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| 1 | Original article Efficacy and safety of Changfu peritoneal dialysis solution: a multi-center prospective randomized controlled trial显示文摘 | ZHOU Jian-hui NI Zhao-hui MEI Chang-lin YU Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong YUAN Wei-jie ZHANG Ai-ping LIN Hong-li CHEN Meng-hua CHEN Jiang-hua ZHANG Jin-yuan HE Ya-ni CHEN Jian ZHAO Jiu-yang DING Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU Wen-hu XING Chang-ying WANG Rong DENG Yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YANG Xiao LIU Hong SUN Jing YU Yu-sheng LIU Jun SHI Shu-mei LI Long-kai TIAN Na ZHANG Xiao-hui ZHOU Wei YANG Jie ZHANG Yong SUN Jing-di JI Jun ZHANG Tao YAN Yan LIU Xiao-gang WANG Gang ZHANG Li ZHANG Hong LUO Jian-hua CHEN Xiang-mei | 2013 | Chinese Medical Journal2013，，22： | 4 |
| 2 | A comparative study of autogenous, allograft and artificial bone substitutes on bone regeneration and immunotoxicity in rat femur defect model显示文摘Repair and reconstruction of large bone defect were often difficult,and bone substitute materials,including autogenous bone,allogenic bone and artificial bone,were common treatment strategies.The key to elucidate the clinical effect of these bone repair materials was to study their osteogenic capacity and immunotoxicological compatibility.In this paper,the mechanical properties,micro-CT imaging analysis,digital image analysis and histological slice analysis of the three bone grafts were investigated and compared after different time points of implantation in rat femur defect model.Autogenous bone and biphasic calcium phosphate particular artificial bone containing 61.4% HA and 38.6%β-tricalcium phosphate with 61.64%porosity and 0.8617±0.0068 g/cm^(3) den-sity(d≤2 mm)had similar and strong bone repair ability,but autogenous bone implant materials caused greater secondary damage to experimental animals;allogenic bone exhibited poor bone defect repair ability.At the early stage of implantation,the immunological indexes such as Immunoglobulin G,Immunoglobulin M concentration and CD4 cells'population of allogenic bone significantly increased in compared with those of autologous bone and artificial bone.Although the repair process of artificial bone was relatively inefficient than autologous bone graft,the low immunotoxicological indexes and acceptable therapeutic effects endowed it as an excellent alter-native material to solve the problems with insufficient source and secondary trauma of autogenous bone. | Wen Zou Xing Li Na Li Tianwei Guo Yongfu Cai Xiaoqin Yang Jie Liang Yong Sun Yujiang Fan | 2021 | Regenerative Biomaterials2021，8，1： | 3 |
| 3 | Pseudomonas syringae Effector AvrPto Blocks Innate Immunity by Targeting Receptor Kinases显示文摘 | Tingting Xiang Na Zong Yan Zou Yong Wu Jie Zhang Weiman Xing Yan Li Xiaoyan Tang Lihuang Zhu Jijie Chai Jian-Min Zhou | 2008 | Current Biology2008，，1： | 1 |
| 4 | Biomimetic inorganic-organic hybrid nanoparticles from magnesium-substituted amorphous calcium phosphate clusters and polyacrylic acid molecules显示文摘Amorphous calcium phosphate(ACP)has been widely found during bone and tooth biomineralization,but the meta-stability and labile nature limit further biomedical applications.The present study found that the chelation of polyacrylic acid(PAA)molecules with Ca^(2+)ions in Mg-ACP clusters(~2.1±0.5 nm)using a biomineralization strategy produced inorganic-organic Mg-ACP/PAA hybrid nanoparticles with better thermal stability.Mg-ACP/PAA hybrid nanoparticles(~24.0±4.8 nm)were pH-responsive and could be efficiently digested under weak acidic conditions(pH 5.0-5.5).The internalization of assembled Mg-ACP/PAA nanoparticles by MC3T3-E1 cells occurred through endocytosis,indicated by laser scanning confocal microscopy and cryo-soft X-ray tomography.Our results showed that cellular lipid membranes remained intact without pore formation after Mg-ACP/PAA particle penetration.The assembled Mg-ACP/PAA particles could be digested in cell lysosomes within 24 h under weak acidic conditions,thereby indicating the potential to efficiently deliver encapsulated functional molecules.Both the in vitro and in vivo results preliminarily demonstrated good biosafety of the inorganic-organic Mg-ACP/PAA hybrid nanoparticles,which may have potential for biomedical applications. | Na Li Wei Cui Peifang Cong Jie Tang Yong Guan Caihao Huang Yunen Liu Chengzhong Yu Rui Yang Xing Zhang | 2021 | Bioactive Materials2021，6，8： | 1 |
| 5 | Increment of hFIX expression with endogenous intron 1 in vitro显示文摘This paper probes into the feasibility of increasing expression level of hFIX gene with endogenous nitron 1 sequence. hFIX minigene was obtained with middle sequence truncated nitron 1 inserted into the relative site of hFIX cDNA, and plasmid vector pKG5i’IX, retroviral vector GINaCi’IX were constructed. These vectors were transduced into target cells of PA317, C2C12, primary rabbit skin fibroblasts (RSF) and primary human skin fibroblasts (HSF). The expression level of mixed colonies are PA317/pKG5i’IX, 151 'g/106 cells/24h; PA317/GINaCi’IX, 308ng/106 cells/24 h; C2C12/G1 NaCi’IX, 186 ng/106 cells/24 h; RSF/GINaCi’IX, 1929 ng/106 cells/24 h; HSF/GlNaCi’IX, 1646 ng/106 cells/ 24 h. These results indicated that hFIX minigene with nitron 1 is able to increase the expression level to about 3 times of that of hFIX cDNA. Meanwhile, in order to study the application of hFIX minigene in the retroviral-mediated gene transfer system and refrain from nitron splicing during viral production, a retroviral vector GlNaCi’IXR with reversely inserted hFIX minigene expression cassette was constructed. The expression level of reverse constructor in PA317 cells was 390 ng/106 cells/24 h with 79% of bioactivity. PCR detection of HT/GlNaCi’IXR cells infected with PA317/ClNaCi’IXR supernatant confirmed the existence of nitron 1 sequence. These results suggested that expression vector with forward-inserted intronl-carrying hFIX expression cassette can be used in directed gene Human factor IX expression with nitron transfer, but when using the retroviral-mediated gene transfer system, reversely-inserted intronl-carrying hFIX expression cassette should be considered. | ZHENG BING XIAO YUN QIU MIN TAN YONG NA XING DARU LU JING LUN XUE XIN FANG QIU(Institute of Genetics, Fudan Univerisity, Shanghai 200433) | 1997 | Cell Research1997，7，1： | 0 |
| 6 | Synthesis of micron-sized hollow silica spheres with a novel mesoporous shell of MCF显示文摘其壳由中央组成是细胞的硅石泡沫(MCF ) 的微米大小的空硅石范围被一个壶 sol– 综合了;在 benzene/water/P123 的胶化方法乳剂。材料与 SEM, TEM,赌注和 29 Si 妈 NMR。结果证明空硅石范围的唯一的壳的 MCF 在直径与 10 nm 的狭窄的分布由大窗户被连接,空范围的内部空间是可存取的。并且空硅石范围的形成机制被建议。 | An Feng Zhang Yong Chun Zhang Na Xing Ke Ke Hou Jing Wang Xin Wen Guo | 2009 | Chinese Chemical Letters2009，20，7： | 0 |
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