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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | Initial/final state selection of the spin polarization in electron tunneling across an epitaxial Fe/GaA(OOI) interface显示文摘 | KUREBAYASHI H STEINMULLER S J LALOE J B TRYPINIOTIS T EASTON S IONESCU A YATES J R BLAND J A C | 2007 | Appl Phys Lett2007，91，10： | 1 |
| 3 | Canine distemper epizootic in lions,tigers,and leopards in North America显示文摘 | APPEL M J YATES R A FOLEY G L | 1994 | J Vet Diagn Invest1994，6，3： | 1 |
| 4 | A catalytic loop within Pseudomonas aerugi nosa exotoxin A modulates its transferase activity显示文摘 | Yates S P Merrill A R | 2001 | J Biol Chem2001，276，35： | 1 |
| 5 | Persistence of maternal antibodies against Mycoplasma agassizii in desert tortoise hatchlings显示文摘 | SCHUMACHER I M ROSTAL D C YATES R A | 1999 | Am J Vet Res1999，60，： | 1 |
| 6 | Estimating soil water content using cokriging显示文摘 | Yates S R Warrick A W | 1987 | Soil Science Society of America Journal1987，51，： | 1 |
| 7 | Using the Precede - proceed model of health program planning in breast cancer nursing re- search显示文摘 | Tramm R McCarthy A Yates P | 2012 | J Adv Nuts2012，68，8： | 1 |
| 8 | The effect of alkali metals on combustion and pyrolysis of Lolium and Festuca grasses,switchgrass and willow显示文摘 | FAHMI R BRIDGWATER A DARVELL L JONES J YATES N THAIN S DONNISON I | 2007 | Fuel2007，86，10： | 1 |
| 9 | Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomona aerug/nosa exotoxin A 显示文摘 | Yates S P and Merrill A R | 2004 | The Biochemical Journal2004，379，： | 1 |
| 10 | Dynamic Interaction of DNA Damage Checkpoint Protein Rad53 with Chromatin Assembly Factor Asf1显示文摘 | Emili A Schieltz D M Yates J R | 2001 | Mol Cell2001，7，1： | 1 |
| 11 | IP-10 blocks vascular endothelial growth factor-induced endothelial cell motility and tube formation via inhibition of calpain显示文摘 | Bodnar R J Yates C C Wells A | 2006 | Circ Res2006，98，5： | 1 |
| 12 | Changes in vanilloid receptor 1 ( TRPV1 ) expression following lingual nerve injury 显示文摘 | Biggs J E Yates J M Loescher A R | 2007 | Eur J Pain2007，11，2： | 1 |
| 13 | Analysis of steroid hormones in a typical dairy waste disposal system显示文摘 | Zheng W Yates S R Bradford S A | 2008 | Environmental Science and Technology2008，42，2： | 1 |
| 14 | Spark ignition parameters of cryogenic hydrogen in oxygen and nitrogen mixture显示文摘 | Yate G B Pel A R | 1964 | Advance in Cryogenic Engineering 101964，，： | 1 |
| 15 | Increased nitric oxide in exhaled air of asthmatic patients显示文摘 | KHARITONOV S A YATES D ROBBINS R A | 1994 | Lancet1994，343，8890： | 1 |
| 16 | Hyperglycemia is a marker for poor outcome in the post- operative pediatric cardiac patient 显示文摘 | YATES A R DYKE PC II TAEED R | 2006 | Pediatr Crit Care Med2006，7，： | 1 |
| 17 | GutenTag: High-throughput sequence tagging via an empirically derived fragmentation model显示文摘 | Tabb D L Saraf A Yates Iii J R | 2003 | Anal Chem2003，75，： | 1 |
| 18 | Effect of Propargyl Bromide and 1,3-Dichloropropene on Microbial Communi- ties in an Organically Amended Soil显示文摘 | DUNGAN R S IBEKWE A M YATES S R | 2003 | FEMS Microbiol Ecol2003，43，1： | 1 |
| 19 | Canine distemper in terrestrial carnivores: a review显示文摘 | Deem S L Spelman L H Yates R A | 2000 | Zoo Wild Med2000，31，： | 1 |
| 20 | IP-10 blocks VEGF-induced endothelial cell motility and tube formation via inhibition of calpain显示文摘 | Bodnar R Yates C Wells A | 2006 | Circ Res2006，98，： | 1 |
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