|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Inhibition of Cdk5 increases osteoblast differentiation and bone mass and improves fracture healing显示文摘Identification of regulators of osteoblastogenesis that can be pharmacologically targeted is a major goal in combating osteoporosis,a common disease of the elderly population. Here, unbiased kinome RNAi screening in primary murine osteoblasts identified cyclin-dependent kinase 5(Cdk5) as a suppressor of osteoblast differentiation in both murine and human preosteoblastic cells. Cdk5 knockdown by si RNA, genetic deletion using the Cre-lox P system, or inhibition with the small molecule roscovitine enhanced osteoblastogenesis in vitro. Roscovitine treatment significantly enhanced bone mass by increasing osteoblastogenesis and improved fracture healing in mice. Mechanistically, downregulation of Cdk5 expression increased Erk phosphorylation, resulting in enhanced osteoblast-specific gene expression. Notably, simultaneous Cdk5 and Erk depletion abrogated the osteoblastogenesis conferred by Cdk5 depletion alone, suggesting that Cdk5 regulates osteoblast differentiation through MAPK pathway modulation. We conclude that Cdk5 is a potential therapeutic target to treat osteoporosis and improve fracture healing. | Mubashir Ahmad Benjamin Thilo Krüger Torsten Kroll Sabine Vettorazzi Ann-Kristin Dorn Florian Mengele Sooyeon Lee Sayantan Nandi Dilay Yilmaz Miriam Stolz Naveen Kumar Tangudu David Carro Vázquez Johanna Pachmayr Ion Cristian Cirstea Maja Vujic Spasic Aspasia Ploubidou Anita Ignatius Jan Tuckermann | 2022 | Bone Research2022，10，3： | 2 |
| 2 | Perivascular epithehoid cell tumor ( PEComa ) of the uterine cervix associated with entraabdominal PEComatosis: Aclinicopathological study with comparative genomic hybridization analysis 显示文摘 | Fadare O Parkash V Yilmaz Y | 2004 | World J Surg Oncol2004，2，： | 1 |
| 3 | Changes in oxygen satura- tion in patients undergoing fiberoptie bronchoscopy显示文摘 | Yildiz P OzgiJl A Yilmaz V | 2002 | Chest2002，121，3： | 1 |
| 4 | Thermal de- composition of β- cyclodextrin inclusion complexes of ferrocene and their derivatives 显示文摘 | Yilmaz V T Karadag A Icbudak H | 1995 | Thermochimica Acta1995，261，： | 1 |
| 5 | The use of tacker and arthroscopy cannules in SILS cholecystectomy 显示文摘 | Ertem M Ozben V Yilmaz S | 2010 | J Laparoendosc Adv Surg Tech A2010，20，6： | 1 |
| 6 | Di-and Tetranuclear Silver(I)-Saecharinate Complexes with 2-Pyridineethanol and 2- Pyridinepropanol : Syntheses, Crystal Structures, Spectroscopic and Thermal Analyses of l-Agz (Sac) 2 (Pyet) z-1 and 显示文摘 | Yilmaz V T Hamamci S Harrison W T A | 2005 | Polyhedron2005，24，1： | 1 |
| 7 | The effects of using lime andstyrene-butadiene-styrene on moisture sensitivity resistanceof hot mix asphalt 显示文摘 | KOK B V YILMAZ M | 2009 | Construction and BuildingMaterials2009，23，5： | 1 |
| 8 | A Three-Dimensional Lead(Ⅱ) Polymer with Bridging Saccharinate and Unusually Coordinated Acetate Ligand-Synthesis, IR Spectra and Crystal Structure of 显示文摘 | V T Yilmaz S Hamamci O Andac | 2003 | Z Anorg Allg Chem2003，629，： | 1 |
| 9 | Decreased total antioxidant status and increased oxidative stress in women with polycystico vary syndrome may contribute to the risk of cardiovascular disease显示文摘 | Fenkci V Fenkci S Yilmazer M | 2003 | Fertil Steril2003，80，1： | 1 |
| 10 | Risk driving attitudes and self-reported traffic violations among turkish drivers : thecase of eskisehir显示文摘 | Yilmaz V?Celik H E | 2006 | Dogus Universitesi Dergisi2006，7，1： | 1 |
| 11 | Crystal structure and physico-chemical properties of diaquabis (1,10-phenan-throline) manganese (Ⅱ) disaccharinate monohydrate显示文摘 | YILMAZ V T YILMAZ F TOPCU Y | 2001 | Journal of Molecular Structure2001，560，： | 1 |
| 12 | IL - 12 and IL - 10 polymorphisms and their effects on cytokine production 显示文摘 | Yilmaz V Yentllr SP Saruhan - Direskeneli G | 2005 | Cytokine2005，30，4： | 1 |
| 13 | Aortic pulse pressure and aortic pul satil ity in patients with coronary slow flow显示文摘 | Guray U Guray Y Yilmaz V | 2007 | Cardiology2007，107，4： | 1 |
| 14 | A model for risky driving attitudes in Turkey 显示文摘 | YILMAZ V CELIK H E | 2004 | Social Behavior and Personality:an International Jour- nal2004，32，8： | 1 |
| 15 | Reaction of alkali - resistant glass fibers with cement 显示文摘 | YILMAZ V T GLASSER F P | 1991 | Glass Technology1991，32，3： | 1 |
| 16 | Selective solid phase extraction of copper using a new Cu ( II ) -imprinted poly- mer and determination by inductively coupled plasma op-tical emission spectroscopy (ICP-OES) 显示文摘 | Yilmaz V Arslan Z Hazer O | 2014 | Microchemi- cal Journal Devoted to the Application of Microtechniques in all Branches of Science2014，114，： | 1 |
| 17 | Expression of matrix metalloproteinases 2 and 9 in donor liver,cirrhotic liver,and acute rejection after human liver transplantation显示文摘 | Kirimlioglu H Kirimlioglu V Yilmaz S | 2008 | Transplant Proc2008，40，10： | 1 |
| 18 | Examining of Chemical Fertilizer Use Levels in Terms of Agriculture Environment Relations and Eco- nomic Losses in the Agricultural Farms: The Case of Isparta, Turkey显示文摘 | Yilmaz H Demircan V Gul M | 2010 | Bulgarian Journal of Agricuhural Science2010，16，2： | 1 |
| 19 | Selectivemethane bromination over sulfated zirconia in SBA - 15catalysts显示文摘 | DEGIRMENCI V YILMAZ A UNER D | 2009 | Catalysis Today2009，142，： | 1 |
| 20 | An unusual form of intraeardiae throm- bosis and fibrinolytic process in a ehild with dilated cardiomyopathy显示文摘 | Yilmazer MM Guven B Tavli V | 2010 | Acta Cardiol2010，65，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员