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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | The development of abdominal aortic aneurysms in mice is enhanced by benzo(a) pyrene 显示文摘 | Zhang Y Ramos KS | 2008 | Vasc Health Risk man- age2008，4，5： | 1 |
| 3 | Sequence analysis of RNase MRP RNA reveals its origination from eukaryotic RNase P RNA显示文摘 | Zhu Y Stribinskis V Ramos K S | 2006 | RNA2006，12，5： | 1 |
| 4 | Whey and soy protein hydrolysates inhibit lipid oxidation in cooked pork patties 显示文摘 | Pena- Ramos E A Xiong Y L | 2003 | Meat Science2003，64，： | 1 |
| 5 | Physico-chemical characteristics of goat and sheep milk 显示文摘 | PARK Y W JUAREZ M RAMOS M | 2007 | Small Ruminant Research2007，68，： | 1 |
| 6 | Reduced- dimension blind space - time 2 - D Rank receivers for DS - CDMA communication systems 显示文摘 | CHEN Y F ZOLTOWSKI M D RAMOS J | 2000 | IEEE Trans on Signal Process2000，48，： | 1 |
| 7 | The induction of prolifera- tive vascular smooth muscle cell phenotypes by benzo(a) pyrene is characterized by up-regulation of inositol phospholipid metabo- lism and c-Ha-ras gene expression 显示文摘 | Ramos KS Zhang Y Sadhu DN | 1996 | Arch Biochem Biophys1996，332，2： | 1 |
| 8 | Novel sites of aldose reductase immunolocalization in normal and streptozotocin- diabetic rats显示文摘 | Jiang Y Calcutt NA Ramos KM | 2006 | J Peripher Nerv Syst2006，11，4： | 1 |
| 9 | Whey and soy protein hydrolysates inhibit lipid oxidation in cooked pork pattie 显示文摘 | Pefia- Ramos E A Xiong Y L | 2003 | Meat Science2003，6，3： | 1 |
| 10 | The induction of proliferative vascular smooth muscle cell phenotypes by benzo ( a ) pyrene is characterized by up-regulation of inositol phospholipid metabolism and c-Ha-ras gene expression显示文摘 | Ramos KS Zhang Y Sadhu DN | 1996 | Arch Biochem Biophys1996，332，2： | 1 |
| 11 | Medullary carcinoma of the breast: a malignant lesion mimicking a benign one 显示文摘 | Lorente Ramos RM del Valle Sanz Y Alcaraz Mexia MJ | 2006 | Radiologia2006，48，3： | 1 |
| 12 | In silico analysis of accurate proteomics, complemented by selective isolation of pep- tides显示文摘 | Y Perez - Riverol A S Nchez Y Ramos | 2011 | Journal of Proteomics2011，74，10： | 1 |
| 13 | Detection of moisture and methanol gas using a single electrospun tin oxide nanofiber显示文摘 | Wang Y Ramos I Santiago-Aviles J J | 2007 | Sensors Journal IEEE2007，7，9： | 1 |
| 14 | AC electrokinetic pumping on symmetric electrode arrays 显示文摘 | YANG H K JIANG H Y RAMOS A | 2009 | Mierofluid Nanofluid2009，7，6： | 1 |
| 15 | Mechanistic studies on Lewis acid catalyzed Biginelli reactions in ionic liquids: Evidence for the reac- tive intermediates and the role of the reagents 显示文摘 | Ramos L M Ponce de Leon Y Tobio A Y dos Santos M R | 2012 | Journal of Organic Chemistry2012，77，10： | 1 |
| 16 | Detection of moisture and methanol gas using a single electro- spun tin oxide nanofiber 显示文摘 | WANG Y RAMOS I SANTIAGO AVILES J J | 2007 | Sensors Journal IEEE2007，7，9： | 1 |
| 17 | Relationship between occupational stress and burnout among Chinese teachers:a cross-sectional survey in Liaoning,China显示文摘 | Wang Y Ramos A Wu H | 2015 | Int Arch Occup Environ Health2015，88，5： | 1 |
| 18 | In vivo bioluminescence imaging to evaluate systemic and topical antibiotics against community-acquired methicillin-resistant Staphylococcus aureus-infected skin wounds in mice显示文摘 | Guo Y Ramos R I Cho J S | 2013 | Antimicrobial agents and chemotherapy2013，57，2： | 1 |
| 19 | Prediction of surgical site infection after colorectal surgery显示文摘 | Pedroso-Fernandez Y Aquirre-Jaime A Ramos MJ | 2016 | Am J Infect Control2016，44，4： | 1 |
| 20 | Whey and soy protein hydrolysates inhibit lipid oxidation in cooked pork patties显示文摘 | Ramos E A Xiong Y L | 2003 | Meat Scince2003，64，3： | 1 |
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