|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Design,synthesis,and anti-inflammatory evaluation of a series of novel amino acid-binding 1,5-diarylpyrazole derivatives显示文摘Aim: To design and synthesize a series of novel amino acid-binding 1,5-diarylpyrazole derivatives, which are intended to act as prodrugs with better aqueous solubility than celecoxib, and which will exert potent anti-inflammatory activi-ties after being converted to their parent compounds in vivo. Methods: To introduce an amino acid, celecoxib analogs containing amino or methylamino group were synthesized first through multi-step chemical reactions. All the synthesized compounds were screened in an intact cell-based assay in vitro and in carrageenan-induced mouse paw edema in vivo. Some active compounds were selected for further evaluation in a carrageenan-induced rat paw edema model. The preliminary pharmacokinetics experiments were conducted using high performance liquid chromatography/mass spectrometry (HPLC/MS). Results: Celecoxib, 6 of the 1,5-diarylpyrazole class of celecoxib analogs, and their amino acid derivatives (hydrochloride salts) were synthesized. In vitro screening, the hydrochloride salts showed decreased inhibitory effects on cyclooxygenase (COX)- 1 and COX-2 compared with their parent compounds, but some exhibited potent anti-inflammatory activity in vivo. Compound 4a was selected for further evaluation, and its anti-inflammatory effect was equivalent to that of celecoxib after oral administration in the carrageenan-induced rat paw edema model. At three doses (25 mg/kg, 50 mg/kg, and 100 mg/kg) the percentage inhibition on edema was 20.7%, 52.6%, and 62.6% (for compound 4a) and 27.8%, 38.4%, and 40.1% (for celecoxib), respectively. Preliminary pharmacokinetic evaluations support the hypothesis that compound 4a was actually converted to its parent compound, compound 4. Conclusion: The compound bound with amino acid acts like prodrug, which can exert anti-inflammatory effect similar to celecoxib after being converted to its parent compound. This finding will be of great benefit in carrying out structural modifications of prodrug-like selective COX-2 inhibitors. | Li MH Yin LL Cai MJ Zhang WY Huang Y Wang X Zhu XZ Shen JK | 2005 | Acta Pharmacologica Sinica2005，26，7： | 2 |
| 3 | PF-04691502, a potent and selective oral inhibitor of PI3K and roTOR kinases with antitumor activity显示文摘 | Yuan J Mehta PP Yin MJ | 2011 | Mol Cancer Ther2011，10，11： | 1 |
| 4 | Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated显示文摘 | Eis MJ Yin M | 1995 | Proc Natl Acad Sci USA1995，92，12： | 1 |
| 5 | TAT-mediated delivery of Bel-xL protein is neuroprotective against neonatal hypoxic-ischemic brain injury via inhibition of caspases and AIF显示文摘 | Yin W Cao G Johnnides MJ | 2006 | Neurobiol Dis2006，21，2： | 1 |
| 6 | Sulindac inhibits activation of the NF-kappaB pathway 显示文摘 | Yamamoto Y Yin MJ Lin KM | 1999 | J Biol Chem1999，274，27： | 1 |
| 7 | Role of AMP-activated protein kinase in cyclic AMP-dependent lipolysis In 3T3-LI adipocytes显示文摘 | Yin W Mu J Birnbaum MJ | 2003 | J Biol Chem2003，278，43： | 1 |
| 8 | Transmission disequilibrium test and haplotype analysis of the MCP-1-2518A/G polymorphism with Tourette syndrome in Chinese Harn trios显示文摘 | Wang MJ Yin YY Ren W | | 0，，： | 1 |
| 9 | The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis显示文摘 | Yin MJ Shao L Voehringer D | 2003 | J Biol Chem2003，278，52： | 1 |
| 10 | I kappa B kinase alpha (IKK alpha) regulation of IKK beta kinase activity显示文摘 | Yamamoto Y Yin MJ Gaynor RB | 2000 | Mol Cell Biol2000，20，10： | 1 |
| 11 | Clusterin inhibition using OGX-O11 synergistically enhances Hsp90 inhibitor activity by suppress- ing the heat shock response in eastrate-resistant prostate cancer 显示文摘 | Lamoureux F Thomas C Yin MJ | 2011 | Cancer Res2011，71，17： | 1 |
| 12 | Current and future national costs to medicare for the treatment of distal radius fracture in the e1derly显示文摘 | SHAUVER MJ YIN H BANERJEE M | 2011 | J Hand Surg Am2011，36，8： | 1 |
| 13 | Sulindac inhibits activation of the NF-κB pathway显示文摘 | Yamamoto Y Yin MJ Lin KM | 1999 | J Biol Ghem1999，74，8： | 1 |
| 14 | PF-04691502,a potent and selective oral inhibitor of PI3K and mTOR kinases with antitumor activity显示文摘 | Yuan J Mehta PP Yin MJ | 2011 | Mol Cancer Ther2011，10，： | 1 |
| 15 | The combination of CRISPR-MVLST and PFGE provides increased discriminatory power for differentiating human clinical isolates of Salmonella enterica subsp, enterica serovar Enteritidis显示文摘 | Shariat N DiMarzio MJ Yin S | 2013 | Food Microbiology2013，34，1： | 1 |
| 16 | The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta 显示文摘 | Yin MJ Yamamoto Y Gaynor RB | 1998 | Nature1998，396，6706： | 1 |
| 17 | Sulindac inhibits activation of the NF-kappa B pathway显示文摘 | Yamamoto Y Yin MJ Lin KM | 1999 | J Biol Chem1999，274，27： | 1 |
| 18 | Addictive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivio显示文摘 | Russell Yin R Caplan MJ | 1998 | circulation1998，98，： | 1 |
| 19 | A novel HSP90 inhibitor delays castrate-resistant PSA levels and inhibits prostate cancer without altering serum osteodastogenesis显示文摘 | Lamoureux F Thomas C Yin MJ | 2011 | Clin Cancer Res2011，17，8： | 1 |
| 20 | The anti - inflammatory agents aspirin and salicylate inhibit the activity of I(kappa) B kinase - beta 显示文摘 | Yin MJ Yamamoto Y Gaynor RB | 1998 | Nature1998，396，6706： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员