| 2 | 血小板活化因子在缺血再灌注损伤中电生理作用的实验研究显示文摘目的 研究正常灌注、模拟缺血 /再灌注下血小板活化因子的电生理作用 ,初步探讨血小板活化因子的作用机制。方法 通过标准微电极技术 ,分析豚鼠左心室乳头肌在正常灌注、缺血 /再灌注时的血小板活化因子的电生理作用以及CV 6 2 0 9和格列本脲对其作用的影响。结果 血小板活化因子明显缩短了动作电位时相 ,灌注前后APD90 (90 %复极水平的动作电位时相 )分别为 (14 4 0± 5 8)ms和 (12 0 3±5 8)ms (n =8,P <0 0 0 1) ,CV 6 2 0 9(血小板活化因子受体阻断剂 )和格列本脲 (ATP敏感性K+ 通道阻断剂 )明显抑制了血小板活化因子诱发的动作电位持续时间缩短。CV 6 2 0 9组 (n =5 )、格列本脲组 (n =6 )和对照组相比较 ,血小板活化因子诱发的APD90 缩短率分别为 (5 8± 1 9) % ,(1 1± 1 9) %比 (16 4±1 8) % (P <0 0 5 ,P <0 0 0 1)。血小板活化因子引起了早期的动作电位持续时间的进一步缩短 ,相反 ,血小板活化因子引起再灌注早期的动作电位时相延长。结论 血小板活化因子明显缩短了动作电位时相 ,CV 6 2 0 9和格列本脲阻断血小板活化因子诱发的动作电位持续时间缩短 ,提示血小板活化因子受体和ATP敏感性K+ 通道 ,可能介入血小板活化因子电生理作用 ;血小板活化因子放大缺血 /再灌注时缺血区和? | 张国强 顾承东 Y.Kurata S.Imanishi Matsui 柴枝楠 | 2002 | 中华急诊医学杂志2002，11，6： | 2 |
| 3 | APPLICABILITY OF CREEP CONSTITUTIVE EQUATIONS TOCREEP CURVES UNDER CONSTANT LOAD显示文摘Applicability of the following creep constitutive equations was investigated for normal type creep curves of Ni-18.5Cr alloy and tertiary creep dominant curves of Ni-18.5Cr16W alloy under constant load: the θ projection method describing a creep curse by a sum of two exponential terms, modified θ method describing a primary creep stage by an exponential term and a tertiary creep stage by a logarithmic term, modified Ω method describing a creep curve by a sum of two logarithmic term, 2θ method with only a tertiary creep component and Ω method. The θ, modified θ and modified Ω methods can describe normal type and tertiary creep dominant curves. Tertiary creep dominant curves of Ni-18.5Cr-16W alloy at 900℃ are also described using 2θ and Ω methods. Applicability of the modified θ and modified Ω methods is superior for constant load creep curves because they can predict creep curves up to rupture and rupture life accurately and conservatively. | Y.Kurata H.Utsumi | 1998 | Acta Metallurgica Sinica(English Letters)1998，11，6： | 0 |
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