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| 1 | The Role of TNF Related Apoptosis-Inducing Ligand in Neurodegenerative Diseases显示文摘A hallmark of all forms of neurodegenerative diseases is impairment of neuronal functions, and in many cases neuronal cell death. Although the etiology of neurodegenerative diseases may be distinct, different diseases display a similar pathogenesis, for example abnormal immunity within the central nervous system (CNS), activation of macrophage/microglia and the involvement of proinflammatory cytokines. Recent studies show that neurons in a neurodegenerative state undergo a highly regulated programmed cell death, also called apoptosis. TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, has been shown to be involved in apoptosis during many diseases. As one member of a death ligand family, TRAIL was originally thought to target only tumor cells and was not present in CNS. However, recent data showed that TRAIL was unregulated in HIV-1-infected and immune-activated macrophages, a major disease inducing cell during HIV-1-associated dementia (HAD). TRAIL is also induced on neuron by β-amyloid protein, an important pathogen for Alzheimer's disease. In this review, we summarize the possible common aspects that TRAIL involved those neurodegenerative diseases, TRAIL induced apoptosis signaling in the CNS cells, and specific role of TRAIL in individual diseases. Cellular & Molecular Immunology. 2005;2(2):113-122. | Y.Huang N.Erdmann H.Peng Y.Zhao | 2005 | Cellular & Molecular Immunology2005，2，2： | 15 |
| 2 | Corrosion behavior of Mg-Gd-Zn based alloys in aqueous NaCl solution显示文摘The corrosion behavior of Mg-10Gd-xZn(x=2,6 wt.%)alloys in 0.5 wt.%NaCl solution was investigated.Microstructures of both the alloys consisted of(Mg,Zn)_(3) Gd phase and lamellar long period stacking ordered(LPSO)phase.The morphology of the second phase at the grain boundary differed in both alloys:it was a continuous network structure in Mg-10Gd-6Zn,whereas it was relatively discrete in Mg-10Gd-2Zn.The dendrites were finer in size and highly branched in Mg-10Gd-6Zn.The corrosion results indicated that the increase in Zn content increased the corrosion rate in Mg-10Gd-xZn alloys.Micro-galvanic corrosion occurred near the grain boundary in both alloys initially as the grain boundary phase was stable and acted as a cathode,however,filiform corrosion dominated in the later stage,which was facilitated by the LPSO phase in the matrix.Severe micro-galvanic corrosion occurred in Mg-10Gd-6Zn due to the higher volume of second phase.The stability of the second phase at the grain boundary was altered and dissolved after the long immersion times.Probably the NaCl solution chemically reacted with the grain boundary phase and de-stabilized it during the long immersion times,and was removed by the chromic acid used for the corrosion product removal. | A.Srinivasan C.Blawert Y.Huang C.L.Mendis K.U.Kainer N.Hort | 2014 | Journal of Magnesium and Alloys2014，2，3： | 15 |
| 3 | Amyloid,tau,pathogen infection and antimicrobial protection in Alzheimer’s disease-conformist,nonconformist,and realistic prospects for AD pathogenesis显示文摘Background:Alzheimer’s disease(AD)is a fatal disease that threatens the quality of life of an aging population at a global scale.Various hypotheses on the etiology of AD have been developed over the years to guide efforts in search of therapeutic strategies.Main body:In this review,we focus on four AD hypotheses currently relevant to AD onset:the prevailing amyloid cascade hypothesis,the well-recognized tau hypothesis,the increasingly popular pathogen(viral infection)hypothesis,and the infection-related antimicrobial protection hypothesis.In briefly reviewing the main evidence supporting each hypothesis and discussing the questions that need to be addressed,we hope to gain a better understanding of the complicated multi-layered interactions in potential causal and/or risk factors in AD pathogenesis.As a defining feature of AD,the existence of amyloid deposits is likely fundamental to AD onset but is insufficient to wholly reproduce many complexities of the disorder.A similar belief is currently also applied to hyperphosphorylated tau aggregates within neurons,where tau has been postulated to drive neurodegeneration in the presence of pre-existing Aβplaques in the brain.Although infection of the central nerve system by pathogens such as viruses may increase AD risk,it is yet to be determined whether this phenomenon is applicable to all cases of sporadic AD and whether it is a primary trigger for AD onset.Lastly,the antimicrobial protection hypothesis provides insight into a potential physiological role for Aβpeptides,but how Aβ/microbial interactions affect AD pathogenesis during aging awaits further validation.Nevertheless,this hypothesis cautions potential adverse effects in Aβ-targeting therapies by hindering potential roles for Aβin anti-viral protection.Conclusion:AD is a multi-factor complex disorder,which likely requires a combinatorial therapeutic approach to successfully slow or reduce symptomatic memory decline.A better understanding of how various causal and/or risk factors affecting disease onset and progression will enhance the likelihood of conceiving effective treatment paradigms,which may involve personalized treatment strategies for individual patients at varying stages of disease progression. | Hongmei Li Chia-Chen Liu Hui Zheng Timothy Y.Huang | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 4 | A Single-phase Spindle Motor Design for DVD Application显示文摘A single phase brushless spindle motor with innovative design has been developed for application in a DVD drive. The methods used to reduce the cogging torque and to improve the dynamic performance of this new design motor are proposed in this paper. The single phase brushless spindle motor is usually applied for cooling fan, pump and blower before the performance is improved by the reengineering process. The stator configuration and the drive circuit have been remodeled in order to meet the requirements of the spindle motor used in the DVD applications. | D.R.Huang, T.F.Ying, L.T.Kuo, S.J.Wang, H.C.Huang and C. Y.Huang (Opto-Electronic & System Labs., ITRI, Chutung, Hsinchu, Taiwan-China) | 2000 | Journal of Materials Science & Technology2000，16，2： | 4 |
| 5 | Genes important for survival or reproduction in Varroa destructor identified by RNAi显示文摘The Varroa mite,(Varroa destructor),is the worst threat to honey bee health worldwide.To explore the possibility of using RNA interference to control this pest, we determined the effects of knocking down various genes on Varroa mite survival and reproduction.Double-stranded RNA (dsRNA)of six candidate genes (Da,Pros26S,RpL8, RpL11,RpPO and RpS13)were synthesized and each injected into Varroa mites,then mite survival and reproduction were assessed.Injection of dsRNA for Da (Daughterless)and Pros26S (Gene for proteasome 26S subunit adenosine triphosphatase)caused a significant reduction in mite survival,with 3.57%±1.94% and 30.03%±11.43% mites surviving at 72 h post-inj ection (hpi),respectively.Control mites injected with green fluorescent protein (GFP)-dsRNA showed survival rates of 81.95%±5.03% and 82.36 ±2.81%,respectively. Injections of dsRNA for four other genes (RpL8,RpL11,RpPO and RpS13)did not affect survival significantly,enabling us to assess their effect on Varroa mite reproduction.The number of female offspring per mite was significantly reduced for mites injected with dsRNA of each of these four genes compared to their GFP-dsRNA controls.Knockdown of the target genes was verified by real-time polymerase chain reaction for two genes important for reproduction (RpL8,RpL11)and one gene important for survival (Pros26S). In conclusion,through RNA interference,we have discovered two genes important for mite survival and four genes important for mite reproduction.These genes could be explored as possible targets for the control of Varroa destructor in the future. | Zachary Y.Huang Guowu Bian Zhiyong Xi Xianbing Xie | 2019 | Insect Science2019，26，1： | 3 |
| 6 | The second (main) phase of an open, randomised, multicentre study to investigate the effectiveness of an intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT2)显示文摘 | C.Delcourt Y.Huang J.Wang E.Heeley R.Lindley C.Stapf C.Tzourio H.Arima M.Parsons J.Sun B.Neal J.Chalmers C.Anderson | 2010 | International Journal of Stroke2010，，： | 1 |
| 7 | Material and structural instabilities of single-wall carbon nanotubes显示文摘非线性的原子论的相互作用通常涉及弄软行为。直接源于这弄软的不稳定性被称为材料不稳定性,当对这弄软无关的那些被称为结构的不稳定性时。我们使用有限变丑的壳理论基于内部证明单个墙的碳 nanotubes 的紧张不稳定性是材料不稳定性的原子电位,当压缩和扭转不稳定性是结构的时不稳定性。 | J.Wu K.C.Hwang J.Song Y.Huang | 2008 | Acta Mechanica Sinica2008，24，3： | 1 |
| 8 | 查看详情显示文摘 | Y.Qiao Y.Huang C.Qiu | | 0，，： | 1 |
| 9 | Hydrogen permeation behavior and corrosion monitoring of steel in cyclic wet–dry atmospheric environment显示文摘 | C.Zheng Y.Huang C.Huo Q.Yu | 2007 | Materials and Corrosion2007，，9： | 1 |
| 10 | Z-source inverter for motor drives显示文摘 | F.Z.Peng A.Joseph J.Wang M.S.Shen L.H.Chen Z.G.Pan E.Ortiz-Rivera Y.Huang | | 0，，04： | 1 |
| 11 | Z-source inverter for residential photovoltaic systems显示文摘 | Y.Huang M.S.Shen F.Z.Peng J.Wang | | 0，，06： | 1 |
| 12 | Techno-economic assessment of pulverized coal boilers and IGCC power plants with CO_(2) capture显示文摘The current studies on power plant technologies suggest that Integrated Gasification Combined Cycle(IGCC)systems are an effective and economic CO_(2) capture technology pathway.In addition,the system in conventional configuration has the advantage of being more“CO_(2) capture ready”than other technologies.Pulverized coal boilers(PC)have,however,proven high technical performance attributes and are economically often most practical technologies.To highlight the pros and cons of both technologies in connection with an integrated CO_(2) capture,a comparative analysis of ultrasupercritical PC and IGCC is carried out in this paper.The technical design,the mass and energy balance and the system optimizations are implemented by using the ECLIPSE chemical plant simulation software package.Built upon these technologies,the CO_(2) capture facilities are incorporated within the system.The most appropriate CO_(2) capture systems for the PC system selected for this work are the oxy-fuel system and the postcombustion scheme using Monoethanolamine solvent scrubber column(MEA).The IGCC systems are designed in two configurations:Water gas shift reactor and Selexol-based separation.Both options generate CO_(2)-rich and hydrogen rich-gas streams.Following the comparative analysis of the technical performance attributes of the above cycles,the economic assessment is carried out using the economic toolbox of ECLIPSE is seamlessly connected to the results of the mass and energy balance as well as the utility usages.The total cost assessment is implemented according to the stepcount exponential costing method using the dominant factors and/or a combination of parameters.Subsequently,based on a set of assumptions,the net present value estimation is implemented to calculate the breakeven electricity selling prices and the CO_(2) avoidance cost. | Y.HUANG S.REZVANI D.McILVEEN-WRIGHT N.HEWITT A.MINCHENER J.MONDOL | 2010 | Frontiers of Chemical Science and Engineering2010，4，2： | 1 |
| 13 | 查看详情显示文摘 | G.Xu Jr.C.M.Torres J.Tang J.Bai E.B.Song Y.Huang X.Duan Y.Zhang and K.L.Wang | | 0，，03： | 1 |
| 14 | 查看详情显示文摘 | J.Bai R.Cheng F.Xiu L.Liao MWang A.Shailos K.L.Wang Y.Huang and X.Duan | | 0，，09： | 1 |
| 15 | Tomographic reconstruction of the Earth’s magnetosheath from multiple spacecraft:a theoretical study显示文摘Following our earlier work on tomographic reconstruction of the magnetosheath soft X-ray emissions with superposed epoch analysis of many images recorded from a single spacecraft we now explore the instantaneous reconstruction of the magnetosheath and magnetopause using a few images recorded simultaneously from a few spacecraft.This work is motivated by the prospect of possibly having two or three soft X-ray imagers in space in the coming years,and that many phenomena which occur at the magnetopause boundary,such as reconnection events and pressure pulse responses,do not lend themselves as well to superposed epoch analysis.If the reconstruction is successful-which we demonstrate in this paper that it can be-this collection of imagers can be used to reconstruct the magnetosheath and magnetopause from a single image from each spacecraft,allowing for high time resolution reconstructions.In this paper we explore the reconstruction using,two,three,and four spacecraft.We show that the location of the subsolar point of the magnetopause can be determined with just two satellites,and that volume emissions of soft X-rays,and the shape of the boundary,can be reconstructed using three or more satellites. | A.M.Jorgensen TianRan Sun Y.Huang L.Li R.Xu L.Dai Chi Wang | 2024 | Earth and Planetary Physics2024，8，1： | 1 |
| 16 | Dissemination of multidrug‐resistant, class?1 integron‐carrying Acinetobacter baumannii isolates in Taiwan显示文摘 | L.‐Y.Huang T.‐L.Chen P.‐L.Lu C.‐A.Tsai W.‐L.Cho F.‐Y.Chang C.‐P.Fung L. K.Siu | 2008 | Clinical Microbiology and Infection2008，，11： | 1 |
| 17 | Long‐term outcome of resection of large hepatocellular carcinoma显示文摘 | X.‐P.Chen F.‐Z.Qiu Z.‐D.Wu Z.‐W.Zhang Z.‐Y.Huang Y.‐FChen | 2006 | Br J Surg2006，，5： | 1 |
| 18 | Increased colonic motility in a rat model of irritable bowel syndrome is associated with up‐regulation of L‐type calcium channels in colonic smooth muscle cells显示文摘 | M.Zhang F.‐p.Leung Y.Huang Z.‐x.Bian | 2010 | Neurogastroenterology & Motility2010，，5： | 1 |
| 19 | Single nucleotide polymorphisms in the ORM1-like 3 gene associated with childhood asthma in a Chinese population显示文摘 | F.F.Yang Y.Huang Q.B.Li2 | | 0，，04： | 1 |
| 20 | Electron backscatter diffraction of grain and subgrain structures — resolution considerations显示文摘 | F. J.HUMPHREYS Y.HUANG I.BROUGH C.HARRIS | 2003 | Journal of Microscopy2003，，3： | 1 |
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