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| 1 | Control of apoptosis and mitotic spindle checkpoint by survivin显示文摘 | Li F Ambrosini G Chu E Y | | 0，，： | 8 |
| 2 | 笋芽顶端分生组织在竹秆横切面形态形成中的作用与机制研究显示文摘竹秆的横切面主要由表皮、皮层、维管组织、基本组织及髓腔(早期为髓组织)组成。这些组织均由笋芽茎顶端分生组织分化发育而来,且其在生长发育过程中促使了竹秆横切面形态(本文特指:竹秆横切面外轮廓形状、围度及壁-腔结构)的形成。然而,人们对于这一生长发育过程的生物学机制知之甚少。本研究利用解剖学、数学模拟等方法,对 20 种具不同秆径竹种的笋芽顶端分生组织进行了分析。研究结果发现,笋芽顶端分生组织指状形态的维持是竹子产生圆柱形竹秆的基础;在顶端分生组织细胞数目增加的同时,线性增加原体细胞数目应是竹子在演化过程中产生大径竹秆且保持规则壁-腔结构的方式。进一步通过研究一个竹壁增厚且壁-腔架构紊乱的稳定变异体———实肚竹( Phyllostachys nidularia f. farcta)发现,其笋芽顶端分生组织细胞数目减少且原体/原套细胞数比值降低使其产生了高比例的壁组分组织(指基本分生组织与肋状分生组织)与低比例的髓组织。上述 2 种组织的比例失衡,使得实肚竹笋芽在后续发育中壁组分组织随机挤入到了髓组织中,最终形成了实肚竹异常的竹秆横切面形态(竹壁多样化增厚且壁-腔结构紊乱)。此外,相对较小的顶端分生组织,使得实肚竹笋芽产生了较少的内源激素,如其生长素含量仅约为其原种篌竹的 67. 5%,各细胞分裂素含量也显著低于篌竹笋芽。转录组分析进一步发现,在实肚竹笋芽中与激素及代谢相关的功能基因呈显著下调表达。这些生理与分子变化最终导致了实肚竹竹秆矮化、秆径减小且生物量降低。本论文的研究结果为研究竹秆横切面发育提供了一个重要的视角,同时也为实肚竹厚壁茎秆的形成提出了一个合理的机制。 | Wang Y Sun X Ding Y Fei Z Jiao C Fan M Yao B Xin P Chu J Wei Q 王雨珺 魏强 | 2019 | 世界竹藤通讯2019，17，3： | 5 |
| 3 | Distribution of pericellular matrix molecules in the temporomandibular joint and their chondroprotective effects against inflammation显示文摘The objectives of this study were to(1) determine the distribution and synthesis of pericellular matrix(PCM) molecules(collagen VI, collagen IV and laminin) in rat temporomandibular joint(TMJ) and(2) investigate the effects of PCM molecules on chondrocytes against inflammation in osteoarthritis. Four zones(fibrous, proliferating, mature and hypertrophic) of condylar cartilage and three bands(anterior, intermediate and posterior) of disc were analysed by immunohistochemistry for the presence of PCM molecules in rat TMJs. Isolated chondrocytes were pre-treated with PCM molecules before being subjected to interleukin(IL)-1β treatment to stimulate inflammation. The responses of the chondrocytes were analysed using gene expression, nitric oxide release and matrix metalloproteinase(MMP)-13 production measures. Histomorphometric analyses revealed that the highest areal deposition of collagen VI(67.4%), collagen IV(45.7%) and laminin(52.4%) was in the proliferating zone of TMJ condylar cartilage. No significant difference in the distribution of PCM molecules was noted among the three bands of the TMJ disc. All three PCM molecules were expressed intracellularly by chondrocytes cultured in the monolayer. Among the PCM molecules, pre-treatment with collagen VI enhanced cellular proliferation, ameliorated IL-1β-induced MMP-3, MMP-9, MMP-13 and inducible nitric oxide synthase gene expression, and attenuated the downregulation of cartilage matrix genes, including collagen I, aggrecan and cartilage oligomeric matrix protein(COMP). Concurrently, collagen VI pretreatment inhibited nitric oxide and MMP-13 production. Our study demonstrates for the first time the distribution and role of PCM molecules, particularly collagen VI, in the protection of chondrocytes against inflammation. | Wern Cui Chu Shipin Zhang Timothy J Sng Yu Jie Ong Wen-Li Tan Vivien Y Ang Casper B Foldager Wei Seong Toh | 2017 | International Journal of Oral Science2017，9，1： | 5 |
| 4 | 等离子体浸没离子注入绝缘材料的研究显示文摘等离子体浸没离子注入是一种新形式的离子注入技术,是利用负偏压工件周围形成的等离子体鞘层进行离子加速、进而获得离子注入。等离子体注入的前提条件是工件导电,因此对于绝缘材料的等离子体注入可能存在问题。本文从理论和实际处理的角度论证了绝缘材料等离子体注入的可能性、可操作性,并给出了一些实际例证。 | 田修波 杨士勤 Ricky K Y Fu Paul K Chu | 2006 | 核技术2006，29，5： | 3 |
| 5 | Mechanism of embrittlement of Al alloy by liquid metal 显示文摘 | CHU W Y LIN X M LUO J L | 1999 | Canadian Metallurgical Quarterly1999，38，2： | 2 |
| 6 | 菱面体畸变的钙钛矿结构多铁性氧化物薄膜畴界精细结构显示文摘畴是所有铁性材料的一个共同本质特性,畴及畴界的结构极大影响着材料性能。本文应用高分辨透射电子显微学和定量电子显微学,在原子尺度定量研究了钙钛矿菱面体结构多铁性薄膜BiFeO3的109°畴界的精细结构,包括畴界附近阳离子位移及局部铁电极化分布。结果表明:正是由于畴界附近原子发生微小位移,导致材料能带的变化,带隙减小,从而在绝缘BiFeO3中产生独特的导电性能。这不仅为研究铁电极化反转和磁电效应等科学问题提供关键的定量结构信息,同时也促进相关材料的设计和性能优化。 | 詹倩 于荣 CHU Y H MARTIN L W RAMESH R | 2010 | 电子显微学报2010，29，5： | 2 |
| 7 | Anti-hypertensive drugs in children and adolescents显示文摘Worldwide the prevalence of essential hypertension inchildren and adolescents continues to increase. Tradi-tionally providers have used 'off-label' drugs to treatpediatric hypertension, meaning that rigorous clinicaltrials of these drugs have not been specifically per-formed in pediatric patient populations. Consequentlyproviders have extrapolated dosing, safety and efficacyfrom trials in adults. This practice is sub-optimal as chil-dren demonstrate unique differences in drug metabo-lism and response. Use of unstudied or understudieddrugs increases risk of adverse events and/or can leadto sub-optimal efficacy. Recognizing these concerns,regulatory agencies have created financial incentivesfor industry to conduct pediatric clinical trials. Theseincentives, coupled with the emerging pediatric hyper-tension epidemic, have spurred over 30 clinical trialsof anti-hypertensive drugs over the past 15 years andhave resulted in labeling of 10 new drugs by the UnitedStates Food and Drug Administration for treatment ofhypertension in children and adolescents. Unfortunatelythe financial incentive structures focus on newer drugsand drug classes. Consequently there is now a relativedearth of trial data for older but sometimes commonlyprescribed pediatric antihypertensive drugs. This article reviews recent pediatric antihypertensive drug trials with a focus on trial design and endpoints, drug dosing, safety, efficacy and specific drug indications. We also review the available data and experience for some of the more commonly prescribed, but less well studied 'older' pediatric antihypertensive drugs. | Patricia Y Chu Michael J Campbell Stephen G Miller Kevin D Hill | 2014 | World Journal of Cardiology2014，6，5： | 2 |
| 8 | Faraday current sensor that uses a triangular-shaped bulk-optic sensing element 显示文摘 | CHU B C B NING Y N JACKSON D A | 1992 | Opt Lett1992，17，16： | 2 |
| 9 | The prevalence of dementia in urban and rural areas of China显示文摘 | Jianping Jia Fen Wang Cuibai Wei Aihong Zhou Xiangfei Jia Fang Li Muni Tang Lan Chu Youlong Zhou Chunkui Zhou Yong Cui Qi Wang Weishan Wang Peng Yin Nan Hu Xiumei Zuo Haiqing Song Wei Qin Liyong Wu Dan Li Longfei Jia Juexian Song Ying Han Yi Xing Peijie Y | 2013 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2013，，： | 2 |
| 10 | Hospital lift system simulator: A performance Evaluator Predictor显示文摘 | Sydney C K Chu Lin C K Y Lam S S | 2003 | European Journal of Operational Research2003，146，1： | 1 |
| 11 | Studies on the constituents from the bark of Bauhinia purpurea 显示文摘 | Kuo Y H Chu P H | 2002 | J Chin Chem Soc2002，49，2： | 1 |
| 12 | Synthesis and Preliminary Biological Evaluation of the ^99Tc^m Labeled Nitrobenzoimidazole and Nitrotriazole as Tumor Hypoxia Markers 显示文摘 | Zhang Y Chu T Gao X | 2006 | Bioorg Med Chem Let2006，16，： | 1 |
| 13 | Comparing suprapu bic urine aspiration under real-time ultrasound guidance with conventional blind aspiration显示文摘 | Chu R W Wong Y C Luk S H Wong S N | 2002 | Acta Paediatr2002，91，： | 1 |
| 14 | A very simple and low cost route to Bi2 S3 nanorods bundles and dandelion-like nanostructures显示文摘 | Dong L H Chu Y Zhang W | 2008 | Mater Lett2008，62，27： | 1 |
| 15 | Regulatory CD4^+ CD25^+ T ceils in tumors from patients with early-stage non-small cell lung cancer and latestage ovarian cancer显示文摘 | Woo E Y Chu C S Goletz T J | 2001 | Cancer Res2001，61，： | 1 |
| 16 | l Medicalapplication of NiTi shape memory alloy in China显示文摘 | Y CHU K DAI M ZHU eta | 2000 | Materials Science Forum2000，，327： | 1 |
| 17 | Cutting edge:Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation显示文摘 | YEH H CHU C S | 2002 | J Immunol2002，168，9： | 1 |
| 18 | Coherent temporal oscillations of macroscopic quantum states in a Josephson junction显示文摘 | Yu Y Han S Chu X | 2002 | Science2002，296，5569： | 1 |
| 19 | Wind-induced vibration of high-rise building with tuned mass damper including soil-structure interaction显示文摘 | Liu M Y Chiang W L Hwang J H Chu C R | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，： | 1 |
| 20 | Sexual behavior and risks for HIV infection and transmission among male injecting drug uses in Yunnan, China显示文摘 | Yao Y Wang N Chu J | 2009 | International Journal of Infection Diseases2009，13，2： | 1 |
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