Cell Research2016，26，12： | 0 |
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